122 results about "Amino esters" patented technology

The invention discloses a synthesis method of a non-silicon defoaming agent and application of the non-silicon defoaming agent in the field of scandium extraction in hydrometallurgy. The defoaming agent is synthesized by a component A, a component B and a component C through a two-step reaction, the synthesis method comprises the following specific synthesis steps: 1) carrying out esterification reaction on an amino acid substance A and a fatty alcohol substance B to generate an amino ester substance D; and 2) carrying out substitution reaction on the amino ester substance D and a triazine compound C to obtain the non-silicon defoaming agent. The defoaming agent disclosed by the invention is wide in application range, can be applied to links such as a laterite-nickel ore hydrometallurgy front-end scandium extraction method and an MHP hydrometallurgy scandium impurity removal process, is added as an auxiliary agent in the extraction process, and is used for reducing the surface tension of liquid, preventing the formation and enrichment of a third-phase substance and reducing the occurrence of an emulsification phenomenon; the process stability and the output quality are improved, and the method has important industrial application value.

The invention discloses a synthesis method of dialkyl amino alcohol. The dialkyl amino alcohol is obtained by reacting dialkyl amino ester with a Grignard reagent. According to the synthetic route provided by the invention, the overall synthesis condition is mild, the used raw materials are easy to obtain, and the toxicity is relatively low.

The invention relates to the technical field of oilfield chemistry, in particular to an aminoethanesulfonic acid type surfactant and a preparation method and application thereof.The preparation method of the aminoethanesulfonic acid type surfactant comprises the steps that firstly, fatty amine is dissolved in a first solvent, a sodium chloroethanesulfonate aqueous solution is added, and N-long-chain alkyl-2-sodium aminoethanesulfonate is obtained through a reaction; and 2, dissolving a required amount of N-long-chain alkyl-2-sodium aminoethanesulfonate in a second solvent, adding a required amount of methyl acrylate, and reacting to obtain the aminoethanesulfonic acid type surfactant. The aminoethanesulfonic acid type surfactant disclosed by the invention contains long-chain alkyl, amino, ester groups and sulfonic acid groups, so that the aminoethanesulfonic acid type surfactant has good surface activity and can meet the development requirements of oil and gas fields. The microemulsion cleanup additive prepared from the aminoethanesulfonic acid type surfactant can effectively reduce the surface tension and the interfacial tension of an aqueous solution, and the preparation method is easy and convenient to operate, mild in condition and suitable for industrial production.

The invention discloses antibacterial poly (beta-amino ester) and a preparation method and application thereof, poly (beta-amino ester) macromolecules simultaneously have amino positive charges and fluorine-containing hydrophobic components, existence of the positive charges enables the poly (beta-amino ester) macromolecules to be more easily combined with negatively charged bacterial cell membranes and to be enriched, and the hydrophobic components can enable the poly (beta-amino ester) macromolecules to be inserted into cell membrane phospholipid bilayers, so that the antibacterial effect is improved. Therefore, bacteria are effectively killed, and drug resistance is not easily caused. The polymer has high antibacterial property and low hemolytic toxicity, can be self-assembled into nano particles, and can be combined with antibiotics in an antibiotic loading manner to improve the treatment effect. The compound can be synthesized through simple steps, the reaction condition is simple, the preparation cost, the raw material cost and the application cost are very low, and the compound has a very good prospect when being applied to medicines for treating or preventing diseases caused by bacteria.

The invention relates to the technical field of biological medicine. The invention provides highly branched poly (beta-amino ester) and a preparation method thereof. The invention also provides lipid nanoparticles which contain the compound and are used for efficiently delivering mRNA, a preparation method of the lipid nanoparticles, and application of the lipid nanoparticles in preparation of CD5 antibody targeted nucleic acid drug delivery carriers. The highly branched poly (beta-amino ester) prepared by the scheme of the invention has better mRNA binding capacity and in-vivo stability, the obtained lipid nanoparticles have high transfection efficiency, and efficient transfection of specific tissues or cells can be better realized.

The invention discloses a microcapsule material, a microcapsule using the microcapsule material and a preparation method of the microcapsule, and relates to the technical field of daily chemical products. The microcapsule material comprises an addition polymer formed by a ring-opening reaction of epoxy resin and bio-based polyamine, poly (beta-amino ester) formed by a Michael addition reaction of acrylate and phenyl polyamine, and at least one cationic polymer containing quaternary ammonium groups. The microcapsule material shows certain biodegradability, the biodegradation rate of the microcapsule material exceeds 20% within 28 days, and the applied microcapsule can effectively meet the friction fragrance release performance requirement required by essence wrapping, so that after the obtained essence-encapsulated microcapsule is stored in a lotion at 45 DEG C for 28 days, the fragrance release performance of the microcapsule material is not influenced by the friction fragrance release performance, and the fragrance release performance of the microcapsule material is not influenced by the friction fragrance release performance. The excellent friction aroma releasing capability and the adhesion capability on the fabric can still be maintained, and the excellent thermal stability is shown.

The invention provides a pH-responsive antibacterial multifunctional hydrogel dressing and a preparation method thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: (1) mixing a diacrylate monomer and a diamine monomer according to a molar ratio of 1.1: 1-2: 1 for reaction, and purifying to obtain poly (beta-amino ester); and (2) mixing hyaluronic acid with epsilon-poly-L-lysine, adding a poly (beta-amino ester) solution dissolved in deionized water, repeatedly sucking and extruding, defoaming, and standing to form the hydrogel. The collagen hydrogel has rapid self-repairing performance, good pH intelligent responsiveness and good antibacterial property, the application range of the collagen hydrogel can be widened, and the service life of the collagen hydrogel can be prolonged.

The invention discloses a diselenide-bond-containing poly-beta amino ester carrier for mRNA delivery and a preparation method and application thereof, and the preparation method of the diselenide-bond-containing poly-beta amino ester carrier comprises the following steps: taking a synthesized diselene-1, 6-hexanediol diacrylate monomer (DSEDA) and hydrophobic amine as raw materials to react to obtain a product as a polymer intermediate; the raw material of the hydrophobic amine is one of C8, C12 and C16; the # imgabs0 # hydrophilic amine raw material is one of 2A1, 2A4 and 2A5; a diselenide bond is introduced into a main chain of the structure of the synthesized linear cationic polymer product, tertiary amine N capable of being protonated into cations exists in the main chain structure, and the tertiary amine N can be effectively combined with nucleic acid with negative charges through electrostatic interaction, so that the nucleic acid loading rate is increased; according to the invention, hydrophobic alkane chains with proper number and length are provided, a hydrophobic cavity can be formed when the nanoparticles are formed, the stability of the nanoparticles is improved, and the nanoparticles have good application in delivery of mRNA (messenger Ribonucleic Acid) molecules.

The present application provides biodegradable microcapsules, based on specific poly ß-amino ester shells that can encapsulate and retain cargoes such as, lipophilic, or hydrophobic core materials comprising fragrances, butters, essential or other oils; or oil solubilized ingredients, process of making said biodegradable microcapsules and their applications in various industries. Present application further provides biodegradable shell materials that show evidence of biodegradation or non-persistence in aquatic based and / or soil or compost based environments, and which are stable on storage before use.

The invention discloses branched fluorine-containing poly (beta-amino ester) as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The branched fluorine-containing poly (beta-amino ester) is prepared by polymerizing a diacrylate monomer, a triacrylate monomer, micromolecular organic amine and a fluorine-containing alkyl chain monomer through a Michael addition reaction and then blocking with an end-capping reagent. The preparation method is simple, and the process is controllable. The polymer has controllable molecular weight, branching degree and fluorine content, can be self-assembled with a gene drug to form a stable nano-composite, can mediate efficient gene transfection, has good in-vitro and in-vivo gene editing ability, and can be used for treating genetic metabolic diseases and the like.

The invention provides a polyimide film for optical fibers and a preparation method of the polyimide film, preparation raw materials of polyamide acid slurry for optical fibers comprise aromatic diamine, aromatic dianhydride, ester functional monomers, an organic solvent and a coupling agent, and the ester functional monomers comprise diamino-containing ester and / or ester containing dianhydride groups; the specific ester functional monomer is added into the preparation raw materials, and the coupling agent is added in a matched manner, so that a polyimide coating formed by coating the polyamide acid slurry for the optical fiber outside a bare optical fiber has good adhesion, flexibility, heat resistance and tensile property, can effectively protect the optical fiber, also has excellent chemical peelability, and is suitable for popularization and application. The optical fiber can be quickly dissolved or fused after being infiltrated into a chemical reagent, so that the optical fiber can be thoroughly stripped from a base material without damaging the base material, and connection and use of the optical fiber are facilitated.

The invention discloses a nuclear targeting peptide modified DNA nano-particle based on a microfluidic technology and a preparation method and application thereof, and relates to the technical field of biological medicine, a poly (beta-amino ester) cationic polymer is used as a gene delivery carrier, the gene delivery carrier comprises a microtubule related sequence MTAS and a nuclear localization signal NLS oligopeptide, the gene delivery carrier and the plasmid DNA carrying the target gene are mixed to prepare nano-particles, and the plasmid DNA carrying the target gene is uniformly dispersed in the nano-particles by adopting a microfluidic mixing process; the nuclear targeting peptide modified DNA nano-particle is ingenious in structural design, the mixing uniformity of a nano-carrier and plasmid DNA is improved by adopting a micro-fluidic mixing process, the performance of the nano-particle is further improved by optimizing dialysis conditions, potential cytotoxicity and adverse effects are reduced, and the nuclear targeting peptide modified DNA nano-particle is suitable for large-scale production. And after transduction of non-activated T cells, strong tumor killing ability and cytokine secretion can be generated.

The present application is related to a tissue-selective single-component mRNA delivery carrier and a delivery system. Poly (β-amino ester) polymer is used as the single-component delivery carrier, wherein the poly (β-amino ester) polymer has a structure as shown in Formula I or Formula II. In Formula I or Formula II, the definition of each substituents is the same as in the detailed description. The present invention employs only the poly(β-amino ester) polymer material as the single delivery carrier, and tissue-selective targeting of the delivery system including lung, liver and spleen, etc. can be achieved by locally regulating the chemical structures and the domain charges of the poly(β-amino ester) polymer.

The invention discloses an aluminum oxide plated film for high-barrier packaging and a preparation method of the aluminum oxide plated film, and belongs to the field of films. An aluminum oxide plated film for high-barrier packaging comprises a base material, a plurality of polyurethane coatings and a plurality of aluminum oxide plating layers are alternately arranged on one face of the base material, and the layer structure closest to the base material and the layer structure farthest from the base material are the polyurethane coatings; the polyurethane coating is formed by curing a polyurethane coating, and the polyurethane coating comprises a hydroxyl acrylate emulsion, an isocyanate curing agent, an auxiliary agent and water; the hydroxy acrylate emulsion is obtained by reacting cinnamyl alcohol with long-chain isocyanate and then carrying out polymerization reaction on the generated amino ester product, a hydroxy acrylate monomer and an acrylic monomer. The solar backboard has the advantages that the difficulty of producing the solar backboard is reduced, and the high barrier performance is kept.

The invention discloses MXene-containing conductive hydrogel and a preparation method and application thereof, the hydrogel is injectable conductive hydrogel of MXene-loaded poly-beta amino ester, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate as a support material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with the polyethylene glycol diacrylate through an acrylate bond; the invention relates to an MXene nanosheet serving as a conductive material. The hydrogel is adjustable in mechanical property, excellent in biocompatibility and capable of being slowly released, and is used for filling nerve injury areas, simulating the electrophysiological environment of nervous tissues, promoting transmission of electric signals and promoting synaptic formation and neuronal differentiation.

The invention provides photosensitive resin, an anti-dazzle film, a preparation method of the anti-dazzle film and a degradation method of the anti-dazzle film, and relates to photosensitive resin in the field of display and optical film materials. The photosensitive resin is prepared by reaction of raw materials including a urethane acrylate oligomer, an aziridine compound and an acrylic monomer, and the molecular structure of the photosensitive resin has a beta-amino ester bond and an ultraviolet-curable acrylate group. The degradable photosensitive resin is provided by introducing beta-amino ester bonds into the photosensitive resin, so that the anti-dazzle film prepared from the coating composition containing the photosensitive resin can be quickly hydrolyzed and degraded under a mild hydrothermal condition, the problem of pollution of a polymer coating in electronic waste is fundamentally solved, and the anti-dazzle film has the advantages of high anti-dazzle performance and the like. And the environmental problem caused by the method can be effectively relieved.

Nontoxic, targeted poly beta-amino esters (PBAEs) are synthesized by using click chemistry to attach a targeting moiety. The click chemistry uses a dienophile, such as a strained alkene ring, and a diene, such as tetrazine, to provide rapid attachment of targeting moieties to PBAE polymers and nanoparticle surfaces containing them. Targeting moieties such as aptamers, antibodies or antibody-like proteins can be quickly and safely coupled to PBAEs to provide highly specific localization of nanoparticles for gene therapy or targeted delivery of therapeutics.

Provided herein are tertiary amino ester derivatives of astaxanthin and methods of making the same and using the same, e.g., to improve inflammatory and / or cardiovascular health.

The invention provides polyester resin for a transparent powder coating with excellent adhesive force and leveling as well as a preparation method and application of the polyester resin, and belongs to the technical field of powder coatings. The polyester resin is mainly prepared by taking diethylenetriamine pentaacetic acid, triethyl chlorosilane, 1, 6-hexanediol, N, N-diisopropylethanolamine, 2, 2-dimethyl propanol, neopentyl glycol, 3, 3-tetramethylene glutaric anhydride, 1, 4-cyclohexanedimethanol and the like as raw materials through polymerization. The obtained polyester resin chain segment has many branched structures, the number of amino groups and ester groups in the branched structures is large, the softening point is low, the low-temperature melting fluidity is good, the transparency is high, the adhesive force with a base material is good, then high-functionality diethylenetriamine pentaacetic acid is adopted for carboxyl end capping, the terminal carboxyl functionality is high, the curing activity is high, and the curing effect is good. After being cured with E-12 epoxy resin at low temperature, a coating film is good in leveling property and high in transparency, and can be used in the fields of thermosensitive base materials which are not easy to adhere, such as thin glass materials and the like.

The invention relates to the technical field of oilfield chemistry, in particular to a sulfamic acid type surfactant as well as a preparation method and application thereof.The sulfamic acid type surfactant is prepared according to the following steps: step one, after fatty amine and a first solvent are mixed, adding a 3-chloro-2-hydroxypropyl sodium sulfonate aqueous solution, and stirring to obtain a first mixture; reacting to obtain 3-(long-chain alkylamino)-2-hydroxypropane-1-sodium sulfonate; and 2, dissolving a required amount of 3-(long-chain alkylamino)-2-hydroxypropane-1-sodium sulfonate in a second solvent, adding a required amount of methyl acrylate, and reacting to obtain the sulfamic acid type surfactant. The sulfamic acid type surfactant disclosed by the invention contains long-chain alkyl, amino, ester group, hydroxyl and sulfonic acid group, so that the sulfamic acid type surfactant has good surface activity and meets the development requirements of oil and gas fields, and the microemulsion cleanup additive prepared by utilizing the sulfamic acid type surfactant has excellent water solubility and surface activity and meets the industrial use standards of non-fluorocarbon cleanup additives.

An embodiment provides a method for measuring total chlorine in a solution, including: preparing a thiocarbamate indicator; introducing the thiocarbamate indicator to a solution, wherein the solution contains an amount of monochloramine; adding an additive to the solution, wherein the additive accelerates the reaction rate between the thiocarbamate indicator and monochloramine and causes a change in fluorescence of the solution; and measuring the amount of monochloramine in the solution by measuring an intensity of the fluorescence. Other aspects are described and claimed.

The invention relates to the technical field of biological medicine, and discloses a ROS / pH dual-response carrier-based drug delivery system, which comprises an inner core, a response layer and a targeting layer, wherein the inner core is composed of a poly (beta-amino ester) polymer, and the poly (beta-amino ester) polymer is used for coating a drug; the response layer is composed of an ROS sensitive connecting arm wrapping the outer side of the poly (beta-amino ester) polymer; the targeting layer is composed of heart targeting peptide, and the heart targeting peptide is covalently coupled to the inner side of the ROS sensitive connecting arm; according to the present invention, the cardiac targeting peptide is used for the specific binding with the myocardial cell membrane surface receptor, and the ROS sensitive connecting arm is broken in the high ROS environment, such that the poly (beta-amino ester) polymer is dissolved in the lysosome acid environment so as to pertinently release the drug, and the preparation method and the application thereof are provided. Targeted delivery and targeted release of the drug delivery system are achieved, and the drug delivery system can serve as a drug carrier to be applied to treatment of metabolic cardiovascular diseases.

The present invention provides compounds represented by formula (I), and stereoisomers, solvates, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used as P2X7 receptor antagonists.

The invention discloses a drug delivery system containing loaded adriamycin as well as a preparation method and application of the drug delivery system. The drug delivery system comprises poly (beta-amino ester) coupled with adriamycin, wherein the surface of the poly (beta-amino ester) is coated with dextran sulfate, and the poly (beta-amino ester) takes a fourth-generation lysine dendritic molecule Lys-G4 as a core. The drug delivery system has a pH-dependent drug release characteristic, has remarkable toxicity to C6 and U87MG glioma cells, has the capabilities of inducing apoptosis, inhibiting migration and targeting subcellular localization, and can effectively penetrate through a blood-brain barrier model and 3D tumor spheres. The delivery system is compounded with PLA-PEG-PLA thermosensitive hydrogel, and the thermosensitive hydrogel with a drug storage function is successfully constructed. Good tumor inhibition effect and biocompatibility are shown in nude mouse subcutaneous and in-situ glioma models. The invention not only provides a new strategy for overcoming the blood brain barrier, but also can effectively reduce the systemic toxicity, and opens up a new research thought and method for glioma treatment.

The invention relates to the technical field of compound synthesis, and particularly discloses a method for preparing nafamostat mesylate. The preparation method comprises the following steps: (1) preparing 6-imino ester-2-naphthol hydrochloride; (2) preparing 6-imino ester-naphthalene-2-yl-4-guanidine benzoate hydrochloride in a reaction solvent DMF (Dimethyl Formamide) or DMSO (Dimethyl Sulfoxide); (3) preparing nafamostat carbonate in a reaction solvent DMF (Dimethyl Formamide) or DMSO (Dimethyl Sulfoxide); and (4) preparing nafamostat mesylate. The nafamostat mesylate is prepared by the method disclosed by the invention, a high-quality and high-yield product can be obtained, and the method is suitable for industrial popularization.

The invention discloses injectable hydrogel and a preparation method and application thereof in nerve repair, the hydrogel is medical hydrogel of poly-beta amino ester loaded with indole-3-propionic acid, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate (PEGDA) as a scaffold material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with polyethylene glycol diacrylate (PEGDA) via an acrylate bond; and indole-3-propionic acid (IPA) as an active ingredient. The injectable hydrogel is adjustable in mechanical property and excellent in biocompatibility, can slowly release IPA, and is used for filling nerve injury areas, inhibiting oxidative stress and promoting neuron regeneration and functional recovery.

Provided in the present invention are a β-amino ester monomer compound and a preparation method therefor. The main chain of the β-amino ester monomer has a tertiary amine functional group. Further provided are a poly-β-amino ester compound having an accurate molecular weight, and a preparation method therefor. The poly-β-amino ester compound has an adjustable main chain and side chain. By using an exponential iterative growth strategy with orthogonal protecting groups and by means of performing selective TBDPS deprotection and selective benzyl deprotection on the β-amino ester monomer, and then subjecting the two substances obtained after deprotection to esterification coupling, a poly-β-amino ester having a twice-amplified molecular weight is obtained. In the present invention, the exponential iterative growth polymerization method with orthogonal protecting groups is used to realize accurate synthesis of a poly-β-amino ester, and poly-β-amino esters having completely controllable molecular weights, side chains and end groups, and having single-molecular dispersity are thus obtained. Further provided in the present invention is the use of a deprotected poly-β-amino ester compound having functional groups in the preparation of a gene delivery drug.

A poly(beta-aminoester) polymer of formula (I) or a pharmaceutically salt thereof which comprises one or more zwitterionic polymers. Advantageously, the polymer of the invention shows improved properties when formulated in the form of nanoparticles. Processes for the preparation of the polymer, nanoparticles comprising a polymer of Formula (I) and uses thereof.

In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (β-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject.

The invention provides a polymer and application thereof, a negative plate, a battery, electronic equipment and a water absorption composition, the polymer comprises a repeating unit of a formula I structure, a repeating unit of a formula II structure and a repeating unit of a formula III structure, the number of the repeating units of the formula I structure is n1, n1 is greater than or equal to 0, the number of the repeating units of the formula II structure is n2, n2 is greater than 0, and n1 is greater than or equal to 0. The number of repetitive units of the structure in the formula III is n3, and n3 is greater than or equal to 0; r1 is independently selected from one or more of H, alkyl groups of C1 to C5, alkenyl groups of C1 to C5 and alkynyl groups of C1 to C5; r1 and R2 are independently selected from one or more of COONa, COOLi, SO3Na, SO3Li, PO3Na and PO3Li, and R2 is independently selected from one or more of COONa, COOLi, SO3Na, SO3Li, PO3Na and PO3Li; and R3 is independently selected from one or more of OH, CONH2, an amino group and an ester group. The polymer has good water absorption capacity and has good application prospects in the fields of batteries and the like.