105 results about "Arteriosclerosis" patented technology

The invention relates to the technical field of health status assessment, in particular to a cardiovascular disease layered early warning system, which is characterized in that blood vessel compliance and pulse wave velocity are extracted, arterial dilation capacity is measured, blood vessel elasticity is calculated, blood perfusion distribution is detected, and abnormal vasoconstriction is classified on the basis of a hemodynamic state and a heart electrical activity state; in combination with the thickness of the blood vessel wall and the blood vessel stenosis rate, the plaque deposition condition is analyzed, the arteriosclerosis score is calculated, the thrombosis tendency is detected, the local blood flow blocking degree is quantified, the isolation forest algorithm is adopted, the blood flow dynamic change is calculated, the heart rhythm abnormality is analyzed, the acute vascular occlusion probability is measured, and the sudden heart rhythm abnormality risk is evaluated. And based on a gradient boosting tree algorithm, screening high-risk cases, matching medical intervention measures, setting a risk buffer mechanism, adjusting an individual health management strategy, and optimizing a cardiovascular risk hierarchical early warning system.

The invention relates to the field of computer medical engineering, and discloses a blood pressure continuous measurement abnormity early warning method and system based on AI data analysis, and the method comprises the steps: collecting a pulse wave signal, triaxial accelerometer data, an ambient light intensity signal and a skin conductance signal through a sensor on a preset wearable device; generating multi-scale physiological features; systolic pressure and diastolic pressure are calculated, and blood vessel stiffness is calculated; calculating the main arteriosclerosis risk level; when the main arteriosclerosis risk level is higher than a preset risk level, a user is prompted through the wearable device. According to the invention, the pulse wave, the triaxial accelerometer, the ambient light intensity and the skin conductance signal are synchronously acquired and analyzed to obtain the systolic pressure, the diastolic pressure dynamic trend and the blood vessel stiffness, and the main arteriosclerosis risk level can be accurately quantified. In addition, a'physiological parameter-angiosclerosis-risk decision 'closed-loop management mechanism is established, and automatic and active health management of the user is realized.

The invention discloses a non-invasive wearable vascular arteriosclerosis assessment system and method based on multi-mode pulse wave signal fusion, and belongs to the field of vascular function assessment. The system comprises a distributed acquisition front end, a butterfly-shaped flexible substrate, an integrated double-accelerometer, a four-wavelength LED (530nm / 660nm superficial blood vessel measurement), a 810nm / 940nm deep artery measurement device, a double-photodiode, a double-impedance electrode and a pressure sensor. The central integrated control end processes a multi-mode signal and realizes pressure-LED current closed-loop control; the upper computer terminal extracts the multi-modal pulse wave time difference of the limbs and the neck, the local and regional pulse wave conduction velocity and the blood oxygen hemoglobin change parameters induced by the standardized posture, the dimension is reduced to 30 through principal component analysis, then the parameters are input into the random forest regression model, and the vascular elasticity index is output. Signal stability is improved through flexible fitting, single-source limitation is solved through multi-modal fusion, signal quality is guaranteed through closed-loop control, sensitivity is enhanced through dynamic physiological excitation, and accuracy and universality of arteriosclerosis assessment are improved.

The invention discloses an arteriosclerosis risk prediction method and device based on machine learning, and belongs to the technical field of machine learning, and the method comprises the steps: obtaining electronic medical record data of a target object, and carrying out the standardization processing; inputting the standardized electronic medical record data into a machine learning model based on a LightGBM algorithm to identify high-risk individuals of arteriosclerosis; the influence of each feature on the arteriosclerosis risk prediction result is quantified by combining the contribution values of the input features, and targeted health management suggestions are provided for patients. The arteriosclerosis risk prediction model constructed by learning a large amount of clinical data not only can improve the accuracy of arteriosclerosis risk prediction, but also can reveal the complex relationship between risk factors which are difficult to find by a traditional statistical method, so that the design and implementation of a personalized health management scheme are realized. Therefore, a more scientific basis is provided for preventing and treating arteriosclerosis.

An advanced cardiovascular health monitoring system utilizes an optical pulse wave velocity detection device in combination with a system for analyzing data waveforms structures in combination with personalized patient data integration to determine specific physiological parameters for monitoring and assessing specific health conditions. Using acceleration pulse waves, vascular health is calculated by the ratio of peak to the second derivative of blood volume pulse wave, which can detect various health indices such as vascular age, vascular health index, and arteriosclerosis. The device collects separate pulse points within a time interval. It connects them into a line to form the PPG Image, which is then analyzed through data filtering and fitting methods. The periodic cycle acquisition method excludes abnormal cycle data and ensures correct data acquisition. Artificial Intelligence and data analytics are aiding the software to improve and optimize underlying data ranges continuously; the algorithms are summarized in figures. The invention may be used as part of non-invasive screening testing.

The invention discloses an arteriosclerosis detection method, device and system and an arteriosclerosis detector, and relates to the technical field of medical instruments.The method comprises the steps that after carotid artery pulse waveforms and femoral artery pulse waveforms are subjected to preprocessing and differential processing, division is conducted according to heartbeat cycles; acquiring a carotid artery signal maximum value and a femoral artery signal maximum value in each heartbeat cycle; determining conduction time in each heartbeat cycle according to the carotid artery signal maximum value and the femoral artery signal maximum value in each heartbeat cycle; according to the distance between the carotid artery measuring point and the femoral artery measuring point and the conduction time in each heartbeat cycle, the conduction speed of the pulse wave of the tested person in the arterial system in each heartbeat cycle is determined; determining an average conduction velocity according to the conduction velocity of the pulse wave of the testee in the arterial system in each heartbeat cycle; and determining the arteriosclerosis degree according to the average conduction velocity. The technical problem of low arteriosclerosis measurement precision in the prior art is solved.

According to the arteriosclerosis detection method and device, the upper arm blood pressure is obtained based on the heart and ankle vascular index CAVI; systolic pressure Ps and diastolic pressure Pd are obtained; calculating to obtain a pulse pressure difference delta P, wherein the pulse pressure difference delta P = systolic pressure Ps-diastolic pressure Pd; measuring to obtain the distance Lca from the heart aortic valve to the ankle; measuring to obtain the time difference Tca of the pulse wave propagating from the heart to the ankle; a heart and ankle vascular index CAVI is obtained through calculation according to the following formula; # imgabs0 # is used for measuring and obtaining a pulse wave starting point time point TA1 of the ankle; measuring a pulse starting point TA2 of brachial artery pulse waves, and calculating TA1 to TA2 to obtain a time difference Tba; measuring to obtain a heart sound signal of cardiac pulsation, and obtaining a time difference T2 between a second heart sound and a first incision of the brachial artery; the time difference Tca is equal to the sum of the time difference Tba and the time difference T2. At least three blood pressure measuring devices and at least three electrocardio detection electrodes are arranged; the heart sound detection module is in electric signal connection with the heart sound detection sensor through a signal line; the heart sound detection sensor is used for being placed at the heart position of a detected person to obtain heart sound signals.

The present invention relates to the use of an ROR inverse agonist or a pharmaceutically acceptable salt thereof for the preparation of a medicament for modulating ROR in a patient and / or for controlling autoimmune diseases and antibody-mediated rejection in a patient. The ROR-mediated diseases or autoimmune diseases include HIV, cancer, celiac disease, type 1 diabetes, Graves' disease (Graves' disease), inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, asthma, dermatitis, fatty liver disease, Crohn's disease (Crohn's disease), cardiovascular disease, inflammatory disease, nervous system disorders, multiple sclerosis, and the like. Acute respiratory distress syndrome and arteriosclerosis.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a turbidity-dissolving and lipid-lowering composition and a preparation method thereof.The composition comprises 80-130 parts of polygonum cuspidatum, 50-90 parts of fried semen cassiae, 100-140 parts of hawthorn, 50-90 parts of rhizoma alismatis, 10-60 parts of rhizoma atractylodis macrocephalae fried with bran and 50-90 parts of rhizoma wenyujin concisum. The composition disclosed by the invention has the effects of eliminating phlegm, dissolving turbidity, promoting blood circulation to remove blood stasis, invigorating stomach and promoting diuresis, can be used for treating hyperlipidemia, hyperviscosity and arteriosclerotic cardia-cerebrovascular diseases, and has a very good application prospect.

The invention belongs to the field of medicaments, and discloses a nano-medicinal preparation capable of treating diabetes and a preparation method of the nano-medicinal preparation. The preparation method comprises the following steps: carrying out hydrothermal reaction on fructose-1, 6-strontium diphosphate, vanadium pentoxide and ergothioneine to prepare strontium-vanadate organic framework nanoparticles; the strontium-vanadate organic framework nano-particles, dopamine and polylysine are blended, embedding of polydopamine is achieved under the alkaline condition, polylysine-polydopamine co-embedded organic framework nano-particles are formed, and the nano-drug preparation for treating diabetes is obtained. The nano medicinal preparation can release the vanadyl complex and the ergothioneine and improve the blood strontium concentration and the half-life period thereof, so that the blood sugar is controlled, the symptoms of diabetes mellitus are improved, and the symptoms of osteoporosis, arteriosclerosis and the like complicated by diabetes mellitus are improved.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating lower limb arteriosclerosis obliterans, which is technically characterized by being prepared from ten medicinal materials, namely red ginseng, astragalus membranaceus, cassia twig, morinda officinalis, cistanche deserticola, salvia miltiorrhiza, pseudo-ginseng, radix cyathulae, sargentgloryvine stem and semen brassicae according to a specific weight part ratio. Aiming at the core pathogenesis of yang deficiency and blood stasis of lower limb arteriosclerosis obliterans, the composition disclosed by the invention provides a treatment method of tonifying qi, warming yang, promoting blood circulation to remove blood stasis, removing speckles and dredging vessels, the compatibility of the whole formula is rigorous, and monarch, minister, assistant and guide are clear; moreover, the composition can be prepared into capsules or granules, is used for treating yang deficiency and blood stasis type lower limb arteriosclerosis obliterans, has an exact clinical curative effect, can remarkably improve symptoms of patients and lower limb blood flow, and is good in safety.

The invention belongs to the technical field of edible oil, and particularly relates to edible oil with a blood fat reducing effect and a preparation method of the edible oil. Comprising the following raw materials in parts by weight: 1 to 10 parts of base oil, 90 to 100 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride, 0.3 to 0.5 part of an emulsifier, 0.05 to 0.09 part of an antioxidant and 0.02 to 0.05 part of a stabilizer. The base oil is composed of the sunflower seed oil and the tea seed oil, and the base oil and the 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride are matched for use, so that the oil has a good blood fat reducing effect, and can effectively reduce cholesterol, maintain cardiovascular health and prevent arteriosclerosis. The antioxidant is composed of the vitamin E, the alpha-mangostin and the oryzanol, all the components have a synergistic effect and jointly improve the oxidation stability of the edible oil, and meanwhile, the antioxidant is matched with the stabilizer, so that the storage life of the edible oil can be effectively prolonged, and the storage stability is improved.

The invention discloses a displacement measurement method and device, a laser emitting and receiving system and an arteriosclerosis early warning instrument, and relates to the technical field of medical instruments, and the method comprises the steps: controlling a constant current source to output current to drive an infrared laser to work; acquiring an electric signal input by the optical signal receiving module; determining a phase difference between a measurement optical signal obtained by the first laser through the silicon optical chip and a measurement optical signal reflected by the surface of the to-be-measured object according to the electric signal; and determining the displacement information of the to-be-measured object according to a first mathematical relationship between the phase difference and the displacement of the to-be-measured object. According to the scheme, displacement is measured through the laser emitting and receiving system, noninvasive and high-time-resolution measurement of vibration of the blood vessel wall can be achieved without direct contact with the skin, the limitation that in the prior art, contact with the skin is needed can be overcome, and the obtained measurement result is more accurate and efficient.

The invention discloses a remote ischemia adaptive hypertension treatment and risk assessment system based on artificial intelligence. The system comprises a physiological signal acquisition module, a preprocessing module, an artery function assessment module, a heart rhythm analysis module, a molecular biology assessment module, a user state association module and an assessment module. The physiological signal acquisition module is responsible for executing standard distant ischemia adaptation training and acquiring original data including systolic pressure, diastolic pressure, heart rate and pulse waveform data of upper limbs on two sides in real time in the execution process; the preprocessing module can sequentially carry out band-pass filtering, waveform segmentation and feature extraction processing on original data, then feature values extracted from single waveforms and the waveforms are combined to form a data set, and the data set is output. According to the method, arteriosclerosis can be evaluated, subclavian artery stenosis can be judged, and the nitric oxide amount can be calculated synchronously, so that fusion of multiple physiological data can be ensured in an adaptive treatment process, and meanwhile, multi-data joint evaluation is realized in combination with artificial intelligence.

The invention relates to a construction method of an arteriosclerosis risk assessment model, an arteriosclerosis risk assessment method, and application of an arteriosclerosis biomarker and a reagent for detecting the biomarker in preparation of a kit for predicting, preventing and / or treating arteriosclerosis. The construction method of the arteriosclerosis risk assessment model comprises the steps that correlation analysis is conducted based on genetic data and background data of a population to obtain correlation significance values corresponding to SNP loci, and the genetic data comprises the SNP loci and genotypes of the SNP loci; the arteriosclerosis risk assessment model is constructed on the basis of the SNP loci and the associated significance values corresponding to the SNP loci, and the arteriosclerosis risk assessment model comprises one or more of the SNP loci shown in the table 1. The arteriosclerosis risk assessment model obtained according to the construction method provided by the embodiment of the invention considers the specific genetic background, lifestyle, environmental factors and the like of Chinese population, the AUC of the obtained model reaches 0.693, and the arteriosclerosis risk of an individual to be analyzed can be accurately and effectively assessed.

The invention discloses a production method of meridian-dredging granules. The production method comprises the following steps: (1) extracting; putting salvia miltiorrhiza, ligusticum wallichii and radix puerariae into a decoction tank, and adding water for extraction to obtain an extracting solution; (2) concentrating the extracting solution to prepare extract; (3) weighing dextrin or soluble starch and sodium cyclamate to prepare base powder; step (4), granulating; adding the prepared extract into a spray trolley matched with a spray drying granulator, adding the base powder prepared in the step (3) into the spray drying granulator, spraying the extract into the spray drying granulator through the spray trolley, and intermittently shaking bags to prepare granules; step (5), granulating; step (6): total mixing; carrying out total mixing on the whole granules; step (7), sub-packaging; and packaging the totally mixed particles by using a particle packaging machine. The process links are simpler, the process flow is also obviously optimized, the process links are simpler, and the production efficiency is higher.

The invention discloses wheat malt seedling functional dietary fibers as well as a preparation method and application of the wheat malt seedling functional dietary fibers. The soluble dietary fiber and the insoluble dietary fiber of the wheat malt seedlings are extracted by adopting a wall breaking-extraction mode of synergy of biological enzyme and free radicals. The wheat malt seedling soluble dietary fibers can prolong the life of caenorhabditis elegans in an oxidative stress state, improve the antioxidant enzyme activity and improve the anti-apoptosis capability; the intestinal flora of the obese C57BL / 6J mouse induced by the high-fat feed is regulated; the wheat malt seedling insoluble dietary fiber has better binding water capacity, water-holding capacity and cholesterol and sodium cholate adsorption capacity, and can be used as a functional food additive for improving the texture and nutritional characteristics of food; and the wheat malt seedlings can also be used for assisting in reducing serum cholesterol level, preventing arteriosclerosis, promoting defecation, preventing constipation, colorectal cancer and the like in the field of health medical treatment, so that high-quality reutilization of the wheat malt seedlings is realized.

The invention provides a research device for arteriosclerosis detection, and the device consists of the following parts: a multi-modal data synchronous collection module which achieves the omnibearing data capture of arteriosclerosis through integrating a flexible ultrasonic array, a PPG module, a laser speckle imaging module and a multi-modal sensor, the blood vessel structure thickness, plaque form and microcirculation dynamic parameters are synchronously obtained in the wearable device, the limitation of single function of traditional equipment is broken through, comprehensive diagnosis from macroscopic to microscopic is achieved, continuous wearing is supported through the ultrathin flexible design, the self-adaptive ultrasonic array and high-precision time sequence synchronization are combined, blood vessel elastic changes can be captured in an all-weather mode, and the diagnosis accuracy is improved. And real-time data support is provided for disease course evolution.

A genetically modified mesenchymal stem cell including an exogenous nucleic acid including a Klotho encoding region operably linked to a promoter or promoter / enhancer combination, wherein the genetically modified mesenchymal stem cell exhibits increased Klotho expression compared to an unmodified mesenchymal stem cell. Also disclosed are methods of treating a patient including administering a therapeutically effective number of the genetically modified mesenchymal stem cells to the patient. The methods of treatment include treating the patient for a neurodegenerative disease; cancer; organ fibrosis; renal disease; age-related changes of organs or organ systems; to slow, reverse and / or inhibit aging; arteriosclerosis; dementia; diabetes mellitus; erectile dysfunction; autoimmune diseases or autoimmune-related diseases; an inflammatory disease of the lung and sepsis.

The present invention relates to a composition comprising a complex extract of Coptis japonica, Phellodendron Chinensis, Scutellaria baicalensis, Gardenia jasminoides, and Rheum palmatum. The composition was confirmed to: reduce the levels of blood cholesterol, blood lipids, and blood LDL-cholesterol in patients with dyslipidemia; reduce systolic blood pressure without affecting diastolic blood pressure and pulse rate in patients with hypertension; reduce the level of pulse wave velocity (PWV), which is an indicator of arteriosclerosis, in patients with atherosclerosis, and inhibit the recurrence rate for up to 5 years in patients with cerebral infarction. Accordingly, the composition is provided as a therapeutic agent for dyslipidemia, hypertension, arteriosclerosis, or cerebral infarction. In particular, the composition is made into an encapsulated form rather than conventional decoctions, to reduce the content of geniposide, which is reported as a side effect component, and thus an optimal composition which maintains efficacy against dyslipidemia and does not cause side effects is provided.

The invention provides a warm-keeping device for lower limb arteriosclerosis occlusion patients, and relates to the technical field of lower limb arteriosclerosis warm keeping, the warm-keeping device comprises a sleeve, the bottom end of the sleeve is fixedly connected with a shoe body, the outer wall of the front end of the sleeve is fixedly connected with a first connecting frame, and the inner wall of the first connecting frame is connected with a cooling fan through a cooling assembly; a first connecting frame is fixedly connected to the left end of the sleeve and used for cooling the interior of the sleeve, a second connecting frame is fixedly connected to the right end of the sleeve, a massage head is connected to the left end of the second connecting frame through a massage assembly and used for massaging the legs worn in the sleeve, and a center console is installed at the right end of the second connecting frame. A second hook-and-loop fastener is attached to a first hook-and-loop fastener, it is ensured that the inner diameter is shrunk in place, the wearing stability is improved, meanwhile, heat dissipation is effectively reduced, the internal temperature is maintained, cooling is rapid, the wearing comfort is improved, and rotating extrusion massage is conducted on the legs through massage heads, blood circulation is promoted, and discomfort is relieved.

The imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and / or spectral content of which are varied delivered through the same optical train including the set of apertures.

This invention discloses a traditional Chinese medicine composition and its application for clearing blood vessels, dissolving blood spots, regulating the five internal organs, and preventing and treating arteriosclerosis and its associated coronary heart disease, hypertension, hyperlipidemia, hyperglycemia, hyperuricemia, and diabetic gangrene. It belongs to the field of traditional Chinese medicine composition technology. The preparation method of the traditional Chinese medicine composition is as follows: (1) treating *Salvia miltiorrhiza*, *Polygonatum sibiricum*, and *Polygonum multiflorum* with alcohol using ultrasound to obtain an alcohol extract and residue; (2) extracting *Lycium barbarum*, *Epimedium brevicornu*, *Ligustrum lucidum*, *Angelica sinensis*, *Cuscuta chinensis*, *Astragalus membranaceus*, *Crataegus pinnatifida*, *Ziziphus jujuba*, *Chrysanthemum morifolium*, and *Lycium chinense* with water to obtain an aqueous extract; (3) mixing the residue and aqueous extract and enzymatically hydrolyzing to obtain an enzymatic hydrolysate; (4) mixing the alcohol extract and enzymatic hydrolysate and drying. The enzymes are yeast extractase, cellulase, and bromelain in a mass ratio of 0.5-1:1:0.1-0.3. Compared with existing technologies, this invention can improve microcirculation disorders and can be used to prevent and treat various diseases caused by microvascular circulation disorders.

Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the SPECIFICATION.

The application discloses 3-substituted coumarin derivatives 1a-14a and symmetrical biscoumarin derivatives 1b-25b and pharmaceutically acceptable salts, solvates or hydrates thereof. The compounds provided by the application are specific inhibitors of ATP citrate lyase (ACLY), and the half maximal inhibitory concentration (IC 50 ) of the former is 2-30 muM, and the IC 50 ) of the latter is 0.065-4 muM, so the compounds have potential therapeutic value for a plurality of diseases with abnormally high expression of ACLY, such as cancer, hyperlipidemia and arteriosclerotic cardiovascular diseases.

The application provides an artificial intelligence model and method for predicting a gut age index based on microbiome sequencing data; through a machine learning algorithm and a statistical bias correction method, an artificial intelligence machine learning gut age prediction model is constructed, and a correction value is calculated based on a health cohort, so that a gut age correction is performed on a data sample to be predicted, thereby calculating a gut age index; the prediction of the gut age and the GAI can be used in the fields of evaluation of a gut health condition and prediction of chronic diseases; and preclinical verification results of the application show that the application has a high accuracy rate, and the calculation accuracy rates of the GAI in 20 common chronic diseases, such as metabolic syndrome, obesity and cardiovascular diseases, are between 65.9% and 74.8%, wherein the accuracy rate of arteriosclerosis is as high as 74.8%; the method also has the advantages of good characteristics, strong universality and the like, and has strong application value in the field of health.

The invention relates to granules for promoting blood circulation to remove meridian obstruction and a preparation method thereof. Ginkgo leaves, fried spina date seeds, astragalus membranaceus, radix puerariae, hawthorn, salvia miltiorrhiza, allium macrostemon, rhodiola rosea, fructus lycii, acanthopanax, schisandra chinensis and radix ophiopogonis are selected as raw materials, the raw materials are decocted, filtered, concentrated and granulated, the materials are all selected from natural traditional Chinese medicine components, the effects of promoting blood circulation to remove blood stasis and activating meridians to stop pain are achieved, and the traditional Chinese medicine composition has a remarkable curative effect on chest stuffiness, cardiodynia, dizziness, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals. The traditional Chinese medicine composition has obvious curative effects on symptoms such as hypertension, hyperlipidemia and cerebral arteriosclerosis, has no side effect on the body, is simple in preparation method and low in production cost, and has application and popularization prospects.

The utility model discloses an arteriosclerosis detector, and relates to the technical field of arteriosclerosis detection. The device comprises a main body, a storage box is arranged on one side of the main body, a rotating shaft is fixedly connected to the inner wall of the storage box, a winding drum is rotationally connected to the interior of the storage box, a clockwork spring is arranged between the outer side of the rotating shaft and the inner wall of the winding drum, a spool is arranged on the outer side of the winding drum, and a limiting assembly is arranged on the front face of the storage box. The winding drum automatically rotates under the assistance of the clockwork spring, the rotating winding drum can wind the line pipe, in conclusion, the line pipe can be wound by the winding drum when not used, meanwhile, the wound line pipe can be protected by the storage box, and the winding drum is convenient to use. Therefore, the wire pipe is not easy to abrade due to dragging, and a plurality of wound wire pipes are not easy to wind and knot, so that the service life of the wire pipe is prolonged, and the detector can be used normally all the time.

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.