69 results about "Substituted amide" patented technology

The present invention relates to a heterocyclylalkynyl substituted amide derivative as shown in a formula (I), and a preparation method therefor and the use thereof. The present invention also relates to a pharmaceutical composition comprising the compound as an active ingredient and the use of the compound or pharmaceutical composition for treating and / or preventing related diseases mediated by PRMT5.

Methods are provided. A method comprises contacting a tin (IV) compound with a reagent to form at least one reaction product. The regent comprises at least one of a metal alkoxide compound, a metal amide compound, or any combination thereof. The at least one reaction product comprises at least one of a substituted tin (IV) amide compound, a substituted tin (IV) alkoxide compound, or any combination thereof. Various compositions and various compounds, among other things, are also provided.

The invention provides an aromatic heterocycle substituted amide compound as well as a preparation method and application thereof. The amide compound has a structure as shown in a formula I which is described in the specification. The aromatic heterocyclic ring substituted amide compound provided by the invention can have high insecticidal activity at a low dosage; and due to good effect under low dosage, the medicine dosage is reduced, environmental protection is facilitated, and the application prospect is wide.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

The invention discloses a colored light conversion material, a colored light conversion adhesive film and a photovoltaic module, and the colored light conversion material comprises a compound with a structure shown in the following formula: # imgabs0 #, r1 to R3 and Ra to Rj are each independently selected from the group consisting of H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted heteroalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted amino group, a substituted or unsubstituted amide group, a substituted or unsubstituted cyclic imino group, and a substituted or unsubstituted alkoxy group; r1 represents a hydrogen atom, a substituted or unsubstituted carboxyl group, a substituted or unsubstituted ester group, and a substituted or unsubstituted carbonyl group. According to the colored light conversion material, fluorene which is simple in structure, free of heteroatom rings, free of interaction with metal ions and high in luminous efficiency serves as a structural basis, and the applicability is good; the colored light conversion agent is simple in structure, low in synthesis cost, stable in structure and good in application prospect.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5. # imgabs0 #

The present application provides a polymer, a battery cell, a manufacturing method therefor, a battery device, and an electric device. The polymer comprises a phenyl group, formula (I), a flexible chain segment, and an end group; the end group comprises one or more of a substituted or unsubstituted amide group and a substituted or unsubstituted -NH2, and optionally one or more of a carbonate group, a sulfonate group, a phosphate group, a quaternary ammonium group, and a C6-C18 aryl group; the flexible chain segment comprises one or more of -CH2-O-CH2- and -C(O)O-, and optionally -CH2-; the flexible chain segment is linked to -O- in formula (II); and the end group is linked to the flexible chain segment.

A polythiophene / polyanion composition comprising: i) an oligo- or polythiophene obtained by the polymerization of a monomer according to Formula (I), and wherein A represents a substituted or unsubstituted C1 to C5 alkylene bridge, ii) a polyanion obtained by the polymerization of at least one monomer according to Formula (II), wherein R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group and a substituted or unsubstituted aryl or heteroaryl group; K is selected from the group consisting of a substituted or unsubstituted alkylene group, an ether group, an ester group, a substituted or unsubstituted amide group, a substituted or unsubstituted alkenylene group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; L is selected from the group consisting of a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group, an amine group, an ether group, a thioether group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; R2 and R3 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group; m represents 0 or 1; n is an integer from 1 to 10 000; and wherein the amount of monomer according to Formula (II) in the polyanion is from 0.1 to 20 mol %, relative to the total amount of monomers.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

The application provides an insulating electrophoretic paint, a workpiece with an insulating layer, a battery pack and an electrical device. The insulating electrophoretic paint comprises a modified polyimide polymer, a silsesquioxane, a blocked isocyanate, an acid and water; wherein the silsesquioxane is modified with at least one amino group; at least one end of the modified polyimide polymer is a polyimide-like molecular chain, and the end of the polyimide-like molecular chain has a hydroxyalkyl-substituted amide group. The insulating layer prepared from the insulating electrophoretic paint has not only good electrical insulation performance, but also good high-temperature resistance and excellent low dielectricity.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

Provided is a method for producing a decomposing / cleaning composition which improves etching speed retention. In particular, a method for producing a decomposing / cleaning composition which contains (A) an N-substituted amide compound in which a hydrogen atom is not directly bonded to a nitrogen atom and (B) a quaternary alkyl ammonium fluoride or a hydrate thereof is provided, the method having a preparation step for mixing the (A) and (B) components in an inert gas atmosphere.

Provided is a decomposing / cleaning composition for an adhesive polymer having a high etching rate and suppressed infiltration into a contact interface between a substrate such as a device wafer and an adhesive layer such as a fixing tape. The decomposing / cleaning composition of one embodiment is a decomposing / cleaning composition for an adhesive polymer containing a quaternary alkylammonium fluoride or a quaternary alkylammonium fluoride hydrate and an aprotic solvent, wherein the aprotic solvent contains (A) an N-substituted amide compound having no active hydrogens on the nitrogen atoms and (B) at least one organic sulfur oxide selected from the group consisting of sulfoxide compounds and sulfone compounds.

The invention belongs to the technical field of biological medicine, and particularly relates to an N-aryl substituted amide as a novel HDAC6 (histone deacetylase 6) inhibitor and application of the N-aryl substituted amide in preparation of antitumor drugs. A compound shown as a formula (I) is screened and synthesized on the basis of an artificial intelligence technology; the compound shows excellent inhibitory activity on HDAC6, and can be used for efficiently inhibiting HDAC6 and / or HDAC1; in addition, anti-tumor cell proliferation evaluation further reveals that the compound can significantly inhibit proliferation of tumor cells. Based on the excellent enzyme inhibition activity and the cellular level anti-proliferation effect, the compound can be used for preparing medicines for treating tumors, autoimmune diseases, inflammation or Alzheimer's disease, and has a wide development prospect.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the description; the invention also relates to a preparation method of the compound and application of the compound as a photosensitizer in photodynamic therapy. The mono-substituted protoporphyrin derivative has high permeability, high activity and good biological safety, the preparation method is simple in process and low in cost, a target product can be obtained with good yield, and the mono-substituted protoporphyrin derivative is especially suitable for industrial production and has wide application prospects. The compound can be used as an efficient photosensitizer for treating hyperproliferative diseases such as cancers or precancerous lesions in photodynamic therapy, or treating oral diseases # imgabs0 # (I) such as periodontitis, gingivitis, dental plaque and decayed teeth caused by bacteria such as Gram-negative anaerobic bacillus such as porphyromonas gingivalis.

An indeno-fused naphthopyran having the core skeletal structure (I): (I) wherein R1 is a substituted or unsubstituted alkyl group; R2 is substituted or unsubstituted amino; substituted or unsubstituted alkyl; substituted or unsubstituted alkenyl; substituted or unsubstituted alkynyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; substituted or unsubstituted alkoxy; substituted or unsubstituted aryloxy; substituted or unsubstituted alkylthio; substituted or unsubstituted aryl thio; or substituted or unsubstituted amide, urea, and carbamate; and at least one of R3 and R4 is an electron donating group, wherein the sum of the Hammett σp values for R3 and R4 is less than −0.40, wherein when R1 is a substituted alkyl group, a carbon atom of the alkyl group is directly bonded to the 7-position carbon atom, and the carbon atom of the alkyl group that is directly bonded to the 7-position carbon atom is unsubstituted.

The invention relates to a benzenedicarboxamide compound as well as a preparation method and application thereof. The structure of the benzenedicarboxamide compound or the pharmaceutically acceptable salt thereof is shown as a general formula I, and R is selected from substituted or unsubstituted acylamino. Compared with the prior art, the phthalamide compound provided by the invention can specifically up-regulate secretion of IL-2 cell factors by remarkably enhancing a T cell lysosome function, so that a novel immune regulation strategy is provided. The synthesis route adopted by the invention has the advantages of cheap and easily available raw materials, simple route, common reagents, mild reaction conditions and simple post-treatment, and can be used for efficiently preparing the compounds.

The invention relates to a tetrahydrothebaine derivative as well as a preparation method and application thereof, in particular to a 7alpha-(4 '-substituted amidophenyl)-6alpha, 14alpha-endo-ethylidene (alkenyl)-tetrahydrothebaine derivative as shown in a general formula (I) or pharmaceutically acceptable salts thereof and a preparation method of the 7alpha-(4'-substituted amidophenyl)-6alpha, 14alpha-endo-ethylidene (alkenyl)-tetrahydrothebaine derivative. And to the use of such derivatives in the preparation of medicaments for the treatment and / or prevention of pain, irritable bowel syndrome, pruritus, addiction, depression. The derivative disclosed by the invention has a remarkable improvement effect in the aspects of agonistic activity of the kappa opioid receptor, subtype selectivity of the kappa opioid receptor and central safety.

The invention discloses a preparation method of a deuterated pyridinium salt participated photo-induced bicyclo [1.1. 1] pentane derivative, which comprises the following steps: putting a compound shown in a formula 1 and a compound shown in a formula 2 into an organic solvent, and carrying out illumination reaction on the compound shown in the formula 1 and the compound shown in the formula 2 and a bicyclo [1.1. 1] pentane compound shown in a formula 3 in an alkaline environment to obtain the deuterated pyridinium salt fragment-containing bicyclo [1.1. 1] pentane derivative shown in a formula 4, the reaction process is as follows: a substituent R1 is selected from an ester group or substituted amide, a substituent R2 is selected from phenyl or substituted phenyl, and the substituent of the substituted phenyl is methyl, methoxyl, cyano, an ester group, phenyl, halogen, tertiary butyl, phenoxyl, trifluoromethoxyl or trifluoromethyl. The method has the advantages of mild reaction conditions, no need of a catalyst, complete reaction at room temperature, economy, practicability, environmental friendliness and no generation of harmful substances; the efficiency is high after reaction amplification.

Methods are provided. A method comprises contacting a tin (IV) compound with a reagent to form at least one reaction product. The regent comprises at least one of a metal alkoxide compound, a metal amide compound, or any combination thereof. The at least one reaction product comprises at least one of a substituted tin (IV) amide compound, a substituted tin (IV) alkoxide compound, or any combination thereof. Various compositions and various compounds, among other things, are also provided.

The invention discloses a naphthenic base substituted amide compound as well as a pharmaceutical composition and application thereof. The amide derivative provided by the invention has PDK1 inhibitory activity, and the compound has a good application prospect in preparation of antitumor drugs.

A polythiophene / polyanion composition comprising: i) an oligo- or polythiophene obtained by the polymerization of a monomer according to Formula I, and wherein A represents a substituted or unsubstituted C1 to C5 alkylene bridge, ii) a polyanion obtained by the polymerization of at least one monomer according to Formula II, wherein R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group and a substituted or unsubstituted aryl or heteroaryl group; K is selected from the group consisting of a substituted or unsubstituted alkylene group, an ether group, an ester group, a substituted or unsubstituted amide group, a substituted or unsubstituted alkenylene group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; L is selected from the group consisting of a substituted or unsubstituted alkylene group, a substituted or unsubstituted alkenylene group, an amine group, an ether group, a thioether group, a substituted or unsubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted alkarylene group and a substituted or unsubstituted arylene or heteroarylene group; R2 and R3 are independently selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl group; m represents 0 or 1; n is an integer from 1 to 10 000; and wherein the amount of monomer according to Formula II in the polyanion is from 0.1 to 20 mol %, relative to the total amount of monomers.

A hydrogel includes a dendritic core with 2 to 30 arms, and first and second acrylamide monomers incorporated into each arm. The first acrylamide monomer is: (I), wherein R1 and R2 are independently selected from an alkyl, an alkylamino, an alkylamido, an alkylthio, an aryl, a glycol, and optionally substituted variants thereof; and the second acrylamide monomer is: (II), wherein R3 and R4 are independently hydrogen or an alkyl; L is a linker including a linear chain of 2 to 20 atoms selected from carbon, oxygen, and nitrogen and optional substituents on the carbon and any nitrogen atoms; A is an N substituted amide: (III), where R5 is hydrogen or an alkyl; E is a linear chain of 1 to 4 atom(s) selected from carbon, oxygen and nitrogen, and optional substituents on the carbon and any nitrogen atoms; and Z is an optional nitrogen containing heterocycle.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. The invention relates to an alpha-amino substituted amide derivative, the structural formula of which is # imgabs0 #, and in the formula, X is bromine or chlorine; r is phenyl, phenyl substituted by methyl, phenyl substituted by methoxyl, phenyl substituted by halogen, naphthyl, furyl, thienyl, cyclohexyl, tetrahydropyranyl or ester substituted by C1-C4 alkyl; ar is phenyl, phenyl substituted by C1-C4 alkyl, phenyl substituted by methoxyl, and phenyl or naphthyl substituted by halogen. The synthesis method of the alpha-aminoamide derivative comprises the following steps: taking halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and aromatic amine as raw materials, under the catalysis of metal copper salt, taking Bronsted acid as an additive and taking an organic reagent as a solvent, and carrying out one-step reaction to obtain the alpha-aminoamide derivative. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.

An N-substituted amide derivative inhibitor, and a preparation method and use therefor. In particular, the present invention relates to an N-substituted amide derivative compound, a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in treating cancer.

The invention discloses a method for rapidly constructing a fluorescent array sensor and application of the fluorescent array sensor, and the method comprises the following steps: through four-component Ugi chemical reaction, synthesizing substituted amide fluorescent small molecules by using a carboxyl chemical substance, an amino chemical substance, a ketone or aldehyde chemical substance and an isonitrile compound which are equal in molar weight to construct an element library; and screening out a plurality of elements with the maximum contribution through a machine learning algorithm to quickly and efficiently construct the array sensor. The fluorescent array sensor disclosed by the invention can simultaneously screen healthy sperm samples and sperm samples of different types of diseases, the to-be-screened sperm sample can be cryopreserved for a long time and does not need to be used after being taken, the sperm sample of a to-be-diagnosed person can be collected at home, and the embarrassment of taking the sperm sample from a hospital toilet is avoided. Meanwhile, the array sensor has the advantages of high sensitivity, short detection time, low cost, good repeatability, high accuracy, no need of professional technicians and the like, and semen quality problems caused by different factors can be quickly identified within one minute.

An N-substituted amide derivative inhibitor, its preparation method, and its application. In particular, it relates to N-substituted amide derivative compounds, their preparation methods, pharmaceutical compositions containing the compound, and their use in the treatment of cancer.

The application relates to a methionine probe and application thereof. The methionine probe has structural characteristics shown in the following formula (I): A-L-B (I), wherein A is a reporter group, L is a linking group, and B is a warhead group; the warhead group comprises a phenanthraquinone group; and the linking group comprises a substituted or unsubstituted amide group. The methionine probe has high labeling efficiency and is suitable for active motif spectrum analysis of a complex biological system.

The present invention discloses an extraction solvent and an extraction method for extracting and recovering vanadium pentoxide in a solution by using a synergistic extraction system. The extraction solvent is composed of a mixture of an ionic liquid, an amide extractant, and a diluent; the ionic liquid is a quaternary ammonium salt ionic liquid, the amide extractant is an alkyl-substituted amide extractant, and the diluent is an inert organic solvent; the extraction method is as follows: preparing the above extraction solvent as an extraction organic phase; using the extraction organic phase to extract vanadium in a vanadium pentoxide-containing solution to obtain a loaded organic phase; using a salt solution A to wash the loaded organic phase to obtain a washed organic phase; using a salt solution B to perform back-extraction on the washed organic phase to obtain a back-extracted vanadium solution and a back-extracted organic phase; using a salt solution C to regenerate the back-extracted organic phase to obtain a regenerated organic phase, which is used as the extraction organic phase for recycling. The present invention can solve the problems of low recovery rate of vanadium pentoxide products, poor product purity, and poor recyclability of the extraction solution, etc.