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105results about How to "Increase positive charge" patented technology

Polypeptide Pv26-3 with antimicrobial activity

The application provides polypeptide Pv26-3 with antimicrobial activity, belonging to the technical field of genetic engineering drugs. In the polypeptide Pv26-3, tryptophan W replaces the 7th, 11th,21st and 25th sites in the amino acid sequence of a parent molecule Pv26, and lysine K replaces amino acids at the 1st, 12th, 20th and 24th sites, thereby enhancing the hydrophobicity and positive charge of the parent molecule Pv26. Since a hydrophobic group plays a key role in the process of inserting antimicrobial peptide into a cell membrane, the improvement of hydrophobicity is beneficial to the antimicrobial effect of the antimicrobial peptide; the antimicrobial peptide is bonded to the membrane by electrostatic interaction, so as to promote the combination of the hydrophobic group into the membrane, and then the membrane structure is destroyed to cause cell death, so that positive charge is the key factor affecting the binding of the antimicrobial peptide and the membrane; by improving hydrophobicity and positive charge, the binding ability of the antimicrobial peptide and the membrane can be enhanced, the antimicrobial activity and antibacterial effect of antimicrobial peptide can be improved, and at the same time, the action concentration of antimicrobial peptide is lowered.
Owner:宿烽

Modified composite fiber membrane and layer-by-layer self-assembly method and application thereof

The invention relates to a modified composite fiber membrane and a layer-by-layer self-assembly method and application thereof. The layer-by-layer self-assembly method of the modified composite fibermembrane includes the following steps that a micro/nano high-molecular fiber membrane is prepared; the surface of the micro/nano high-molecular fiber membrane is subjected to plasma modification, anda bottom plate is obtained; a polyelectrolyte A and a polyelectrolyte B which have opposite charges are alternately assembled on the bottom plate with a soaking layer-by-layer self-assembly technologyuntil the required layer number reaches, and the modified composite fiber membrane is obtained. Compared with a traditional layer-by-layer self-assembly method, the layer-by-layer self-assembly method of the modified composite fiber membrane is easy and convenient to operate and high in efficiency, materials which are originally hydrophobic and are not suitable for the fields of biological medicine, environmental protection and the like can have good biocompatibility, the performance of promoting cell reproduction and the like, a selection range of the bottom plate is remarkably widened, andmeanwhile an application range of the layer-by-layer self-assembly method of the modified composite fiber membrane is widened.
Owner:奥美佰玛(武汉)生物科技有限公司 +1
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