Rat model for replantation after vascular injury and assessment method of rat model

A technology of rat model and vascular injury, applied in the fields of application, veterinary surgery, veterinary instruments, etc., can solve the problems of difficult research with large sample size, high cost of purchase and feeding, impact on value and credibility, etc. Achieve the effect of easy minimally invasive suture operation, easy to find and expose, and low price

Inactive Publication Date: 2020-02-28
SHIHEZI UNIVERSITY
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Problems solved by technology

[0005] At present, in the research field of vascular regeneration and repair, there is only a large-eared white rabbit model of vascular replantation after injury. However, for the white rabbit model, there are high purchase and feeding costs; slow reproduction speed and long cycle; difficult feeding; Dif

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  • Rat model for replantation after vascular injury and assessment method of rat model

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Embodiment Construction

[0031] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0032] A rat model for replantation after vascular injury, comprising the following steps: Step 1, model selection: select 10-week-old SD rats, the rats are male or female, the body weight range is 240-300g, healthy and healthy Lesions, normal activity;

[0033] Step 2. Rat anesthesia: place the rat in an anesthesia box, and select sevoflurane as the inhalational anesthetic;

[0034] Step 3. Femoral artery cutting: place the rat on the ultra-clean operating table, take the supine position, fix the limbs, take the left or right femu...

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Abstract

The invention relates to the technical field of revascularization and vascular repair and discloses a rat model for replantation after vascular injury. A process includes: step one, model selection; step two, rat anesthesia; step three, femoral artery cutting; step four, femoral artery suture; step five, postoperative management. The invention further discloses an assessment method of the rat model for replantation after vascular injury. The rat model which is convenient and quick in modeling, economical, low in cost and extensive in application range is provided for the field of vascular injury and repair research. An extensive platform is provided for researching specialized clinical therapeutic methods for hand surgery, plastic surgery, reparative and reconstructive surgery and the like, application to observation of curative effects of related medicines used after vascular injury is realized, and whether endangium, smooth muscle cells and related vascular activating factors participate in a repair process or not and related mechanisms in a vascular injury and repair process can be explored.

Description

technical field [0001] The invention relates to the technical field of blood vessel regeneration and repair, in particular to a rat model for replantation after blood vessel injury and an evaluation method thereof. Background technique [0002] With the development of modern industry and agriculture, in the process of labor, workers are accompanied by a higher risk of trauma, such as machine strangulation, cutting injuries, limb amputation injuries, etc. Similar serious injuries have caused great physical harm to working people, seriously threatening the safety of their lives and property, and many traumas can even cause disability, which has an irreversible impact on the normal life of patients in the future. Therefore, for trauma, timely treatment and surgical intervention are the key to improving the treatment effect and reducing postoperative complications and disability rate, and the anastomotic technique of damaged blood vessels in minimally invasive surgery is the key...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61B5/01A61B8/06A01K67/02
CPCA01K67/02A01K2207/30A01K2227/105A01K2267/03A61B5/01A61B8/06A61B8/488A61B2503/40A61B2503/42A61D1/00
Inventor 王思博王珊陈向今王维山李珂李晶孟德峰
Owner SHIHEZI UNIVERSITY
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