11 results about "Bone lesion" patented technology

The invention relates to the technical field of biomedical materials, in particular to an alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material and a preparation method and application thereof.The alendronate-modified ZIF-8 serves as a carrier, TPP-modified carbon dots are encapsulated in the carrier, citric acid, urea and cerium salt serve as raw materials of the TPP-modified carbon dots, and the alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material is prepared through a one-step method. After cerium-doped carbon quantum dots are synthesized through a hydrothermal method, TPP is grafted through an amide method, alendronate endows the material with a bone targeting function, and TPP modified carbon dots endow the material with antioxidant and mitochondrial targeting functions. According to the invention, the bone targeting property is excellent, and bone focuses are efficiently enriched; the anti-oxidation and anti-inflammatory capacities are high, and the infected microenvironment can be improved; zIF-8 packaging is stable, and functional components can be controllably released; multiple components cooperate to promote bone repair, accumulation of non-target organs is little, and the composition is safe, reliable and suitable for treatment of various bone-related diseases.

The utility model relates to orthopedics medical technology field discloses a bone focus cleaning assembly, include: positioner, the positioner includes the knock bearing structure of locating cylinder and being located on the upper end of locating cylinder, and the positioner is used for setting bone focus, bone drill, the outer diameter D1 of bone drill is less than the inner diameter d of locating cylinder, so that bone drill can extend into the locating cylinder and drill the bone focus. Advantageous effects: can avoid the damage to the intact bone around the focus as far as possible, and it is favorable to accelerate the recovery speed of patient.

Disclosed herein are compositions and methods to create bone implants that are biocompatible and custom designed to implant in a bone lesion. The implant comprises a unique scaffolding customized to the bone lesion and combined with one or more specialized proresolving mediators (SPM). According to certain embodiments, the scaffolding matrix comprises an alloplastic material developed into a matrix and including one or more SPM including synthetic SPM and natural SPM wherein the SPM is released over time.

Disclosed are computer visual guidance systems for guiding surgeons through arthroscopic debridement of bony pathologies, including by automatically generating annotations relating to characteristics of bony pathology in an image. The annotation may be generated in accordance with a determination as to whether a femoral head of the bony pathology is endospherical or exospherical. The annotation may be generated in accordance with a mathematical model created based on anatomies of subjects other than the patient. Further disclosed is a user interfaces for guiding a surgeon through arthroscopic debridement of a bony pathology, wherein intraoperative images are displayed simultaneously with a preoperative plan comprising interactive three-dimensional models of an anatomical feature of a patient. Further disclosed is a user interface for guiding a physician in categorizing images of a patient, wherein the interface comprises an image viewing window and an interactive checklist for different image categories to be captured.

The application relates to the technical field of medical image processing, and provides a target lesion identification method and system based on medical images, which solves the problems of limited and unstable lesion identification precision. The method comprises the following steps: acquiring a cone beam CT image of a mandible before oral implantation and reference gray data; performing metal artifact reduction and adaptive histogram equalization algorithm enhancement processing with limited contrast to obtain an enhanced image; extracting a three-dimensional gray histogram of an implant target area to calculate gray skewness and gray kurtosis, and extracting a texture feature set; performing principal component analysis on the texture feature set to obtain principal component features, and splicing the principal component features with the gray skewness and the gray kurtosis into a fusion feature vector; analyzing the vector by using a density peak value clustering algorithm, and mapping the result to an anatomical partition, and performing Z-score testing in combination with the reference gray data to identify a bone lesion area. The application can realize accurate and automatic positioning of a lesion.

This utility model discloses a bone aspiration sampling needle, belonging to the field of medical devices. One end of the outer needle body is serrated, and an axial sample receiving cavity is provided inside the outer needle. One end of the inner needle body is equipped with a drill bit. The inner needle body is detachably fitted into the sample receiving cavity, with the drill bit extending out of the serrated end of the sample receiving cavity. The outer wall of the inner needle body fits against the inner wall of the serrations. After the drill bit penetrates the cortical bone of the lesion, the inner needle is withdrawn, and only the outer needle advances. During the advancement of the outer needle, the serrations cut the bone marrow, and the cut bone marrow enters the sample receiving cavity. The outer needle is withdrawn, and the bone marrow sample is extracted, preserving the original appearance and structure of the bone marrow sample. A drainage connector is also provided. The outer needle is connected to a flushing device through the drainage connector, allowing for the injection of medication to treat and flush the bone lesion, or for the extraction of diseased bone marrow and waste fluid through a drainage device. The sample receiving cavity can also be cleaned through the drainage connector.

The invention discloses a muscle-bone shock wave treatment path adaptive optimization method based on behavior feature recognition, and belongs to the technical field of medical treatment. According to the method, a behavior characteristic data acquisition system is established, core behavior characteristics related to muscle-bone lesion treatment are extracted, path parameters of shock wave treatment are dynamically adjusted and optimized, an accurate target treatment path conforming to the individual suitability of a treatment object is generated, multi-dimensional data of the treatment object in the whole treatment cycle are synchronously obtained, and the treatment accuracy of the treatment object is improved. According to the method, treatment path parameters are optimized through a multi-objective optimization model, accurate screening of core features and personalized adaptation of the path parameters are achieved, deep matching of a treatment path, a diseased region and an individual state is guaranteed, path deviation is corrected in time through adaptability evaluation at the initial stage of treatment, real-time dynamic adjustment in treatment and data precipitation and reuse after treatment, and the treatment accuracy is improved. State fluctuation of a treated object is quickly responded, it is ensured that a treatment path continuously adapts to real-time conditions of individuals, and the problem of path failure caused by state change in the treatment process is solved.

The invention discloses a probe group for targeted capture and detection of 65 gene variation related to oral and maxillofacial tooth / bone-derived lesions. The probe group comprises sequences as shown in SED ID No. 1 to SED ID No. 130. The invention also provides a kit containing the probe group, and application of the kit in preparation of products for targeted capture and detection of oral and maxillofacial tooth / bone-derived lesion related genes. The invention also provides a method for constructing an oral maxillofacial tooth / bone-derived lesion related gene detection model by using the probe group, and the method comprises the following steps: preparing a pre-library, preparing a probe hybridization capture library, sequencing, analyzing a sequencing result, and classifying obtained mutation sites to construct the model. According to the obtained sequencing result and model, the oral and maxillofacial tooth / bone-derived lesions which are difficult to distinguish in histomorphology can be accurately classified, accurate pathological diagnosis can be conveniently obtained, and help is provided for subsequent treatment and prognosis evaluation of patients.

The application discloses a histopathological evaluation device for the healing degree of bone injury, and relates to the technical field of medical devices, pharmacodynamics and pathological diagnosis. The device comprises a microscope configured to capture an image of a stained bone tissue section; an image processing unit connected to the microscope and configured to obtain semi-quantitative histological measurement results and microscopic bone histomorphometry measurement results based on the image of the stained bone tissue section; the semi-quantitative histological measurement results comprise the state of callus bridging and fracture line, the composition and maturity of callus, new bone formation activity and bone remodeling and structure recovery state; the microscopic bone histomorphometry measurement results comprise the bone volume fraction and the proportion of osteoid surface; and a host computer connected to the image processing unit and configured to generate the bone injury healing condition according to the two kinds of measurement results. The application combines semi-quantitative histological measurement and microscopic bone histomorphometry measurement, and can provide an objective and quantifiable statistical device and method for the healing effect of bone injury.

The invention discloses a visual universal bone lesion grinding device which comprises a handle, an insertion tube, a grinding unit and two sleeves, a whole lesion cavity and the whole grinding process are observed in real time and in all directions by integrating a panoramic camera consistent with the grinding main direction of a grinding drill at the end of the insertion tube, the traditional operation mode of blind vision or local view is changed, and the operation efficiency is improved. A doctor can clearly see lesion boundaries and grinding depth, thoroughness of lesion removal and operation safety are greatly improved, the two sleeves and a bone cavity form a closed water injection operation environment, grinding conditions are created, one sleeve is a water injection port, the other sleeve is a water drainage port, the two sleeves form a circulation channel, and therefore the grinding effect is improved. Chippings generated by polishing are discharged through flushing, the lens is prevented from being sealed or covered by the chippings in blood or flushing fluid, and the feasibility of the whole operation process is ensured through visualization.