69 results about "Arteriosclerosis" patented technology

The present invention relates to the use of an ROR inverse agonist or a pharmaceutically acceptable salt thereof for the preparation of a medicament for modulating ROR in a patient and / or for controlling autoimmune diseases and antibody-mediated rejection in a patient. The ROR-mediated diseases or autoimmune diseases include HIV, cancer, celiac disease, type 1 diabetes, Graves' disease (Graves' disease), inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, asthma, dermatitis, fatty liver disease, Crohn's disease (Crohn's disease), cardiovascular disease, inflammatory disease, nervous system disorders, multiple sclerosis, and the like. Acute respiratory distress syndrome and arteriosclerosis.

The invention belongs to the field of medicaments, and discloses a nano-medicinal preparation capable of treating diabetes and a preparation method of the nano-medicinal preparation. The preparation method comprises the following steps: carrying out hydrothermal reaction on fructose-1, 6-strontium diphosphate, vanadium pentoxide and ergothioneine to prepare strontium-vanadate organic framework nanoparticles; the strontium-vanadate organic framework nano-particles, dopamine and polylysine are blended, embedding of polydopamine is achieved under the alkaline condition, polylysine-polydopamine co-embedded organic framework nano-particles are formed, and the nano-drug preparation for treating diabetes is obtained. The nano medicinal preparation can release the vanadyl complex and the ergothioneine and improve the blood strontium concentration and the half-life period thereof, so that the blood sugar is controlled, the symptoms of diabetes mellitus are improved, and the symptoms of osteoporosis, arteriosclerosis and the like complicated by diabetes mellitus are improved.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating lower limb arteriosclerosis obliterans, which is technically characterized by being prepared from ten medicinal materials, namely red ginseng, astragalus membranaceus, cassia twig, morinda officinalis, cistanche deserticola, salvia miltiorrhiza, pseudo-ginseng, radix cyathulae, sargentgloryvine stem and semen brassicae according to a specific weight part ratio. Aiming at the core pathogenesis of yang deficiency and blood stasis of lower limb arteriosclerosis obliterans, the composition disclosed by the invention provides a treatment method of tonifying qi, warming yang, promoting blood circulation to remove blood stasis, removing speckles and dredging vessels, the compatibility of the whole formula is rigorous, and monarch, minister, assistant and guide are clear; moreover, the composition can be prepared into capsules or granules, is used for treating yang deficiency and blood stasis type lower limb arteriosclerosis obliterans, has an exact clinical curative effect, can remarkably improve symptoms of patients and lower limb blood flow, and is good in safety.

The invention belongs to the technical field of edible oil, and particularly relates to edible oil with a blood fat reducing effect and a preparation method of the edible oil. Comprising the following raw materials in parts by weight: 1 to 10 parts of base oil, 90 to 100 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride, 0.3 to 0.5 part of an emulsifier, 0.05 to 0.09 part of an antioxidant and 0.02 to 0.05 part of a stabilizer. The base oil is composed of the sunflower seed oil and the tea seed oil, and the base oil and the 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride are matched for use, so that the oil has a good blood fat reducing effect, and can effectively reduce cholesterol, maintain cardiovascular health and prevent arteriosclerosis. The antioxidant is composed of the vitamin E, the alpha-mangostin and the oryzanol, all the components have a synergistic effect and jointly improve the oxidation stability of the edible oil, and meanwhile, the antioxidant is matched with the stabilizer, so that the storage life of the edible oil can be effectively prolonged, and the storage stability is improved.

The invention discloses a remote ischemia adaptive hypertension treatment and risk assessment system based on artificial intelligence. The system comprises a physiological signal acquisition module, a preprocessing module, an artery function assessment module, a heart rhythm analysis module, a molecular biology assessment module, a user state association module and an assessment module. The physiological signal acquisition module is responsible for executing standard distant ischemia adaptation training and acquiring original data including systolic pressure, diastolic pressure, heart rate and pulse waveform data of upper limbs on two sides in real time in the execution process; the preprocessing module can sequentially carry out band-pass filtering, waveform segmentation and feature extraction processing on original data, then feature values extracted from single waveforms and the waveforms are combined to form a data set, and the data set is output. According to the method, arteriosclerosis can be evaluated, subclavian artery stenosis can be judged, and the nitric oxide amount can be calculated synchronously, so that fusion of multiple physiological data can be ensured in an adaptive treatment process, and meanwhile, multi-data joint evaluation is realized in combination with artificial intelligence.

The invention relates to a construction method of an arteriosclerosis risk assessment model, an arteriosclerosis risk assessment method, and application of an arteriosclerosis biomarker and a reagent for detecting the biomarker in preparation of a kit for predicting, preventing and / or treating arteriosclerosis. The construction method of the arteriosclerosis risk assessment model comprises the steps that correlation analysis is conducted based on genetic data and background data of a population to obtain correlation significance values corresponding to SNP loci, and the genetic data comprises the SNP loci and genotypes of the SNP loci; the arteriosclerosis risk assessment model is constructed on the basis of the SNP loci and the associated significance values corresponding to the SNP loci, and the arteriosclerosis risk assessment model comprises one or more of the SNP loci shown in the table 1. The arteriosclerosis risk assessment model obtained according to the construction method provided by the embodiment of the invention considers the specific genetic background, lifestyle, environmental factors and the like of Chinese population, the AUC of the obtained model reaches 0.693, and the arteriosclerosis risk of an individual to be analyzed can be accurately and effectively assessed.

The invention discloses a production method of meridian-dredging granules. The production method comprises the following steps: (1) extracting; putting salvia miltiorrhiza, ligusticum wallichii and radix puerariae into a decoction tank, and adding water for extraction to obtain an extracting solution; (2) concentrating the extracting solution to prepare extract; (3) weighing dextrin or soluble starch and sodium cyclamate to prepare base powder; step (4), granulating; adding the prepared extract into a spray trolley matched with a spray drying granulator, adding the base powder prepared in the step (3) into the spray drying granulator, spraying the extract into the spray drying granulator through the spray trolley, and intermittently shaking bags to prepare granules; step (5), granulating; step (6): total mixing; carrying out total mixing on the whole granules; step (7), sub-packaging; and packaging the totally mixed particles by using a particle packaging machine. The process links are simpler, the process flow is also obviously optimized, the process links are simpler, and the production efficiency is higher.

The invention discloses wheat malt seedling functional dietary fibers as well as a preparation method and application of the wheat malt seedling functional dietary fibers. The soluble dietary fiber and the insoluble dietary fiber of the wheat malt seedlings are extracted by adopting a wall breaking-extraction mode of synergy of biological enzyme and free radicals. The wheat malt seedling soluble dietary fibers can prolong the life of caenorhabditis elegans in an oxidative stress state, improve the antioxidant enzyme activity and improve the anti-apoptosis capability; the intestinal flora of the obese C57BL / 6J mouse induced by the high-fat feed is regulated; the wheat malt seedling insoluble dietary fiber has better binding water capacity, water-holding capacity and cholesterol and sodium cholate adsorption capacity, and can be used as a functional food additive for improving the texture and nutritional characteristics of food; and the wheat malt seedlings can also be used for assisting in reducing serum cholesterol level, preventing arteriosclerosis, promoting defecation, preventing constipation, colorectal cancer and the like in the field of health medical treatment, so that high-quality reutilization of the wheat malt seedlings is realized.

A genetically modified mesenchymal stem cell including an exogenous nucleic acid including a Klotho encoding region operably linked to a promoter or promoter / enhancer combination, wherein the genetically modified mesenchymal stem cell exhibits increased Klotho expression compared to an unmodified mesenchymal stem cell. Also disclosed are methods of treating a patient including administering a therapeutically effective number of the genetically modified mesenchymal stem cells to the patient. The methods of treatment include treating the patient for a neurodegenerative disease; cancer; organ fibrosis; renal disease; age-related changes of organs or organ systems; to slow, reverse and / or inhibit aging; arteriosclerosis; dementia; diabetes mellitus; erectile dysfunction; autoimmune diseases or autoimmune-related diseases; an inflammatory disease of the lung and sepsis.

The present invention relates to a composition comprising a complex extract of Coptis japonica, Phellodendron Chinensis, Scutellaria baicalensis, Gardenia jasminoides, and Rheum palmatum. The composition was confirmed to: reduce the levels of blood cholesterol, blood lipids, and blood LDL-cholesterol in patients with dyslipidemia; reduce systolic blood pressure without affecting diastolic blood pressure and pulse rate in patients with hypertension; reduce the level of pulse wave velocity (PWV), which is an indicator of arteriosclerosis, in patients with atherosclerosis, and inhibit the recurrence rate for up to 5 years in patients with cerebral infarction. Accordingly, the composition is provided as a therapeutic agent for dyslipidemia, hypertension, arteriosclerosis, or cerebral infarction. In particular, the composition is made into an encapsulated form rather than conventional decoctions, to reduce the content of geniposide, which is reported as a side effect component, and thus an optimal composition which maintains efficacy against dyslipidemia and does not cause side effects is provided.

The imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and / or spectral content of which are varied delivered through the same optical train including the set of apertures.

The application discloses 3-substituted coumarin derivatives 1a-14a and symmetrical biscoumarin derivatives 1b-25b and pharmaceutically acceptable salts, solvates or hydrates thereof. The compounds provided by the application are specific inhibitors of ATP citrate lyase (ACLY), and the half maximal inhibitory concentration (IC 50 ) of the former is 2-30 muM, and the IC 50 ) of the latter is 0.065-4 muM, so the compounds have potential therapeutic value for a plurality of diseases with abnormally high expression of ACLY, such as cancer, hyperlipidemia and arteriosclerotic cardiovascular diseases.

The application provides an artificial intelligence model and method for predicting a gut age index based on microbiome sequencing data; through a machine learning algorithm and a statistical bias correction method, an artificial intelligence machine learning gut age prediction model is constructed, and a correction value is calculated based on a health cohort, so that a gut age correction is performed on a data sample to be predicted, thereby calculating a gut age index; the prediction of the gut age and the GAI can be used in the fields of evaluation of a gut health condition and prediction of chronic diseases; and preclinical verification results of the application show that the application has a high accuracy rate, and the calculation accuracy rates of the GAI in 20 common chronic diseases, such as metabolic syndrome, obesity and cardiovascular diseases, are between 65.9% and 74.8%, wherein the accuracy rate of arteriosclerosis is as high as 74.8%; the method also has the advantages of good characteristics, strong universality and the like, and has strong application value in the field of health.

The present disclosure provides compounds capable of exhibiting effects similar to those of 2-Cys-peroxyredoxin (2-Cys-Prx) in the body with excellent pharmacological effects and reduced side effects such as reduced cytotoxicity, and pharmaceutical uses thereof. The compounds of the present disclosure and their pharmaceutically acceptable salts are useful for the treatment or prevention of vascular diseases, particularly ischemic coronary artery disease, arteriosclerosis, vascular restenosis, or pulmonary arterial hypertension. The compounds of the present invention and their pharmaceutically acceptable salts are particularly useful for the treatment or prevention of pulmonary arterial hypertension. The invention also provides methods of preparing the compounds of the present disclosure.

The invention discloses an AI-integrated remote ischemia adaptation training and blood pressure management integrated system, and belongs to the technical field of intelligent medical treatment. The system adopts a four-layer distributed architecture and comprises an intelligent sensing layer, an AI analysis layer, a clinical decision-making layer and an application interaction layer. The intelligent sensing layer acquires physiological data through equipment such as an intelligent ischemia training instrument and a multi-guide physiological monitor; the AI analysis layer performs intelligent analysis through five modules, namely a blood pressure analysis module, an arrhythmia detection module, an arteriosclerosis evaluation module, a training effect quantification module and a tolerance screening module; the clinical decision-making layer generates a personalized training scheme based on the analysis result and performs dynamic optimization; the application interaction layer provides multi-terminal services for patients, doctors, family members and management mechanisms. The problems that in the prior art, the function is single, parameters are fixed, and intelligent evaluation is lacked are solved, intellectualization, individuation and closed loop of remote ischemia adaptation training and blood pressure management are achieved, and the treatment effect and safety are remarkably improved.

The application of Guqi Huoxue preparation in the preparation of drugs for treating arteriosclerosis. The application belongs to the technical field of traditional Chinese medicine, and discloses a new use of Guqi Huoxue preparation, in particular, the use of Guqi Huoxue preparation in the preparation of drugs for treating arteriosclerosis. The Guqi Huoxue preparation is mainly prepared from Huangqi, Danggui, Baishao, Heshouwu, Gouqi, Suanzaoren, Lurong, Gushugu, Weilingxian, Tougucao, Mosha, Gegen and Chuanxiong. Modern pharmacological experiments show that the Guqi Huoxue preparation has a good preventive or therapeutic effect on arteriosclerosis, can significantly reduce arteriosclerosis plaques, effectively inhibit the progress of arteriosclerosis, and obviously relieve the symptoms of arteriosclerosis.

The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and / or cancer including colorectal cancer.The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the specification.

The present invention relates to Saikosaponin C as a modulator for vascular aging and arteriosclerosis resulting therefrom, and provides a composition comprising Saikosaponin C as an active ingredient for treating, preventing, or alleviating aging vascular diseases, diseases due to vascular aging, specifically, arteriosclerosis, or symptoms due to vascular aging. The composition of the present invention is expected to be of great use in the treatment, prevention, and alleviation of arteriosclerosis as a supplement, substitute, or combination of an existing arteriosclerosis treatment that lowers LDL-C.

The invention provides a medicine pillow for regulating mind, liver, spleen, lung and kidney based on the theory of five mind of traditional Chinese medicine, and comprehensive regulation of mind stabilization, liver soothing, spleen transformation, lung and kidney qi absorption is realized by implanting a traditional Chinese medicine composition and cooperating with acupoint stimulation. Through clinical verification, the effective rate on insomnia, anxiety and chronic fatigue is greater than 85%. The tea is beneficial to resuscitation and intelligence development, improves learning and memory, and has improvement effects on calming, convulsion resistance, depression resistance, arteriosclerosis resistance, hyperlipidemia resistance, hypertension and cardiovascular and cerebrovascular diseases.

Embodiments of the present application disclose a method for detecting wall shear parameter of a blood vessel, an ultrasonic imaging system and a computer readable storage medium. The method comprises: acquiring, by an ultrasonic probe, a first wall shear stress or a first wall shear rate of a to-be-detected position on a longitudinal section and a second wall shear stress or a second wall shear rate of the to-be-detected position on a transverse section; synthesizing a three-dimensional wall shear stress at the to-be-detected position according to the first wall shear stress and the second wall shear stress, or determining a three-dimensional wall shear rate of the to-be-detected position according to the first wall shear rate and the second wall shear rate; and displaying the three-dimensional wall shear stress or the three-dimensional wall shear rate of the to-be-detected position of the blood vessel wall. In this way, a user can perform clinical evaluation related to arteriosclerosis according to the size and direction of the displayed three-dimensional wall shear stress or three-dimensional wall shear rate, thereby improving the accuracy and repeatability of detection.

The invention relates to a multi-parameter analysis method integrated with arteriosclerosis assessment and a health monitoring system, and the method comprises the steps: determining a pressure oscillatory wave signal based on a cuff pressure signal through synchronously collecting the cuff pressure signal and electrocardiosignals and photoelectric volume pulse wave signals of two-side finger tips; calibrating a blood pressure analysis process of the pressure oscillatory wave signal based on a systolic pressure calibration reference determined by the photoelectric volume pulse wave signal, and determining a blood pressure value; calculating a vascular function evaluation result including the arteriosclerosis degree based on a heartbeat time sequence reference determined by the electrocardiosignal, the cuff pressure signal and the photoelectric volume pulse wave signal; performing multi-parameter correlation analysis on the blood oxygen signal and the electrocardiosignal extracted from the photoelectric volume pulse wave signal to obtain a multi-parameter analysis result; the blood pressure value, the blood vessel function evaluation result and the multi-parameter analysis result are integrated, and a comprehensive health evaluation report is generated; according to the invention, integration of multi-parameter acquisition, accurate calculation and deep analysis can be realized, and comprehensive and reliable health assessment support is provided.

This invention belongs to the field of tea beverage production technology, specifically a method for producing Osmanthus Green Brick Tea beverage, including raw material pretreatment, extraction, cooling and auxiliary material addition, filtration and homogenization, sterilization and bottling. In the extraction step, green brick tea powder and sweet tea are weighed according to the formula, purified water is added, and the extraction temperature is set to 80℃. Osmanthus flowers are added at the 8th minute of extraction, and the temperature is maintained for 10 minutes. In the cooling and auxiliary material addition step, the tea soup is transferred to a cooling device, cooled to room temperature, and then sodium bicarbonate and vitamin C are added and stirred until completely dissolved. In the sterilization and bottling step, sterilization is performed at 121℃ under high pressure for 2 minutes, and the product is then filled into sealed containers under aseptic conditions to obtain the finished product. By combining sweet tea and green brick tea, this method not only aids digestion and regulates fat metabolism, but also effectively prevents various diseases caused by free radicals, such as tumors, cerebral ischemia, and arteriosclerosis, providing health and wellness benefits.

The invention discloses a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, and relates to the technical field of pharmacy, in particular to a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, the traditional Chinese medicine composition is prepared from the following raw material medicines: 100g of radix puerariae, 100g of herba epimedii, 100g of herba leonuri, 50g of dioscorea panthaica, 50g of raw endothelium corneum gigeriae galli, 50g of fructus aurantii immaturus, 50g of rhizoma dioscoreae nipponicae, 50g of lumbricus and 50g of kapok leaves. Pharmacodynamic tests prove that compared with related traditional Chinese medicine prescriptions in the prior art, the traditional Chinese medicine composition can significantly reduce the intima-media thickness of blood vessels, reduce the area proportion of plaques, improve the blood vessel stenosis rate, and improve the curative effect. 0.05 in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride and low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol), protecting vascular endothelial function (increasing the content of vascular endothelial relaxation factor NO and reducing endothelin ET level) and the like, and the pharmaceutical composition is superior to the prior art group (Plt: 0.05) in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol).

A composition, in particular for the prophylaxis and / or treatment of caries, gingivitis, halitosis and / or arteriosclerosis, comprises N-cetylpyridinium chloride, at least one flavonoid, at least one polymer, in particular a homopolymer comprising at least one monomer having a polar functional group, in particular polylysine, and optionally chlorhexidine, wherein the weight ratio of chlorhexidine to N-cetylpyridinium chloride is between 0 and 7, in particular between 0.01 and 6, especially between 0.1 and 5, more especially between 0.2 and 4, for example between 0.4 and 3.2.

According to the arteriosclerosis distinguishing method based on the traditional Chinese medicine constitution, multi-source data such as texts, voices and images are collected, feature information of the multi-source data is fused to construct a constitution distinguishing model, feature extraction and fusion processing are conducted on all types of data, and traditional Chinese medicine constitution classification is achieved by inputting the distinguishing model; the purpose of comprehensively identifying the traditional Chinese medicine constitution state based on the multi-modal data is achieved, so that the technical effects of automatic traditional Chinese medicine constitution identification of the target disease, high accuracy and high adaptability are achieved, and the problems that traditional constitution identification depends on subjective experience, discrimination standards are not uniform, and the capacity of identifying the constitution type of the specific disease is insufficient are solved.

Provided herein are processes of producing volixibat and volixibat analogs, or their pharmaceutically acceptable salts, hydrates, or solvates thereof. Further provided herein are compounds of volixibat analogs, intermediates, or their pharmaceutically acceptable salts, hydrates, or solvates thereof. Additionally provided herein are crystalline forms of potassium volixibat salts. Provided herein are pharmaceutical compositions and dosage forms of the compositions comprising the compounds as described herein. Further provided herein are methods and kits of treating liver disease, hyperlipidemia, high cholesterol, arteriosclerosis, or Syndrome X using the compositions comprising the compounds as described herein.

The invention relates to an indole derivative shown in general formula (I-1) and its use in preparing drugs for preventing and / or treating indications of S1P receptor related disorders. The indole derivative of the invention is replaced by R1, R2, R5, and R6 at different sites respectively, and the obtained modified indole derivative has excellent biological activity and is an ideal S1P receptor regulator with high efficiency. Compounds of general formula (I-1) can be used to treat and / or prevent Crohn's disease, ulcerative colitis, psoriasis, rheumatoid arthritis, multiple sclerosis, atopic dermatitis, eosinophilic esophagitis, alopecia areata, primary cholangitis, pyoderma gangrenosum, graft-versus-host disease, amyotrophic lateral sclerosis, systemic lupus erythematosus, type I diabetes arteriosclerosis, atherosclerosis, scleroderma, autoimmune hepatitis, acne, microbial infection, viral infection, and other autoimmune and inflammatory diseases.

The invention discloses synthesis of an organic covalent nanotube and application of the organic covalent nanotube in ascorbic acid transmembrane transport, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: reacting hepta (6-O-tert-butyldimethylsilyl)-beta-cyclodextrin with 1, 3-bis (bromomethyl) benzene, and heating to react, so as to obtain a covalent organic covalent nanotube 1-3; the organic covalent nanotube disclosed by the invention is simple in synthesis process, and a covalent organic covalent nanotube skeleton based on cyclodextrin can be conveniently constructed. The compound has excellent lipid bilayer insertion capability, and can be effectively embedded into lipid bilayer to mediate the transmembrane transport of ascorbic acid. The invention provides a new treatment thought for treating diseases such as low immunity and hypertension in virus infection caused by ascorbic acid deficiency, and has a wide prospect in the fields of virus resistance, inflammation resistance, arteriosclerosis resistance and the like.

This application discloses a method for detecting the wall shear parameters of blood vessels, an ultrasound imaging system, and a computer-readable storage medium. The detection method includes acquiring a first wall shear stress or a first wall shear rate on a longitudinal section and a second wall shear stress or a second wall shear rate on a cross section at a test location using an ultrasound probe; synthesizing a three-dimensional wall shear stress at the test location based on the first and second wall shear stresses, or determining the three-dimensional wall shear rate at the test location based on the first and second wall shear rates; and displaying the three-dimensional wall shear stress or three-dimensional wall shear rate at the test location of the blood vessel wall. Thus, users can perform clinical assessments related to arteriosclerosis by observing the magnitude and direction of the displayed three-dimensional wall shear stress or three-dimensional wall shear rate, improving the accuracy and repeatability of the detection.