2807results about "Rotary centrifuges" patented technology

Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.

The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium separates red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends puncture the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container blocks flow through the cannula upon entering therein.

The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

A multiple function pump station performs different on-line processing tasks. The pump station can be operated in one mode to draw blood from a donor can, in another mode, be operated to return blood to the donor. The pump station used to draw blood from a donor can also be used to perform subsequent blood processing tasks, such as mixing processing or additive fluids with the blood, or transfering a harvested blood component to a storage container, or finishing the processing of a harvested blood component, e.g., by passage through a filter to remove leukocytes.

A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports. The rake can comprise a longitudinal body, the center of which is secured to the rigid outlet tube. The separator-concentrator includes a valve assembly connecting the separation chamber and the concentration chamber. PRP concentrate is produced by contacting PRP with desiccated beads while the beads are stirred with a stationary rake, and rotating the concentration chamber at centrifugal speeds to separate PRP concentrate from the beads.

A system for automatically processing blood components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.

Centrifuge systems and methods for controlling centrifuge systems, the systems in certain aspects for processing material, e.g., but not limited to drilling fluids with solids therein. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure and is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims, 37 C.F.R. 1.72(b).

A centrifuge for separating particulate matter from circulating fluid includes a centrifuge enclosure including a housing and a base joined together so as to define a hollow interior. A rotor is positioned in the hollow interior and is supported by the base in a manner to permit rotary motion of the rotor relative to the centrifuge enclosure. A coalescing filter assembly is secured to the rotor and is constructed and arranged for removing oil aerosol from a blowby gas which is introduced into the centrifuge. A roller bearing, press fit into the centrifuge housing, receives a portion of the coalescing filter assembly.

A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.

Preferred aspects of the present invention relate to advances in rotating, vortex-enhanced reverse osmosis filtration. More particularly, the filtration device and methods incorporate a rotational drive mechanism adapted to use the flow of pressurized process fluid to cause rotation of a rotor within a housing, thereby creating shear and Taylor vortices in the gap between the rotor and housing. The improvements disclosed herein facilitate continuous use of vortex-enhanced filtration for prolonged periods of time.

A computerized system for monitoring, diagnosing, operating, and controlling various parameters and processes of basket centrifuges is presented. The computer control system actuates at least one of a plurality of control devices based on input from one or more monitoring sensors so as to provide real time, continuous, operational control of certain parameters. In a preferred embodiment, the apparatus comprises a basket centrifuge with at least one sensor for providing input which is analyzed to provide information regarding cake moisture at a given time. As a result of the analysis, at least one output may be generated to activate a control device that effects changes or adjustments in the operation of the centrifuge.

A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an elongated sidewall having a first cross-sectional inner diameter. The float consists of a main body portion and one or more support members protruding from the main body portion to engage and support the sidewall of the sample tube. The main body portion and the support members of the float have a cross-sectional diameter less than that of the first cross-sectional inner diameter of the tube when the sample tube is expanded, such as by centrifugation. The main body portion of the float together with an axially aligned portion of the sidewall define an annular volume therebetween. The support members protruding from the main body portion of the float traverse said annular volume to produce one or more analysis areas. During centrifugation, the centrifugal force enlarges the diameter of the tube to permit density-based axial movement of the float in the tube. Thereafter, the centrifugal force is reduced to cause the tube sidewall to return to its first diameter, thereby capturing the float and trapping the buffy coat constituents in the analysis area. The buffy coat constituents can then be evaluated or measured.

A centrifuge labware includes a container and a removable, non-threaded lid. The container has a top opening which is at least about 90% of the cross-sectional area of the container.

In a centrifugal separator for cleaning gases generated by an internal combustion engine a housing defines an interior separation chamber. A centrifugal rotor is coupled for rotation to the housing and extends into the separation chamber. A drainage chamber is positioned adjacent the separation chamber and is delimited therefrom by a partition wall. A flow path is provided through which oil, separated from gases generated by the internal combustion engine and collecting on the partition wall, can travel from the separation chamber to the drainage chamber. A pump wheel is coupled to a shaft portion defined by the rotor and extends radially outwardly therefrom. During operation the oil, upon exiting the separation chamber, contacts the pump wheel. Centrifugal forces generated due to the rotation of the pump wheel cause the oil to be thrown into the drainage chamber. The pump wheel also minimizes the potential for oil resident in the drainage chamber to re-enter the separation chamber.

Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and / or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.

The invention relates to a device and a method for collecting blood and separating blood plasma as a liquid sample, by means of a canal that absorbs the liquid sample by capillary forces. The aim of the invention is to obtain a uniform filling of the canal with the liquid sample and an effective separation. To achieve this, deaeration takes place in a transverse direction to the main filling direction or to the longitudinal direction of the canal, immediately downstream of a separation device in an inlet region of the canal.

Disclosed herein is a thin-film layered centrifuge device and an analysis method using the same. One example of an embodiment of the present invention is a thin film layered centrifuge device where a device, such as a lab on a chip, a protein chip and a DNA chip, for diagnosing and detecting a small amount of material in a fluid is integrated into a rotatable thin-film layered body, and to an analysis method using the thin-film layered centrifuge device.

The invention refers to a centrifugal separator comprising a stationary casing defining an inner space, a spindle and a rotating member, which is attached to the spindle and arranged to rotate around an axis of rotation with a rotary speed. The rotating member comprises a number of separating discs which are provided in the inner space. A drive member drives the spindle and the rotating member with said rotary speed. A sensor device senses the rotation of the rotating member in relation to the casing. The sensor device comprises at least one transmitter element which is provided in the inner space on the rotating member and a receiver element which is provided at the casing and arranged to sense the transmitter element. The receiver element is provided on the casing outside the inner space.

A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed.

An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.