The invention provides a block chain-based artwork trading method. The method is suitable for use in the field of network technology, and includes: receiving a buying application request, determiningseller information according to a target artwork, and sending a trading request to the seller; sending a smart contract to the seller and a buyer if selling willing information is received; judging whether the smart contract becomes valid, and if yes, generating trading records, and sending the same to a block chain for saving; and judging whether an ownership change condition of the target artwork is met, and if yes, generating ownership change records, and sending the same to the block chain for saving. According to the embodiment of the invention, all servers of a node network in the blockchain are used to participate in management and maintenance thereof through a decentralized structure of the block chain, thus credibility of databases in the block chain are guaranteed, and the servers are built on the peer-to-peer network at the same time, an effect that property rights and trading records stored in the block chain can be all accessed under any complex network environment is guaranteed, and effective and smooth performing and security of trading are guaranteed.