The invention relates to the technical field of clinical oral medicine, and discloses an intelligent marking method for an oral lesion three-dimensional model. The implementation method comprises the following steps: S10, generation of an oral model; S20, oral image collection; S30, image analysis; S40, oral information marking. The invention further discloses an intelligent marking device for the oral lesion three-dimensional model, which comprises a shooting module, a detection module and a display module. Through generation of the oral model, oral image collection, image analysis and oral information marking in sequence, lesion information can be intelligently recognized and analyzed, lesion conditions are marked on the oral model, lesion types, positions and numbers are distinguished through different colors or chartlet materials, caries, dental plaque, colored teeth, dental calculus and other diseases in the oral cavity can be intelligently marked on the model and presented to a patient, the patient can rapidly know various diseases in the oral cavity, a doctor does not need to judge through visual diagnosis or display through X-ray shooting, and the intelligent marking device is convenient and rapid to use.