The invention discloses a river and lake water quality monitoring method based on high-resolution satellite images. The river and lake water quality monitoring method comprises satellite image radiometric calibration, atmospheric correction, RPC orthographic correction, image splicing, automatic water body extraction, water quality quantitative inversion modeling, water quality quantitative inversion model precision verification and water quality quantitative inversion model application. The invention relates to the technical field of inland water environment remote sensing science, in particular to a river and lake water quality monitoring method based on a high-resolution satellite image, which has the advantages of wide monitoring range, high speed, low cost and convenience in long-termdynamic monitoring by utilizing a remote sensing technology. A multiple linear regression model between different water quality parameter concentrations and image waveband reflectivity is establishedby combining sampling data of a water quality monitoring station and representation of various substances in a water body on a remote sensing image, and a relative error and an absolute error of themodel are calculated according to an inversion result, so as to promote the model, and water quality evaluation of the whole river and even a water area with a larger range is achieved.