10 results about "Physiological fluid" patented technology

Methods and systems for analyzing lipid nanoparticles using size exclusion chromatograph coupled with multi angle light scattering are disclosed.

The embodiments herein provide hemostatic compositions, methods, and kits comprising composite polymer particles. Upon contact with blood or other physiological fluids, the composite particles adsorb fluid and aggregate into a shape-retentive mass that halts bleeding. In certain embodiments, the particles comprise polymers of 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, or combinations thereof. The particles may be used alone or blended with additional hemostatic agents. Methods of inducing hemostasis are provided for diffuse oozing, or surgical, mucosal, organ surface, fragile tissue or traumatic bleeding, including in patients receiving anticoagulant or antiplatelet therapy. Kits comprising sterile packages of composite particles, optionally with applicators, substrates, or sprays, are disclosed. The compositions exhibit intrinsic hemostatic activity and synergistically enhance the performance of conventional hemostats, achieving rapid clotting. After hemostasis is achieved, the compositions remain in situ as a conforming protective layer, reducing the need for additional covering materials and decreasing risk of re-bleeding.

The invention relates to an antithrombotic catheter. The antithrombotic catheter comprises a hydrogel coating containing a thrombolytic agent. The thrombolytic agent may be a lyophilized tissue plasminogen activator. The catheter has an inner lumen surface and an outer lumen surface, and a hydrogel coating is disposed on the inner lumen surface and / or the outer lumen surface. The hydrogel coating may have a thickness in the range of about 50 nm to about 150 nm. The hydrogel coating may contain from about 0.1 wt% to about 1 wt% of a tissue plasminogen activator. The hydrogel coating may be made from a synthetic hydrogel or a natural hydrogel. Presently preferred synthetic hydrogels include polyacrylamide based hydrogels. Presently preferred natural hydrogels include hyaluronic acid based hydrogels. The hydrogel coating reacts in the presence of a physiological liquid to absorb water and elute the solvating suppository. The hydrogel controls elution of the thrombolytic agent. Examples of physiological fluids include interstitial fluids and blood.

A system for the preparation of fluids for bioprocess and pharmaceutical applications uses one or more flexible bags that are pre-loaded with solid tablets contained therein of various buffer / media / physiological fluid constituents. Examples include salts, acids, bases, preservatives, proteins, amino acids, growth factors, small molecules, and drugs. The flexible bag contains one or more sealed or sealable openings that are used to add water to the interior of the flexible bag as well as remove fluid from the flexible bag. The one or more sealed openings may also be used as an outlet to remove fluid (e.g., buffer) from the flexible bag. The flexible bag may be stored in a deflated state aiding in the storage and / or transport of the flexible bag. Multiple flexible bags may be coupled to a manifold with valves to selectively fill and empty the flexible bags.

The connector (1) for medical, diagnostic and physiological fluid containers, comprises: - at least a first portion (3) comprising at least one substantially hollow tubular element (4), having a substantially elongated conformation along a central axis (5) and comprising at least one inlet opening (6) couplable to at least one hooking portion (7) of a first line of infusion (8); - at least a second portion (9) associated with the first portion (3) from the opposite side of the inlet opening (6) and comprising at least one male element (10) which is arranged within the tubular element (4), has a substantially elongated conformation along the central axis (5) and is substantially hollow and provided with at least a first opening (12) for the fluidic connection to a second line of infusion (13) and with at least a second opening (14), opposite the first opening (12), for the fluidic connection to the inlet opening (6); - joining means (15) by interlocking adapted to associate the first portion (3) with the second portion (9), the first portion (3) and the second portion (9) being linked together to allow the fluidic passage between the first line of infusion (8) and the second line of infusion (13) of at least one fluid to be administered (16) to a patient; wherein the tubular element (4) comprises at least one containment chamber (17) configured to house at least one sock sealing element (18) which consists of a single body piece made of an elastically deformable material and shod by close fitting around the male element (10), the sock sealing element (18) being movable as a result of the pressure exerted by the fluid to be administered in the passage from the first portion (3) to the second portion (9), between a closed position and an open position, wherein the second opening (14) is cleared to allow the fluid-operated communication between the first line of infusion (8) and the second line of infusion (13).

A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.

In some aspects, this disclosure is directed toward polymer coatings that may be used in medical devices such as tampons or intravaginal contraceptives to generate a seal that prevents the transmission of sperm or infectious particles. In some embodiments, a seal may be formed when the polymer coating is exposed to a physiological fluid such as semen.

A method for producing an autologous anti-inflammatory / anti-catabolic composition useful for treating mammals with damaged and / or injured connective tissue, chronic tendonosis, chronic muscle rupture, chronic degenerative joint disease, and / or inflammatory skin disorders is provided. The method includes the steps of: transferring blood collected from a mammal into a tube; storing the blood in the presence of sodium citrate at a temperature of about 20°C to about 40°C for at least about 3.5 hours; centrifuging the blood to separate it into a supernatant component and a cellular fraction; and recovering the supernatant component. TIFF2023518085000002.tif104128

This invention proposes an organic field-effect transistor (OFET) biosensor based on interface topology engineering, its fabrication method, and its application, belonging to the field of biosensor technology. The OFET biosensor comprises a substrate, electrodes, an organic semiconductor layer, an interface topology modification layer, and a biorecognition probe. Through a kinetically controlled vacuum deposition process, an interface topology modification layer with a nanoscale uniform rough morphology is constructed on the semiconductor surface. This topology induces double-layer overlap at the solid-liquid interface, significantly reducing interface capacitance and physically stretching the effective Debye length, thereby overcoming the Debye shielding effect in the high ionic strength environment of physiological fluids. Simultaneously, the aldehyde groups on the surface of the modification layer achieve covalent fixation of the probe without connecting arms and provide encapsulation protection. This sensor achieves ultrasensitive detection of allergen-specific IgE and exhibits excellent stability and signal-to-noise ratio in undiluted human serum, providing a universal physical sensitization strategy for the point-of-care testing of complex clinical samples.