1982 results about "Biodegradation" patented technology

The invention discloses an in-situ biomineralizable mineral-PHA water-based seed coating based on microphase separation and soil water potential response and a preparation method and application thereof, and belongs to the technical field of green coatings, the in-situ biomineralizable mineral-PHA water-based seed coating comprises a structural mineral skeleton, a PHA and resin composite matrix and a pore-forming disintegrating agent. According to the invention, a resin enrichment layer and island microphase structure is innovatively constructed, and the contradiction between poor wear resistance and difficult disintegration of a bio-based material is effectively solved. Compared with the prior art, the wear-resistant and dust-reducing coating has the advantages that the wear-resistant and dust-reducing performance far better than that of the traditional PHA coating is realized by utilizing an interface enhancement effect under the condition of equal or even lower polymer dosage; meanwhile, the coating is endowed with a sensitive soil water potential response'switch ', so that dry-state tough seed protection and wet-state rapid disintegration are ensured, and germination is not hindered. Organic components of the composition can be biodegraded in aerobic soil, inorganic components are natural minerals, the environmental compatibility is good, the composition has the advantages of high performance and low cost, and an excellent seed treatment scheme is provided for green agriculture.

The invention discloses a water-based PHA (Polyhydroxyalkanoate) coating and PHA extrusion layer compounded paper-based high-barrier material as well as a preparation method and application thereof, and belongs to the technical field of biodegradable high polymer materials and environment-friendly packaging. According to the scheme, a double-component system with a specific melting point difference is innovatively introduced to construct the water-based pre-coating layer, and efficient sealing and strong anchoring of a rough base material can be achieved under the extremely low coating weight by means of the double mechanisms of'microcosmic leveling and interface thermal fusion '. Compared with a traditional thick-layer lamination process, the material achieves more excellent barrier integrity and oil-resistant and moisture-resistant performance through a thinner extrusion surface layer, the moisture-resistant and oxygen-resistant performance is remarkably improved, and meanwhile the requirement for puncture resistance of dry and hard food packaging materials is thoroughly met through the unique double-layer system stress balance design. The material does not contain fluorine additives, is completely biodegradable, and meets the high-standard requirements of food safety and compliance.

The invention provides an environment-friendly water-based acrylic emulsion adhesive without containing an organic solvent. The environment-friendly water-based acrylic emulsion adhesive is prepared from the following raw materials: 55-60 wt% of eleostearic acid hydroxyethyl acrylate (TMA), 15-25 wt% of butyl acrylate (BA), 3-10 wt% of acrylic acid (AA), 2-5 wt% of a cross-linking agent, 3-8 wt% of modified soil and 0.5-1 wt% of an initiator as a solid phase; the liquid phase is deionized water, and the environment-friendly water-based acrylic emulsion adhesive is prepared through semi-continuous emulsion polymerization. The prepared environment-friendly water-based acrylic emulsion adhesive is high in biodegradability and low in VOC content, has the mechanical property matched with that of a traditional acrylic emulsion adhesive and also has the self-repairing capacity, waste materials can be treated by changing the temperature or pH condition, the environment-friendly water-based acrylic emulsion adhesive can be recycled for multiple times, and the recycling cost is reduced.

The invention discloses a bacteriostatic and antiviral bamboo pulp paper-based sanitary isolation bag as well as a preparation method and application thereof, and belongs to the field of functional paper-based packaging materials. The isolation bag takes bamboo pulp fiber paper as a base material, and the surface of the isolation bag is coated with a water-based polyhydroxyalkanoate functional coating. According to the preparation method, a special polyphenol derivative-chitosan quaternary ammonium salt-nano zinc oxide organic-inorganic hybrid factor is introduced, and the problem of agglomeration of nano particles is effectively solved by utilizing the special bridging effect of polyphenol, so that high-density cation capture and oxidation inactivation sites are constructed on the surface of the coating. Compared with the prior art, the method has the advantages that the method does not need to depend on organic fluorine compounds, and the excellent waterproof and oil-proof barrier effect and the efficient inactivation of viruses can be achieved only through the extremely low coating amount. In addition, the isolation bag has unique environmental chemical responsiveness, can be efficiently dissociated under the alkaline condition to facilitate repulping recovery, can be completely biodegraded in the natural environment, and perfectly considers the requirements of biological safety protection and green environmental protection.

The application relates to the technical field of garden engineering, and discloses a garden rainwater collection and purification treatment device based on multistage filtration, which comprises a support, a purification tank is fixedly connected to the top of the support, a biological filtration assembly for biodegradation and purification of rainwater is further arranged in the purification tank, and a sedimentation tank for rainwater collection is further arranged at the top of the purification tank. Compressed air is released into the cylinder through the aeration disc, the closed structure of the cylinder restricts the bubbles from diffusing in disorder, the screw thread flow guide groove in the cylinder guides the bubbles to spiral upward, the rising bubble flow impacts the broken paddle at the bottom of the shaft support to rotate, the large bubbles are broken into micro-bubbles through shearing to increase the specific surface area, the bubbles are efficiently utilized, the problem that the bubbles and the water body are not fully contacted and the dissolved oxygen is insufficient is solved, and the water quality requirement of the garden water is met.

Disclosed in the present invention are a gel having a regulatable free water content and morphology, a preparation method therefor, and the use thereof. The method comprises: S1, preparing a solution A from a natural polymer material; S2, mixing a small molecule material containing a positively charged polar group with the solution A to obtain a composite solution B; S3, mixing the composite solution B with a regulator to obtain a composite solution C, stirring same, then adding a condensing agent to the reaction system, and carrying out a curing crosslinking reaction; and S4, removing the regulator and the condensing agent to obtain the gel. By adjusting the concentrations of the natural polymer material and the regulator, gels having different morphologies can be prepared; the gel undergoes a physical process to remove hydrogen bond interaction between the gel and free water, so that the content of free water attached to the surface of the gel can be regulated, thereby regulating the physical and chemical properties of the gel. The gel of the present invention has regulatable morphology and controllable elastic modulus, and has many advantages such as good lubrication effect, good biocompatibility and biodegradability, capability of being biologically active, and capabilities of stimulating cell growth and accelerating wound repair.

The invention discloses a paper base-PHA double-sided composite soil biodegradable agricultural mulching film as well as a preparation method and application thereof, and belongs to the technical field of agricultural mulching materials and green high polymer materials. The mulching film comprises a paper base layer and a homologous polyhydroxyalkanoate covering layer arranged on the surface of the paper base layer. Through double-sided synergy of the water-based PHA coating on the soil sticking surface and the thermoplastic PHA extrusion film layer on the windward and rainy surface, and in combination with a'wet-to-heat 'integrated composite process and trace anhydride grafting, super-strong combination of a paper-plastic interface fiber tearing level is realized, and the problem that traditional paper-plastic is easy to layer is solved. Compared with a traditional fluorine-containing product, on the premise that total organic fluorine is not detected, the excellent barrier and moisture conservation performance is achieved with the thinner coating thickness by means of double barriers. The product has excellent mechanical laying adaptability and long-season weather resistance, is fully biodegradable, thoroughly solves the hidden dangers of micro-plastic residues and persistent organic pollutants, and is an ideal green agricultural covering material.

The invention discloses a preparation method of a composite slow-release carbon source, which comprises the following steps: preparing an inner core: uniformly dry-mixing lignin powder and a quick-acting carbon source, and adding a first binder to prepare inner core particles; middle layer wrapping: alternately spraying a second binder and middle layer coating powder until the middle layer is completely wrapped to obtain double-layer particles; outer layer wrapping: alternately spraying a third binder and outer layer coating powder until the outer layer is completely wrapped to obtain three layers of particles; and spraying a biodegradable polymer solution on the surfaces of the three layers of particles to form a coating film. Through the three-layer structural design of the quick start layer, the stable maintenance layer and the long-acting guarantee layer, accurate matching of carbon source release and microbial metabolism requirements is realized. The outer-layer quick-acting carbon source quickly starts microbial activity, the middle layer provides stable and continuous carbon source supply, and the inner core ensures the tail-section treatment effect. The sequential release mechanism effectively avoids burst release waste of the carbon source, so that the utilization rate of the carbon source is greatly improved.

An apparatus and method for aerosol delivery, wherein the apparatus includes a biodegradable outer body, a power source, an aerosolizable material reservoir, a control circuit comprising an aerosol generation mechanism, a channel on top of the aerosolizable material reservoir, an absorption pad encasing the channel, and a support feature on either side of the channel on top of the reservoir. The method includes using a processing unit of the apparatus to configure the control circuit after determining a device usability.

A biodegradable composition is disclosed. The biodegradable composition includes (i) a biodegradable polymer and (ii) a cellulose ester. Films that include or are formed from the biodegradable composition, as well as articles that include a substrate and a layer of the biodegradable composition on a surface thereof, are also described.

The invention provides a full-biodegradable shopping bag production full-process intelligent monitoring system and method, and the system comprises the steps: a sensor disposed by a data collection module collects multi-dimensional data during the production of a full-biodegradable shopping bag, and uploads the multi-dimensional data to a cloud platform; the data analysis module determines the product performance index of the full-biodegradable shopping bag based on the cloud platform in combination with the production process parameter requirements, and performs real-time inversion prediction on the degradation performance index of the biodegradable shopping bag; the abnormity monitoring module carries out whole-process abnormity monitoring based on the product performance index and the real-time inversion prediction result, and carries out abnormity early warning and process parameter optimization when abnormity exists; and the data recording module uploads the product performance index, the real-time inversion prediction result and the abnormal early warning during the production of the full-biodegradable shopping bag to the block chain, and generates a full-chain quality tracing file based on the uploading result. Production defects are effectively prevented, production efficiency and product consistency are improved, and product transparency and credibility are enhanced.

An environmentally friendly fresh-keeping can and a method of manufacturing the same are provided. The environmentally friendly fresh-keeping can includes a housing, an inner container, an easy-open lid, and a bottom cover. The housing, the inner container, the easy-open lid, and the bottom cover are respectively made of a spiral paper tube, bio-based polyethylene 2,5-furanoate (PEF), aluminum, and biodegradable plastic. The inner container is mounted into the housing through an inner opening on a top of the inner container. Then the easy-open lid and the bottom cover are respectively used to seal the inner opening of the inner container and a bottom opening of the housing. The respective components are made of biodegradable, recyclable and reusable materials and able to be disassembled for recycling and reuse. Thereby the can meets requirements for environmental protection and recycling.

A device and method for introducing new vegetation into a forest floor includes seeds, seedlings, and / or saplings carried within a plurality of tapered shells having polygonal cross sections, possibly mixed with soil, sand, gravel, fertilizer, SAP granules, and / or water. The tapered shells are inserted into the ground through the hydrophobic layer by dropping or propelling them from an aircraft, or manually pressing on them. One or more holes proximate the bottoms of the tapered shells enable rain water and germinating roots to penetrate into soil beneath the hydrophobic layer. A perforated lid can prevent the seeds or seedlings from being ejected upon impact with the forest floor. A weighted tip can improve penetration of the tapered shells into the forest floor. A plurality of tapered shells can extend downward from a tray or frame. The tapered shell and / or perforated lid can be made from biodegradable materials.

The invention discloses a field returning method based on straw covering and reinforced decomposition fertilizer preparation, and belongs to the technical field of agricultural waste recycling and soil improvement. By constructing a straw-biochar-decomposition agent composite functional system, integrating physical coverage and a biodegradation mechanism, agricultural wastes are used as raw materials to prepare a porous biochar carrier, and the porous biochar carrier has a high specific surface area and a multi-stage pore structure, so that the microbial inoculum loading capacity and the nutrient retention capacity are remarkably improved, and the microbial inoculum decomposition efficiency is improved. The composite decomposition microbial inoculum and concentrated biogas slurry are stabilized by combining an atomization loading technology, efficient decomposition and nutrient slow release of straws are realized, and meanwhile, the forming stability is enhanced by utilizing a degradable adhesive, so that the field applicability and durability of the material are improved.

The invention relates to the technical field of biodegradable high polymer materials, in particular to a tear-resistant high-barrier biodegradable mulching film and a preparation method thereof, and the tear-resistant high-barrier biodegradable mulching film is prepared from the following raw materials in parts by weight: 60-90 parts of poly (butylene adipate-co-terephthalate); 10 to 40 parts of poly (propylene carbonate); 0.5-5 parts of a plasticizer; 0.05 to 0.3 part of a cross-linking agent; 0.1 to 10 parts of talcum powder; 0.1 to 2 parts of a lubricant; 0.1-1 part of an anti-blocking agent; 0.1 to 1 part of an antioxidant; 0.1 to 1 part of an anti-ultraviolet agent; 0.1-1 part of a light stabilizer; 0.1 to 1 part of an anti-hydrolysis agent; 0.1-1 part of a nucleating agent; the plasticizer is poly (1, 2-propylene glycol adipate); and the cross-linking agent is 1, 4-bis (tert-butylperoxy) diisopropyl benzene. The film has good mechanical properties and water vapor transmission amount, can be completely biodegraded, and has good aging resistance.

The invention relates to the field of high polymer material processing, and discloses a high-efficiency low-energy-consumption granulation process and system for a full-biodegradable multiphase composite material, and the process comprises the following steps: feeding raw materials such as polypropylene carbonate, polyester, plant fibers and four-stage activated biomass hydroxyapatite into a double-screw extruder with the length-diameter ratio of not less than 64: 1 in a grading manner according to heat sensitivity; the temperature, the pressure and the shear field are cooperatively controlled, and three-section type temperature distribution of intensified melting, short-time reaction and rapid cooling is established; and carrying out three-stage gradient vacuum devolatilization and underwater pelletizing to obtain a finished product. The four-stage activated biomass hydroxyapatite is prepared by plasma etching, hydrophobic coating, interface coupling and melt pre-dispersion. The problem of degradation of heat-sensitive components is solved through graded feeding and asymmetric temperature control, the dispersity and interface bonding force of the filler are improved by utilizing a four-stage activation technology, closed-loop control is realized by combining online rheology monitoring and an energy consumption model, and continuous production of the full-biodegradable material with low energy consumption, low volatile matter and high mechanical property is realized.

This invention discloses a probiotic microcapsule and its preparation method, belonging to the field of microcapsule preparation technology. The preparation method includes the following steps: (1) dissolving Sophora japonica extract in water, stirring, adding sodium alginate, and stirring again to obtain a wall material solution; (2) centrifuging and washing the activated probiotics, preparing a bacterial suspension, mixing it with the wall material solution obtained in step (1), stirring, and obtaining a wall material bacterial suspension; (3) adding the wall material bacterial suspension obtained in step (2) to a calcium chloride solution and letting it stand, then adding the formed gel to a chitosan solution, stirring, washing, and obtaining the final product. The preparation process of this invention is simple and convenient, and the raw materials are inexpensive and easy to obtain, which can effectively reduce the production cost of microcapsules, facilitate large-scale industrial production and application promotion, effectively improve the biocompatibility, biodegradability, mechanical strength and encapsulation rate of microcapsules, and enhance the storage stability and resistance to gastrointestinal fluid stress of microcapsules.

The utility model provides a biomass methanol sewage treatment device which comprises the following steps: S1, gasification wastewater, ground flushing water, methanol rectification wastewater, test wastewater and domestic sewage are generated in a biomass methanol production process; carrying out oil removal, two-stage air flotation reaction, deamination reaction, coagulation cyanogen breaking and Fenton pre-oxidation treatment on the gasified wastewater to obtain pretreated gasified wastewater; s2, performing comprehensive treatment on the ground flushing water, the methanol rectification wastewater, the test wastewater, the domestic sewage and the pretreated gasification wastewater. The biomass methanol wastewater treatment system has the beneficial effects that the high-concentration gasified wastewater is pretreated by adopting classified and quality-divided treatment, the pretreated wastewater is biodegradable wastewater, and a comprehensive treatment process which mainly adopts biochemical treatment and is high-grade oxidation security is adopted, so that the treatment cost of the biomass methanol wastewater is reduced, and the effluent is ensured to reach the emission standard of pollutants in the petrochemical industry.

The application discloses a functional carrier filler, a preparation method and application thereof. The functional carrier filler comprises a polyethylene carrier and a functional layer loaded on the surface of the polyethylene carrier; and the functional layer comprises amino graphene. The application fixes the amino graphene on the surface of the polyethylene carrier, so that the surface of the filler is rich in nitrogen functional groups capable of mediating electron transfer, the electron transfer of microorganisms is promoted, the biodegradation of antibiotics is strengthened, the specific surface area of the carrier is improved, and the biofilm is hung, the functional carrier filler is used as a suspended filler of a moving bed biofilm reactor, and is used in a post-denitrification MBBR process after sewage treatment, so that the denitrification rate is improved, the degradation of antibiotics is promoted, the use of carbon sources is reduced, and energy saving and emission reduction are facilitated.

A granular composition for agricultural is disclosed. The granular composition is made up of a plurality of granulates having a biodegradable coating applied over the granulates. The granulates are selected from the group consisting of seeds, fertilizers, and pesticides. The biodegradable coating is made up of polylactic acid and polyhydroxyalkanoates. A method for making the coated granular composition and a method for controlled release of the granular material in the field are also disclosed.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The invention provides a core-shell microsphere for feed detoxification and a preparation method and application thereof.The core-shell microsphere comprises a sclerotium layer, a magnetic shell layer and a catalytic layer from inside to outside, and the sclerotium layer is composed of bacillus licheniformis and lactobacillus rhamnosus composite flora and a chitosan-sodium tripolyphosphate semipermeable membrane wrapping thalli; the magnetic shell layer is a Fe3O4 nano-particle coating, and the catalytic layer is a porous Mn-Ce-O shell. The microspheres have the double functions of biodegradation and chemical catalysis, the internal flora can degrade various toxins, the external catalytic layer efficiently decomposes stubborn toxins, the magnetic layer realizes rapid magnetic separation and recovery, and the microspheres are suitable for removing mycotoxins from feed raw materials such as corn and soybean meal.

The invention belongs to the technical field of renewable resource utilization and new energy, and relates to a wood-based water photovoltaic power generation material and a preparation method and application thereof.The wood-based water photovoltaic power generation material is prepared by taking natural wood as a raw material, performing chemical modification treatment and combining directional freeze drying and salting-out treatment. The wood-based water photovoltaic power generation material with relatively good mechanical strength is prepared by using the wood-based material as a raw material, the wood-based material has a highly-oriented porous structure, and under the conditions of 25 DEG C, standard atmospheric pressure and relative air humidity RH 30%, a 200-mesh copper mesh is used as an electrode, and the open-circuit voltage of a nano power generation device obtained by assembling in deionized water reaches 110 mV, and the short-circuit circuit reaches 0.74 mA. The material is simple in preparation process and wide in application scene, adopts natural high polymer materials as raw materials, has the environment-friendly advantages of reproducibility and biodegradability, and has a wide application prospect in the field of new energy materials.

Disclosed are a biopolysaccharide-based polymer and a preparation method therefor and use thereof, which relate to the technical field of polymers. The preparation method comprises: adding a polysaccharide substance, a first monomer, and a first oxidant at a formulation ratio for reaction to obtain a first mixed system; adding an alcohol solvent to the first mixed system for reaction to obtain a second mixed system; adding a second monomer and a second oxidant to the second mixed system for reaction to obtain a third mixed system; and then heating the resulting third mixed system to obtain a biopolysaccharide-based polymer. The raw materials used for preparing the biopolysaccharide-based polymer are phosphorus-free and safe, and also have biodegradability and other functional properties. The raw materials demonstrate excellent hard water resistance and effective ability to disperse various inorganic scales, iron oxide, and kaolin, and can be used for making cleaning agents. The whole preparation process is safe, environmentally friendly, easier to control, and readily scalable for industrial production.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The invention belongs to the technical field of environmental governance, and particularly relates to a waste gas treatment system, application thereof and a treatment method for malodorous gas generated by a household garbage landfill. The waste gas treatment system provided by the invention comprises an alkali washing spray tower, a biological filter bed of which a bottom first gas inlet is communicated with a top outlet of the alkali washing spray tower, a deodorization spray tower of which a bottom gas second inlet is communicated with a top outlet of the biological filter bed, and an emptying pipe communicated with a top outlet of the deodorization spray tower. When the waste gas treatment system is used for treating malodorous gas, the malodorous gas can be subjected to three-step purification treatment of primary gas-liquid mass transfer, microbial degradation and secondary gas-liquid mass transfer, various harmful substances in the waste gas can be efficiently removed, meanwhile, the system is not prone to leakage, continuous treatment can be achieved, and the waste gas treatment efficiency is improved. And the secondary pollution is reduced while the treatment effect is ensured.

The invention discloses a degradable plastic modification enhanced biodegradability system, which relates to the technical field of pollution abatement, and comprises an environmental data analysis module, a degradation factor modeling module, a scheme matching engine module and an intelligent recommendation module, the environment data analysis module is used for acquiring and processing environment data of a target region, analyzing degradation scenes related to the region and outputting a comprehensive environment feature vector of the region; and the degradation factor modeling module is electrically connected with the environmental data analysis module. According to the degradable plastic modification enhanced biodegradability system provided by the invention, through integration of multi-source environmental data and implementation of deep analysis, dominant degradation scenes and key environmental influence factors in different regions can be accurately identified, the problems of incomplete environmental feature extraction and fuzzy scene discrimination in a traditional method are effectively solved, and the method is suitable for popularization and application. The system utilizes a coupling dynamic model, and the scientificity and pertinence of degradation scheme design are remarkably improved.

The invention discloses a method for preparing a sodium-ion battery hard carbon negative electrode material by microbial degradation of biomass, which comprises the following steps: carrying out degradation treatment on the biomass by selecting microorganisms with specific functions, and treating the biomass by adopting a non-high-temperature sterilization mode before degradation treatment so as to reduce the influence on the structure and components of the biomass; and carrying out carbonization treatment and post-treatment on the biomass subjected to degradation treatment to finally prepare the hard carbon negative electrode material with expanded carbon layer spacing, rich defect sites and a multi-element pore structure. The prepared hard carbon negative electrode material has the advantage of low cost and excellent electrochemical performance, not only has a pseudo-graphite layered structure, rich defects and a multi-element pore structure, but also has the specific capacity of an assembled sodium ion battery as high as 361.1 mAh / g and the first coulombic efficiency exceeding 89%, and also has excellent cycle stability.

The invention relates to the technical field of food packaging, in particular to a dual-antioxidant packaging film as well as a preparation method and application thereof. The dual antioxidant packaging film disclosed by the invention is prepared from the following components in parts by mass: 3.2 to 4 parts of starch, 0.8 to 1 part of glycerol, 0.8 to 1 part of polysaccharide, 0.02 to 0.16 part of berberine / anthocyanin self-assembled nanoparticles and 93.98 to 95.2 parts of water. The packaging film prepared by the invention is uniform in structure, has good mechanical properties and moisture and oxygen barrier properties, shows an intelligent slow release characteristic in a pH value change or oxidation environment, can realize controllable release of the tea tree essential oil, and significantly improves the antioxidant and antibacterial activity of the film. The material source is natural, renewable and biodegradable, and the environment-friendly fresh-keeping packaging material is suitable for fresh-keeping packaging of foods such as fruits, vegetables and meat products, and has good environment friendliness and industrial application prospects.

A reservoir device comprising an active agent formulation contained within a reservoir is described. The reservoir is defined by a biodegradable, permeable polymer membrane having a thickness of at least 45 μm. The membrane allows for diffusion of an active agent of the formulation there through when positioned subcutaneously in a body of a subject.