The invention discloses a reverse vascular sheath. The reverse vascular sheath includes a sheath pipe, an outer sheath connecting body and a ball valve guide reversing device; the outer sheath connecting body is a columnar connector provided with an inner cavity, one end of the outer sheath connecting body is provided with a main guide pipe connecting hole, the other end of the outer sheath connecting body is provided with a sheath pipe connecting hole, and the sheath pipe connecting hole is connected with the sheath pipe; the ball valve guide reversing device includes a front ball valve, a first air pipe, a push rod, a guide pipe and an air source, the first air pipe is arranged in the inner cavity of the push rod, and the front end and rear end of the first air pipe are connected with the front ball valve and the air source respectively; the push rod is arranged in the inner cavity of the sheath pipe, one end of the push rod is connected with the front ball valve, and the other end of the push rod is connected with a sacculus filling hole; the guide pipe is arranged in the inner cavity of the sheath pipe. According to the above technical scheme, since the reverse vascular sheath can complete all kinds of operation in blood vessels only by puncturing arteria femoralis on one side, the surgical operation time can be reduced, incision infection and other complications are reduced, medical expenses are reduced, medical materials are saved and the patients' pain is relieved.