The invention belongs to the technical field of natural
polymer functional material preparation, and discloses a temperature and pH dual-affected
xylan-based hydrogel as well as a manufacturing method and application thereof. The temperature and pH dual-affected
xylan-based hydrogel is prepared through the following steps: dissolving
xylan by using hot water, so that a xylan solution is obtained; adding N-isopropylacrylamide and
acrylamide into the xylan solution, adding a crosslinking agent, feeding
nitrogen for bubbling, adding a
photoinitiator, uniformly mixing, cooling the obtained mixture to
room temperature, putting the obtained mixture into an
ultraviolet radiation reactor, carrying out
ultraviolet irradiation at
room temperature, carrying out closed placement and reaction at
room temperature, and after the reaction is completed, washing the obtained product by using deionized water, so that an obtained
solid is the temperature and pH dual-affected xylan-based hydrogel. The preparation process and method of the hydrogel disclosed by the invention are easy to operate, and the hydrogel has environmental friendliness; and the obtained temperature and pH dual-affected xylan-based hydrogel has
biocompatibility, and has good sustained-release behavior on medications, and the release of medications in a simulated intestinal
physiological fluid is up to 80%.