3859 results about "Coronary heart disease" patented technology

Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.

An apparatus for electrocardiogram measurement including a first non-conductive pad. A first and second electrode are disposed on the first non-conductive pad. The first electrode represents any one of V₄, V₅, or V₆ and the second electrode is either (i) positioned on the subject below the first electrode in order to represent left leg (LL) or (ii) is placed on a line on the subject defined by the V₄, V₅, and V₆ precordial positions in order to represent any one of V₄, V₅, or V₆ not represented by the first electrode. The apparatus includes a second non-conductive pad. A third electrode is disposed on the second non-conductive pad. The third electrode is a right arm (RA) electrode that is for positioning at a position that is on or close to the right arm of the subject. Each electrode is adapted for electrical connection with the skin in order to receive and transmit electrical impulses. The apparatus further includes an electrical connection that connects each electrode disposed on the first and second non-conductive pads to an electrocardiological measuring apparatus. The electrocardiological measuring apparatus is capable of measuring a first lead and a different second lead without user intervention.

The present invention relates to traditional Chinese medicine for treating coronary heart disease and stenocardia is made from (by wt.%) salvia root 50-97%, notoginseng 2-48% and borneol 0.2-3%, in which the salvia root and notoginseng and hot extracted with water, then filtering, concentrating, alcohol precipitating, standing still, recovering ethyl alcohol, concentrating, into extractum, further blended with borneol and adjuvant polyglycol-6000 to form into product.

Methods and devices are provided for applying retrograde perfusion of blood at various locations within the body. In certain exemplary embodiments, the methods and devices are particularly useful during open or translumenal surgical approaches to apply long-term retrograde perfusion of the myocardium, the neurosystem, or a periphery, such as the arm or leg, thereby treating various medical conditions, such as coronary artery disease, stroke, renal failure, etc.

The present invention provides one medicine composition for treating coronary heat disease ventricular premature beat based on the Chinese medicine theory of benefiting vital energy, nourishing Yin, promoting blood circulation, dredging meridian, clearing away heat-evil in the pericardium and tranquilizing. The medicine composition has 12 kinds of Chinese medicinal materials including ginseng, ophiopogon root, dogwood, red sage, common jujube seed, etc. The pharmacological test shows that the composite medicine capsule has obvious effect of preventing mouse's arrhythmia caused by CaCl2 and decreasing the sustained time of rat's arrhythmia caused by aconitine.

The invention discloses a noninvasive continuous human body arterial blood pressure measuring method and equipment. The noninvasive continuous human body central arterial blood pressure measuring method comprises the steps as follows: calculating individualization parameters of a to-be-measured person artery blood vessel network model according to acquired pulse wave forms of radial arteries and brachial arteries; calculating radial artery blood pressure systolic pressure, diastolic pressure and blood pressure wave forms according to radial artery pulse wave speeds and artery blood vessel network parameters; calculating ascending aorta-radial artery transfer functions; further calculating central arterial blood pressure. The noninvasive continuous human body central arterial blood pressure measuring equipment consists of a signal processing and analyzing unit, a pulse wave and motion signal acquisition unit worn on the wrist as well as an electro-cardio and motion signal acquisition unit worn in front of the chest. According to the method and the equipment, electrocardiograms, the radial artery blood pressure, the central arterial blood pressure as well as motions and postures are monitored simultaneously, heart rate and electro-cardio morphological parameters are analyzed in various motion states, artery network model parameters and blood pressure parameters, particularly central arterial pressure wave form parameters, are analyzed, and the method and the equipment have great significance for prevention and control on cardiovascular diseases, particularly for prevention and control on high-risk diseases such as the hypertension, the coronary heart disease and the like.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or/and 22, or/and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

A method for reconstructing 3D blood vessels belongs to the field of medical detection technology for solving the accuracy problem in blood vessel reconstruction. The technical scheme is that the method can accurately reconstruct the anatomic structure of a blood vessel by combining cross section information of the blood vessel acquired by an IVUS image sequence and ultrasonic duct spatial geometrical information obtained by 3D reconstruction based on X-ray angiographic images. Compared with the reconstruction result obtained by using two single images, the method can completely and accurately reflect the actual shapes of blood vessels and possibly-existing plaques, thus providing more reliable basis for clinical treatment of coronary heart diseases and other angiopathies.

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

The invention relates to a production process of chewable tablets of barley shoot powder and a product thereof and belongs to the deep processing technology field of agricultural products. The production process is characterized in that the barley shoot powder is main base material, and the chewable tablets of the barley shoot powder with smooth appearance, green color and crispness and freshness is made after the processes of composite stabilizer, making soft material, granulation, drying, tabletting, sterilization and packing. The method has the advantages of simple process, higher industrialization degree, low production cost, realizing the full utilization of the barley shoot and promoting the added value of the barley shoot. The chewable tablets of the barley shoot powder produced by the invention which is leisure-base health care food can fully enhance physique and body immune, simultaneously has the function of catharsis, reducing blood lipid and preventing cerebral thrombosis and coronary heart disease.

The invention provides compound probiotics fermented Chinese herbal medicine active health care liquid and a preparation method thereof. The health care liquid is prepared by the following raw materials: folium ginkgo, gingko pollen, fructus lycii, tea leaves, bacillus natto, saccharomyces cerevisiae, lactobacilli, acetobacter xylinum, bifidobactirium, white granulated sugar, brown sugar, defatted soy flour, honey, oligosaccharide, sodium chloride, deionized water and the like. The compound probiotics fermented Chinese herbal medicine active health care liquid integrates disease treatment and health care functions of several single products, contains Chinese herbal medicine active ingredients with the functions of preventing and treating hyperlipidemia, hyperglycemia and hypertension, preventing tumors and cancers, enhancing memory, protecting livers, improving immunity, preventing and treating coronary heart diseases, and also contains probiotics groups and metabolic products of the probiotics groups which can regulate balance in the stomach and intestines, resist aging, prolong the life, facilitate digestion, expel toxin for beauty, and prevent and treat thrombi, constipation and diarrhea. The health care liquid integrates health care and treatment, is very wide in market prospect, and conforms to the existing medical viewpoint of people that the prevention, health care, treatment and recovery are combined.

The invention relates to highly concentrated DHA and EPA formulations in a soft gel capsule. A capsule may contain at least 80% omega-3 fatty acids, salts or derivatives thereof, where EPA and DHA are present in relative amounts of greater than or equal to 3:1 or less than or equal to 1:3, and constitute at least 75% to greater than 95% of the total fatty acids present in the capsule. Capsules of the invention may be provided in a blister package so as to provide clean and protected oils that are easy to travel with. Compliance is improved with one-pill-a-day dosing and the days of the week imprinted on the foil packing. Anitoxidant protection may be provided by rosemary and vitamin C. The invention also provides a methods of treatment, modulation or prophalaxis of coronary disease, altering serum LDL-cholesterol and/or HDL-cholesterol, lowering serum triglycerides, lowering blood pressure, pulse rate, altering the activity of the blood coagulation factor VII complex, mild hypertension, protection from cyclosporine toxicity in kidney transplant, rheumatoid arthritis, development and progression of retinopathy, hypertriglyceridemia, and neurological disorders in a subject.

A system and method for acoustic detection of coronary artery disease (CAD) are provided. The system includes a transducer for acoustically detecting heart signals of a patient and a computer system which executes detection software for processing the detected heart signals to identify the presence of CAD from the heart signals. The software allows for the automatic definition of a diastolic “window” of the acoustic signal for analysis, and automatically edits the sampled acoustic signal to eliminate unwanted artifacts and/or noise in the acoustic signal. The edited signal is then processed by a plurality of signal processing algorithms, including spectral analysis algorithms, time-frequency algorithms, global feature algorithms, kurtosis algorithms, mutual information algorithms, negenthropy algorithms, and principal component analysis algorithms, to generate a disease vector. The disease vector is then classified to determine whether CAD is present in the patient. Classification can be accomplished using linear discriminant analysis or a support vector machine.

The invention relates to a quality control method of Yixinshu traditional chinese medicine preparation for nourishing qi, restoring pulse, and activating blood circulation to dissipate blood stasis, belonging to medicine domain. The Yixinshu traditional chinese medicine preparation is composed of panax, astragalus root, radix salviae miltiorrhizae, lityturf root, chinese magnoliaving, chuanxiong rhizome and haw, with ability of nourishing qi, restoring pulse, activating blood circulation to dissipate blood stasis, nourishing yin and production of body fluid, applicable for the patients who suffer for deficiency of both vital energu and yin, heart-throb knotted pulse, chest oppression, chest pain, and angina pectoris of coronary heart disease. At present, on clinical usage, it is applied extensively in the treatment of angina pectoris, myocardial ischemia, various type of arrhythmias, atrial premature beat, chest pain, angina pectoris of coronary heart disease and so on. The said quality control method provides the criterion of detection, means of detection, technical method and so on for the associated production and detection mechanism, therefore the quality of Yixinshu traditional chinese medicine preparation can be better controlled to ensure the safety of the said preparation. The quality method can better guide the production to make the production process control more strict and reasonable, therefore the users could have an overall acquaintance with the product quality.

The Chinese medicine for treating cardiac and cerebral vascular diseases is prepared with American ginseng, astragalus root, angelica, leatherleaf milletia, saffron and other 23 kinds of Chinese medicinal materials. It has the functions of dilating blood vessel, antagonizing coagulation, eliminating thrombus, improving blood circulation, etc. It is used in treating coronary heart disease, angina, myocardial ischemia and other cardiac and cerebral vascular diseases. It has the advantages of short treating period, fast acting, no resistance, no toxic side effect and high effective rate.

This invention also provides a method to prevent, control, and treata lipid metabolism disorder, a billary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases.

This invention relates to methods for performing myocardial perfusion imaging for diagnosing and characterizing coronary artery disease using an intravenous (IV) bolus injection of regadenoson while the patient is undergoing sub-maximal exercise.

A composite dispersing breviscapine tablet for treating apoplexy, coronary heart disease and angina pectoris is prepared from breviscapine (7-15 wt.%), excipient, disintegrant, diluent, lubricant, antisticking agent, pH regulator and sweetening agent. Its advantages are high disintegrating and dissolving speed in the water at 19-21 deg.C, fast absorption, and high biologic utilization rate.

The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes.

A oral-cavity effervescent talbet for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction, etc. is prepared from breviscapine, diluent, disintegrant, effervescent agent, flavouring, flowing aid,and lubricant.