7716results about "Group 3/13 element organic compounds" patented technology

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Provided herein are inhibitors of KRAS, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the KRAS inhibitory compounds for the treatment of diseases or disorders.

Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and / or prevent a wide range of diseases associated with Ras.

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The invention discloses a self-assembled monomolecular layer hole transport material, a hole transport layer and a battery thereof. According to the present invention, the compound having different anchoring groups and represented by the formula (I) can be subjected to firm self-assembly with the substrate surface through the chemical bonding manner, such that the good coverage rate is provided, the film forming quality is increased, and the transmission performance is improved; and meanwhile, the material has a rigid conjugate large-plane condensed ring core structure, so that the hole transmission performance of the material is ensured, and the photovoltaic performance is favorably improved. When the material is applied to a perovskite solar cell to prepare a hole transport layer, the hole extraction capability can be enhanced, and the open-circuit voltage, the filling factor and the photoelectric conversion efficiency of a device can be improved.

The invention discloses a double-boron polycyclic compound for an organic electroluminescent device, and belongs to the technical field of organic electroluminescent materials. The double-boron polycyclic compound takes a spiro derivative as a center B atom to be directly bonded with N, O, S and Se, has relatively high singlet and triplet energy, proper HOMO and LUMO energy levels and relatively small singlet-triplet energy difference, and can be used as a luminescent material to be applied to an organic electroluminescent device to improve the luminous efficiency of the device and improve the color purity of the device. After the double-boron polycyclic compound is applied to an OLED as a luminescent material, the relative value of external quantum efficiency of a luminescent device is 105.6%-126.9%, the half-peak width is 22-29 nm, and compared with an OLED using BD01 as the luminescent material, the luminescent efficiency is obviously improved, the half-peak width of an emission spectrum is narrower, and the color purity is higher. The invention provides an MR-TADF material for improving the color purity of a blue light device.

An organic electroluminescence device is provided and including a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer, and a second electrode disposed on the electron transport region, wherein the emission layer may include an organometallic compound, thereby exhibiting high luminous efficiency and long service life characteristics.

The present invention relates to zwitterionic metal chelators and their use as imaging, diagnostic, chemical processing, and treatment agents. These zwitterionic metal chelators have desirable properties that maximize solubility in aqueous environments, minimize non-specific interactions, and retain the ability to target thus resulting in an improved performance in a variety of medical, agricultural, and chemical processes. In in vivo and medical applications, zwitterionic metal chelators improve the signal-to-background ratio and therapeutic window as compared to other metal chelators while retaining high stability.

The invention relates to the technical field of flame retardants, and discloses an enhanced ceramic zinc borate nano flame retardant and a preparation method thereof.The enhanced ceramic zinc borate nano flame retardant is obtained by adding ceramic zinc borate, a sulfur-containing flame retardant and sodium sulfonate modified silane into a stirrer and stirring. The enhanced ceramic zinc borate nano flame retardant is obtained by adding ceramic zinc borate, a sulfur-containing flame retardant and sodium sulfonate modified silane into a stirrer and stirring. Boron elements, sulfur elements, phosphorus elements, silicon elements and sodium sulfonate groups in the sulfur-containing flame retardant and the sodium sulfonate modified silane jointly form a flame-retardant system, and synergistic flame retardance is achieved.

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

The invention discloses a porphyrin copper ion covalent organic framework material with excellent biocompatibility, and belongs to the technical field of biological medicines. The porphyrin copper ion covalent organic framework material is obtained by carrying out solvothermal reaction copolymerization on a porphyrin compound and a novel copper Schiff base boric acid complex in a protective atmosphere; the porphyrin compound is 5, 10, 15, 20-tetra (3, 4-dihydroxyphenyl) porphyrin, and the structural formula of the porphyrin compound is shown in the specification. The structural formula of the novel copper Schiff base boric acid complex is # imgabs0 #. According to the invention, a novel copper Schiff base complex and 5, 10, 15, 20-tetra (3, 4-dihydroxyphenyl) porphyrin are copolymerized to obtain Cu-COF with negligible biotoxicity, and the material realizes the synergistic effect of three antibacterial modes of PDT, PTT and hydroxyl free radicals. The prepared Cu-COF can also be slowly degraded in an acid environment, the infected microenvironment is improved in the degradation process, and the antibacterial effect is improved.

The invention relates to the technical field of preparation of organic photoelectric materials, in particular to a boron-nitrogen compound with a polynary fused ring, an OLED (Organic Light Emitting Diode) with the compound and an organic light-emitting device with the compound. According to the boron-nitrogen compound disclosed by the invention, through matching of a fused heterocyclic structure and limited groups such as tertiary butyl and naphthenic base, the thermal stability of the compound can be improved, and the boron-nitrogen compound has an excellent luminescence characteristic; the boron-nitrogen compound provided by the invention is used as a light-emitting layer material, so that the organic light-emitting device can effectively have lower driving voltage and maintain the stability of the voltage, and the light-emitting efficiency is improved.

The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

The present invention relates to an organic molecule, in particular for application in optoelectronic devices, which comprises or consists of a structure represented by formula I, in which p, q are each integers selected from 0 and 1, where p+q=1, r in each occurrence is an integer selected from 0, 1, 2 or 3, s in each occurrence is an integer selected from 0, 1, 2, 3 or 4, and Z in each occurrence is independently a direct bond, CR 3 R 4 , C=CR 3 R 4 , C=O, C=NR 3 , N.R. 3 , O, SiR 3 R 4 , S, S(O) and S(O) 2 is selected from the group consisting of: [Chemical formula I] JPEG2025505116000078.jpg58170

The invention belongs to the technical field of flame-retardant materials, and particularly relates to a phenylboronic acid-based P / N / B-containing halogen-free flame retardant, a preparation method thereof and application of the phenylboronic acid-based P / N / B-containing halogen-free flame retardant in epoxy resin. The preparation method comprises the following steps: by taking diphenyl hypophosphorous chloride as a basis, preparing a flame-retardant intermediate through nucleophilic substitution reaction between diphenyl hypophosphorous chloride and an aldehyde group-containing phenolic compound, then reacting a phenylboronic acid structure with 3-amino-1, 2-propylene glycol to obtain an amino group-containing phenylboronic acid compound, and finally reacting the phenylboronic acid compound with 3-amino-1, 2-propylene glycol to obtain the amino group-containing phenylboronic acid compound. And finally, carrying out a Schiff base reaction on the flame-retardant intermediate and an amino-containing phenylboronic acid compound to obtain the halogen-free flame retardant containing phosphorus, nitrogen and boron elements. The flame retardant provided by the invention can significantly improve the flame retardant property and mechanical property of epoxy resin. A flame-retardant epoxy resin prepared based on the flame retardant; the influence on Tg of an epoxy resin cured product is small, the smoke suppression and char formation performance and the mechanical performance of the cured product can be remarkably improved, and meanwhile, the flame retardant has excellent flame retardant efficiency; the limit oxygen index of the flame-retardant epoxy resin can reach 31%; the vertical combustion grade is V-0 or above, and the carbon residue amount can reach 18% or above.

The invention provides a boron-nitrogen heterocyclic compound as well as an intermediate and a preparation method thereof, the boron-nitrogen heterocyclic compound has a structure as shown in a general formula (1), and is prepared by taking compounds as shown in a formula A, a formula B and a formula C as intermediates. Compared with similar carbon skeleton molecules, the boron-nitrogen heterocyclic compound provided by the invention shows an excellent narrow-band luminescence property. The half-peak width of the emission spectrum of the boron-aza compound is as low as 6.4 nm, and meanwhile, the fluorescence quantum yield is as high as 97%.

The present invention relates to an organic molecule, in particular for application in optoelectronic devices. According to the invention, the organic molecule has a structure according to formula I, in which p, q are integers selected from 0 and 1, where p+q=1, r is, in each occurrence, an integer selected from 0, 1, 2 or 3, s is, in each occurrence, an integer selected from 0, 1, 2, 3 or 4, and Z is, in each occurrence, independently, a direct bond, CR 3 R 4 , C=CR 3 R 4 , C=O, C=NR 3 , N.R. 3 , O, SiR 3 R 4 , S, S(O) and S(O) 2 is selected from the group consisting of: [Chemical formula I] JPEG2025506369000072.jpg58170

The invention provides a compound with methyltransferase inhibitory activity, and particularly provides a compound with PRMT5 inhibitory activity. The compound can be used for preparing a pharmaceutical composition for treating diseases related to PRMT5 activity. # imgabs0 #

The present application relates to a multi-specific bioconjugate linker and a method for synthesizing the same, and specifically to a compound or its tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt thereof. The present application also relates to a method for preparing the compound and its use in tumor treatment.

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase:whereinR1 is —NHR1a;R1a is —H or —C(O)CH(R1b)NHR1c; andR1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; orR1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; andR1d is H or —CH3.

The invention discloses an aniline pyridine amino-aluminum catalyst and a preparation method and application thereof, belonging to the technical field of polyester catalysts. The invention can directly utilize an aniline pyridine amino ligand to react with an aluminum source, and directly drain the solvent after the reaction to obtain a corresponding catalyst. The invention also utilizes the synthesized catalyst to catalyze monomers such as cyclic esters and lactones to prepare biodegradable aliphatic polyesters, and the monomer conversion rate is greater than 96%. Compared with the currently commercialized stannous isooctanoate catalyst, the aniline pyridine amino-aluminum catalyst provided by the invention has higher catalytic activity and lower biological toxicity, and has certain application prospects.

An organic electroluminescence device includes a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer, and a second electrode disposed on the electron transport region. The emission layer includes a polycyclic compound represented by Formula 1 to thereby achieve high luminous efficiency:

The invention relates to the technical field of preparation of organic photoelectric materials, in particular to a boron-nitrogen compound and an organic electroluminescent device comprising the same. The boron-nitrogen compound disclosed by the invention has good electron and hole receiving capability, and interaction among luminescent molecules can be effectively inhibited by introducing a spirocyclic group with large steric hindrance. And the energy transmission performance between a subject and an object or a sensitizer can be improved by the large conjugated spiro structure unit. Specifically, the boron-nitrogen compound provided by the invention is used as a functional layer, especially as an organic electroluminescent device manufactured by a luminescent layer, the current efficiency is improved, the lighting voltage is reduced, and meanwhile, the service life of the device is greatly prolonged. Therefore, after most electrons and holes are compounded, energy is effectively transferred to the boron-nitrogen compound, so that high luminous efficiency is realized.

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Provided is a light emitting device including a first electrode, a second electrode, and an emission layer between the first electrode and the second electrode, and the emission layer may include a condensed cyclic compound represented by Formula 1 below, thereby exhibiting high luminous efficiency and improved service life characteristics.

The invention relates to an organic compound, a solar cell and application thereof. The organic compound is shown as a formula (1), wherein Ar is selected from any one of substituted or unsubstituted aryl with the ring-forming atom number of 6-50, substituted or unsubstituted heteroaryl with the ring-forming atom number of 5-50, a group shown as a formula (A) and a group shown as a formula (B), Ar'is selected from an electrically neutral organic group, and L is selected from a paraffin subunit with the carbon atom number of 1-10; r1 is an oxyacid group; n1 is selected from any integer of 1-3, and m1 is selected from any integer of 1-10; or the organic compound is an oxyacid radical salt of the compound as shown in the formula (1). The organic compound not only can be used as a passivation material, but also can be used as a hole transport material, and can improve the photoelectric conversion efficiency of a solar cell when being applied to preparation of the solar cell.