2776 results about "Trifluoromethyl" patented technology

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention relates to a pharmaceutically acceptable salt of a fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 3-chloro-5-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxy)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptan-2-yl)-4-(trifluoromethyl) aniline, a crystal form, and a preparation method thereof, and a preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The invention discloses an OCA optical adhesive and a preparation method thereof, and relates to the technical field of adhesives, and the OCA optical adhesive is prepared from the following raw materials in parts by weight: 35-45 parts of acrylate-terminated hyperbranched organosilicon modified polyurethane, 2-4 parts of allyl succinimido carbonate, 1-3 parts of hexafluorobisphenol A diacrylate, 1-3 parts of 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 1-3 parts of 1, 3-pentanediol monoisobutyrate, 1-3 parts of 1, 3-pentanediol monoisobutyrate, 1-3 parts of 1, 3-pentanediol The invention relates to a photocurable adhesive, which is prepared from the following components in parts by weight: 20 to 30 parts of a diluent, 0.6 to 1.2 parts of a photoinitiator, 0.5 to 1 part of an antioxidant and 0.5 to 1 part of a de-foaming agent. The photocurable adhesive is prepared from the following components in parts by weight: 1 to 5 parts of 1, 3-bis (oxiranyl methyl)-5-(2-propenyl)-1, 3, 5-triazine-2, 4, 6 (1H, 3H, 5H)-triketone, 3 to 5 parts of 2, 2 '-bis (trifluoromethyl) diaminodiphenyl, 6 to 8 parts of other polymerizable monomers, 20 to 30 parts of the diluent, 0.6 to 1.2 parts of the photoinitiator, 0.5 to 1 part of the antioxidant and 0.5 to 1 part of the de-foaming agent. The OCA optical adhesive is good in bonding performance, sufficient in weather resistance and environmental protection performance and good in oil resistance.

The invention discloses an electrolyte with a temperature switch function and a preparation method and application thereof, and relates to the technical field of lithium ion batteries. The electrolyte provided by the invention comprises the following components: lithium salt, a first organic solvent and a polymer, the lithium salt is at least one of lithium bis (trifluoromethylsulfonyl) imide, lithium bis (fluorosulfonyl) imide, lithium hexafluorophosphate, lithium tetrafluoroborate, lithium difluoro (oxalato) borate and lithium bis (oxalato) borate; the polymer is polymethacrylate, and the first organic solvent is [Cnmim] [TFSI]. According to the electrolyte, the reversible phase transformation process is realized, the electrode reaction can be closed at high temperature, and the lithium battery is prevented from being out of control due to overheating; and when the temperature is reduced to normal temperature, the battery can work normally. The phase transition temperature of the electrolyte is flexible and controllable, and the phase transition temperature can be regulated and controlled to a reasonable interval by optimizing the composition of the electrolyte and the dosage (concentration) of each component, that is, the phase transition temperature is higher than the normal working temperature of the battery and lower than the initial temperature of the heat release side reaction.

The invention discloses a wear-resistant and high-temperature-resistant synchronous belt and a preparation method thereof. The wear-resistant and high-temperature-resistant synchronous belt comprises a synchronous belt framework and a synchronous belt rubber sheet, the synchronous belt rubber sheet is prepared from the following raw materials: a fluorosilicone thermoplastic polyurethane elastomer containing a benzene ring structure, an amino-containing hyperbranched liquid crystal polymer, methyl vinyl phenyl silicone rubber, epoxidized natural rubber, molybdenum sulfide nanosheets, reinforced fibers, bis (1-vinyl imidazole-2-) ketone, 2-acrylamido-2-methylpropanesulfonic acid, 4, 4 '-difluoro-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1 The high-temperature-resistant rubber is prepared from 2, 6-hydroxy-2-cyanobenzothiazole, bis (3-aminophenyl) 3, 5-bis (trifluoromethyl) phenylphosphine oxide, a catalyst, a coupling agent, a vulcanizing agent, an anti-aging agent, a scorch retarder and a lubricating agent. The synchronous belt is good in mechanical property, sufficient in high-temperature resistance and cold resistance, good in wear resistance and excellent in aging resistance and flame retardance.

The invention belongs to the field of medical chemistry, and particularly relates to a crystal form of a heterocyclic compound and a pharmaceutical composition thereof. Specifically, the invention relates to a crystal form of 4-((2R, 3S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-5-methyl-5-(trifluoromethyl) thiacyclopentane-2-formamido) pyridine-2-formamide and a pharmaceutical composition of the crystal form of 4-((2R, 3S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-5-methyl-5-(trifluoromethyl) thiacyclopentane-2-formamido) pyridine-2-formamide. The crystal form is good in crystallinity, excellent in chemical stability and crystal form stability, high in process safety and capable of playing a good drug effect in various animal models.

The present invention relates to novel (3,3-dimethyl-2-oxo-butoxy)phenyl derivatives and (2- aryl-2-oxo-ethoxy]phenyl derivatives and to their application in a process for the preparation of (3,3,3-trifluoro-2-oxo-propoxy)phenyl derivatives and their further transformation into [(2- trifluoromethyl-1,3-dioxolan-2-yl)methoxy]phenyl derivatives and (2-ethoxy-3,3,3-trifluoro- prop-1-enoxy)phenyl derivatives suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.

Disclosed herein are (6-(4-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, (6-(4-(difluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, and (6-(2-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

The invention relates to an electrolyte additive, an electrolyte and a battery. The electrolyte additive comprises a first additive and lithium trifluoromethanesulfinate, the structural formula of the first additive is as shown in a formula (I): # imgabs0 # formula (I), and in the electrolyte additive, the mass ratio of the first additive to the lithium trifluoromethanesulfinate is 0.02-10. When the electrolyte additive is added into the electrolyte of the battery, the rate capability and the high-temperature performance of the battery can be effectively improved.

The invention belongs to the technical field of refrigerants, and provides a mixed refrigerant for replacing R290 and a preparation method and application thereof, the mixed refrigerant comprises a first component, a second component and a third component; the first component is trans-1, 2-difluoroethylene, the second component is 2, 3, 3, 3-tetrafluoropropene, and the third component is trifluoromethyl methyl ether; compared with R290 refrigerants in the prior art, the mixed refrigerant has the advantages that flammable and explosive components do not exist, and high-risk combustible gas clusters cannot be formed due to density layering after leakage, so that the mixed refrigerant has high safety performance, and the safety level can be not lower than A2L; the mixed refrigerant has the environment-friendly characteristic of low GWP, the GWP is smaller than or equal to 150, and the environment-friendly requirement is met; the thermophysical property and the refrigeration and / or heating cycle performance of the mixed refrigerant are similar to or better than those of R290; the mixed refrigerant can be used for directly replacing an R290 refrigerant.

The invention discloses an environment-friendly flame-retardant polyester yarn and a preparation method thereof, and relates to the technical field of textile, and the environment-friendly flame-retardant polyester yarn is prepared from the following raw materials in parts by weight: 100 parts of polyester chips, 10-15 parts of a flame-retardant polymer containing an organic salt structure, 1-3 parts of an antioxidant, 0.8-2 parts of a lubricant, 1-2 parts of benzotriazole sodium and 0.8-1.2 parts of quinoline yellow. The flame-retardant polymer containing the organic salt structure comprises a structural unit introduced by the following monomers: bis (3-aminophenyl) (3, 5-bis (trifluoromethyl) phenyl) phosphine oxide, 3, 7-diamino-5-phenylphenazine chloride and 3, 5-isoxazole dicarboxylic acid. The environment-friendly flame-retardant polyester yarn is good in ultraviolet aging resistance and flame retardance, high in strength and sufficient in softness.

The invention relates to a perfluoro wide-temperature electrolyte for a lithium battery and application thereof, the wide-temperature electrolyte comprises a lithium salt, an additive and a plurality of perfluoro mixed solvents, the electrolyte capable of stably working in a wide temperature range (-80-80 DEG C) is successfully constructed, and the excellent electrochemical performance of the lithium battery at the wide temperature is realized. The electrolyte additive disclosed by the invention mainly comprises one or more of hexafluoroisopropoxy cyclotriphosphazene, 3-(2, 2, 2-trifluoroethoxy) propionitrile, 3-(2, 2, 2-trifluoroethoxy) butyronitrile, 3, 4-fluoroethylene sulfate and 4-trifluoromethyl-ethylene sulfate, and the fluorine-containing additive is good in flame retardant effect, moderate in viscosity, good in system compatibility, good in corrosion resistance and good in corrosion resistance. And a protective film can be formed on the surface of the positive electrode of the lithium battery, so that the high-pressure and high-temperature cycle performance of the battery is improved, the electrochemical performance of the battery is not influenced at all, the self-extinguishing time of the electrolyte is obviously shortened, the flame retardant property and the conductivity are excellent, the overcharge resistance of the lithium ion battery is also obviously improved, and the safety performance of the battery is improved.

The invention relates to the technical field of pesticide production, in particular to a synthesis method of 1-methyl-3-trifluoromethyl-4-chloromethyl-5-difluoromethoxy-1-H-pyrazole, which at least comprises the following steps: firstly, mixing trioxymethylene and 1-methyl-3-trifluoromethyl-5-difluoromethoxy-1-H-pyrazole to prepare a solution A; the solution A and chlorosulfonic acid are mixed and then subjected to a chloromethylation reaction, 1-methyl-3-trifluoromethyl-4-chloromethyl-5-difluoromethoxy-1-H-pyrazole is obtained through aftertreatment after sampling detection is qualified, and the method is high in product yield, high in purity, low in production cost, high in production efficiency, easy to operate, capable of meeting the green and environment-friendly requirements and suitable for industrial production. The industrial production is easy to realize.

The invention relates to environment-friendly hydrophobic ink and a preparation method thereof, and belongs to the technical field of water-based ink. A copolymerization modifier capable of being combined in a water-based polyacrylate emulsion in an initiation polymerization mode in the stage of preparing the modified water-based polyacrylate emulsion is prepared, and an o-hydroxy aromatic ketone structure in the copolymerization modifier can endow water-based ink with lasting ultraviolet absorption performance; the trifluoromethyl structure can reduce the surface energy of the water-based ink, and the benzimidazole ring structure can form stable coordinate bonds with metal ions, so that the bonding performance of the water-based ink and a metal substrate is enhanced; when the copolymerization modifier is used for modifying the water-based polyacrylate emulsion, the long-term performance, the hydrophobic and oil-resistant performance and the adhesion performance on the surface of a metal base material of the finished water-based ink can be effectively improved.

The invention relates to a perovskite solar cell, which comprises a substrate, a hole transport layer, a perovskite film layer, an electron transport layer and an electrode layer, the perovskite film layer comprises a perovskite material ABX3 and an additive, the additive contains an electron withdrawing group, the additive and the perovskite material are mixed to form the perovskite film layer, and the hole transport layer is arranged between the hole transport layer and the perovskite film layer. A modification material layer is arranged between the perovskite film layer and the electron transport layer, and the modification material layer forms n-type doping on a contact interface of the perovskite film layer. According to the cell, diethyl (3-(trifluoromethyl) benzyl) phosphonate is doped in a perovskite film layer, so that intrinsic weak n-type perovskite is converted into a p-type perovskite at a position close to a hole transport layer, and a surface modification material is arranged between the perovskite film layer and an electron transport layer, so that the perovskite film layer close to the electron transport layer is converted into an n-type perovskite film layer, an efficient p-n junction is formed, and the photoelectric conversion efficiency of the cell is improved. And the efficiency of the perovskite cell is improved.

The invention discloses a preparation method of 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile, and belongs to the technical field of organic synthesis.The preparation method comprises the steps of acylation reaction, cyclization reaction, bromination reaction and recovery. The preparation method disclosed by the invention is high in safety, the prepared 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile is high in purity and yield, the equipment investment is small, the bromination reaction speed is high, the acid-binding agent can be recycled, the drying time during recycling is short, and the water content in the recycled acid-binding agent is low.

The application discloses a specific palmitoyl transferase inhibitor and application thereof, and an active ingredient of the palmitoyl transferase inhibitor is 4-(3-(2-(trifluoromethyl)-9H-thioxanthene-9-ylidene)propyl)-1-piperazine ethanol or a salt thereof. Current palmitoylation inhibitors, 2-bromohexadecanoic acid (2-BP), cerulenin and tunicamycin can all inhibit protein palmitoylation in cells, but all are not selective. And the existing palmitoylation inhibitors are similar to endogenous fatty acids, and inevitably affect lipid metabolism in the body, which limits the clinical application. The application discloses, for the first time, the application of 4-(3-(2-(trifluoromethyl)-9H-thioxanthene-9-ylidene)propyl)-1-piperazine ethanol as a specific palmitoyl transferase inhibitor, and the palmitoyl transferase inhibitor is better in specificity and reversible in inhibition.

The invention discloses a synthesis method of 2-bromomethyl-5-trifluoromethyl furan, which comprises the following steps: S1, carrying out reaction on acetoacetate and halogenated trifluoroacetone under the action of an alkaline substance and a catalyst to generate a 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product; s2, carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product, so as to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product, and carrying out a cyclization reaction on the 2-acetyl-5, 5, 5-trifluoro-4-oxovalerate crude product to obtain a 2-methyl-5-(trifluoromethyl) furan-3-formate crude product; s3, adding an alkaline substance into the crude product, carrying out hydrolysis, and adding acid to adjust the pH value after the hydrolysis is completed, so as to obtain 2-methyl-5-(trifluoromethyl) furan-3-formic acid; s4, the 2-methyl-5-(trifluoromethyl) furan-3-formic acid is subjected to a heating decarboxylation reaction, and 2-methyl-5-(trifluoromethyl) furan is obtained; and S5, carrying out a bromination reaction on the 2-methyl-5-(trifluoromethyl) furan and a bromination reagent to obtain a final product 2-bromomethyl-5-(trifluoromethyl) furan. The raw materials used in the synthesis method are easy to obtain, use of control chemicals is not involved, and industrialization is easy to achieve.

The invention provides a preparation method of a covalent organic framework material and application of the covalent organic framework material in a tin-air battery, and the preparation method comprises the following steps: dispersing 2, 2 '-bis (trifluoromethyl) diaminobiphenyl in a mixed solution of 1, 3-dioxolane and ethylene glycol dimethyl ether to obtain a solution I; 2, 4, 6-triformyl phloroglucinol is dispersed in a tetraethylene glycol dimethyl ether solution, and a solution II is obtained; dripping the solution I on a polished tin sheet; after the solution is volatilized, dripping the solution II at the same position; reacting at room temperature for 12 hours, washing with a tetrahydrofuran solution for one time, and washing with a mixed solution of 1, 3-dioxolane and ethylene glycol dimethyl ether for 1-3 times; and then carrying out vacuum drying at room temperature for 8-12h, and finally preparing the covalent organic framework material on the tin sheet. According to the invention, an in-situ preparation method is adopted, the covalent organic framework film and the tin anode are compounded together, and the tin anode is separated from the electrolyte by the film, so that the corrosion of the electrolyte to the anode in room-temperature and high-temperature environments can be reduced, and the formation of by-products and dead tin on the surface of the anode is reduced to improve the battery performance.

The invention provides a perovskite passivation layer and a preparation method thereof. According to the invention, a perovskite passivation layer is arranged on the surface of a perovskite absorption layer, and the material of the perovskite passivation layer contains an alkyl diamine compound and a phenylethyl ammonium compound; the phenethyl ammonium compound is selected from p-trifluoromethyl phenylethylamine hydrochloride and / or p-fluorophenethyl hydriodate. According to the perovskite solar cell and the preparation method thereof, the alkyl diamine compound and the phenylethyl ammonium compound are cooperated to form the passivation layer, the simultaneous effect of surface passivation and interface passivation can be exerted, the carrier recombination of the surface and the interface is reduced, the electron extraction capability is improved, and the energy conversion efficiency of the perovskite solar cell is further improved.

The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4] oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.

The present invention belongs to the field of water treatment technology, and relates to a fluorinated ZIF-67 / graphene composite catalyst for coal chemical wastewater treatment and a preparation method thereof. The catalyst uses porous graphene as a carrier to load fluorinated ZIF-67. First, 2-trifluoromethylimidazole is introduced into ZIF-67 to prepare fluorinated ZIF-67, and an in-situ preparation method is used to make it grow evenly on the surface of a porous graphene carrier to obtain a fluorinated ZIF-67 / graphene composite catalyst. 2-trifluoromethylimidazole modification can improve the hydrophobicity of the catalyst, making it less susceptible to erosion during water treatment; The porous structure of graphene provides a larger specific surface area, increases the number of active sites of the catalyst, prevents nanoparticles from agglomerating, and improves its mechanical strength. The catalyst has the ability to highly degrade organic pollutants, is suitable for treating pollutants such as phenols and greases that are difficult to biodegrade in coal chemical wastewater, and has broad market prospects.

The invention discloses a synthesis method of a 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative, and belongs to the technical field of organic synthesis.The 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative is obtained by synthesizing 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] in the presence of visible light, a photocatalyst and alkali. CF3Br and a 3-(3-hydroxypropyl) indole derivative are subjected to a free radical tandem cyclization reaction in an organic solvent to prepare the 3-(3-hydroxypropyl) indole derivative. According to the 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative and the preparation method thereof, CF3Br is used as a trifluoromethyl source under photocatalysis for the first time, trifluoromethyl is directly introduced into an indoline ring of 4, 5-dihydro-spiro [furan-2, 3 '-indoline], the 2'-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3 '-indoline] derivative is obtained, and the compound has good activity and selectivity on cancer cells such as Huh-7, A549 and A549 / DDP.

The invention provides a preparation method of hexafluoroisobutylene, which comprises the following steps: (1) mixing a first solvent, a first alkali liquor and a sulfonium salt compound in an inert gas atmosphere for primary reaction, then mixing with hexafluoroacetone for secondary reaction, and purifying to obtain 2, 2-bis (trifluoromethyl) ethylene oxide; (2) mixing a second solvent and 2, 2-bis (trifluoromethyl) ethylene oxide in an inert gas atmosphere, carrying out first cooling treatment, then mixing a reducing agent, carrying out a reduction reaction, and purifying to obtain hexafluoroisobutanol; and (3) mixing a third solvent and second alkali liquor, carrying out second cooling treatment, mixing hexafluoroisobutanol, carrying out third reaction, condensing and rectifying to obtain the hexafluoroisobutene. The preparation method provided by the invention is short in process route and mild in reaction condition, the solvent used in the preparation process can be recycled, the pollution in the preparation process is reduced, and the preparation method is less in three wastes, environment-friendly and suitable for large-scale production.

The invention discloses a high-temperature-resistant ethylene-tetrafluoroethylene copolymer as well as a preparation method and application thereof. The copolymer comprises the following raw materials: 10-30 parts of ethylene; 60 to 80 parts of tetrafluoroethylene; and 6 to 30 parts of 4-(trifluoromethyl) styrene. The preparation method comprises the following steps: adding a perfluorocarbon solvent and 4-(trifluoromethyl) styrene into a reaction kettle, stirring, and keeping the temperature at 30-50 DEG C; and adding a mixed gas of ethylene and tetrafluoroethylene and a perfluorobutyryl peroxide compound in a molar ratio of 1: 1 into the system to initiate a polymerization reaction under the reaction pressure of 1-4MPa for 15-30 minutes. The application comprises the following steps: adding the prepared high-temperature-resistant ethylene-tetrafluoroethylene copolymer into an extruder; extruding at the temperature of 260-300 DEG C to coat the outer surface of the electric wire or the cable; and carrying out annealing treatment on the wire or the cable coated with the high-temperature-resistant ethylene-tetrafluoroethylene copolymer at the annealing temperature of 120-180 DEG C for 12-24 hours. The preparation method of the high-temperature-resistant ethylene-tetrafluoroethylene copolymer is simple, low in cost and convenient for large-scale production and application.

The invention relates to the field of battery materials, in particular to a halogen-free electrolyte for a magnesium metal battery and a preparation method of the halogen-free electrolyte. The magnesium salt comprises at least one of bis (trifluoromethanesulfonyl) imide magnesium and magnesium trifluoromethanesulfonate; the additive is prepared from at least one of indole, 3-azaindole, 4-azaindole, 5-azaindole, 6-azaindole, 4-amino indole, 5-amino indole, 6-amino indole and 7-amino indole; the organic solvent comprises ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether, 1, 3-dioxolame or 1, 3-dioxane. The preparation method comprises the following steps: sequentially adding the magnesium salt and the additive into the organic solvent, and stirring and reacting at room temperature for 1 min to 24 h to obtain the halogen-free electrolyte for the magnesium metal battery. And the prepared electrolyte has excellent performances of small overpotential, long service life and wide electrochemical window, and has a good commercial application prospect.

The invention discloses an antibacterial material rich in a bismuth metal organic framework and a preparation method thereof, the method comprises the following steps: adding an indole monomer and an alcohol monomer into a solvent, and then adding nitrosalicylaldehyde into the solvent to obtain a spiropyran compound; the preparation method comprises the following steps: adding humic acid into a binary solvent consisting of dioxane and butanol to obtain a mixed solution; the ratio of the mass of the humic acid to the volume of the binary solvent is (2-3): (20-40) g / ml; sequentially adding a bismuth source, 2-bromo-5-(trifluoromethyl) pyridine and 4-(trifluoromethyl) phenylboronic acid into the mixed solution to obtain a bismuth metal organic framework; and adding the spiropyran compound into the bismuth metal organic framework to obtain the antibacterial material rich in the bismuth metal organic framework. The antibacterial capability of the antibacterial material is improved.

The invention discloses a gamma-aminobutyric acid gated chloride ion channel allosteric modifier compound and an application thereof, namely (S)-4-(5-(3-chloro-5-(trifluoromethyl) phenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazole-3-yl)-2-methyl-N-(2-oxo-2-((2, 2, 2-trifluoroethyl) amino) ethyl) benzamide, and a preparation method of the gamma-aminobutyric acid gated chloride ion channel allosteric modifier compound. The compound has an excellent control effect on pests of thysanoptera, acarina, lepidoptera and the like, is very friendly to bees and high in environmental ecological safety, can be used for preparing efficient, low-toxicity and safe insecticides, and has a wide application prospect in agricultural production.