51 results about "Substituted amide" patented technology

The invention provides an aromatic heterocycle substituted amide compound as well as a preparation method and application thereof. The amide compound has a structure as shown in a formula I which is described in the specification. The aromatic heterocyclic ring substituted amide compound provided by the invention can have high insecticidal activity at a low dosage; and due to good effect under low dosage, the medicine dosage is reduced, environmental protection is facilitated, and the application prospect is wide.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

The present application provides a polymer, a battery cell, a manufacturing method therefor, a battery device, and an electric device. The polymer comprises a phenyl group, formula (I), a flexible chain segment, and an end group; the end group comprises one or more of a substituted or unsubstituted amide group and a substituted or unsubstituted -NH2, and optionally one or more of a carbonate group, a sulfonate group, a phosphate group, a quaternary ammonium group, and a C6-C18 aryl group; the flexible chain segment comprises one or more of -CH2-O-CH2- and -C(O)O-, and optionally -CH2-; the flexible chain segment is linked to -O- in formula (II); and the end group is linked to the flexible chain segment.

A polythiophene / polyanion composition comprising: i) an oligo- or polythiophene obtained by the polymerization of a monomer according to Formula (I), and wherein A represents a substituted or unsubstituted C1 to C5 alkylene bridge, ii) a polyanion obtained by the polymerization of at least one monomer according to Formula (II), wherein R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group and a substituted or unsubstituted aryl or heteroaryl group; K is selected from the group consisting of a substituted or unsubstituted alkylene group, an ether group, an ester group, a substituted or unsubstituted amide group, a substituted or unsubstituted alkenylene group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; L is selected from the group consisting of a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group, an amine group, an ether group, a thioether group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; R2 and R3 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group; m represents 0 or 1; n is an integer from 1 to 10 000; and wherein the amount of monomer according to Formula (II) in the polyanion is from 0.1 to 20 mol %, relative to the total amount of monomers.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

The application provides an insulating electrophoretic paint, a workpiece with an insulating layer, a battery pack and an electrical device. The insulating electrophoretic paint comprises a modified polyimide polymer, a silsesquioxane, a blocked isocyanate, an acid and water; wherein the silsesquioxane is modified with at least one amino group; at least one end of the modified polyimide polymer is a polyimide-like molecular chain, and the end of the polyimide-like molecular chain has a hydroxyalkyl-substituted amide group. The insulating layer prepared from the insulating electrophoretic paint has not only good electrical insulation performance, but also good high-temperature resistance and excellent low dielectricity.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

Provided is a method for producing a decomposing / cleaning composition which improves etching speed retention. In particular, a method for producing a decomposing / cleaning composition which contains (A) an N-substituted amide compound in which a hydrogen atom is not directly bonded to a nitrogen atom and (B) a quaternary alkyl ammonium fluoride or a hydrate thereof is provided, the method having a preparation step for mixing the (A) and (B) components in an inert gas atmosphere.

The invention belongs to the technical field of biological medicine, and particularly relates to an N-aryl substituted amide as a novel HDAC6 (histone deacetylase 6) inhibitor and application of the N-aryl substituted amide in preparation of antitumor drugs. A compound shown as a formula (I) is screened and synthesized on the basis of an artificial intelligence technology; the compound shows excellent inhibitory activity on HDAC6, and can be used for efficiently inhibiting HDAC6 and / or HDAC1; in addition, anti-tumor cell proliferation evaluation further reveals that the compound can significantly inhibit proliferation of tumor cells. Based on the excellent enzyme inhibition activity and the cellular level anti-proliferation effect, the compound can be used for preparing medicines for treating tumors, autoimmune diseases, inflammation or Alzheimer's disease, and has a wide development prospect.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

An indeno-fused naphthopyran having the core skeletal structure (I): (I) wherein R1 is a substituted or unsubstituted alkyl group; R2 is substituted or unsubstituted amino; substituted or unsubstituted alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkynyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; substituted or unsubstituted alkoxy; substituted or unsubstituted aryloxy; substituted or unsubstituted alkylthio; substituted or unsubstituted aryl thio; or substituted or unsubstituted amide, urea, and carbamate; and at least one of R3 and R4 is an electron donating group, wherein the sum of the Hammett σp values for R3 and R4 is less than −0.40, wherein when R1 is a substituted alkyl group, a carbon atom of the alkyl group is directly bonded to the 7-position carbon atom, and the carbon atom of the alkyl group that is directly bonded to the 7-position carbon atom is unsubstituted.

The invention relates to a benzenedicarboxamide compound as well as a preparation method and application thereof. The structure of the benzenedicarboxamide compound or the pharmaceutically acceptable salt thereof is shown as a general formula I, and R is selected from substituted or unsubstituted acylamino. Compared with the prior art, the phthalamide compound provided by the invention can specifically up-regulate secretion of IL-2 cell factors by remarkably enhancing a T cell lysosome function, so that a novel immune regulation strategy is provided. The synthesis route adopted by the invention has the advantages of cheap and easily available raw materials, simple route, common reagents, mild reaction conditions and simple post-treatment, and can be used for efficiently preparing the compounds.

The invention relates to a tetrahydrothebaine derivative as well as a preparation method and application thereof, in particular to a 7alpha-(4 '-substituted amidophenyl)-6alpha, 14alpha-endo-ethylidene (alkenyl)-tetrahydrothebaine derivative as shown in a general formula (I) or pharmaceutically acceptable salts thereof and a preparation method of the 7alpha-(4'-substituted amidophenyl)-6alpha, 14alpha-endo-ethylidene (alkenyl)-tetrahydrothebaine derivative. And to the use of such derivatives in the preparation of medicaments for the treatment and / or prevention of pain, irritable bowel syndrome, pruritus, addiction, depression. The derivative disclosed by the invention has a remarkable improvement effect in the aspects of agonistic activity of the kappa opioid receptor, subtype selectivity of the kappa opioid receptor and central safety.

The invention discloses a preparation method of a deuterated pyridinium salt participated photo-induced bicyclo [1.1. 1] pentane derivative, which comprises the following steps: putting a compound shown in a formula 1 and a compound shown in a formula 2 into an organic solvent, and carrying out illumination reaction on the compound shown in the formula 1 and the compound shown in the formula 2 and a bicyclo [1.1. 1] pentane compound shown in a formula 3 in an alkaline environment to obtain the deuterated pyridinium salt fragment-containing bicyclo [1.1. 1] pentane derivative shown in a formula 4, the reaction process is as follows: a substituent R1 is selected from an ester group or substituted amide, a substituent R2 is selected from phenyl or substituted phenyl, and the substituent of the substituted phenyl is methyl, methoxyl, cyano, an ester group, phenyl, halogen, tertiary butyl, phenoxyl, trifluoromethoxyl or trifluoromethyl. The method has the advantages of mild reaction conditions, no need of a catalyst, complete reaction at room temperature, economy, practicability, environmental friendliness and no generation of harmful substances; the efficiency is high after reaction amplification.

The invention discloses a naphthenic base substituted amide compound as well as a pharmaceutical composition and application thereof. The amide derivative provided by the invention has PDK1 inhibitory activity, and the compound has a good application prospect in preparation of antitumor drugs.

A polythiophene / polyanion composition comprising: i) an oligo- or polythiophene obtained by the polymerization of a monomer according to Formula I, and wherein A represents a substituted or unsubstituted C1 to C5 alkylene bridge, ii) a polyanion obtained by the polymerization of at least one monomer according to Formula II, wherein R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group and a substituted or unsubstituted aryl or heteroaryl group; K is selected from the group consisting of a substituted or unsubstituted alkylene group, an ether group, an ester group, a substituted or unsubstituted amide group, a substituted or unsubstituted alkenylene group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; L is selected from the group consisting of a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group, an amine group, an ether group, a thioether group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; R2 and R3 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group; m represents 0 or 1; n is an integer from 1 to 10 000; and wherein the amount of monomer according to Formula II in the polyanion is from 0.1 to 20 mol %, relative to the total amount of monomers.

A hydrogel includes a dendritic core with 2 to 30 arms, and first and second acrylamide monomers incorporated into each arm. The first acrylamide monomer is: (I), wherein R1 and R2 are independently selected from an alkyl, an alkylamino, an alkylamido, an alkylthio, an aryl, a glycol, and optionally substituted variants thereof; and the second acrylamide monomer is: (II), wherein R3 and R4 are independently hydrogen or an alkyl; L is a linker including a linear chain of 2 to 20 atoms selected from carbon, oxygen, and nitrogen and optional substituents on the carbon and any nitrogen atoms; A is an N substituted amide: (III), where R5 is hydrogen or an alkyl; E is a linear chain of 1 to 4 atom(s) selected from carbon, oxygen and nitrogen, and optional substituents on the carbon and any nitrogen atoms; and Z is an optional nitrogen containing heterocycle.

An N-substituted amide derivative inhibitor, and a preparation method and use therefor. In particular, the present invention relates to an N-substituted amide derivative compound, a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in treating cancer.

An N-substituted amide derivative inhibitor, its preparation method, and its application. In particular, it relates to N-substituted amide derivative compounds, their preparation methods, pharmaceutical compositions containing the compound, and their use in the treatment of cancer.

The application relates to a methionine probe and application thereof. The methionine probe has structural characteristics shown in the following formula (I): A-L-B (I), wherein A is a reporter group, L is a linking group, and B is a warhead group; the warhead group comprises a phenanthraquinone group; and the linking group comprises a substituted or unsubstituted amide group. The methionine probe has high labeling efficiency and is suitable for active motif spectrum analysis of a complex biological system.

The present invention discloses an extraction solvent and an extraction method for extracting and recovering vanadium pentoxide in a solution by using a synergistic extraction system. The extraction solvent is composed of a mixture of an ionic liquid, an amide extractant, and a diluent; the ionic liquid is a quaternary ammonium salt ionic liquid, the amide extractant is an alkyl-substituted amide extractant, and the diluent is an inert organic solvent; the extraction method is as follows: preparing the above extraction solvent as an extraction organic phase; using the extraction organic phase to extract vanadium in a vanadium pentoxide-containing solution to obtain a loaded organic phase; using a salt solution A to wash the loaded organic phase to obtain a washed organic phase; using a salt solution B to perform back-extraction on the washed organic phase to obtain a back-extracted vanadium solution and a back-extracted organic phase; using a salt solution C to regenerate the back-extracted organic phase to obtain a regenerated organic phase, which is used as the extraction organic phase for recycling. The present invention can solve the problems of low recovery rate of vanadium pentoxide products, poor product purity, and poor recyclability of the extraction solution, etc.

The application relates to the technical field of organic synthesis, in particular to a method for efficiently preparing 1-silicon-based-2-alkyl compounds, which comprises the following steps: reacting a compound of formula 2, a compound of formula 3 and a compound of formula 4 in the presence of a nickel salt catalyst, a copper salt catalyst, a diamine ligand and a base or in the presence of a nickel salt catalyst, a copper salt catalyst, a diamine ligand, a base and an additive, to obtain a compound of formula 1; wherein the compound of formula 2 is the compound of formula 3 is R 3 R 2 R 1 Si-Bpin, the compound of formula 4 is Alkyl-X, and the compound of formula 1 is wherein R is any one of a hydroxyl group, an ester group, an alkoxy group, an alkenyl group, an alkyl-substituted amine group, an alkyl-substituted amide group and an ether group, n is any integer within the range of 1-4, R 1 , R 2 , R 3 is a methyl group, an ethyl group, a phenyl group or a tert-butyl group, Alkyl represents an alkyl substituent, and X is a halogen.

A polythiophene / polyanion composition comprising: i) an oligo- or polythiophene obtained by the polymerization of a monomer according to Formula (I), and (I) wherein A represents a substituted or unsubstituted C1 to C5 alkylene bridge, ii) a polyanion obtained by the polymerization of at least one monomer according to Formula (II), (II) wherein R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group and a substituted or unsubstituted aryl or heteroaryl group; K is selected from the group consisting of a substituted or unsubstituted alkylene group, an ether group, an ester group, a substituted or unsubstituted amide group, a substituted or unsubstituted alkenylene group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; L is selected from the group consisting of a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group, an ether group, a thioether group, an amine group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; B is a metal ligand, n represents 0 or 1.

The invention discloses a bis (trifluoromethyl) oxadiazole substituted amide compound represented by a general formula (I): # imgabs0 #, wherein each substituent group is shown in the specification. The invention also provides application of the compound. The bis (trifluoromethyl) oxadiazole substituted amide compound provided by the invention is suitable for preventing and treating diseases caused by fungi.

By using a specific lubricant in the heat-fusible resin layer of the battery packaging material, slidability during molding is improved, and deterioration of battery performance is suppressed. A battery packaging material (1) comprising at least a base material layer (13), a barrier layer (11), and a heat-fusible resin layer (15) in this order from the outside to the inside, the heat-fusible resin layer (15) comprising a polyolefin resin and one or more types of lubricant, and at least one type of lubricant being an N-substituted amide represented by formula (I). R1 is a hydrocarbon chain represented by Cm1Hn1; and R2 represents a hydrocarbon chain represented by Cm < 2 > Hn < 2 >. [Chemical Formula 4] # imgabs0 #

A method of improving the lubricity of a diesel fuel composition, the method comprising admixing into the composition: (a) at least one hydrocarbyl substituted amide or imide compound; and (b) at least one aromatic compound including a single carboxylic acid functional group.

polishing slurry including an abrasive, an oxidizing agent, and a first histidine derivative including a substituted or unsubstituted cyclic imide group, optionally a second histidine derivative including a substituted or unsubstituted amic acid group, or a combination thereof. A method of manufacturing a semiconductor device using the same is described.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

This N-substituted amide having a bulky amide bond and having a group represented by general formula (3A) at least at one terminal thereof can be efficiently produced by reacting an acid chloride having a group represented by general formula (1A) at least at one terminal thereof with an N-substituted amino acid represented by general formula (2) in the presence of a tertiary amine having a pKaH of 10-17.

A dispersant and a preparation method thereof, a slurry composition, an electrode plate, and an electrical device including the electrode plate. The dispersant includes a first polymer and a second polymer, the weight average molecular weight of the first polymer is less than the weight average molecular weight of the second polymer, the first polymer includes structural units I) and II), (I), (II), the second polymer includes structural units III) and IV), (III), (IV), R1, R2, R3, R6, R7, and R8 are independently selected from hydrogen, halogen, carboxyl, amino acid, acyl halide, carbonyl, cyano, anhydride, nitro, nitroso, substituted or unsubstituted amide, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted ester, substituted or unsubstituted sulfonic acid, substituted or unsubstituted C6-C12 aryl, R4, R5, R9, R 10 All have dipole moments greater than 2×10 ‑30 C·m group. The dispersant can improve the dispersion effect of the slurry.