25 results about "High myopia" patented technology

The invention provides an application of WNT7B in construction of a myopia animal model. Homologous genes wnt7ba and wnt7bb of the WNT7B in the zebra fish are knocked out or knocked down by applying a CRISPR / Cas9 gene editing technology, an animal model of which the eye axis length is remarkably increased, the eyeball movement frequency is remarkably reduced and the light response is reduced is obtained, and the result shows that the WNT7B is related to the high myopia. The model provides a favorable tool for pathogenesis and drug screening of high myopia, and has a good application prospect.

The invention discloses a multi-modal information fused high-myopia retina image classification method and system. The method comprises the following steps: acquiring an OCT image of a to-be-classified high-myopia retina and structured numerical data corresponding to the image; the OCT image is preprocessed, the preprocessed image is input into an image encoder for high-dimensional semantic representation learning, and overall semantic vector representation of the image is obtained; converting the structured numerical data into a medical language description text, and inputting the medical language description text into a text encoder for deep semantic modeling to obtain overall semantic vector representation of the text; inputting to a multi-modal fusion module, carrying out feature interaction and fusion through a bidirectional cross attention mechanism, and generating a fused multi-modal feature; and outputting a retina splitting stage category corresponding to the OCT image through a classification module. According to the method, the OCT image, the structured numerical data and the split staging definition text are utilized to perform multi-modal feature fusion, so that the accuracy of image staging recognition is improved.

This utility model discloses an adjustable pupillary distance clip-on eyeglasses lens suitable for clinical optometry, comprising a frame and a replaceable lens body. The frame has a clamping part; the frame includes a frame beam, which is hollow inside and contains a first magnet, the length of which is less than the length of the frame beam. The bottom of the frame beam is flat, and the first magnet has an adjustment slider for adjusting the position of the first magnet inside the frame beam; the replaceable lens body includes a frame beam, which contains a second magnet, which is cylindrical and can rotate around an axis inside the frame beam; a lens is fixedly mounted on the bottom surface of the frame beam, and the top of the frame beam is a flat surface that matches the bottom of the frame beam. This solution allows people with moderate to high myopia, hyperopia, and astigmatism who need different prescriptions for near and far vision to conveniently clip an additional near lens onto their existing lenses while wearing their original eyeglasses, and the pupillary distance can be adjusted to suit different people.

The application provides an eyeball three-dimensional model construction method, a macular buckle surgery navigation method and system, and the eyeball three-dimensional model construction method comprises the following steps: panoramic scanning of the posterior sclera of a high myopia patient based on wide-angle OCT; three-dimensional reconstruction of the scanned part is performed by using MATLAB software to obtain the posterior segment three-dimensional structure of the high myopia patient's variation area; and a three-dimensional full eye model of the high myopia patient is constructed according to the posterior segment three-dimensional structure of the high myopia patient's variation area and the fixed parameter model of the high myopia patient's constant area. The application constructs an eyeball three-dimensional model based on a wide-angle OCT scanning method, which is more convenient than the traditional MRI method for constructing an eyeball three-dimensional model, has higher detection accuracy for the posterior structure, and is more suitable for navigation application in macular buckle surgery.

A ring focus spectacle lens (1) for controlling the progression of myopia, and a manufacturing method therefor. The ring focus spectacle lens (1) can provide clear vision for a patient, and also has a plurality of ring-shaped defocusing zones to provide an optical defocusing effect. Since there is no joint between successive concentric rings of different optical powers that are tangent to each other, the ring focus spectacle lens (1) is as aesthetic as a common spectacle lens. In the manufacturing method, three front mold cores (71), a rear mold core (72), and a planar rear mold core are used to manufacture a series of ring focus spectacle lenses (1) having different powers, thereby reducing the number of mold cores and the production cost. In addition, for the requirements of individuals with severe myopia and astigmatism, a semi-finished lens is provided by means of the manufacturing method, which not only greatly reduces the number of mold cores, but also reduces the inventory quantity of desired lenses, thereby reducing costs.

The light and thin diopter lens comprises a negative-focal-power lens, film layers used for achieving the light splitting effect are arranged on the surfaces of the two sides of the negative-focal-power lens respectively, environment light enters from the environment side surface of the negative-focal-power lens, is reflected on the human eye side surface and then is reflected on the environment side surface again, and the light splitting effect is achieved. The light is emitted from the side surface of the human eye and finally enters the human eye for imaging; the two side surfaces of the negative focal power lens reflect the ambient light twice, so that part of the ambient light forms the turn-back light path in the negative focal power lens, and the diopter of the vision correction light path comprising the turn-back light path is matched with the vision of human eyes. According to the light and thin type diopter lens, the myopia correction function is achieved mainly through the reflecting surface of the negative-focal-power lens, the thickness of the lens can be greatly reduced, the wearing feeling and attractiveness are improved on the premise that vision correction is guaranteed, and the light and thin type diopter lens is particularly suitable for correction of high myopia of 600 degrees or above.

A posterior chamber intraocular lens with a function of reducing postoperative vaulting, the lens comprising an optical part and a support part: the optical part is provided with a through hole at the center and the edge of the optical area for maintaining aqueous humor circulation and balancing intraocular pressure; the support part adopts a four-foot haptic structure that is folded inward by 50-60 degrees, and the lower surface of the structure is configured with an array of microvilli that are 0.25 mm long, spaced 0.1 mm apart, and 0.5 mm x 0.5 mm in size; the through hole design ensures the efficiency of aqueous humor circulation, and the foot haptic shape and microvilli anchoring system are optimized in combination, which can effectively embed the ciliary groove tissue and realize a double fixation mechanism; the structure innovation can inhibit the axial displacement of the artificial lens after surgery, prevent excessive postoperative vaulting from falling, solve the problem of vaulting attenuation caused by the change of aqueous humor dynamics and insufficient mechanical fixation of the existing implant, and provide a long-term stable refractive solution for high myopia correction.

The invention discloses a highly myopic retina splitting automatic staging system, which mainly comprises an image input module, a structured information input module, an image encoder, a structured information encoder, a bimodal feature fusion module and a staging judgment module, and is characterized in that the image encoder adopts a DenseNet-161 trunk to extract visual features; the structured information encoder converts structured information into vectors and maps the vectors to a high-dimensional space; and the bimodal feature fusion module fuses the extracted image features and the structured information vector, and finally sends the fused image features and the structured information vector to the staging discrimination module for classification. The system can be embedded into OCT equipment to operate, and real-time reasoning is achieved. According to the method, the accuracy and the intelligent level of the retina splitting stage can be improved, the deployment convenience and the operation efficiency of the system are also considered, and the method has wide clinical popularization and application prospects in the field of intelligent assistance of high-myopia eye bottom lesions.

The application provides an rs10045697 related SNP marker combination for predicting the risk and susceptibility of high myopia based on equivalent spherical lenses and an application thereof, and relates to the field of biological medicine. Specifically, the application screens a key SNP marker rs10045697 and a plurality of SNP sites related to high myopia in a high myopia queue based on whole genome association study (GWAS), and a model constructed based on the SNP marker combination can realize risk stratification and susceptibility detection of high myopia, is suitable for ophthalmic screening, high-risk population identification and precise prevention and control intervention, and has important clinical transformation value.

The application discloses a refractive correction implant, which is used for implanting into an anterior chamber of a human eye and comprises a lens body, a connecting part and a fitting part, the fitting part is used for being adsorbed to an inner wall of a cornea of the human body, the lens body is used for correcting the refractive of the eye, the lens body is located at a middle position of the inner wall of the cornea, and a gap is formed between the lens body and the inner wall of the cornea, the connecting part is located between the lens body and the fitting part and is used for connecting the lens body and the fitting part, and a through hole is formed in the connecting part and is used for allowing aqueous humor in the anterior chamber to flow through. The refractive correction implant can be used for treating refractive ophthalmic diseases such as high myopia and the like, and does not cause damage to the cornea of the human body, and is safe and reliable.

The invention relates to the field of image processing, in particular to a high-myopia cataract image processing system based on image recognition, and the system comprises a target analysis module which is used for determining an image analysis strategy of a target processing object according to an image reference index and an imaging interference proportion; the reference processing module is used for determining a setting mode of a reference analysis set of the target processing image based on the feature dynamic reproduction coefficient and the reproduction region overlapping coefficient, and determining a reference processing mode of the target processing image in response to a processing reference condition; the reference division module is used for executing the setting mode of the reference analysis set of the target processing image determined by the reference processing module; and the stability analysis module is used for determining whether signal attenuation compensation is carried out on the target processing image according to the signal attenuation index of the execution reference image according to the effect execution difference coefficient, and the image processing efficiency of the eye image of the patient is improved.

The invention relates to the technical field of high polymer materials, and discloses an artificial lens as well as a preparation method and application thereof. The intraocular lens is prepared from the following raw materials: 2-phenylethyl acrylate, 2-styrene methacrylate, a cross-linking agent and an initiator. According to the artificial lens provided by the invention, the balance between the crosslinking density and the material toughness is relatively good, the microcavitation density after accelerated aging is remarkably reduced compared with that of an existing product, the flashing phenomenon is effectively inhibited, and long-term definition and visual quality can be better kept; the intraocular lens is high in thermal stability, the initial decomposition temperature can reach 295 DEG C, and high-temperature sterilization and subsequent processing are facilitated; in clinical application, the artificial lens can reduce visual interference such as glare and halo, reduces secondary operation risks, is suitable for long-term implantation of ametropia patients such as cataract and high myopia, and can provide safer and more lasting visual quality guarantee for the patients.

The present application relates to the field of image processing, especially to a high myopia cataract image processing system based on image recognition, comprising a target analysis module, used to determine the image analysis strategy of the target processing object according to the image reference index and the imaging interference proportion; a reference processing module, used to determine the setting mode of the reference analysis set of the target processing image based on the feature dynamic recurrence coefficient and the recurrence area overlap coefficient, and respond to the processing reference condition to determine the reference processing mode of the target processing image; a reference division module, used to execute the setting mode of the reference analysis set of the target processing image determined by the reference processing module; a stable analysis module, used to determine whether to perform signal attenuation compensation on the target processing image according to the signal attenuation index of the execution reference image according to the effect execution difference coefficient, the present application improves the image processing efficiency of the patient's eye image.

The invention discloses an image processing method and device and an image evaluation method, and relates to the technical field of image processing. The image processing method comprises the steps of determining a leopard spot region corresponding to a to-be-processed fundus image based on the to-be-processed fundus image; based on the leopard spot region, determining a leopard spot density corresponding to the fundus image to be processed; and based on the to-be-processed fundus image, the leopard spot region and the leopard spot density, determining the leopard spot dispersion degree of the to-be-processed fundus image. According to the image processing method provided by the embodiment of the invention, the leopard spot dispersion degree of the to-be-processed fundus image is determined by combining the to-be-processed fundus image, the leopard spot region and the leopard spot density, so that the leopard spot dispersion degree of the to-be-processed fundus image can be more accurately obtained, and a doctor is assisted in determining the condition of high-myopia eye bottom change.

The invention discloses an rs62226057 related SNP marker combination for evaluating a high myopia risk based on an ocular axis and application of the rs62226057 related SNP marker combination, and relates to the field of biological medicines. According to the invention, through large-scale queue analysis, a group of SNP marker combination based on the length of the ocular axis is screened and verified, and the key site in the SNP marker combination is rs62226057. The invention further provides a method, a system and equipment for evaluating the high myopia risk based on the SNP marker combination, an important tool is provided for identification and accurate intervention of people with the high myopia risk, and the method, the system and the equipment have wide clinical application value.

A posterior chamber type intraocular lens with a lens and a function of reducing postoperative arch height reduction comprises an optical part and a supporting part, and through holes are formed in the center of the optical part and the edge of an optical area and used for maintaining aqueous humor circulation and balancing intraocular pressure; the supporting part is of a structure with four foot loops folded inwards by 50-60 degrees, array type micro-villus with the length of 0.25 mm, the interval of 0.1 mm and the size of 0.5 mm * 0.5 mm is arranged on the lower surface of the supporting part, the aqueous humor circulation efficiency is guaranteed through the design of through holes, the angle-optimized foot loop form and a micro-villus anchoring system are combined, the supporting part can be effectively embedded into ciliary sulcus tissue, a double-fixing mechanism is achieved, and the supporting part can be used for fixing the ciliary sulcus tissue. The structure innovation can restrain the axial displacement of the intraocular lens after operation, prevents the arch height from being excessively reduced after operation, solves the problem of arch height attenuation caused by aqueous humodynamic change and insufficient mechanical fixation of the existing implant, and provides a long-term stable refraction solution for high myopia correction.

The invention discloses a sun-worn orthokeratology lens for high myopia, and relates to the technical field of orthokeratology lenses, the orthokeratology lens comprises an orthokeratology lens body, the orthokeratology lens body is provided with an optical zone, a reversal arc zone, a positioning arc zone and a peripheral arc zone which are sequentially distributed from the center to the periphery; the positioning arc area and the peripheral arc area are used for positioning the whole orthokeratology lens body, the reverse arc area is used for storing tears and receiving thickening of a corneal epithelial cell layer, and the optical area is used for abutting against a corneal central epithelial cell layer to migrate to the periphery; and the concave lens is integrated at the optical area and can cover the cornea vision light area, so that the purpose that the patient with high myopia can also normally wear and use the lens in the daytime is achieved.

The invention discloses a ring focus spectacle lens for controlling myopia deepening. The ring-focus spectacle lens can provide clear vision for a patient, and is also provided with a plurality of ring-shaped defocusing areas to form an optical defocusing effect. Due to the tangent continuous connection mode, no seam exists between the concentric rings with different focal powers, so that the ring-focus spectacle lens is as attractive as a common spectacle lens. According to the manufacturing method disclosed by the invention, the three front mold cores, the set of rear mold core and the planar rear mold core are used for manufacturing a series of ring-focus spectacle lenses with different degrees, so that the number of the mold cores and the production cost are reduced. Meanwhile, according to the manufacturing method, a semi-finished lens is provided aiming at the requirements of high myopia degree and high astigmatism degree, so that the number of mold cores is greatly reduced, the stock number of required lenses is also reduced, and the cost is reduced.

The present disclosure provides a myopia prevention and control method, device, electronic equipment and storage medium, which is applied to a red light therapeutic instrument. The method comprises the following steps: determining a myopia level based on a numerical range of the user's diopter, including a first myopia level, a second myopia level and a third myopia level; obtaining the diopter value of the user's both eyes; determining the target myopia level of the user according to the diopter value, which is one of the first myopia level, the second myopia level and the third myopia level; matching the corresponding myopia prevention and control mode according to the target myopia level, which is applied to the red light therapeutic instrument to prevent and control myopia; wherein the myopia prevention and control mode is one of the first myopia prevention and control mode, the second myopia prevention and control mode and the third myopia prevention and control mode corresponding to the myopia level. Thus, through the personalized myopia prevention and control mode matching based on the user's diopter value, the risk of retinal light damage of the high myopia population can be effectively reduced, and the prevention and control effect and safety can be improved.

The invention provides an rs10045697 related SNP (Single Nucleotide Polymorphism) marker combination for predicting high myopia risk and susceptibility based on an equivalent spherical mirror and application of the rs10045697 related SNP marker combination, and relates to the field of biological medicines. Specifically, a key SNP marker rs10045697 and a plurality of SNP loci related to high myopia are screened based on equivalent spherical power in a high myopia queue through genome-wide association study (GWAS), and a model constructed based on the SNP marker combination can realize risk stratification and susceptibility detection of high myopia. The method is suitable for ophthalmology screening, high-risk group identification and accurate prevention and control intervention, and has important clinical transformation value.

The present invention discloses a toric contact lens for controlling myopia progression and its manufacturing method. The toric contact lens can provide clear vision for the patient while having multiple annular defocus zones to form optical defocus effect. Since the different power concentric rings are connected by tangential continuity, there is no joint between the different power concentric rings, making the toric contact lens as beautiful as ordinary contact lens. The manufacturing method of the present invention uses three front mold cores, a set of rear mold cores and a flat rear mold core to manufacture a series of toric contact lenses with different powers, thereby reducing the number of mold cores and production cost. At the same time, the manufacturing method provides a semi-finished lens for the demand of high myopia and high astigmatism, which not only greatly reduces the number of mold cores, but also reduces the required inventory of lenses, thereby reducing the cost.

This invention discloses a combination of rs62226057-related SNP biomarkers for assessing the risk of high myopia based on axial length and its applications, relating to the biomedical field. Through large-scale cohort analysis, this invention screened and validated a set of SNP biomarkers based on axial length, with rs62226057 as the key locus. This invention also provides a method, system, and device for assessing the risk of high myopia based on this SNP biomarker combination, providing an important tool for identifying and precisely intervening in individuals at high myopia risk, and has broad clinical application value.

The application discloses a kind of comprehensive prevention and control methods of juvenile myopia, comprising the following steps: implement centralized scientific prevention and control propaganda and education;For intervention object, establish and maintain a set of personalized dynamic vision health records;According to the baseline refractive state of intervention object, determine and execute one of the four types of hierarchical prevention and control targets, namely "preclinical prevention, low myopia management, moderate myopia control, high myopia complication prevention";Synchronous execution includes six-dimensional collaborative intervention measures, including health education push, eye behavior supervision, visual environment standardization, structured nutritional support, mandatory outdoor activities and professional clinical intervention package.The comprehensive scheme of the application shows significant advantages in eye axis growth control, myopia degree progress control and naked eye vision improvement and other key indicators compared with only routine refractive correction.The scheme can effectively slow down the growth of eye axis, control myopia deepening and improve naked eye vision, and its effect is significantly better than single intervention or routine correction.

The application provides an application of WNT7B in constructing a myopia animal model. Homologous genes wnt7ba and wnt7bb of WNT7B in zebrafish are knocked out or knocked down by using a CRISPR / Cas9 gene editing technology, and an animal model with a significantly increased eye axial length, a significantly reduced eyeball movement frequency and a reduced light response is obtained, which indicates that WNT7B is related to high myopia. The model provides an advantageous tool for a pathogenesis and drug screening of high myopia and has a good application prospect.

The invention discloses a biomarker for detecting high myopia complicated with optic neuropathy, a detection kit and application, and belongs to the technical field of biomedical detection. The technical problem to be solved is that a biomarker for detecting high myopia complicated with optic neuropathy is lacked in the prior art. The key point of the technical scheme is to provide application of CCN2 (Cell Communication Network Factor 2) in preparation of a reagent for detecting high myopia concurrent optic neuropathy.