6 results about "Amino esters" patented technology

Provided are polymeric compounds of Formula I which include cationic poly(alpha-amino ester) monomers and lipid functionalized beta-amido carbonate (bAC) monomers, and related compositions and methods for transport and delivery of polyanions, including nucleic acids, into cells in vitro, ex vivo, and in vivo.

Polymers comprising two building blocks obtained by click chemistry and uses thereof It relates to a polymer or a salt thereof which comprises a first polymer building block and a second polymer building block wherein: a) the first and second polymer building blocks are covalently bonded through at least a common lateral chain, and b) the first polymer building block is an oligopeptide-modified poly(beta-aminoester). The polymer comprising the two building blocks can be conveniently prepared by click chemistry. It also relates to nanoparticles comprising this polymer, to pharmaceutical and cosmetic compositions comprising the polymer or the nanoparticles, and to their use as a delivery system and in therapy, diagnosis or cell-targeting.

The application discloses a dynamic cross-linking polymer additive containing aromatic disulfide bond and urea group / urethane group and application thereof in perovskite solar cells. The additive is formed in-situ during perovskite film formation by free radical polymerization reaction of cross-linkable monomer A and cross-linking agent B. The additive constructs a dynamic polymer network at perovskite grain boundaries, in which the strong coordination groups of urea group / urethane group form coordination bonds and hydrogen bonds with lead ions, halogen ions and organic cations in perovskite, passivate intrinsic defects and optimize the crystallization process, significantly improve photoelectric conversion efficiency; the reversible exchange reaction of aromatic disulfide bond at room temperature endows the device with the ability of room temperature rapid autonomous repair of mechanical bending cracks without external field triggering, and synchronously restores electrical performance; at the same time, the dense cross-linking network acts as a physical barrier to inhibit long-range migration of halogen ions excited by ultraviolet light and block water and oxygen erosion, greatly enhancing the ultraviolet light stability of the device. The application synchronously realizes device efficiency improvement, room temperature rapid self-repair and ultraviolet stability enhancement by constructing a dynamic cross-linking polymer network at perovskite grain boundaries, providing an effective solution to the comprehensive stability problem of perovskite solar cells in dynamic use environment.

Provided herein are hyperbranched poly(β-amino esters) polymers that serve as effective transfection carriers of small interfering RNA (siRNA) for RNA interference (RNAi) mediated gene silencing therapy. These disclosed polymers exhibit outstanding gene silencing efficiency in both easy-to-transfect and hard-to-transfect cells. Furthermore, they are biodegradable and non-toxic.

It relates to a polymer or a salt thereof which comprises a first polymer building block and a second polymer building block wherein: a) the first and second polymer building blocks are covalently bonded through at least a common lateral chain, and b) the first polymer building block is an oligopeptide-modified poly(beta-aminoester). The polymer comprising the two building blocks can be conveniently prepared by click chemistry. It also relates to nanoparticles comprising this polymer, to pharmaceutical and cosmetic compositions comprising the polymer or the nanoparticles, and to their use as a delivery system and in therapy, diagnosis or cell-targeting.

Polyethylene glycol (PEG)-b-poly(β-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed.