75results about How to "Improve bone quality" patented technology

An acetabular cup assembly for attachment to an acetabulum is provided. The cup includes a body having an interior wall and defining an opening in the body. The cup also includes a fastener having a portion thereof fitted through the opening of the body. The fastener is rigidly connected to the body.

Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fracure, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

The present invention is an apparatus, method and system for determining the coefficient of elasticity of a target by detecting determining simultaneously two or more critical-angle reflections of an ultrasound wave from the target using an ultrasound transducer that includes a transmitter and two or more receivers and calculating the elasticity coefficients of the target.

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.

The invention relates to application of collagen chelate in the preparation of medicament or food for enhancing bone quality. The medicament or food can enhance bone strength, can enhance bone strength and bone density at the same time and can be used for curing and / or preventing osteoporosis. The collagen chelate is a metalloprotein conjugate; compared with calcium carbonate (CaCO3) with the same calcium concentration, the collagen chelate can enhance the bone density by 4.4 percent and enhance the bone strength by 9.9 percent; and compared with a mixture of collagen and calcium carbonate (CaCO3) with the same concentration of collagen and calcium carbonate, the collagen chelate has a more obvious effect.

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

The invention provides a health care medicinal liquor for strengthening muscles and bones, and the health care medicinal liquor is prepared through repeated clinical test verification. The health care medicinal liquor accords with the principles of the traditional Chinese medicine. The health care medicinal liquor is prepared from the following raw traditional Chinese medicine materials: seeds ofChinese dodder, lotus stamen, herba epimedii, eucommia ulmoides, fructus psoraleae, cynomorium songaricum, cornu cervi degelatinatum, teasel roots, fructus ligustri lucidi, rhizoma cibotii, drynaria rhizome, centipedes, obscured homalomena rhizome, dog bones, chicken shells, pawpaw, fruit of Chinese wolfberry, poria cocos, schisandra chinensis, gentiana macrophylla, seeds of Chinese milk vetch, polygonum multiflorum, antler glue and raspberries. After being taken, the health care medicinal liquor has the functions of efficiently enhancing the bone mass, improving the bone quality, maintainingthe integrity degree of the microstructure of the bones, enhancing the activity of bone cells, and promoting the calcium deposition. The health care medicinal liquor can be used for relieving the pain of the waist, the back and the limbs, improving the microcirculation, increasing the bone density, adjusting the functions of the hypothalamus pituitary gland gonad, and improving the disorder status of the bone adjusting hormone and the cell factors in the metabolic process of the bones.

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

The invention discloses a composition for resisting ageing and improving male energy. The composition is prepared from a raw material and an auxiliary material; the raw material is prepared from the following components in parts by weight: 1-15 parts of nicotinamide mononucleotide, 1-10 parts of protopanoxadiol, 1-9 parts of icarisid I, 2-8 parts of baohuoside I, 3-7 parts of dehydroepiandrosterone and 2-10 parts of ursodesoxycholic acid. The composition is reasonable in composing prescription and proper in compatibility; in the composition, the four of the nicotinamide mononucleotide (NMN), the icarisid I, the baohuoside I and protopanoxadiol are used as monarch drugs together, the composition is capable of comprehensively regulating gonad axis and invigorating kidney-yang and liver, candelay ageing period of the gonad axis and improve the sexual function after being taken for a long time; through intercoordination and synergistic effect of various components, the composition is comprehensive in nutrition, has very good palatability, is particularly suitable for males to take and thus relieving the symptoms of male ageing syndrome and improving the male energy. The invention alsoprovides a preparation containing the composition and a preparation method of the preparation. The preparation method is simple, is moderate in condition and is suitable for industrial batch production.

The invention relates to formula milk powder for middle-aged and elderly people. Every 100g of the formula milk powder comprises the following components in grams by weight: 46-60 g of whole milk powder; 27-40 g of skimmed milk powder, 3-7.5 g of dietary fiber, 0-0.5 g of docosahexaenoic acid grease, 0.2-1.0 g of milk mineral salt, 0.4-5 g of phytosterol ester, 0.015-0.02 g of selenium-enriched yeast, 0.1-0.2 g of a compound vitamin premix and 0.1-0.2 g of a compound mineral premix. The product is designed according to physiological characteristics and nutritional requirements of middle-aged and elderly people, and soluble dietary fiber-inulin, precious natural calcium raw material-milk mineral salt in whey, organic selenium-selenium-enriched yeast and phytosterol ester with a blood fat reducing function are added, so that the intestinal health of the middle-aged and elderly people is cared; bone mineral density of middle-aged and elderly people is maintained, and osteoporosis is prevented; and cholesterol, blood pressure and blood fat in blood are reduced.

The invention relates to a filling stent material containing a three-layer structure and suitable for bone repairing and a preparation method of the filling stent material. The bottom end of a bone repairing stent has a multi-stage pore structure with high porosity, can slowly release bioactive factors and improve the inflammatory state of a bone lesion portion, has good biological activity and bone induction ability, and is beneficial to enhancing osteogenesis and bone remodelling; and an upper end is a bone cement matrix barrier layer with low porosity, and a middle layer is an adhesive layer. The composite stent provided by the invention utilizes a barrier effect of an upper layer and an osteogenesis promoting effect of a lower layer, and can effectively promote repairing and regeneration of bone tissues; and besides good adhesion and filling effects, the filling gel auxiliary material also has a bone growth promoting component, and has a synergistic effect with a skeleton.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fracure, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

The invention provides a preparation for effectively treating osteoporosis. The preparation is made of the root bark of white mulberry, tortoise plastron, radix clematidis, pseudo-ginseng, the fruit of Chinese wolfberry, the rhizome of chuanxiong, fructus cannabis, sealwort, morinda officinalis, turtle shell, herba epimedii, safflower carthamus, moutan bark, rhizoma anemarrhenae, polygonum multiflorum, teasel roots, pyrolusite pyrolusitum, golden cypress, the root of bidentate achyranthes, white-hair grass, saururus chinensis, artemisia anomala and pyrrosia lingua. After a patient takes the preparation, the bone mass can be effectively increased, the bone quality is improved, the integrity degree of a bone microstructure is kept, the osteoblast activity is improved, and calcium deposit is promoted; meanwhile, the bone pain of the waist, back and extremities can be relieved, microcirculation is improved, the bone intensity is improved, bone growth is promoted, and microcirculation is effectively expanded to achieve smooth blood flowing, so that the effects of promoting circulation and removing stasis are effectively achieved, and osteoporosis healing is accelerated.

The invention discloses a traditional Chinese medicine preparation for treating osteoporosis by means of tonifying qi and warming channels, and the traditional Chinese medicine preparation is prepared from the following crude medicines in proportion: 18-22 g of cornu cervi degelatinatum, 23-27 g of caulis lonicerae, 23-27 g of caulis spatholobi, 13-17 g of gentiana macrophylla, 13-17 g of saposhnikovia divaricata, 18-22 g of nidus vespae, 8-12 g of cinnamon, 18-22 g of ligusticum wallichii, 28-32 g of astragalus mongholicus, 18-22 g of rhizoma drynariae, 13-17 g of eucommia ulmoides, and 28-32 g of dipsacus asperoides. A method for preparing the preparation comprises the following steps of: placing the medicines in a medicine pot, adding water until the medicines are submerged, and soaking for 30-40 minutes at first; and then decocting to boil, keeping the boiling state for 20-40 minutes, taking off the medicine pot, and taking out the medicine solution in the medicine pot; and adding water until the medicines are submerged again, decocting to boil, keeping the boiling state for 20-40 minutes, taking off the medicine pot, taking out the medicine solution in the medicine pot, and combining the medicine solution obtained twice. The traditional Chinese medicine preparation disclosed by the invention has an obvious treatment effect on osteoporosis, and can be used for achieving the purpose of the invention..

The present invention provides a method of massage wherein a massage practitioner works with a person and a ball. Using the ball enables the massage practitioner to work two areas of the persons body at the same time. The ball also creates leverage that allows easier elongation of muscle and release of bone out of the person's joints.

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.

The invention provides a pharmaceutical composition for improving osteoarticular diseases, a disintegrating tablet and a preparation method thereof. The pharmaceutical composition comprises main materials and auxiliary materials. The main materials are composed of, by weight, 90-120 parts of glucosamine and 0.001-0.05 part of vitamin K. The glucosamine can stimulate chondrocytes to synthesize protein polysaccharide and collagen fiber so as to generate cartilage matrix and repair articular cartilage. Vitamin K controls bone and calcium metabolism such that effective mineral deposition and retention of calcium intake on bones are guaranteed, bone quality and bone mineral density are enhanced and repairing function of articular cartilage is effectively raised. By using glucosamine and vitamin K as the main material and controlling ratio of the two components within the above range, the two active components have a synergistic interaction so as to raise mechanical strength of bone tissues of a patent, effectively inhibit decline in bone mineral density of middle-aged and old people, completely improve symptoms of osteoarthritis and mitigate arthralgia. Therefore, bone health problems such as bone aging of middle-aged and old people are alleviated.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine for treating postmenopausal osteoporosis. The traditional Chinese medicine is prepared from prepared rehmannia, rhizoma cibotii, herba epimedii, fructus psoraleae, oyster, yam, prepared fleece-flower root, eucommia bark, gastrodia elata, medlar, dogwood fruit pulp, radix achyranthis bidentatae, codonopsis pilosula, donkey-hide gelatin, black sesame, parasitic loranthus, glossy privet and schisandra chinensis. The traditional Chinese medicine is in accordance with the theory of traditional Chinese medicinal differentiation, and is combined with the fact that the occurrence of postmenopausal osteoporosis is related to kidney deficiency and spleen deficiency, wherein kidney deficiency is a main pathogenesis of postmenopausal osteoporosis. From the view of traditional Chinese medicine, kidney governs bones and belongs to water in five elements, liver governs tendons and belongs to wood in five elements, so that deficiency of spleen and kidney means the loss of water and wood, which causes that wood is nourished; and tendons and bones are not tonified to cause postmenopausal osteoporosis with the passing of time. Thus, postmenopausal osteoporosis is treated by tonifying spleen and nourishing liver kidney to achieve the fundamental treatment effects of treating both principal and secondary aspect of disease, and preventing relapse.

Belonging to the field of medical technology, the invention discloses a Chinese medicinal compound preparation for osteoporosis and a preparation method thereof. The Chinese medicinal compound preparation for osteoporosis is composed of, by weight part, drynaria rhizome, clematis root, Chinese angelica, Ligusticum wallichii, radix paeoniae rubra, rhizoma corydalis, rhizoma cibotii, eucommia and licorice. The invention also discloses a preparation method. By adopting the technologies and methods of modern cytobiology and molecular biology, from the aspects of molecule, cell, tissue, overall animal level and the like, the invention proves that waist impediment analgetic decoction can regulate BMP-2 / Smad pathway to inhibit senile osteoporosis. The successful completion of the invention can provide a new strategy for prevention and treatment of senile osteoporosis.

The invention discloses application of injectable microRNA activated hydrogel to promotion of the healing of alveolar bone for an implant tooth. According to the invention, microRNAs are wrapped by acopolymer of the monomer N-(3-aminopropyl)methacrylamide, the monomer acrylamide and the cross-linking agent ethylene glycol dimethacrylate to form a microRNA nanometer microcapsule; and then the microRNA nanometer microcapsule is mixed with carboxymethyl chitosan and bone meal so as to obtain a composite material. Compared with the prior art, the invention has the advantages that the ossificationquality of alveolar bone can be improved and ossification time can be shortened; the sites of tooth sockets are retained, space is provided for the growth of bone tissue, and the problem of no osteogenesis performance and osteoinductivity of bone meal is overcome; and the healing time of tooth sockets is greatly shortened, and the quality of alveolar bone is improved.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fractures, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

“A nutritional supplement composition suitable for improving lean tissue mass status in a mammal” A nutritional supplement suitable for increasing lean tissue mass in a mammal comprises protein, vitamin D, and calcium. The protein comprises a casein-based milk protein composition, a hydrolyzed whey-based milk protein composition having insulinotropic bioactivity, and a hydrolyzed whey-based milk protein composition having anti-oxidant bioactivity. The supplement increases lean tissue mass in a subject.

The invention discloses a scaffold material of chitosan calcic liquid colloid. The scaffold material of the invention is prepared by the steps that chitosan particles precisely weighed and sub-packaged are radiated for 1000min by 10K Gy Co<60> for sterilization; 0.1 percent of acetic acid is served as a solvent to be made into 1.2 percent of water solution; 0.108g of tricalcium phosphate powder and 5 percent of gelatin granules are added and evenly blended under the constant stirring by a magnetic rotor in the water bath of 60 DEG C; 1M NaOH solution titration is added until the pH is 7 after the still standing and cross-linking for 1.5h. The scaffold material of chitosan calcic liquid colloid of the invention is used for being injected into a bone bioreactor at the subperiosteum cavity in a human body to induce osteogenesis and has good biocompatibility, strong flexibility, good quality of osteogenesis, low cost and great potential in bone transplant with simple operation without being cultured by external cells and adding cell factors or growth factors, is absorbable in the human body, and also ensures no risks of infection, immune rejection and the like. In addition, the end product of the metabolism of glucose can also provide energy for series osteoblastic responses. Therefore, the invention provides the good scaffold material for the bone bioreactor.

The invention provides feed capable of promoting the meat quality of pheasants and relates to the technical field of pheasant breeding. The feed is prepared from the following raw materials: corn flour, soybean meal, bran, table salt, purslane herb powder, calyx seu fructus physalis, tenebrio molitor powder, wheat, fish meal and a nutrition accelerating agent. The feed is prepared through the following steps: mixing casein phosphopeptide, casein calcium peptide, pea protein peptide, Majidou protein peptide deep sea fish oil and corn starch with a complex enzyme; heating the mixture at an oxygen environment to 30 to 35 DEG C and fermenting for 2 to 4 hours; transferring the mixture to an oxygen-free environment, heating to 35 to 40 DEG C and fermenting for 1 hour; mixing the obtained mixture with herba cynomorii extract, sea coconuts and compound mountain flour; grinding the raw materials except the nutrition accelerating agent in the feed respectively; after grinding, sufficiently mixing; sufficiently mixing the nutrition accelerating agent with the ground raw materials and granulating to obtain the feed. The feed provided by the invention can be used for accelerating absorption on nutrient substances by the pheasants, so that the growth of the pheasants is accelerated, the meat quality and the bone quality of the pheasants are improved, and economic benefits are easily improved.

The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

The invention provides an application of N-acetyl-D-glucosamine in preparing medicines for treating orthopedic disorders as well as the medicines and health-care products, and relates to the field ofmedicines. The invention provides the application of the N-acetyl-D-glucosamine in preparing the medicines for treating the orthopedic disorders; and with the application of N-acetyl-D-glucosamine which serves as an active ingredient, the orthopedic disorders can be relieved or treated, with a short treatment cycle and without toxic and side effects.