39 results about "Isobutyramide" patented technology

The invention discloses a method for preparing perfluoro-isobutyronitrile. The method includes carrying out reaction on perfluoro-isobutyryl fluoride and ammonia solution or ammonia gas in water or organic solvents to generate perfluoro-isobutyramide at first; dehydrating the perfluoro-isobutyramide by dehydrating agents to obtain the perfluoro-isobutyronitrile. The method has the advantages of novel raw materials and routes, simplicity in reaction operation, high product yield and low waste gas, wastewater and industrial residue quantities.

The RE light transferring agent possessing ecological physiologic feature has the general expression of ReML1(L2)1-3, where, the RE element Re is Eu(III) or Sm(III); the RE element M is Gd(III), La(III) Al(III) orMn(II); L1 is poly-N-vinyl acetamide or poly-N-vinyl isobutyramide; and L2 is acetyl salicylic acid, benzoyl acetone, o-phenanthroline or triphenyl oxyphosphine. The light transferring polyvinyl chloride film containing the light transferring agent consists of the light transferring agent 0.005-0.1 weight portions, polyvinyl chloride 100 weight portions, dispersing medium 100-1000 weight portions and assistant 0-10 weight portions. The light transferring polyvinyl chloride film can absorb 202-330 nm ultraviolet light and emit 380-580 nm bluish violet light and 580-710 nm red orange light, so as to meet the requirement of plant photosynthesis, increase yield of crop and improve quality of crop.

The present application belongs to the technical field of inorganic chemistry, and particularly relates to a preparation method for perfluoroisobutyronitrile. The method includes the following steps:step 1, in the presence of an organic solvent and an alkaline solution, performing condensation on heptafluoroisobutyramide and p-toluenesulfonyl chloride to obtain heptafluoroisobutyryl p-toluenesulfonate; and step 2, performing a reaction on the heptafluoroisobutyryl p-toluenesulfonate at the temperature of -30 DEG C to 20 DEG C to produce the perfluoroisobutyronitrile and p-toluenesulfonate. The preparation method for the perfluoroisobutyronitrile disclosed by the present application can effectively solve the technical defects that a current method for preparing perfluoroisobutyronitrile has a low yield and high costs, and the generated perfluoroisobutyronitrile is difficult to store in the system.

The invention relates to the field of medicine and chemical industry, in particular to a preparation method of thioisobutyramide. In the present invention, isobutyramide is reacted with phosphorus pentasulfide under normal temperature and normal pressure under alkaline conditions, and the thioisobutyramide is synthesized in high yield, the yield is ≥90%, and the content is ≥99%.

The invention discloses a method for preparing isobutylamido thiazolyl resorcinol. The method comprises the following steps: (1) reacting resorcinol with bromoacetic acid under the action of a catalyst to generate an intermediate shown as a formula I; (2) reacting thiourea with isobutyryl chloride to generate an intermediate shown as a formula II; and (3) reacting the intermediate shown in the formula I with the intermediate shown in the formula II under the action of alkali to generate isobutylamido thiazolyl resorcinol shown in a formula III. The synthesis steps provided by the invention aresimplified to three-step reaction, the process route is simple, the raw materials are easy to obtain, the reaction time is short, the post-treatment is simple and convenient, the purity is 99% or above, the total yield is 29.1% or above, the operation is simple, and the method is suitable for continuous industrial production.

This invention is directed to pharmaceutical combination compositions and methods containing (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N-(2-(3a(R)-benzyl-2-methyl-3-oxo-2,3, 3a, 4,6,7-hexahydro-pyrazolo-[4,3-c]pyridin-5-yl)-1(R)-benzyloxymethyl-2-oxo-ethyl)-isobutyramide or a pharmaceutically acceptable salt thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass, frailty and low muscle mass.

The invention provides a preparation method of 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octane, which comprises the following steps successively: taking N-(8-benzyl-8-azabicyclo(3.2.1)oct-3-yl)-isobutyramide as a raw material and heating to reflux with a chlorinating agent in an aprotic solvent, then reacting with alcohol under the action of triethylamine to obtain isobutyl-N-(8-benzyl-8-azabicyclo(3.2.1)oct-3-yl)imidate, and heating to reflux with acetohydrazide in alcohol of C2-C5 to obtain 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo [3.2.1] octane crude, and finally purifying by n-heptane and ethyl acetate to obtain the target product with high purity. The 8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo [3.2.1] octane prepared by the method provided by the invention has the advantages of less byproducts, high yield and high product purity.

The invention relates to a preparation method of isobutyramide. The method comprises the following steps: conducting a hydration reaction of isobutyronitrile and de-ionized water, which serve as raw materials, under the action of a nitrile hydratase catalyst so as to obtain isobutyramide, and conducting simple treatment on an obtained isobutyramide water solution so as to obtain a high-purity isobutyramide crystal product. According to the preparation method provided by the invention, the high-purity isobutyramide crystal product can be prepared by conducting simple treatment on the obtained isobutyramide water solution; and the product, which is higher than 99.95% in purity and is free from such harmful ingredients as an organic solvent and the like, is especially applicable to medical field. The method is mild in reaction conditions and simple to operate, simple in preparation process and easy for industrialization, and the yield of the product reaches 99% or above.

The present invention relates to the technical field of cosmetics, and particularly relates to an isobutyramide derivative compound and an application thereof. The obtained compound can be used for preparing a cosmetic reagent or a pharmaceutical reagent by preparing the series compound which has antihistamine and inhibits skin erythema, pruritus and hyaluronidase. The cosmetic reagent and the pharmaceutical reagent are not specifically limited. For example, the reagents can be washing cosmetics such as skin softening lotion, nutritional lotion, massage cream, body lotion, gel, nutritional cream, facial masks and hair gel or bath cream shampoo, and also can be drug preparation products such as similar cream, ointment, cream, plaster or spray; and when the compound is used for the sensitiveskin, infant and child cosmetics can be also added with the compound to reduce irritation.

A sulphonyl tetrazole compound 7 with the following structure, its preparation method and its use for preparing laetispicine. The said sulphonyl tetrazole compound 7, (1-phenyl-5-(3,4-methylenedioxyphenyl ethyl) sulphonyl tetrazole), is obtained from piperonal as raw material and by steps of Darzens condensation, hydrolysis, decarboxylation, reduction, condensation and oxidation. Laetispicine is prepared from the said compound as raw material, by condensation with 9-carbonyl-2E-4E-nonadienoic acid isobutyramide (compound 14), or by reaction with 5-(tetrahydropyran-2-oxo) n-pentanal (compound 10), deprotection, Swern oxidation, Wittig-Horner reaction, hydrolysis and amidation. As shown in H NMR, C NMR, MS and IR, the laetispicine prepared from the above-said compound is consistent with the laetispicine extracted from natural products.

The present invention discloses a vulcanizing agent preparing and deodorizing method for hydrogenation catalyst ex-situ pre-vulcanizing. The vulcanizing agent preparing and deodorizing method comprises vulcanizing agent synthesis and vulcanizing agent deodorizing, wherein excessive ammonia water is adopted as a catalyst, isobutene and sulphur are subjected to addition to produce the main product vulcanizing agent and concurrently produce the byproduct isobutyramide, and the physical method treatment technology of gas stripping and the chemical method treatment technology of hydrogen peroxide oxidation and ethylene carbonate treatment are used to carry out combined deodorizing on the vulcanizing agent. According to the present invention, the physical method treatment technology of the gas stripping and the chemical method treatment technology of the hydrogen peroxide oxidation and the ethylene carbonate treatment are used to carry out combined deodorizing, such that mercaptan, thioketone, thio thioketone and other odor components in the coarse vulcanizing agent product can be effectively removed so as to effectively reduce the odor; and after the reaction, the catalyst and the product are easily separated, the ammonia water can be recovered and recycled, the wastewater and the waste gas are not produced, only a small amount of the waste residue is produced during the filtering, and the isobutyramide product with the purity of more than 95% can be obtained by carrying out the crystallization purification treatment on the waste residue.

The invention discloses a preparation method of a nickel molybdenum sulfide / foamed nickel electrode material, which comprises the following steps: taking foamed nickel as a working electrode, taking nickel salt as an electrolyte, and carrying out constant-potential anode electrodeposition to obtain nickel hydroxide / foamed nickel; mixing with molybdate and an organic sulfur source, and carrying out hydrothermal reaction to prepare a nickel molybdenum sulfide / foamed nickel electrode material; the nickel salt is one or two of nickelous nitrate, nickelous chloride, nickelous bromide, nickelous sulfate and nickelous acetate; the molybdate is one of sodium molybdate, potassium molybdate and ammonium molybdate; the organic sulfur source is one or two of thioformamide, thioacetamide, thiopropanamide, thiobutyramide and thiobutyramide; the organic sulfur source is one or two of thiobutyramide, thioacetamide, thiopropanamide, thiobutyramide and thiobutyramide; the material has good electrochemical performance and has a good application prospect in the field of supercapacitors.

The invention discloses a method for preparing isobutyrylamide thiazolyl resorcinol, comprising the following steps: (1) reacting resorcinol and bromoacetic acid under the action of a catalyst to generate an intermediate shown in formula I; ( 2) thiourea reacts with isobutyryl chloride to generate the intermediate shown in formula II; (3) the intermediate shown in formula I and the intermediate shown in formula II are reacted under the action of a base to generate isoform shown in formula III. Butanamidothiazolyl resorcinol. The synthesis steps provided by the invention are simplified to three-step reactions, the process route is simple, the raw materials are readily available, the reaction time is short, the post-processing is convenient, the purity is over 99%, the total yield is over 29.1%, the operation is simple, and it is suitable for continuous industrial production. .