75 results about "Amino amide" patented technology

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.

An agricultural formulation for transporting nutrients to a plant includes poly(aminoamide) dendrimers (PAMAM) and a fertilizer active ingredient.

A liquid composition that is an aqueous liquid composition that emits light when irradiated with ultraviolet light contains a resin particle, the resin particle containing a unit that has a polar group and containing a complex composed of a sulfur-bridged calixarene and a lanthanoid ion, the polar group being at least one selected from the group consisting of an ester group, a carboxy group, a hydroxy group, an ether group, an amino group, an amide group and a cyano group.

A compound according to formula (I) or formula (Ia), and a composition comprising the compound for use as an antimicrobial: wherein, X1, X2, X3 and X4 are each independently selected from: N, O, S; Y1 and Y2 are each independently selected from: N, O, S, C(Ra); M1 and M2 are each a metal centre; R1, R2, R3, R4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A1, A2, A3 and A4 are each bidentate ligands; and rings D1 and D2 are each independently comprise one or more heteroatoms selected from N, O, S, C(Ra); wherein said compound is for use as an antimicrobial.

The present invention discloses a β-aminoamide compound and its preparation method and application. The structural formula of the β-aminoamide compound of the present invention is as follows: 1 is one of hydrogen, methyl, methyl substituted with one or more halogen atoms, ethyl, methoxy, and halogen, R 2 is one of hydrogen, methyl, ethyl, methoxy, and halogen, R 3 is one of hydrogen, methyl, phenyl, and benzyl, R 4 The β-aminoamide compound of the present invention can be used to prepare drugs for treating heart disease. The preparation method has the advantages of cheap and readily available raw materials, wide substrate applicability, high atom economy, and high diastereoselectivity, and has broad prospects for industrial application.

A treated article includes fibers, a sizing agent, and a retention aid. The sizing agent includes a wax or a component thereof having an acid value of from 10 mg to 220 mg, KOH / g as measured in accordance with USP 401. The retention aid includes a nitrogen-containing polymer independently selected from the group consisting of (i) a nitrogen-containing polymer of Formula I, (ii) a polyethyleneimine, (iii) a polyaminoamide, (iv) a copolymer formed from the reaction product of epichlorohydrin and dimethylamine, and (v) combinations thereof.

The invention discloses an aminoamide alkyl thioester compound (I), pharmaceutically acceptable salts thereof, a preparation method of the aminoamide alkyl thioester compound, a pharmaceutical composition of the aminoamide alkyl thioester compound and application of the aminoamide alkyl thioester compound in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases; # imgabs0 #

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

To provide a monomer capable of polymerizing by homopolymerization as a raw material of a biomass-derived constituent.SOLUTION: A bifunctionalized monomer of phenylpropanoid is expressed by formula (1a), (1b), or (1c). In the formulae (1a), (1b) and (1c), R1 to R5 each mutually independently express a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an aralkyloxy group, an aryloxy group, a nitro group, an amino group, an amide group, a carboxy group, an alkyloxycarbonyl group, an aryloxycarbonyl group, a formyl group, a cyano group, an alkyl group, a cycloalkyl groupe, an aralkyl group, or an aryl group, and L expresses a linker group.SELECTED DRAWING: Figure 1

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

The invention discloses a construction method of a 1, 3-dinitrogen heterocyclic compound. According to the construction method, an acyloin compound is used as a raw material to react with an anthranilamide compound and analogues thereof, an anthranilamide compound, an anthranilic compound or various amino amide compounds in a solvent containing a catalyst and an oxidizing agent respectively, and the corresponding 1, 2, 3-triazole compound is obtained at a medium to higher yield. The invention discloses a 1, 3-diazacyclo compound. The construction method has the characteristics of cheap and easily available raw materials, moderate reaction temperature, high atom utilization rate and diversified product structures.

The invention belongs to the field of inorganic enrichment materials, and discloses a preparation method of a lithium adsorption material, which comprises the following steps: S1, mixing a lithium source with a non-lithium metal source to prepare a precursor of the lithium adsorption material; s2, cleaning the precursor, performing primary crushing, and performing ball milling to obtain precursor powder; s3, a hydrophilic branch chain is chemically grafted to the molecular surface of the activated nanoscale silicon oxide, a modified polymer is prepared, and the hydrophilic branch chain comprises one or more of hydroxyl, carboxyl, amino, amido, sulfonic acid group, phosphate group, ether group, pyridine group and quaternary ammonium salt group; and S4, mixing the modified polymer with the crushed precursor powder, and granulating to obtain the lithium adsorption material. According to the preparation method, the lithium adsorption material which can be rapidly infiltrated by the lithium-containing solution can be prepared, so that the lithium extraction rate is increased.

The invention provides a preparation method of a foamed nickel-based composite material for photocatalytic degradation of p-nitrophenol, and the preparation method sequentially comprises the following steps: step [1] preparation of 2, 5-dibromo-3-aminothiophene and 2, 5-dibromo-3-amide thiophene; (2) synthesizing graphdiyne / tungsten trioxide nanoparticles; and (3) loading poly (3-amino / 3-amide thiophene) and the graphdiyne / tungsten trioxide nanoparticles on the surface of a foamed nickel matrix to finally obtain the foamed nickel-based composite material. The foamed nickel-based composite material prepared by the method disclosed by the invention has excellent p-nitrophenol ultraviolet light and visible light degradation rate and outstanding p-nitrophenol photocatalytic degradation repetitive stability performance.

The present invention relates to pharmaceutical agents useful for therapy and / or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.

A marker for gene recombination of Starmerella bombicola and a method for using the same. The present invention provides an adenine auxotrophic selection marker consisting of a gene encoding a phospho

The present application provides an electrolyte and a secondary battery, wherein the electrolyte contains a flame retardant additive having the general structural formula shown in Formula (I): #imgabs0# wherein R, R1, R2, R3, R4, and R5 are independently selected from one or more of a hydrogen atom, a halogen, an amino group, an amide group, an ester group, an alkyl group, a halogenated alkyl group, an alkoxy group, a halogenated alkoxy group, an aryl group, a halogenated aryl group, an aryloxy group, and a halogenated aryloxy group. The electrolyte containing the flame retardant additive can have good flame retardant properties while not increasing the viscosity of the electrolyte and preventing the electrode active material from peeling off from the electrode due to co-embedding, thereby ensuring good electrochemical performance of the battery.

The invention discloses a beta-hairpin antibacterial peptide WIFrPG designed for a trypsin restriction enzyme cutting site as well as a preparation method and application of the beta-hairpin antibacterial peptide WIFrPG. A sequence of the antibacterial peptide is shown as SEQ ID No.1, the antibacterial peptide contains a PG corner unit, a C terminal adopts amino amidation, and arginine in the sequence is D-type amino acid. On the basis of arrangement of beta-hairpin amphiphilic peptides and trypsin restriction enzyme cutting sites, D-type amino acid is added into an antibacterial peptide sequence of a beta-hairpin structure, and the obtained antibacterial peptide is named WIFrPG; the invention further discloses application of the antibacterial peptide in preparation of drugs for treating infectious diseases caused by gram-negative bacteria or / and gram-positive bacteria. The antibacterial peptide has extremely high antibacterial activity and extremely low hemolysis on various bacteria, the therapeutic index reaches 216.95, in addition, the antibacterial peptide has high stability under the conditions of trypsin and simulated intestinal juice, and it is indicated that the antibacterial peptide has high potential for replacing antibiotics.

The present invention discloses a waterborne curing agent composition for epoxy coatings, a coating formulation comprising said curing agent composition and a coating comprising the cured coating formulation. The curing agent composition comprises an adduct of a polyaminoamide and an epoxide; a polyoxyalkyleneamine; a cycloaliphatic amine; and water.

The invention discloses self-crosslinking epoxy silicone oil as well as a preparation method and application thereof. The self-crosslinking epoxy silicone oil is side epoxy silicone oil with terminal acylamino. The preparation method comprises the following steps: by taking a dimethyl cyclosiloxane monomer, tetramethylcyclotetrasiloxane and an amino double-end socket as raw materials, firstly synthesizing terminal primary amino side hydrogen silicone oil through ring-opening polymerization; amidating amino at the tail end of the silicone oil; then a side epoxy group is introduced through a side hydrogen hydrosilylation reaction, and the end group of the obtained epoxy silicone oil is an amide group which does not react with the side epoxy group at room temperature and lower temperature, so that the epoxy silicone oil can be reprocessed and stably stored; the terminal group amide group can be subjected to addition reaction with the epoxy group under the condition of high temperature, and the organosilicon material belongs to a high-temperature self-crosslinking type organosilicon material and has the characteristic of single-component high-temperature curing. The epoxy silicone oil disclosed by the invention can be applied as a single-component high-temperature curing type adhesive or a resin matrix, the reaction conditions adopted for preparation are mild, the raw materials are all industrial products, bulk, cheap and easily available, the preparation process is simple and convenient, and the epoxy silicone oil is suitable for industrial production.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. The invention relates to an alpha-amino substituted amide derivative, the structural formula of which is # imgabs0 #, and in the formula, X is bromine or chlorine; r is phenyl, phenyl substituted by methyl, phenyl substituted by methoxyl, phenyl substituted by halogen, naphthyl, furyl, thienyl, cyclohexyl, tetrahydropyranyl or ester substituted by C1-C4 alkyl; ar is phenyl, phenyl substituted by C1-C4 alkyl, phenyl substituted by methoxyl, and phenyl or naphthyl substituted by halogen. The synthesis method of the alpha-aminoamide derivative comprises the following steps: taking halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and aromatic amine as raw materials, under the catalysis of metal copper salt, taking Bronsted acid as an additive and taking an organic reagent as a solvent, and carrying out one-step reaction to obtain the alpha-aminoamide derivative. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

The present invention discloses a preparation method and application of a branched antibacterial peptide KW, belonging to the field of biotechnology. The antibacterial peptide KW includes a Lys and two heptapeptide groups with two α-helix structures. The amino acid sequence of the heptapeptide group is shown in SEQ ID No.1. The C-terminus of Arg at the 7th position of the first heptapeptide group is connected to the ε-N terminus of Lys, and the N-terminus of Leu at the 1st position of the second heptapeptide group is connected to the C-terminus of Lys. Moreover, the C-terminus of the antibacterial peptide KW is amidated with an amino group. The branched antibacterial peptide can significantly improve the problem of high toxicity caused by linear polypeptides and further enhance cell selectivity on the basis of ensuring a certain antibacterial activity. In addition, the branched antibacterial peptide KW has the potential to become a broad-spectrum antibacterial drug for treating Gram-positive and Gram-negative bacterial infections and has high application value.

The invention discloses an amphiphilic polymer, relates to the technical field of reservoir fracturing and extraction integrated transformation in the petroleum industry, and in particular relates to an amphiphilic polymer as well as a preparation method and application thereof. The preparation raw materials of the amphiphilic polymer comprise acrylamide or a derivative thereof, a hydrophobic monomer, a cationic monomer, an amphoteric active monomer and an initiator. The hydrophobic monomer is prepared from the following raw materials: chlorinated olefin, N-dimethylalkylamine or N, N-dimethylalkylamine; the preparation raw materials of the cationic monomer comprise amino amide containing double bonds and alkyl bromide; the preparation raw materials of the amphoteric active monomer comprise long-chain fatty acid, amine or alcohol amine; the amphiphilic polymer and the fracturing fluid have a synergistic effect, and the properties of oil and gas replacement, extraction efficiency and the like can be improved.

The invention relates to the technical field of finishing agents, in particular to an environment-friendly organic silicon finishing agent and a preparation method thereof. Comprising the following components: 50-80 parts of biomass-derived methylsilane, 8-12 parts of hydrogen-containing silicone oil, 5-10 parts of polyether modified polysiloxane, 13-21 parts of a cross-linking agent, 6-9 parts of a regulator, 15-22 parts of a surfactant and 5-12 parts of functional aids, the functional aids comprise a fiber protective agent, a degerming agent and an environment-friendly solvent, and the mass ratio of the fiber protective agent to the degerming agent to the environment-friendly solvent is (3-5): (1-2): (8-11). According to the prepared environment-friendly organic silicon finishing agent, active groups such as amino groups, acyl fluoride amino groups, amide and cyano groups are introduced, so that the composite effects of antibiosis, mildew prevention, flame retardance and the like are achieved.

The invention relates to novel iminoamides of general formula (I) and to the use thereof as ligands in copper-catalyzed coupling reactions in which (hetero) aryl halides form C-C, C-N, C-S, C-O, C-P-bonds and other bonds, in particular to the use of compounds of formula (I) as ligands in copper-catalyzed coupling reactions in which aryl halides form C-O-bonds.

The invention belongs to the field of organic synthesis, and discloses a method for preparing an indole-dipyrromethene derivative, which comprises the following steps: firstly, carrying out Ugi reaction on glyoxal dimethyl acetal, isonitrile, trifluoroacetic acid and amine to obtain an alpha-acylamino amide compound; and then under the action of an acid catalyst, carrying out [3 + 2] cyclization aromatization on the indole-dipyrromethene derivative, 4-methoxy ethyl acetoacetate and an indole derivative to obtain the indole-dipyrromethene derivative. According to the method, the indole-dipyrromethene derivative is prepared from the Ugi adduct prepared through the Ugi reaction in which glyoxal dimethyl acetal participates through [3 + 2] cyclization aromatization with ethyl 4-methoxyacetoacetate and the indole derivative, precious metal is not used in the overall reaction, the final target product can be obtained through a one-pot two-step method, and the step operation is simple. In addition, no additional ligand or additive needs to be added, and the method has the advantages of being good in reaction selectivity, high in yield, easy in product separation and the like.

A catalyst composition comprising at least one compound represented by formula (I). TIFF2025524162000022.tif34150[wherein R1, R2, and R3 are each independently a straight-chain or branched C1-C3 alkyl group, or a straight-chain or branched C2-C6 alkenyl group; R4 is hydrogen, a straight-chain or branched C1-C3 alkyl group, or a straight-chain or branched C2-C6 alkenyl group.]

Provided are: a phenazine derivative; and a method for producing a phenazine derivative, in which a reaction proceeds under mild conditions without the use of a catalyst such as a metal or an enzyme.　The phenazine derivative is represented by general formula (1). (In the formula, R1 moieties are each independently a hydrogen atom, a primary amino group (-NH2), a secondary amino group (-NHR'), an acylamido group (-NHCOR') or a hydroxyl group (-OH), R2 moieties are each independently an alkoxycarbonyl group (-C(=O)OR'), an aryloxycarbonyl group (-C(=O)OR'), a carbonyl group (-C(=O)R'), an amido group (-C(=O)NR'R''), a sulfinyl group (-S(=O)R'), a sulfinamido group (-S(=O)NR'R''), a sulfonyl group (-S(=O)2R'), a sulfonamido group (-S(=O)2NR'R''), a sulfonate group (-S(=O)2OR'), a phosphinyl group (-P(=O)2R') or a nitrile group (-CN), R3 moieties are each independently a hydrogen atom, a primary amino group (-NH2), a secondary amino group (-NHR'), an acylamido group (-NHCOR'), a hydroxyl group (-OH) or a monovalent organic group, R44 moieties are each independently an alkoxycarbonyl group (-C(=O)OR'), an aryloxycarbonyl group (-C(=O)OR'), a carbonyl group (-C(=O)R'), an amido group (-C(=O)NR'R''), a sulfinyl group (-S(=O)R'), a sulfinamido group (-S(=O)NR'R''), a sulfonyl group (-S(=O)2R'), a sulfonamido group (-S(=O)2NR'R''), a sulfonate group (-S(=O)2OR'), a phosphinyl group (-P(=O)R'2), a nitrile group (-CN) or a monovalent organic group, R' moieties are each independently an alkyl group or aryl group in which at least one hydrogen may be substituted, R'' is a hydrogen atom or an alkyl group or aryl group in which at least one hydrogen atom may be substituted, and alkyl groups and aryl groups in R' and R'' may be the same as, or different from, each other.)

An internal electron donor compound, a catalyst component and an olefin polymerization method. The internal electron donor compound has structural formula (I) as shown below. In the formula, R0 is C or D, wherein C is selected from H, halogen, a cyano group, saturated or unsaturated C1-C10 linear or branched alkyl, cycloalkyl, alkenyl, an ester group, phenyl, alkylphenyl, phenylalkyl, indenyl, benzyl, and halogenated or heteroatom-substituted alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, the heteroatom being selected from N, O, S, P and Si, or C is selected from a heteroaryl substituent, and D has 4-30 carbon atoms, and is substituted or unsubstituted alkyl containing at least two rings, heteroatom-substituted heteroaryl containing at least two rings or an amino group containing at least two rings; R1-R3 are the same or different, and are each independently selected from H, halogen, C2-C18 alkenyl, C1-C18 substituted or unsubstituted linear or branched alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, and two or more of R1-R3 can be bonded to each other to form a ring or an unsaturated bond; A and B are the same or different, and are each independently selected from an ester group, an amino group, an amide group, a sulfonyl ester group and a sulfonamide group; a substituent used for substitution is alkenyl, halogen or a heteroatom, and the heteroatom is selected from N, O, S, P and Si; and when R0 is C, R1 and R2 are bonded to each other to form a ring, A is an ester group connected to the parent benzene ring by means of a hydroxyl group, and B is an ester group connected to the parent benzene ring by means of a carboxyl group. The catalyst prepared from the internal electron donor exhibits very high catalytic activity and hydrogen sensitivity in olefin polymerization.

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.