82 results about "Amino esters" patented technology

The invention relates to the technical field of oilfield chemistry, in particular to an aminoethanesulfonic acid type surfactant and a preparation method and application thereof.The preparation method of the aminoethanesulfonic acid type surfactant comprises the steps that firstly, fatty amine is dissolved in a first solvent, a sodium chloroethanesulfonate aqueous solution is added, and N-long-chain alkyl-2-sodium aminoethanesulfonate is obtained through a reaction; and 2, dissolving a required amount of N-long-chain alkyl-2-sodium aminoethanesulfonate in a second solvent, adding a required amount of methyl acrylate, and reacting to obtain the aminoethanesulfonic acid type surfactant. The aminoethanesulfonic acid type surfactant disclosed by the invention contains long-chain alkyl, amino, ester groups and sulfonic acid groups, so that the aminoethanesulfonic acid type surfactant has good surface activity and can meet the development requirements of oil and gas fields. The microemulsion cleanup additive prepared from the aminoethanesulfonic acid type surfactant can effectively reduce the surface tension and the interfacial tension of an aqueous solution, and the preparation method is easy and convenient to operate, mild in condition and suitable for industrial production.

The invention discloses antibacterial poly (beta-amino ester) and a preparation method and application thereof, poly (beta-amino ester) macromolecules simultaneously have amino positive charges and fluorine-containing hydrophobic components, existence of the positive charges enables the poly (beta-amino ester) macromolecules to be more easily combined with negatively charged bacterial cell membranes and to be enriched, and the hydrophobic components can enable the poly (beta-amino ester) macromolecules to be inserted into cell membrane phospholipid bilayers, so that the antibacterial effect is improved. Therefore, bacteria are effectively killed, and drug resistance is not easily caused. The polymer has high antibacterial property and low hemolytic toxicity, can be self-assembled into nano particles, and can be combined with antibiotics in an antibiotic loading manner to improve the treatment effect. The compound can be synthesized through simple steps, the reaction condition is simple, the preparation cost, the raw material cost and the application cost are very low, and the compound has a very good prospect when being applied to medicines for treating or preventing diseases caused by bacteria.

The invention relates to the technical field of biological medicine. The invention provides highly branched poly (beta-amino ester) and a preparation method thereof. The invention also provides lipid nanoparticles which contain the compound and are used for efficiently delivering mRNA, a preparation method of the lipid nanoparticles, and application of the lipid nanoparticles in preparation of CD5 antibody targeted nucleic acid drug delivery carriers. The highly branched poly (beta-amino ester) prepared by the scheme of the invention has better mRNA binding capacity and in-vivo stability, the obtained lipid nanoparticles have high transfection efficiency, and efficient transfection of specific tissues or cells can be better realized.

The invention discloses a microcapsule material, a microcapsule using the microcapsule material and a preparation method of the microcapsule, and relates to the technical field of daily chemical products. The microcapsule material comprises an addition polymer formed by a ring-opening reaction of epoxy resin and bio-based polyamine, poly (beta-amino ester) formed by a Michael addition reaction of acrylate and phenyl polyamine, and at least one cationic polymer containing quaternary ammonium groups. The microcapsule material shows certain biodegradability, the biodegradation rate of the microcapsule material exceeds 20% within 28 days, and the applied microcapsule can effectively meet the friction fragrance release performance requirement required by essence wrapping, so that after the obtained essence-encapsulated microcapsule is stored in a lotion at 45 DEG C for 28 days, the fragrance release performance of the microcapsule material is not influenced by the friction fragrance release performance, and the fragrance release performance of the microcapsule material is not influenced by the friction fragrance release performance. The excellent friction aroma releasing capability and the adhesion capability on the fabric can still be maintained, and the excellent thermal stability is shown.

The invention provides a pH-responsive antibacterial multifunctional hydrogel dressing and a preparation method thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: (1) mixing a diacrylate monomer and a diamine monomer according to a molar ratio of 1.1: 1-2: 1 for reaction, and purifying to obtain poly (beta-amino ester); and (2) mixing hyaluronic acid with epsilon-poly-L-lysine, adding a poly (beta-amino ester) solution dissolved in deionized water, repeatedly sucking and extruding, defoaming, and standing to form the hydrogel. The collagen hydrogel has rapid self-repairing performance, good pH intelligent responsiveness and good antibacterial property, the application range of the collagen hydrogel can be widened, and the service life of the collagen hydrogel can be prolonged.

The present application provides biodegradable microcapsules, based on specific poly ß-amino ester shells that can encapsulate and retain cargoes such as, lipophilic, or hydrophobic core materials comprising fragrances, butters, essential or other oils; or oil solubilized ingredients, process of making said biodegradable microcapsules and their applications in various industries. Present application further provides biodegradable shell materials that show evidence of biodegradation or non-persistence in aquatic based and / or soil or compost based environments, and which are stable on storage before use.

The invention discloses MXene-containing conductive hydrogel and a preparation method and application thereof, the hydrogel is injectable conductive hydrogel of MXene-loaded poly-beta amino ester, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate as a support material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with the polyethylene glycol diacrylate through an acrylate bond; the invention relates to an MXene nanosheet serving as a conductive material. The hydrogel is adjustable in mechanical property, excellent in biocompatibility and capable of being slowly released, and is used for filling nerve injury areas, simulating the electrophysiological environment of nervous tissues, promoting transmission of electric signals and promoting synaptic formation and neuronal differentiation.

The invention provides photosensitive resin, an anti-dazzle film, a preparation method of the anti-dazzle film and a degradation method of the anti-dazzle film, and relates to photosensitive resin in the field of display and optical film materials. The photosensitive resin is prepared by reaction of raw materials including a urethane acrylate oligomer, an aziridine compound and an acrylic monomer, and the molecular structure of the photosensitive resin has a beta-amino ester bond and an ultraviolet-curable acrylate group. The degradable photosensitive resin is provided by introducing beta-amino ester bonds into the photosensitive resin, so that the anti-dazzle film prepared from the coating composition containing the photosensitive resin can be quickly hydrolyzed and degraded under a mild hydrothermal condition, the problem of pollution of a polymer coating in electronic waste is fundamentally solved, and the anti-dazzle film has the advantages of high anti-dazzle performance and the like. And the environmental problem caused by the method can be effectively relieved.

Nontoxic, targeted poly beta-amino esters (PBAEs) are synthesized by using click chemistry to attach a targeting moiety. The click chemistry uses a dienophile, such as a strained alkene ring, and a diene, such as tetrazine, to provide rapid attachment of targeting moieties to PBAE polymers and nanoparticle surfaces containing them. Targeting moieties such as aptamers, antibodies or antibody-like proteins can be quickly and safely coupled to PBAEs to provide highly specific localization of nanoparticles for gene therapy or targeted delivery of therapeutics.

The invention provides polyester resin for a transparent powder coating with excellent adhesive force and leveling as well as a preparation method and application of the polyester resin, and belongs to the technical field of powder coatings. The polyester resin is mainly prepared by taking diethylenetriamine pentaacetic acid, triethyl chlorosilane, 1, 6-hexanediol, N, N-diisopropylethanolamine, 2, 2-dimethyl propanol, neopentyl glycol, 3, 3-tetramethylene glutaric anhydride, 1, 4-cyclohexanedimethanol and the like as raw materials through polymerization. The obtained polyester resin chain segment has many branched structures, the number of amino groups and ester groups in the branched structures is large, the softening point is low, the low-temperature melting fluidity is good, the transparency is high, the adhesive force with a base material is good, then high-functionality diethylenetriamine pentaacetic acid is adopted for carboxyl end capping, the terminal carboxyl functionality is high, the curing activity is high, and the curing effect is good. After being cured with E-12 epoxy resin at low temperature, a coating film is good in leveling property and high in transparency, and can be used in the fields of thermosensitive base materials which are not easy to adhere, such as thin glass materials and the like.

The invention relates to the technical field of oilfield chemistry, in particular to a sulfamic acid type surfactant as well as a preparation method and application thereof.The sulfamic acid type surfactant is prepared according to the following steps: step one, after fatty amine and a first solvent are mixed, adding a 3-chloro-2-hydroxypropyl sodium sulfonate aqueous solution, and stirring to obtain a first mixture; reacting to obtain 3-(long-chain alkylamino)-2-hydroxypropane-1-sodium sulfonate; and 2, dissolving a required amount of 3-(long-chain alkylamino)-2-hydroxypropane-1-sodium sulfonate in a second solvent, adding a required amount of methyl acrylate, and reacting to obtain the sulfamic acid type surfactant. The sulfamic acid type surfactant disclosed by the invention contains long-chain alkyl, amino, ester group, hydroxyl and sulfonic acid group, so that the sulfamic acid type surfactant has good surface activity and meets the development requirements of oil and gas fields, and the microemulsion cleanup additive prepared by utilizing the sulfamic acid type surfactant has excellent water solubility and surface activity and meets the industrial use standards of non-fluorocarbon cleanup additives.

The invention relates to the technical field of biological medicine, and discloses a ROS / pH dual-response carrier-based drug delivery system, which comprises an inner core, a response layer and a targeting layer, wherein the inner core is composed of a poly (beta-amino ester) polymer, and the poly (beta-amino ester) polymer is used for coating a drug; the response layer is composed of an ROS sensitive connecting arm wrapping the outer side of the poly (beta-amino ester) polymer; the targeting layer is composed of heart targeting peptide, and the heart targeting peptide is covalently coupled to the inner side of the ROS sensitive connecting arm; according to the present invention, the cardiac targeting peptide is used for the specific binding with the myocardial cell membrane surface receptor, and the ROS sensitive connecting arm is broken in the high ROS environment, such that the poly (beta-amino ester) polymer is dissolved in the lysosome acid environment so as to pertinently release the drug, and the preparation method and the application thereof are provided. Targeted delivery and targeted release of the drug delivery system are achieved, and the drug delivery system can serve as a drug carrier to be applied to treatment of metabolic cardiovascular diseases.

The present invention provides compounds represented by formula (I), and stereoisomers, solvates, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used as P2X7 receptor antagonists.

The invention discloses a drug delivery system containing loaded adriamycin as well as a preparation method and application of the drug delivery system. The drug delivery system comprises poly (beta-amino ester) coupled with adriamycin, wherein the surface of the poly (beta-amino ester) is coated with dextran sulfate, and the poly (beta-amino ester) takes a fourth-generation lysine dendritic molecule Lys-G4 as a core. The drug delivery system has a pH-dependent drug release characteristic, has remarkable toxicity to C6 and U87MG glioma cells, has the capabilities of inducing apoptosis, inhibiting migration and targeting subcellular localization, and can effectively penetrate through a blood-brain barrier model and 3D tumor spheres. The delivery system is compounded with PLA-PEG-PLA thermosensitive hydrogel, and the thermosensitive hydrogel with a drug storage function is successfully constructed. Good tumor inhibition effect and biocompatibility are shown in nude mouse subcutaneous and in-situ glioma models. The invention not only provides a new strategy for overcoming the blood brain barrier, but also can effectively reduce the systemic toxicity, and opens up a new research thought and method for glioma treatment.

The invention discloses injectable hydrogel and a preparation method and application thereof in nerve repair, the hydrogel is medical hydrogel of poly-beta amino ester loaded with indole-3-propionic acid, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate (PEGDA) as a scaffold material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with polyethylene glycol diacrylate (PEGDA) via an acrylate bond; and indole-3-propionic acid (IPA) as an active ingredient. The injectable hydrogel is adjustable in mechanical property and excellent in biocompatibility, can slowly release IPA, and is used for filling nerve injury areas, inhibiting oxidative stress and promoting neuron regeneration and functional recovery.

Provided in the present invention are a β-amino ester monomer compound and a preparation method therefor. The main chain of the β-amino ester monomer has a tertiary amine functional group. Further provided are a poly-β-amino ester compound having an accurate molecular weight, and a preparation method therefor. The poly-β-amino ester compound has an adjustable main chain and side chain. By using an exponential iterative growth strategy with orthogonal protecting groups and by means of performing selective TBDPS deprotection and selective benzyl deprotection on the β-amino ester monomer, and then subjecting the two substances obtained after deprotection to esterification coupling, a poly-β-amino ester having a twice-amplified molecular weight is obtained. In the present invention, the exponential iterative growth polymerization method with orthogonal protecting groups is used to realize accurate synthesis of a poly-β-amino ester, and poly-β-amino esters having completely controllable molecular weights, side chains and end groups, and having single-molecular dispersity are thus obtained. Further provided in the present invention is the use of a deprotected poly-β-amino ester compound having functional groups in the preparation of a gene delivery drug.

A poly(beta-aminoester) polymer of formula (I) or a pharmaceutically salt thereof which comprises one or more zwitterionic polymers. Advantageously, the polymer of the invention shows improved properties when formulated in the form of nanoparticles. Processes for the preparation of the polymer, nanoparticles comprising a polymer of Formula (I) and uses thereof.

In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (β-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject.

The invention provides a polymer and application thereof, a negative plate, a battery, electronic equipment and a water absorption composition, the polymer comprises a repeating unit of a formula I structure, a repeating unit of a formula II structure and a repeating unit of a formula III structure, the number of the repeating units of the formula I structure is n1, n1 is greater than or equal to 0, the number of the repeating units of the formula II structure is n2, n2 is greater than 0, and n1 is greater than or equal to 0. The number of repetitive units of the structure in the formula III is n3, and n3 is greater than or equal to 0; r1 is independently selected from one or more of H, alkyl groups of C1 to C5, alkenyl groups of C1 to C5 and alkynyl groups of C1 to C5; r1 and R2 are independently selected from one or more of COONa, COOLi, SO3Na, SO3Li, PO3Na and PO3Li, and R2 is independently selected from one or more of COONa, COOLi, SO3Na, SO3Li, PO3Na and PO3Li; and R3 is independently selected from one or more of OH, CONH2, an amino group and an ester group. The polymer has good water absorption capacity and has good application prospects in the fields of batteries and the like.

Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and / or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and / or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.

The invention belongs to the technical field of tumor targeted drug carriers, and discloses a siRNA nano-drug carrier, the active ingredient of the siRNA nano-drug carrier is a nano-particle formed by loading siRNA on a triblock copolymer, the middle block of the triblock copolymer is poly (beta-amino ester), one terminal block is polyethylene glycol, and the other terminal block is polyethylene glycol. One terminal block is poly (3-acrylamido phenylboronic acid) pinacol ester, and the other terminal block is poly (3-acrylamido phenylboronic acid) pinacol ester, and the molecular weight of the poly (3-acrylamido phenylboronic acid) pinacol ester is 3-7 kDa. According to the siRNA nano-drug carrier, siRNA can be prevented from being degraded by nuclease in blood, the in-vivo circulation time of siRNA and Gboxin drugs is greatly prolonged, the permeability of tumor tissues is improved, and the siRNA nano-drug carrier is effectively endocytosed by tumor cells.

Methods and compositions directed to a novel particle system using poly(P-amino ester) (PBAE) resins for applications in drug delivery, where the PBAE particle is fabricated via lithography.

The invention discloses a linear poly (beta-amino ester) compound loaded with hepatocyte growth factors as well as a preparation method and application of the linear poly (beta-amino ester) compound, and belongs to the technical field of biological medicines. The compound is obtained by self-assembly of linear poly beta-amino ester DD90-C12-DMEN and HGF mRNA in a buffer solution, the compound is suitable for aerosol inhalation delivery, higher mRNA transfection efficiency is obtained in lung-related epithelial / stromal cells, macrophages and other cells difficult to transfect, and particularly, the compound shows remarkable transfection advantages on the macrophages.

In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (β-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject.

The invention provides a CO2 oil displacement foam composition and application thereof. The composition is prepared from the following components in parts by weight: 0.1 to 1.5 parts of foaming agent, 0.1 to 3 parts of foam stabilizer and 95.5 to 99.8 parts of water, the foaming agent is selected from a mixture of an anionic surfactant and a nonionic surfactant; the foam stabilizer is selected from grafted modified nano cellulose; the grafted modified nano cellulose comprises a grafting group, the grafting group is selected from one or more of amino, ester group, carbonyl and carboxyl, and the content of the grafting group is 1.5-2.0 mmol / g. Compared with a single-component foaming agent, the foam performance of the composition can be improved by adopting a mixture of the anionic surfactant and the nonionic surfactant. The grafted modified nanocellulose is used as a foam stabilizer, so that the tackifying effect of the foam stabilizer can be exerted, the precipitation rate of liquid in foam is reduced, and the formed CO2 oil displacement foam system has the characteristics of high network structure strength and good shear resistance.

This invention belongs to the field of biomedical materials technology and discloses a highly branched poly(β-amino ester) containing hydrophobic alkyl chains, its preparation method, and its application in mRNA delivery. The highly branched poly(β-amino ester) is prepared by a Mike addition reaction of acrylate monomers and small molecule amine monomers. Using an amino monomer as a capping agent, the highly branched poly(β-amino ester) is functionalized and capped to obtain a highly branched poly(β-amino ester) containing hydrophobic alkyl chains, achieving efficient mRNA delivery in cells such as HeLa. The highly branched poly(β-amino ester) containing hydrophobic alkyl chains of this invention is inexpensive, easy to design and prepare, and exhibits superior transfection performance, showing significant clinical application potential in mRNA drug delivery.

Provided are polymeric compounds of Formula I which include cationic poly(alpha-amino ester) monomers and lipid functionalized beta-amido carbonate (bAC) monomers, and related compositions and methods for transport and delivery of polyanions, including nucleic acids, into cells in vitro, ex vivo, and in vivo.

The invention relates to the technical field of high polymer materials, in particular to a hyperbranched temperature-resistant and salt-resistant lubricant as well as a preparation method and application thereof.The hyperbranched temperature-resistant and salt-resistant lubricant comprises a methyl acrylate modified amine compound and sodium allysulfonate modified polyether amine, the sodium allysulfonate modified polyether amine contains amino, and the hyperbranched temperature-resistant and salt-resistant lubricant prepared by connecting the methyl acrylate modified amine compound and the sodium allysulfonate modified polyether amine through an amido bond formed by the ester group and the amino through an amine-ester exchange reaction has excellent lubricating performance, high temperature resistance and salt resistance.

The application provides a perovskite solar cell doped with 3-amino-2-thiophene methyl formate and a preparation method thereof. The amino group, the ester group, the nitrogen atom, the oxygen atom and the sulfur atom on the thiophene in the 3-amino-2-thiophene methyl formate can be coordinated with cation and anion vacancy defects in the perovskite to synergistically passivate defects on the surface and the grain boundary of the perovskite crystal, reduce trap state density, inhibit non-radiative recombination of the perovskite film and prolong carrier lifetime. The introduction of the dopant can promote the growth of a high-quality perovskite film, obtain a perovskite film with better crystallinity and fewer grain boundaries, promote light absorption and carrier transport and improve the photoelectric conversion efficiency of the doped perovskite solar cell. The 3-amino-2-thiophene methyl formate can also improve the hydrophobicity of the perovskite film and the aging resistance of the perovskite film under the conditions of light, heating, water vapor and oxygen, and improve the environmental stability, light stability and thermal stability of the doped perovskite solar cell.