23 results about "Amino amide" patented technology

An agricultural formulation for transporting nutrients to a plant includes poly(aminoamide) dendrimers (PAMAM) and a fertilizer active ingredient.

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

The invention discloses a beta-hairpin antibacterial peptide WIFrPG designed for a trypsin restriction enzyme cutting site as well as a preparation method and application of the beta-hairpin antibacterial peptide WIFrPG. A sequence of the antibacterial peptide is shown as SEQ ID No.1, the antibacterial peptide contains a PG corner unit, a C terminal adopts amino amidation, and arginine in the sequence is D-type amino acid. On the basis of arrangement of beta-hairpin amphiphilic peptides and trypsin restriction enzyme cutting sites, D-type amino acid is added into an antibacterial peptide sequence of a beta-hairpin structure, and the obtained antibacterial peptide is named WIFrPG; the invention further discloses application of the antibacterial peptide in preparation of drugs for treating infectious diseases caused by gram-negative bacteria or / and gram-positive bacteria. The antibacterial peptide has extremely high antibacterial activity and extremely low hemolysis on various bacteria, the therapeutic index reaches 216.95, in addition, the antibacterial peptide has high stability under the conditions of trypsin and simulated intestinal juice, and it is indicated that the antibacterial peptide has high potential for replacing antibiotics.

The invention relates to the technical field of finishing agents, in particular to an environment-friendly organic silicon finishing agent and a preparation method thereof. Comprising the following components: 50-80 parts of biomass-derived methylsilane, 8-12 parts of hydrogen-containing silicone oil, 5-10 parts of polyether modified polysiloxane, 13-21 parts of a cross-linking agent, 6-9 parts of a regulator, 15-22 parts of a surfactant and 5-12 parts of functional aids, the functional aids comprise a fiber protective agent, a degerming agent and an environment-friendly solvent, and the mass ratio of the fiber protective agent to the degerming agent to the environment-friendly solvent is (3-5): (1-2): (8-11). According to the prepared environment-friendly organic silicon finishing agent, active groups such as amino groups, acyl fluoride amino groups, amide and cyano groups are introduced, so that the composite effects of antibiosis, mildew prevention, flame retardance and the like are achieved.

The invention relates to novel iminoamides of general formula (I) and to the use thereof as ligands in copper-catalyzed coupling reactions in which (hetero) aryl halides form C-C, C-N, C-S, C-O, C-P-bonds and other bonds, in particular to the use of compounds of formula (I) as ligands in copper-catalyzed coupling reactions in which aryl halides form C-O-bonds.

An internal electron donor compound, a catalyst component and an olefin polymerization method. The internal electron donor compound has structural formula (I) as shown below. In the formula, R0 is C or D, wherein C is selected from H, halogen, a cyano group, saturated or unsaturated C1-C10 linear or branched alkyl, cycloalkyl, alkenyl, an ester group, phenyl, alkylphenyl, phenylalkyl, indenyl, benzyl, and halogenated or heteroatom-substituted alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, the heteroatom being selected from N, O, S, P and Si, or C is selected from a heteroaryl substituent, and D has 4-30 carbon atoms, and is substituted or unsubstituted alkyl containing at least two rings, heteroatom-substituted heteroaryl containing at least two rings or an amino group containing at least two rings; R1-R3 are the same or different, and are each independently selected from H, halogen, C2-C18 alkenyl, C1-C18 substituted or unsubstituted linear or branched alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, and two or more of R1-R3 can be bonded to each other to form a ring or an unsaturated bond; A and B are the same or different, and are each independently selected from an ester group, an amino group, an amide group, a sulfonyl ester group and a sulfonamide group; a substituent used for substitution is alkenyl, halogen or a heteroatom, and the heteroatom is selected from N, O, S, P and Si; and when R0 is C, R1 and R2 are bonded to each other to form a ring, A is an ester group connected to the parent benzene ring by means of a hydroxyl group, and B is an ester group connected to the parent benzene ring by means of a carboxyl group. The catalyst prepared from the internal electron donor exhibits very high catalytic activity and hydrogen sensitivity in olefin polymerization.

Described herein is a method of using a polyaminoamide including a group of formula N1in a composition for electrodepositing nanotwinned copper,that is obtained by reacting a diamine compound including two primary or secondary amino groups with an aminoacid in a molar ratio of approx. 1:2 to form an aminoamide compound that is afterwards reacted with a coupling agent and optionally with a diamine or other co-monomers.

A multi-target RNA inhibitor, relating to the field of nucleic acid drugs, and having specific structures as shown in the following general formulae Ia and Ib. X1 and X2 are orthogonal reactive groups, and the orthogonal reactive groups comprise, but are not limited to: one or more of amino groups, amido groups, carboxylic acid groups, azides, alkynes, propargyl groups, dibenzocyclooctyne (DBCO), phosphoesters, maleimide groups, aminooxy groups, N-hydroxysuccinimide (NHS), PNP, TFP, PFP, bromo groups, aldehydes, carbonate groups, tosyl groups, tetrazines, trans-cyclooctene (TCO), hydrazides, hydroxyl groups, disulfides and o-pyridyl disulfide groups, bicyclo[6.1.0]nonyne (BCN), and free or protected thiol groups. Za, Zb, Zc and Zd are delivery ligands or H, k is an integer from 0 to 4; and L1, L2, L3 and L4 are connecting chains or bonds. The present invention can achieve the goal of delivering a multi-target siRNA drug or a plurality of same-target siRNA drugs to the same cells.

The present disclosure relates to compounds according to Formula I or a pharmaceutically acceptable salt and / or solvate thereof, as well as compositions including such compounds and uses thereof, where R1 is alkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl; R2 is H, alkyl, halo, amino, amide, hydroxyl, or O-R5; R3 is alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R4 is H or alkyl; R5 is alkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl; Z1 is CH, N, or C-R6; Z2 is CH, N, or C-R7; Z3 is CH, N, or C-R8; and R6, R7, and R8 are each independently alkyl, cycloalkyl, halo, amino, amide, hydroxy, or alkoxy. As evidenced by this application, these compounds and compositions are suitable for, among other things, treating cancer.

Provided are: a hyaluronic acid derivative composition that comprises (A) a hyaluronic acid derivative having a steryl group introduced therein; and (B) a polar group-containing compound having at least one functional group selected from the group consisting of hydroxy group, carboxy group, amino group, amide group, carbamate group, urea group and thiol group, wherein the steryl group has been introduced at a ratio of 0.1% or more and less than 35% relative to the hyaluronic acid derivative (A); a pharmaceutical composition that contains the hyaluronic acid derivative composition as a carrier; and a hyaluronic acid derivative-drug conjugate composition wherein, in the hyaluronic acid derivative composition, one or more drugs are conjugated to the hyaluronic acid derivative (A).

The application relates to a preparation method of a low-viscosity polyamide acid slurry and a polyimide product, and belongs to the technical field of polyimide synthesis. In the application, a monocarboxylic anhydride is reacted with amino groups in part of diamine monomers to generate monoamino amide, then the monoamino amide is reacted with dianhydride, the end groups of the generated polyamide acid molecular chain are amide groups and anhydride groups, the molecular chain length is controlled, and finally the purpose of controlling the viscosity of the polyamide acid slurry is achieved. In the subsequent imidization process, the end amide groups are reacted with the end anhydride groups, the polyimide molecular chain is further lengthened, the molecular weight is further increased, and the performance of the polyimide product is improved, and meanwhile, the generated monocarboxylic anhydride is volatilized and removed at high temperature. The method has the advantages of large viscosity control range of the polyamide acid slurry, obvious effect, simple process and wide application range.

The invention relates to self-assembled gel of boron nitride nanosheet reinforced supramolecules and a bactericide as well as a preparation method and application of the self-assembled gel, and belongs to the technical field of nano pesticide preparations. Boron nitride nanosheets are integrated into supramolecules formed by amino-amide and polybasic acid, the self-assembled gel of the boron nitride nanosheet reinforced supramolecules and the bactericide is prepared by combining the bactericide and utilizing hydrogen bonds, hydrophobic interaction and pi-pi accumulation, and the self-assembled gel can prolong the soil durability of the bactericide and improve the soil durability of the bactericide. The soil adhesion of the bactericide is enhanced, accurate release is realized, and the environmental toxicity is reduced. The invention provides a simple and environment-friendly strategy to enhance the adhesion and retention capacity of the bactericide and improve the targeting efficiency of the bactericide. The self-assembled gel can also improve the leaf surface wetting, leaf surface adhesion and anti-scouring performance of the bactericide; not only is the product library of the bactericide enriched, but also a new and more effective choice is provided for prevention and treatment of soil-borne diseases.

An aqueous curing agent composition for an epoxy coating, a coating formulation comprising the curing agent composition, and a coating comprising the cured coating formulation are disclosed. The curing agent composition comprises an adduct of a polyaminoamide and an epoxide; a polyoxyalkylene amine; an alicyclic amine; and water.

The invention provides a triazine derivative, the structural formula of the triazine derivative is shown as a formula I, a formula II or a formula III, R is any one independently selected from ether group, amino group, amido group, carbonyl group and / or ester group, R1 and R2 are respectively independently selected from straight-chain or branched-chain alkyl group with the carbon atom number of 1-10, R3 is independently selected from straight-chain or branched-chain alkyl group with the carbon atom number of 6-20, R2 is independently selected from alkyl group with the carbon atom number of 6-20, and R3 is independently selected from alkyl group with the carbon atom number of 6-20. And n1 is an integer from 2 to 10. The long-chain alkyl ester / amide is introduced into the triazine derivative, so that the adsorbability of the compound on the metal surface and the solubility of the compound in base oil can be improved. The triazine derivative serving as an additive has good solubility in base oil, the friction coefficient of the base oil can be remarkably reduced within the wide temperature range of 25-200 DEG C, the synthesis route of the triazine derivative is simple and convenient, and the triazine derivative is a novel ash-free environment-friendly organic friction modifier.

A compound according to formula (I) or formula (Ia), and a composition comprising the compound for use as an antimicrobial:wherein,X1, X2, X3 and X4 are each independently selected from: N, O, S; Y1 and Y2 are each independently selected from: N, O, S, C (Ra); M1 and M2 are each a metal centre; R1, R2, R3, R4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A1, A2, A3 and A4 are each bidentate ligands; and rings D1 and D2 are each independently comprise one or more heteroatoms selected from N, O, S, C(Ra); wherein said compound is for use as an antimicrobial.

The invention discloses a high-energy-conversion-efficiency perovskite light-emitting diode based on amino amide hydrochloride molecular passivation and a preparation method thereof, and belongs to the field of light-emitting diodes. The structure of the high-energy-conversion-efficiency perovskite light-emitting diode based on amino amide hydrochloride molecular passivation is a conductive glass substrate, an electron transport layer, an electron transport layer, a perovskite light-emitting layer, a hole transport layer, a hole injection layer and a metal electrode. The passivation method comprises the step of adding amino amide hydrochloride molecules into a perovskite precursor solution to form the perovskite thin film passivated by the amino amide hydrochloride. The perovskite thin film is passivated through amino amide hydrochloride, the crystallization degree of perovskite is improved, precursor liquid is induced to be crystallized into luminous alpha-phase perovskite, the carrier radiation recombination rate is increased, the non-radiation recombination rate is reduced, and the fluorescence quantum yield of the perovskite thin film is remarkably improved; therefore, the external quantum efficiency and the energy conversion efficiency of the perovskite light-emitting diode are obviously improved.

The application provides a polysiloxane containing a side group of an alpha-amidoamide structure and a preparation method and application thereof, the polysiloxane is prepared from a polysiloxane containing a carboxyl side group, a primary amine, a monohydric aldehyde and an isocyanide compound, has a linear structure with a side group of an alpha-amidoamide, the side group includes aliphatic and aromatic groups and the like, and the structure is unique, the polysiloxane containing the side group of the alpha-amidoamide structure can be further crosslinked into a polar organosilicon elastomer as a prepolymer, the glass transition temperature and the dielectric constant of the organosilicon elastomer are obviously improved, meanwhile, the organosilicon elastomer has excellent mechanical properties, has a good application prospect, and further widens the application range of the polysiloxane.

The invention provides a tetra-fused ring derivative and a preparation method and application thereof, and belongs to the technical field of organic compound synthesis and medicine. The structural formula of the tetra-fused ring derivative is as shown in formula (1): (I), in the formula (I), R is selected from the following substituted or unsubstituted groups: a C3-C9 saturated or unsaturated carbon heterocyclic group, a C3-C9 saturated or unsaturated spiro heterocyclic group, a C3-C9 saturated or unsaturated fused heterocyclic group and a benzene ring; when R is the substituted group, the substituent group is one or more of methyl, halogen, cyano, amino, acylamino and N-methyl acylamino. The compound disclosed by the invention has an excellent DNA-PK inhibition effect, shows good pharmacokinetic properties in a living body, and can synergistically enhance an immunotherapy effect, so that a relatively good anti-tumor effect is achieved.

The present disclosure relates to radiolabeled amino amide compounds, particularly radiolabeled compounds that can bind to (e.g., block) Navs and can be used for imaging, and pharmaceutically acceptable salts and pharmaceutical compositions of the same. The present disclosure also relates to methods of using the radiolabeled amino amide compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and methods of preparing the same.

This invention discloses an N-aryl(2-acylaminobenzoyl)aminoamide compound, its preparation method, and its uses. This compound is generated by reacting Boc-amino acids and aromatic amines in dichloromethane under the action of EDCI, DMAP, and triethylamine. The N-Boc-aminobenzoyl compound is then acid-hydrolyzed with trifluoroacetic acid to obtain an aminobenzoyl compound. Next, the aminobenzoyl compound is reacted with indomethacin anhydride in acetonitrile under the action of potassium carbonate to generate a diamide compound. Finally, the diamide compound is reacted with an acyl halide in the action of triethylamine to obtain the N-aryl(2-acylaminobenzoyl)aminoamide compound. The raw materials used in the synthesis are inexpensive and readily available, and the synthesis method is simple. This compound exhibits good inhibitory activity against crop pathogens, particularly against Sclerotinia sclerotinia, Phytophthora blight, Fusarium head blight, rice blast fungus, gray mold, sheath blight, and rot fungus.

Embodiments of the present technology may include piping insulation products. The piping insulation product may include glass fibers and a binder. The binder may include cured products from a binder composition that includes a carbohydrate, a nitrogen-containing compound, and a catalyst that catalyzes the reaction between the carbohydrate and the nitrogen-containing compound. The catalyst may be water soluble before curing but water insoluble after curing. The nitrogen-containing compound may include an amino-amide, an amine salt of an organic acid, an ammonium salt of a carboxylic acid, or a reaction product of a urea compound and an aldehyde-containing compound. The catalyst may include a polymer including a sulfate, sulfonate, phosphate, or phosphonate moiety. The catalyst may be a crosslinker.