56 results about "Amino amide" patented technology

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.

An agricultural formulation for transporting nutrients to a plant includes poly(aminoamide) dendrimers (PAMAM) and a fertilizer active ingredient.

A liquid composition that is an aqueous liquid composition that emits light when irradiated with ultraviolet light contains a resin particle, the resin particle containing a unit that has a polar group and containing a complex composed of a sulfur-bridged calixarene and a lanthanoid ion, the polar group being at least one selected from the group consisting of an ester group, a carboxy group, a hydroxy group, an ether group, an amino group, an amide group and a cyano group.

A compound according to formula (I) or formula (Ia), and a composition comprising the compound for use as an antimicrobial: wherein, X1, X2, X3 and X4 are each independently selected from: N, O, S; Y1 and Y2 are each independently selected from: N, O, S, C(Ra); M1 and M2 are each a metal centre; R1, R2, R3, R4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A1, A2, A3 and A4 are each bidentate ligands; and rings D1 and D2 are each independently comprise one or more heteroatoms selected from N, O, S, C(Ra); wherein said compound is for use as an antimicrobial.

The present invention discloses a β-aminoamide compound and its preparation method and application. The structural formula of the β-aminoamide compound of the present invention is as follows: 1 is one of hydrogen, methyl, methyl substituted with one or more halogen atoms, ethyl, methoxy, and halogen, R 2 is one of hydrogen, methyl, ethyl, methoxy, and halogen, R 3 is one of hydrogen, methyl, phenyl, and benzyl, R 4 The β-aminoamide compound of the present invention can be used to prepare drugs for treating heart disease. The preparation method has the advantages of cheap and readily available raw materials, wide substrate applicability, high atom economy, and high diastereoselectivity, and has broad prospects for industrial application.

The invention discloses an aminoamide alkyl thioester compound (I), pharmaceutically acceptable salts thereof, a preparation method of the aminoamide alkyl thioester compound, a pharmaceutical composition of the aminoamide alkyl thioester compound and application of the aminoamide alkyl thioester compound in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases; # imgabs0 #

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

The invention discloses a construction method of a 1, 3-dinitrogen heterocyclic compound. According to the construction method, an acyloin compound is used as a raw material to react with an anthranilamide compound and analogues thereof, an anthranilamide compound, an anthranilic compound or various amino amide compounds in a solvent containing a catalyst and an oxidizing agent respectively, and the corresponding 1, 2, 3-triazole compound is obtained at a medium to higher yield. The invention discloses a 1, 3-diazacyclo compound. The construction method has the characteristics of cheap and easily available raw materials, moderate reaction temperature, high atom utilization rate and diversified product structures.

The invention belongs to the field of inorganic enrichment materials, and discloses a preparation method of a lithium adsorption material, which comprises the following steps: S1, mixing a lithium source with a non-lithium metal source to prepare a precursor of the lithium adsorption material; s2, cleaning the precursor, performing primary crushing, and performing ball milling to obtain precursor powder; s3, a hydrophilic branch chain is chemically grafted to the molecular surface of the activated nanoscale silicon oxide, a modified polymer is prepared, and the hydrophilic branch chain comprises one or more of hydroxyl, carboxyl, amino, amido, sulfonic acid group, phosphate group, ether group, pyridine group and quaternary ammonium salt group; and S4, mixing the modified polymer with the crushed precursor powder, and granulating to obtain the lithium adsorption material. According to the preparation method, the lithium adsorption material which can be rapidly infiltrated by the lithium-containing solution can be prepared, so that the lithium extraction rate is increased.

The present application provides an electrolyte and a secondary battery, wherein the electrolyte contains a flame retardant additive having the general structural formula shown in Formula (I): #imgabs0# wherein R, R1, R2, R3, R4, and R5 are independently selected from one or more of a hydrogen atom, a halogen, an amino group, an amide group, an ester group, an alkyl group, a halogenated alkyl group, an alkoxy group, a halogenated alkoxy group, an aryl group, a halogenated aryl group, an aryloxy group, and a halogenated aryloxy group. The electrolyte containing the flame retardant additive can have good flame retardant properties while not increasing the viscosity of the electrolyte and preventing the electrode active material from peeling off from the electrode due to co-embedding, thereby ensuring good electrochemical performance of the battery.

The invention discloses a beta-hairpin antibacterial peptide WIFrPG designed for a trypsin restriction enzyme cutting site as well as a preparation method and application of the beta-hairpin antibacterial peptide WIFrPG. A sequence of the antibacterial peptide is shown as SEQ ID No.1, the antibacterial peptide contains a PG corner unit, a C terminal adopts amino amidation, and arginine in the sequence is D-type amino acid. On the basis of arrangement of beta-hairpin amphiphilic peptides and trypsin restriction enzyme cutting sites, D-type amino acid is added into an antibacterial peptide sequence of a beta-hairpin structure, and the obtained antibacterial peptide is named WIFrPG; the invention further discloses application of the antibacterial peptide in preparation of drugs for treating infectious diseases caused by gram-negative bacteria or / and gram-positive bacteria. The antibacterial peptide has extremely high antibacterial activity and extremely low hemolysis on various bacteria, the therapeutic index reaches 216.95, in addition, the antibacterial peptide has high stability under the conditions of trypsin and simulated intestinal juice, and it is indicated that the antibacterial peptide has high potential for replacing antibiotics.

The present invention discloses a preparation method and application of a branched antibacterial peptide KW, belonging to the field of biotechnology. The antibacterial peptide KW includes a Lys and two heptapeptide groups with two α-helix structures. The amino acid sequence of the heptapeptide group is shown in SEQ ID No.1. The C-terminus of Arg at the 7th position of the first heptapeptide group is connected to the ε-N terminus of Lys, and the N-terminus of Leu at the 1st position of the second heptapeptide group is connected to the C-terminus of Lys. Moreover, the C-terminus of the antibacterial peptide KW is amidated with an amino group. The branched antibacterial peptide can significantly improve the problem of high toxicity caused by linear polypeptides and further enhance cell selectivity on the basis of ensuring a certain antibacterial activity. In addition, the branched antibacterial peptide KW has the potential to become a broad-spectrum antibacterial drug for treating Gram-positive and Gram-negative bacterial infections and has high application value.

The invention relates to the technical field of finishing agents, in particular to an environment-friendly organic silicon finishing agent and a preparation method thereof. Comprising the following components: 50-80 parts of biomass-derived methylsilane, 8-12 parts of hydrogen-containing silicone oil, 5-10 parts of polyether modified polysiloxane, 13-21 parts of a cross-linking agent, 6-9 parts of a regulator, 15-22 parts of a surfactant and 5-12 parts of functional aids, the functional aids comprise a fiber protective agent, a degerming agent and an environment-friendly solvent, and the mass ratio of the fiber protective agent to the degerming agent to the environment-friendly solvent is (3-5): (1-2): (8-11). According to the prepared environment-friendly organic silicon finishing agent, active groups such as amino groups, acyl fluoride amino groups, amide and cyano groups are introduced, so that the composite effects of antibiosis, mildew prevention, flame retardance and the like are achieved.

The invention relates to novel iminoamides of general formula (I) and to the use thereof as ligands in copper-catalyzed coupling reactions in which (hetero) aryl halides form C-C, C-N, C-S, C-O, C-P-bonds and other bonds, in particular to the use of compounds of formula (I) as ligands in copper-catalyzed coupling reactions in which aryl halides form C-O-bonds.

The invention belongs to the field of organic synthesis, and discloses a method for preparing an indole-dipyrromethene derivative, which comprises the following steps: firstly, carrying out Ugi reaction on glyoxal dimethyl acetal, isonitrile, trifluoroacetic acid and amine to obtain an alpha-acylamino amide compound; and then under the action of an acid catalyst, carrying out [3 + 2] cyclization aromatization on the indole-dipyrromethene derivative, 4-methoxy ethyl acetoacetate and an indole derivative to obtain the indole-dipyrromethene derivative. According to the method, the indole-dipyrromethene derivative is prepared from the Ugi adduct prepared through the Ugi reaction in which glyoxal dimethyl acetal participates through [3 + 2] cyclization aromatization with ethyl 4-methoxyacetoacetate and the indole derivative, precious metal is not used in the overall reaction, the final target product can be obtained through a one-pot two-step method, and the step operation is simple. In addition, no additional ligand or additive needs to be added, and the method has the advantages of being good in reaction selectivity, high in yield, easy in product separation and the like.

A catalyst composition comprising at least one compound represented by formula (I). TIFF2025524162000022.tif34150[wherein R1, R2, and R3 are each independently a straight-chain or branched C1-C3 alkyl group, or a straight-chain or branched C2-C6 alkenyl group; R4 is hydrogen, a straight-chain or branched C1-C3 alkyl group, or a straight-chain or branched C2-C6 alkenyl group.]

Provided are: a phenazine derivative; and a method for producing a phenazine derivative, in which a reaction proceeds under mild conditions without the use of a catalyst such as a metal or an enzyme.　The phenazine derivative is represented by general formula (1). (In the formula, R1 moieties are each independently a hydrogen atom, a primary amino group (-NH2), a secondary amino group (-NHR'), an acylamido group (-NHCOR') or a hydroxyl group (-OH), R2 moieties are each independently an alkoxycarbonyl group (-C(=O)OR'), an aryloxycarbonyl group (-C(=O)OR'), a carbonyl group (-C(=O)R'), an amido group (-C(=O)NR'R''), a sulfinyl group (-S(=O)R'), a sulfinamido group (-S(=O)NR'R''), a sulfonyl group (-S(=O)2R'), a sulfonamido group (-S(=O)2NR'R''), a sulfonate group (-S(=O)2OR'), a phosphinyl group (-P(=O)2R') or a nitrile group (-CN), R3 moieties are each independently a hydrogen atom, a primary amino group (-NH2), a secondary amino group (-NHR'), an acylamido group (-NHCOR'), a hydroxyl group (-OH) or a monovalent organic group, R44 moieties are each independently an alkoxycarbonyl group (-C(=O)OR'), an aryloxycarbonyl group (-C(=O)OR'), a carbonyl group (-C(=O)R'), an amido group (-C(=O)NR'R''), a sulfinyl group (-S(=O)R'), a sulfinamido group (-S(=O)NR'R''), a sulfonyl group (-S(=O)2R'), a sulfonamido group (-S(=O)2NR'R''), a sulfonate group (-S(=O)2OR'), a phosphinyl group (-P(=O)R'2), a nitrile group (-CN) or a monovalent organic group, R' moieties are each independently an alkyl group or aryl group in which at least one hydrogen may be substituted, R'' is a hydrogen atom or an alkyl group or aryl group in which at least one hydrogen atom may be substituted, and alkyl groups and aryl groups in R' and R'' may be the same as, or different from, each other.)

An internal electron donor compound, a catalyst component and an olefin polymerization method. The internal electron donor compound has structural formula (I) as shown below. In the formula, R0 is C or D, wherein C is selected from H, halogen, a cyano group, saturated or unsaturated C1-C10 linear or branched alkyl, cycloalkyl, alkenyl, an ester group, phenyl, alkylphenyl, phenylalkyl, indenyl, benzyl, and halogenated or heteroatom-substituted alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, the heteroatom being selected from N, O, S, P and Si, or C is selected from a heteroaryl substituent, and D has 4-30 carbon atoms, and is substituted or unsubstituted alkyl containing at least two rings, heteroatom-substituted heteroaryl containing at least two rings or an amino group containing at least two rings; R1-R3 are the same or different, and are each independently selected from H, halogen, C2-C18 alkenyl, C1-C18 substituted or unsubstituted linear or branched alkyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, indenyl and benzyl, and two or more of R1-R3 can be bonded to each other to form a ring or an unsaturated bond; A and B are the same or different, and are each independently selected from an ester group, an amino group, an amide group, a sulfonyl ester group and a sulfonamide group; a substituent used for substitution is alkenyl, halogen or a heteroatom, and the heteroatom is selected from N, O, S, P and Si; and when R0 is C, R1 and R2 are bonded to each other to form a ring, A is an ester group connected to the parent benzene ring by means of a hydroxyl group, and B is an ester group connected to the parent benzene ring by means of a carboxyl group. The catalyst prepared from the internal electron donor exhibits very high catalytic activity and hydrogen sensitivity in olefin polymerization.

A Method for the synthesis of ω-amino acids or derivatives thereof, includes the following steps synthesis of an ω-oxoester / linear acid by hydroformylation by CO / H2 mixture of at least one monounsaturated acid / ester, the monounsaturated acid / ester preferably resulting from a reaction of metathesis of oils / fats from renewable sources; synthesis of a linear ω-amino acid / ester and / or ω-aminoamide, subjecting the aforementioned ω-oxoester / linear acid to reductive amination; and possible synthesis of a linear ω-amino acid, subjecting the aforementioned linear ω-aminoester and / or ω-aminoamide to hydrolysis.

The invention discloses a preparation method of a dabigatran etexilate precursor, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: S1, under the protection of nitrogen, reducing nitro of a compound IV into amino by taking tetrahydroxy diboron and 4, 4 '-dipyridyl as a concerted catalytic system, and purifying to obtain a compound III; s2, pretreating a compound III, a compound II and a condensing agent, performing low-temperature activation and microwave reaction in a DMF / DCM mixed solvent in the presence of HATU, HOAt and DIPEA, and performing post-treatment and recrystallization to obtain an amino amide intermediate; and S3, dissolving the amino amide intermediate in glacial acetic acid, carrying out reflux cyclization, and carrying out post-treatment and recrystallization to obtain a compound I. According to the invention, tetrahydroxy diboron and 4, 4 '-dipyridyl are adopted to synergistically catalyze nitro reduction, the conditions are mild, and the reaction is rapid; by means of synergistic catalysis of HATU and HOAt, water removal through a 4molecular sieve, batch addition of HATU, microwave assistance and the like, the reaction time is shortened, the yield is increased, side reactions are reduced, and the method is suitable for industrial production.

The present invention relates to a class of aminoamide lipid compounds, compounds represented by chemical formula (I), or pharmaceutically acceptable salts and prodrugs thereof, and also discloses a preparation method of the compound and its use as a delivery therapeutic component in the preparation of drugs.

The present invention relates to a laminate. Provided is a laminate which has excellent low-temperature impact resistance and compressive strength at high temperatures even if the layer of a modified polyolefin is thick. A laminate having two or more layers including a layer (a) and a layer (b), the layer (a) including an aliphatic polyamide composition (A), and the layer (b) including a modified polyolefin (B), the modified polyolefin (B) contains a unit derived from a monomer based on an alpha-olefin having 2-10 carbon atoms and a unit derived from an unsaturated compound having a functional group. The unsaturated compound having a functional group is at least one selected from the group consisting of an unsaturated compound having at least one group selected from the group consisting of a carboxyl group, a hydroxyl group, an epoxy group, an amino group, an amide group, an imide group, a nitrile group, a thiol group, and an isocyanate group, and a derivative of an unsaturated compound having a carboxyl group. The modified polyolefin (B) has a Shore hardness (D scale) of 30 to 61 (inclusive) as measured in accordance with ASTM D2240.

Described herein is a method of using a polyaminoamide including a group of formula N1in a composition for electrodepositing nanotwinned copper,that is obtained by reacting a diamine compound including two primary or secondary amino groups with an aminoacid in a molar ratio of approx. 1:2 to form an aminoamide compound that is afterwards reacted with a coupling agent and optionally with a diamine or other co-monomers.

The invention discloses an axially chiral nitrogen-containing heteroaromatic ring sulfonamide ligand as well as a preparation method and application thereof. The axially chiral nitrogen-containing heteroaromatic ring sulfonamide ligand has a structure shown in a general formula (I), wherein an axially chiral part A of a # imgabs0 # ligand is selected from A-1 or A-2; and the nitrogen-containing heteroaromatic ring part B of the ligand is selected from B-1 or B-2. The axially chiral nitrogen-containing heteroaromatic ring sulfonamide ligand and a transition metal compound form a complex catalyst in situ in a reaction system, and in the reaction of catalyzing free radical coupling of halogenated amide and amine to synthesize a chiral amino amide compound, good to excellent yield, enantioselectivity and good substrate universality are shown; good industrial application prospects are realized. The invention belongs to the field of asymmetric synthetic chemistry.

The present application provides a lithium-replenishing additive, a preparation method thereof, and a secondary battery. The lithium-replenishing additive comprises a lithium-rich material core and a coating disposed on the lithium-rich material core. The coating comprises an organophosphorus compound, the organophosphorus compound comprising an organophosphate or an organophosphate salt, and / or the organophosphorus compound comprising an organophosphorus acid or an organophosphorus acid salt. The substituents in the organophosphate or the organophosphate salt, the organophosphorus acid or the organophosphorus acid salt are independently selected from substituted or unsubstituted alkyl groups or silicon-containing groups, and the substituents of the alkyl groups comprise fluorine atoms, hydroxyl groups, carboxyl groups, amino groups, and amide groups. The lithium-replenishing additive not only effectively replenishes lithium in lithium secondary batteries and improves the initial efficiency of the battery, but also has good stability and is not easily reacted in air, which facilitates the production, storage, and transportation of the lithium-replenishing additive.

A method efficiently produces a compound containing an N-acyl-amino group by an enzymatic method. Specifically, a method of producing a compound containing an N-acyl-amino group includes producing the compound containing an N-acyl-amino group by reacting a compound containing an amino group with a compound containing a carboxyl group in the presence of an enzyme having an ability to bond a carboxyl group and an amino group in an ATP dependent manner to form an amide bond.

The present invention provides a hard coat forming material having excellent scratch resistance and stretchability, both of which exhibit a trade-off. The means for solving the problem is a curable composition comprising: (a) 100 parts by mass of a urethane (meth)acrylate; (b) 5 to 70 parts by mass of silica particles surface-modified with a silane coupling agent having at least one nitrogen-containing proton-donating group selected from an amino group, an amide group, a urea group, a thiurea group, a thiourethane group, a urea group, and a thiourea group; (c) 0.05 to 10 parts by mass of a perfluoropolyether having an active energy ray-polymerizable group at the end of a molecular chain containing a poly(perfluorooxyalkylene) group; and (d) 1 to 20 parts by mass of a polymerization initiator that generates free radicals in response to active energy rays.

A multi-target RNA inhibitor, relating to the field of nucleic acid drugs, and having specific structures as shown in the following general formulae Ia and Ib. X1 and X2 are orthogonal reactive groups, and the orthogonal reactive groups comprise, but are not limited to: one or more of amino groups, amido groups, carboxylic acid groups, azides, alkynes, propargyl groups, dibenzocyclooctyne (DBCO), phosphoesters, maleimide groups, aminooxy groups, N-hydroxysuccinimide (NHS), PNP, TFP, PFP, bromo groups, aldehydes, carbonate groups, tosyl groups, tetrazines, trans-cyclooctene (TCO), hydrazides, hydroxyl groups, disulfides and o-pyridyl disulfide groups, bicyclo[6.1.0]nonyne (BCN), and free or protected thiol groups. Za, Zb, Zc and Zd are delivery ligands or H, k is an integer from 0 to 4; and L1, L2, L3 and L4 are connecting chains or bonds. The present invention can achieve the goal of delivering a multi-target siRNA drug or a plurality of same-target siRNA drugs to the same cells.