5 results about "Molecular array" patented technology

Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, a method disclosed herein comprises using photoresist for photocontrollable hybridization and / or ligation of nucleic acid molecules, wherein photoresist removal allows hybridization and / or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.

Methods of collecting diffraction patterns from a microcrystal having an ordered array of a molecule are disclosed, which include using an exposure rate of at most 0.02 electrons per square angstrom per second on the microcrystal and using a direct electron detector to record electron diffraction patterns. Also disclosed are methods of determining a structural model for a molecule, identifying a material present in a trace amount within a sample, identifying a polymorph, and identifying the stereochemistry of a molecule.

The invention relates to the technical field of a cesium feed-in system in a magnetic confinement nuclear fusion negative neutral beam system, in particular to an optimization method for DSMC numerical simulation of a cesium feed-in system based on CUDA parallel. According to the technical scheme, the method comprises the following steps: setting a molecular initial state at a host end, and preparing initial conditions for analog computation; allocating a memory space for the molecular array and the related data structure at the equipment end; molecular motion is calculated in parallel through a GPU at an equipment end, and collision between molecules and a wall surface is processed. According to the method, the simulation efficiency is improved to the minute level through a CUDA parallel computing architecture, a grid-based molecular index and memory access mechanism is optimized, the statistical reliability is guaranteed by adopting a thread-independent random number generator, near-vacuum molecular index is accurately restored by means of a decoupled physical model, and the statistical reliability is improved. Therefore, an efficient and practical analysis tool is provided for cesium feed-in system engineering design on the premise that the numerical precision is guaranteed.

The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.