1033 results about "Block group" patented technology

Compounds of the formulas LAn-Z-X-WwD and BZ-X-WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and / or excipient, and methods of delivery the drug D via the compounds.

Compounds of the formulaeLAn-Z-X—WwD and BZ-X—WwDwherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide residue; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and / or excipient, and methods of delivery the drug D via the compounds.

A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second asymmetrical oligonucleotide adapter that does not comprise the 5′ overhang. Also provided are a pair of double-stranded Y oligonucleotide adapters and a pair of double-stranded bubble oligonucleotide adapters and methods of using said asymmetrical adapters for amplification of at least one double stranded nucleic acid molecule, wherein the amplification produces a plurality of amplified nucleic acid molecules having a different nucleic acid sequence at each end are also described. Also provided is a method for exponentially amplifying one strand in a double-stranded nucleic acid molecule. Also provided are methods for preparing libraries of paired tags using COS-linkers. Also provided are cleavable adapters comprising an affinity tag and a cleavable linkage, wherein cleaving the cleavable linkage produces two complementary ends. Methods of using the cleavable adapters to produce a paired tag library are also described.

The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

The present invention concerns a method to detect the presence of an enzyme in in vivo or in vitro tissue or cell, which method comprises:(a) obtaining a tissue or cell sample to be analyzed;(b) contacting the tissue or cell sample with a substrate of the structure selected from the group consisting of:X=H or one or more natural or synthetic amino acids with or without amino blocking groups,Y=H or one or more natural or synthetic amino acids with or without amino blocking groups,wherein X and Y are the same or different and are amino acid sequences of between about 1 to 1,000,000 amino acids wherein each amino acid is the same or a different amino acid, with the proviso that at least one of X or Y is at least one amino acid;(c) when an enzyme is present in the tissue or cell sample which degrades X, Y and combinations thereof, fluorescent cresyl violet is released in the tissue sample producing a color change;(d) detecting the presence and amount of the enzyme present by the detection and quantification of the fluorescence produced; and(e) optionally comparing the fluorescence to a pre-calibrated fluorescence scale to quantify the fluorescence present. A diagnostic kit for use and a method to prepare amino acid cresyl violet derivatives are described.

Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a base, Y is a linker comprising an enzyme-cleavable group, R2 is a reporter moiety, R3 is selected from H or OH, Z and Z′ are selected from H, OH, or a group X—R1, wherein X is a linker comprising an enzyme-cleavable group and R1 is a polymerase enzyme blocking group, provided that at least one of Z and Z′ is X—R1.

Embodiments described herein disclose methods, devices, and media for storing data. Methods including the steps of: receiving data to be stored in a memory that includes at least three blocks, wherein each block, for storing the data, has at least one metadata value, associated with each block, that is dependent upon a writing time of each block; grouping at least three blocks into at least two block groups, wherein at least one block group contains at least two blocks; associating a respective metadata value with each block group; and associating the respective metadata value of a respective block group with each block storing the data contained in the respective block group, without storing a dedicated copy of at least one metadata value for each block. In some embodiments, at least one metadata value is stored in a block-group table.

Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III)wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH2, azide or DL wherein D is O, S or NH and L is a heteroatom-protecting group, unsubstituted hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; B is a nucleobase; and one of R11 and R12 is a blocking group and the other is (IV) or (VI)in which W, X, Y, Z, R1 and n are as defined herein.

An automatic imaging method is provided that selects and images one target in a monitoring environment where multiple target candidates exist on input video images. The method acquires tracking video images of a target by steps of: estimating, for each block obtained by dividing an imaging region of input video image I, whether a part or all of an object to be tracked and imaged appears in the block, and extracting set of blocks P in which the object is estimated to appear; presetting N number of regions Si (i=1, 2, 3 . . . N) of arbitrary shape on an imaging region of input video image I, together with priorities pi (i=1, 2, 3 . . . N) of each region, examining correlations between the regions Si and set of blocks P, and extracting and outputting connecting region T′ that overlaps with a region Si having highest priority among connecting regions included in the set of blocks P and overlapping with any of regions Si; and controlling second imaging means 2 to contain an object appearing in a region covered by connecting region T′ on input video image I in a field of view of second imaging means 2.

The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and / or a blocking group.

A wear leveling method for a flash is provided, wherein the flash memory includes a plurality of physical blocks grouped into at least a data area and a spare area. The method includes setting a first predetermined threshold value as a wear-leveling start value and randomly generating a random number as a memory erased count, wherein the random number is smaller than the wear-leveling start value. The method also includes counting the memory erased count each time when the physical blocks are erased and determining whether the memory erased count is smaller than the wear-leveling start value, wherein a physical blocks switching is performed between the data area and the spare area when the memory erased count is not smaller then the wear-leveling start value. Accordingly, it is possible to uniformly use the physical blocks, so as to effectively prolong a lifetime of the store system.

A NAS (network attached storage) controller managing file system data is configured for use in a storage system having thin provisioning capability. Physical storage capacity is used efficiently by making it possible for the NAS controller to identify to a disk array system having thin provisioning capability which segments of a thin provisioned volume are no longer in use. File system blocks or block groups no longer in use by the NAS controller are identified by the NAS controller. The NAS controller sends a release request to the disk array system specifying thin provisioning segments that correspond to the identified FS blocks or block groups. The release request instructs the disk array system to release chunks of physical storage capacity assigned to the specified thin provisioning segments so that the physical storage capacity can be made available for reuse in the disk array storage system.

A system and method for memory mapping are provided, the system including a logical unit to physical unit map table, data unit groups in signal communication with the map table, and log unit groups, each associated with a corresponding one of the data unit groups, where updated data for any data unit within one of the data unit groups is stored in any log unit within the corresponding one of the log unit groups, and the method including receiving write data for a logical unit number from a host determining which of a plurality of data block groups comprises the logical unit number, and storing the write data in any unfilled log unit of a log block group corresponding to the determined data block group.

A method for performing block management is provided. The method is applied to a controller of a Flash memory having multiple channels. The Flash memory includes a plurality of blocks respectively corresponding to the channels. The method includes: temporarily storing at least one index of at least one good block that is not grouped into any meta block into a spare good block table, where the good block is a block that is not determined as a bad block within the plurality of blocks; and when it is detected that a specific block corresponding to a specific channel within blocks currently grouped into meta blocks is a bad block, dynamically updating the spare good block table for use of block management. In particular, when needed, the good block is utilized for replacing a block grouped into a meta block. An associated memory device and a controller thereof are also provided.

Data storage systems and methods perform error correction on a single physical storage disk. The technique includes arranging a plurality of addressable blocks on the single physical storage disk into error correction groups, wherein each error correction group includes N data blocks and M coding blocks. M is determined in accordance with a desired failure tolerance of the error correction groups and an error-correcting code. For each error correction group, error-correcting code data is computed across the N data blocks in the error correction group. The computed error-correcting coding data is stored in the M coding blocks in the error correcting group. The arranging, computing and storing steps are performed by a hardware or software component external to the single physical storage disk.

The invention discloses a differential compression method based on data de-duplication. The differential compression method includes steps of partitioning files in data flow to obtain multiple data blocks; computing data block fingerprint of each data block for searching duplicate data; grouping all the data blocks to establish data block groups and double link lists thereof; searching the fingerprint of each data block in each data block group for realizing data de-duplication so as to determine whether the data block is duplicated or not; searching similar data locally to the data block group which is subjected to the data de-duplication process according to the duplicated data information in the double link lists of the data block groups, namely, determining the non-duplicated data blocks adjacent to the duplicated data blocks as potential similar data blocks; verifying the similarity of the similar data blocks by differential compression; and finally complementarily searching similarity data to the data block groups according to the similarity. The differential compression method based on data de-duplication has the advantages of rapidness in similar data searching, low computing and indexing overhead and high data compression efficiency.

A data transmitting and receiving method is disclosed. In transmitting a response signal for a transmission signal from at least one transmitter, the present invention includes receiving at least one data block from the at least one transmitter, the at least one data block grouped into at least one group and then transmitted by the at least one transmitter, checking whether each data block is successfully received for the at least one data block belonging to the corresponding group per the group, selecting a transmission scheme of transmitting a response signal instructing a presence or non-presence of successful reception of the each data block to the at least one transmitter, and transmitting a response signal for the each data block to the at least one transmitter by the selected response signal transmission scheme. Hence, the present invention reduces overhead of control information necessary for data transmission.

The invention discloses a lifting-adjustable processing device with a movable processing head. The processing device is used for machining a workpiece (200), and comprises a rack (9), a movable frame (8) and a connecting part (89) which is fixed below the movable frame (8) and is used for connecting the processing head (890), wherein a screw (6) which is driven by a motor (2), is movably mounted on the rack (9), and extends to the left and right penetrates through the movable frame (8) through extension; the movable frame (8) is supported on a rail cross beam (5) which is fixedly connected with the rack (9) and extends to the left and right in a sliding manner; a left screw block group and a right thread block group are arranged in the movable frame (8); and the left thread block group comprises a left group front thread block (32) and a left group back thread block (31).

An emulator uses code translation and recompilation to execute target computer system applications on a host computer system. Target application code is partitioned into target application code blocks, and related target application code blocks are combined into block groups and translated. Translated application code block groups are sized to comply with restrictions on branch instruction size. Upon selecting an application code block group for execution, a cache tag is used to determine if a corresponding translated code block group is available and valid. If not, the block group is translated and executed. Sequentially executed translated code blocks are located in adjacent portions of memory to improve performance when switching between translated code blocks. The emulator may use a link register of the host computer system to prefetch instructions and data from translated code blocks. The emulator also takes into account structural hazards in translating instructions.

Methods of producing nucleic acid molecules using an in situ nucleic acid synthesis protocol are provided. The method can comprise contacting a substrate comprising an attached blocked nucleoside monomer or polymer with a deblocking fluid to remove the blocking group, thereby generating an unblocked attached nucleoside monomer or polymer; displacing the deblocking fluid from the substrate surface comprising the attached unblocked nucleoside monomer or polymer with a purging fluid; and reacting the attached unblocked nucleoside monomer or polymer with another blocked nucleoside monomer. Nucleic acid molecules produced by the methods are also provided and can be attached to or released from the substrate (e.g., provided in solution or in a lyophilized form).

A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second asymmetrical oligonucleotide adapter that does not comprise the 5′ overhang. Also provided are a pair of double-stranded Y oligonucleotide adapters and a pair of double-stranded bubble oligonucleotide adapters and methods of using said asymmetrical adapters for amplification of at least one double stranded nucleic acid molecule, wherein the amplification produces a plurality of amplified nucleic acid molecules having a different nucleic acid sequence at each end are also described. Also provided is a method for exponentially amplifying one strand in a double-stranded nucleic acid molecule. Also provided are methods for preparing libraries of paired tags using COS-linkers. Also provided are cleavable adapters comprising an affinity tag and a cleavable linkage, wherein cleaving the cleavable linkage produces two complementary ends. Methods of using the cleavable adapters to produce a paired tag library are also described.

The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

An emulator uses code translation and recompilation to execute target computer system applications on a host computer system. Target application code is partitioned into target application code blocks, and related target application code blocks are combined into block groups and translated. Translated application code block groups are sized to comply with restrictions on branch instruction size. Upon selecting an application code block group for execution, a cache tag is used to determine if a corresponding translated code block group is available and valid. If not, the block group is translated and executed. Sequentially executed translated code blocks are located in adjacent portions of memory to improve performance when switching between translated code blocks. The emulator may use a link register of the host computer system to prefetch instructions and data from translated code blocks. The emulator also takes into account structural hazards in translating instructions.

Provided are a method and apparatus capable of reducing a metadata processing time associated with address mapping performed to input / output burst data at a high speed in a virtual file system of a storage unit having a plurality of non-volatile data storage media. The method includes: determining a block group including a block included in each of a plurality of the non-volatile data storage media; determining an access unit including each page included in the determined block group; and mapping an address of input / output data to the determined block group and the access unit. Therefore, it is possible to significantly reduce an address mapping processing time in the virtual file system that may function as a bottleneck in high-speed input / output in a large-capacity storage unit.

The invention relates to a method and apparatus for compensating the lens shading phenomenon in image sensor. The invention first stores an inputted compensation reference value, identifies a center pixel using digital image signals received sequentially in correspondence to each pixel from a sensor, generates analysis data corresponding to each pixel, generates and stores block compensation values for blocks grouped according to the distance from the center pixel, calculates the distance from a compensation target pixel to the center pixel, calculates a compensation value corresponding to the compensation target pixel using the block compensation value corresponding to the distance, and generates for output correction pixel data by aggregating analysis data and the compensation value corresponding to the compensation target pixel. Thus, the invention allows the maintaining of colors as close as possible to the original through the respective compensation of RGB which takes into consideration the respective characteristics of the color filters and through the respective compensation of gain and level for the disparity in transmissivity according to position.

A hub and distribution system (600) is disclosed. It comprises the steps of: delivering (602) a container via rail to a terminal; assigning (604) a corridor as to where to deliver the container, the corridor including a block of pathways in proximity to a track side location; picking (606) the container from a rail car and placing (608) it in one of the pathways in the corridor; and transporting (610) the container to a desired remote destination. The system provides an efficient, effective and semi-automated post-blocking method, such that each post-blocked group of containers has a similar desired remote destination, so that the containers can be easily located, loaded, handed-off and transported to a desired location.

The invention relates to a super-resolution method based on a single image. The super-resolution method includes the steps that S1, bicubic interpolation is carried out on the input low-resolution image to obtain an initial high-resolution image; S2, the initial high-resolution image is divided into a plurality of image blocks overlapped mutually, then a similar image block grouping is obtained, and image noise of the similar image block grouping is removed; S3, the multiple denoised image blocks are fused into a whole high-resolution image, a non-local similar image block and a weighting coefficient of each image block are solved, and the redundancy weight of a non-local similar image block grouping is calculated; S4, an on-line dictionary is updated according to the similar image block grouping and fused with an off-line dictionary; S5, the sparse representation coefficient, about a fused dictionary, of each image block is solved; S6, all the image blocks and the whole high-resolution image are reconstructed, if iterations do not converge and the number of the iterations is smaller than a preset threshold value, the previous steps are executed again, and otherwise the high-resolution image is output. The reality sense and accuracy of super-resolution reconstruction are promoted, and the super-resolution method has the advantage of removing the image noise at the same time.

A multileaf collimator includes a first leaf block group including plural leaf blocks, a second leaf block group including plural leaf blocks arranged in the same direction as the first leaf block group and disposed opposite the leaf blocks of the first leaf block group, plural magnetic layers located on the respective leaf blocks of the first and second leaf block groups so as to be positioned on faces of the leaf blocks along a moving direction of the leaf blocks, plural magnetic sensors mounted on the respective leaf blocks and varying output signals when the respective leaf blocks are moved in an oncoming direction or a departing direction, and a control device controlling drive mechanisms according to the output signals delivered by the respective magnetic sensors so that spacing between the leaf blocks of the first and second leaf blocks is adjusted into a target configuration.