19 results about "Physiological fluid" patented technology

The invention discloses an information processing method, device and equipment for analyte concentration monitoring and a medium, and relates to the technical field of physiological signal analysis, applied to a computer device.The method comprises the steps that an original analyte response signal set generated by an analyte sensor based on a reference physiological fluid is obtained, the signal group comprises response sensitivity, a base line and response current; performing temperature compensation on the signal group according to the current temperature fed back by the temperature sensor, and determining the concentration value of the target analyte in the reference physiological fluid by using the compensated signal group; substituting the concentration value of the target analyte in the reference physiological fluid into a target model to obtain the concentration of the target analyte in the target physiological fluid; the target model is constructed on the basis of a regulation and control mechanism of the temperature to the transport relation of the analyte and a regulation and control mechanism of the temperature to the metabolic relation of the analyte, and the concentration of the target analyte in the target physiological fluid is determined as a concentration monitoring result. By means of the scheme, the accuracy of analyte concentration monitoring is improved.

Methods and systems for analyzing lipid nanoparticles using size exclusion chromatograph coupled with multi angle light scattering are disclosed.

The embodiments herein provide hemostatic compositions, methods, and kits comprising composite polymer particles. Upon contact with blood or other physiological fluids, the composite particles adsorb fluid and aggregate into a shape-retentive mass that halts bleeding. In certain embodiments, the particles comprise polymers of 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, or combinations thereof. The particles may be used alone or blended with additional hemostatic agents. Methods of inducing hemostasis are provided for diffuse oozing, or surgical, mucosal, organ surface, fragile tissue or traumatic bleeding, including in patients receiving anticoagulant or antiplatelet therapy. Kits comprising sterile packages of composite particles, optionally with applicators, substrates, or sprays, are disclosed. The compositions exhibit intrinsic hemostatic activity and synergistically enhance the performance of conventional hemostats, achieving rapid clotting. After hemostasis is achieved, the compositions remain in situ as a conforming protective layer, reducing the need for additional covering materials and decreasing risk of re-bleeding.

The invention relates to the field of medicine, namely to biosensor analytical devices and can be used for quantitatively assessment of glucose content in blood, plasma and serum. The device comprises a graphite screen printed electrodes, whose surface is modified by a hybrid composite comprising an organosilicon matrix and inclusions of a biorecognition element in the form of glucose oxidase, as well as inclusions of carbon nanotubes and polyvinyl alcohol placed in the matrix. The organosilicon matrix consists of (3-aminopropyl)triethoxysilane and tetraethoxysilane in volume ratios of 20:80 and is covalently bound to a Nile blue mediator. The invention has the technical result of an increased upper limit of detectable glucose concentrations in physiological fluids up to 1.4 mmol / dm3.

The invention relates to an antithrombotic catheter. The antithrombotic catheter comprises a hydrogel coating containing a thrombolytic agent. The thrombolytic agent may be a lyophilized tissue plasminogen activator. The catheter has an inner lumen surface and an outer lumen surface, and a hydrogel coating is disposed on the inner lumen surface and / or the outer lumen surface. The hydrogel coating may have a thickness in the range of about 50 nm to about 150 nm. The hydrogel coating may contain from about 0.1 wt% to about 1 wt% of a tissue plasminogen activator. The hydrogel coating may be made from a synthetic hydrogel or a natural hydrogel. Presently preferred synthetic hydrogels include polyacrylamide based hydrogels. Presently preferred natural hydrogels include hyaluronic acid based hydrogels. The hydrogel coating reacts in the presence of a physiological liquid to absorb water and elute the solvating suppository. The hydrogel controls elution of the thrombolytic agent. Examples of physiological fluids include interstitial fluids and blood.

The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.

A system for the preparation of fluids for bioprocess and pharmaceutical applications uses one or more flexible bags that are pre-loaded with solid tablets contained therein of various buffer / media / physiological fluid constituents. Examples include salts, acids, bases, preservatives, proteins, amino acids, growth factors, small molecules, and drugs. The flexible bag contains one or more sealed or sealable openings that are used to add water to the interior of the flexible bag as well as remove fluid from the flexible bag. The one or more sealed openings may also be used as an outlet to remove fluid (e.g., buffer) from the flexible bag. The flexible bag may be stored in a deflated state aiding in the storage and / or transport of the flexible bag. Multiple flexible bags may be coupled to a manifold with valves to selectively fill and empty the flexible bags.

An automated oscillating rack comprises a base having a first side surface attached to a support frame with a mounting space for a fluid collection bag, a primary driving unit disposed on a second side surface of the base, and an oscillating assembly comprising a main body disposed at a first end of the primary driving unit, which drives the main body between a first and a second position; a flow channel communicating with an outlet of the fluid collection bag; a secondary driving unit disposed on a second side of the main body; and a flow control switch having a first end attached to a middle section of the flow channel for opening or closing the flow channel and a second end at the secondary driving unit driving the first end to move between a third and a fourth position for opening or closing the flow channel.

The connector (1) for medical, diagnostic and physiological fluid containers, comprises: - at least a first portion (3) comprising at least one substantially hollow tubular element (4), having a substantially elongated conformation along a central axis (5) and comprising at least one inlet opening (6) couplable to at least one hooking portion (7) of a first line of infusion (8); - at least a second portion (9) associated with the first portion (3) from the opposite side of the inlet opening (6) and comprising at least one male element (10) which is arranged within the tubular element (4), has a substantially elongated conformation along the central axis (5) and is substantially hollow and provided with at least a first opening (12) for the fluidic connection to a second line of infusion (13) and with at least a second opening (14), opposite the first opening (12), for the fluidic connection to the inlet opening (6); - joining means (15) by interlocking adapted to associate the first portion (3) with the second portion (9), the first portion (3) and the second portion (9) being linked together to allow the fluidic passage between the first line of infusion (8) and the second line of infusion (13) of at least one fluid to be administered (16) to a patient; wherein the tubular element (4) comprises at least one containment chamber (17) configured to house at least one sock sealing element (18) which consists of a single body piece made of an elastically deformable material and shod by close fitting around the male element (10), the sock sealing element (18) being movable as a result of the pressure exerted by the fluid to be administered in the passage from the first portion (3) to the second portion (9), between a closed position and an open position, wherein the second opening (14) is cleared to allow the fluid-operated communication between the first line of infusion (8) and the second line of infusion (13).

A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.

In some aspects, this disclosure is directed toward polymer coatings that may be used in medical devices such as tampons or intravaginal contraceptives to generate a seal that prevents the transmission of sperm or infectious particles. In some embodiments, a seal may be formed when the polymer coating is exposed to a physiological fluid such as semen.

The invention discloses a multifunctional active nerve scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering nerve scaffolds. The nerve scaffold is composed of a gel layer, a response layer and a cell layer. Wherein the gel layer has conductivity similar to that of nervous tissue and program-controlled deformation and tissue wet adhesion capability under the triggering of water or physiological liquid; the response layer has specific surface topological morphology and power generation capacity under the remote control of external fields such as light, ultrasound and magnetism, and can regulate and control migration and proliferation of cells in the cell layer and release of bioactive substances such as growth factors and exosomes based on topological morphology mediated biomechanical signals and bioelectrical signals generated under the remote control of the external fields. Based on the functions, the multifunctional active nerve scaffold can be used for tissue regeneration and functional reconstruction of nerve injury (such as brain, spinal cord, optic nerve and peripheral nerve). The invention also provides a preparation method of the multifunctional active nerve scaffold.

A method for producing an autologous anti-inflammatory / anti-catabolic composition useful for treating mammals with damaged and / or injured connective tissue, chronic tendonosis, chronic muscle rupture, chronic degenerative joint disease, and / or inflammatory skin disorders is provided. The method includes the steps of: transferring blood collected from a mammal into a tube; storing the blood in the presence of sodium citrate at a temperature of about 20°C to about 40°C for at least about 3.5 hours; centrifuging the blood to separate it into a supernatant component and a cellular fraction; and recovering the supernatant component. TIFF2023518085000002.tif104128

This invention proposes an organic field-effect transistor (OFET) biosensor based on interface topology engineering, its fabrication method, and its application, belonging to the field of biosensor technology. The OFET biosensor comprises a substrate, electrodes, an organic semiconductor layer, an interface topology modification layer, and a biorecognition probe. Through a kinetically controlled vacuum deposition process, an interface topology modification layer with a nanoscale uniform rough morphology is constructed on the semiconductor surface. This topology induces double-layer overlap at the solid-liquid interface, significantly reducing interface capacitance and physically stretching the effective Debye length, thereby overcoming the Debye shielding effect in the high ionic strength environment of physiological fluids. Simultaneously, the aldehyde groups on the surface of the modification layer achieve covalent fixation of the probe without connecting arms and provide encapsulation protection. This sensor achieves ultrasensitive detection of allergen-specific IgE and exhibits excellent stability and signal-to-noise ratio in undiluted human serum, providing a universal physical sensitization strategy for the point-of-care testing of complex clinical samples.

The invention discloses a system and a method for testing compliance of an artificial blood vessel, and relates to the technical field of medical instrument testing equipment. The device comprises a testing bin, a sample to be tested can be contained in the testing bin, and the testing bin is provided with a liquid inlet pipe and a liquid outlet pipe which are communicated with an inner cavity of the sample to be tested; and the main circulation liquid path comprises a liquid inlet channel and a liquid outlet channel which are communicated with the test bin, and an external liquid circulation system communicated with the liquid inlet channel and the liquid outlet channel. Under the constant temperature condition of 37 DEG C, a physiological liquid flowing environment is simulated, pulse type and continuous liquid flow modes are compatible, different operation cycles and target flows can be set according to test requirements, and structural response evaluation and compliance endpoint evaluation of a sample under long-term dynamic loading are achieved; the system has the advantages of being closed in structure, stable in operation, adjustable in parameter, high in repeatability and the like, and is suitable for compliance characteristic verification and comparative study of catheter instruments.

A system for monitoring an organ in vitro, comprising: a machine perfusion apparatus for perfusing the organ with a perfusate comprising an indicator; a spectrometer coupled to an input flow cell and an output flow cell, the input flow cell fluidically coupled to a perfusate recirculation input to the machine perfusion apparatus, and the output flow cell fluidically coupled to a physiological fluid output from the organ; and a controller comprising a processor coupled to the input flow cell, the output flow cell, and the spectrometer.

A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.