75 results about "Indoxacarb" patented technology

The invention provides an indoxacarb degrading enzyme as well as a coding gene, a production strain and application thereof. Wherein the amino acid sequence of the indoxacarb degrading enzyme is as shown in SEQ ID NO. 1, and the sequence of the coding gene is as shown in SEQ ID NO. 2. The production strain is a recombinant engineering strain comprising the coding gene. The application refers to the application of the indoxacarb degrading enzyme in degrading indoxacarb and repairing an indoxacarb polluted environment, and a corresponding method for degrading indoxacarb or repairing the indoxacarb polluted environment. The indoxacarb degrading enzyme has the advantages that the screened indoxacarb degrading enzyme can efficiently and rapidly degrade indoxacarb, can also be used for repairing environments such as water bodies and soil polluted by indoxacarb, and has important application value.

The present invention discloses an indoxacarb finished product crystallization method, which comprises a crystallization cylinder mechanism, a lifting cover plate mechanism, a crystallization plate mechanism, a driving mechanism and a collection disc, and during use, a mixed solution of indoxacarb and an organic solvent is poured into a crystallization chamber, the indoxacarb finished product with the mass being 3-5% of the mass of the reaction liquid is added as a seed crystal, and the seed crystal is crystallized; a pipeline valve on a feeding pipe is opened, the feeding pipe and a refrigerating fluid conveying pipe are connected, refrigerating fluid is conveyed into a material distributing piece through a pipeline pump machine and conveyed into a crystallization plate mechanism through a first material distributing hole and a second material distributing hole, and the first pump machine and the second pump machine are started to enable the refrigerating fluid to circulate between a circulating refrigerating pipe and a material distributing channel of the material distributing piece; the temperature of the surface of the crystallization plate shell is rapidly reduced, indoxacarb crystals are separated out on the surface of the crystallization plate shell, the temperature of the surface of the crystallization plate shell is rapidly reduced by accurately controlling the temperature of the surface of the crystallization plate shell, and the crystallization separation efficiency is improved.

The invention relates to the technical field of insecticides, and discloses an indoxacarb finished product crystallization device and method.The indoxacarb finished product crystallization device comprises a supporting bracket, a stirring tank is arranged at the top of the supporting bracket, an opening plate is arranged on one side of the stirring tank, a mounting frame is arranged at the top of the stirring tank, a driving source is arranged on the mounting frame, and a rotating shaft is arranged at the output end of the driving source; a fixing frame is arranged at the bottom of the inner wall of the stirring tank, and a homogenizing assembly is arranged on the fixing frame; the fixing frame is further provided with a vibration assembly. The homogenizing assembly is used for uniformly mixing the indoxacarb finished product solution in the stirring tank; the vibration assembly is used for reducing the phenomenon of local supersaturation of liquid in the stirring tank through vibration. Compared with the prior art, crystal agglomeration can be reduced, the particle distribution uniformity can be improved, the wall surface scaling risk can be reduced, the cleaning and maintenance frequency can be reduced, and the production efficiency and the product quality can be improved.

The invention discloses application of an epidermal protein gene SlituCP26 in prevention and treatment of prodenia litura, and relates to the technical field of biology. The nucleotide sequence of the SlituCP26 gene is shown as SEQ ID NO: 1, the SlituCP26 gene is highly expressed in an indoxacarb resistant strain, dsRNA of the gene is prepared, the dsRNA is micro-injected into prodenia litura larvae, after injection, the expression level of the SlituCP26 gene is obviously reduced, the body type of the larvae is obviously reduced, the epidermis thickness is obviously reduced, and the sensitivity to indoxacarb is obviously improved. The invention also provides a SlituCP26 gene promoter, and the drug resistance of the prodenia litura can be detected through the difference in sequence after the promoter is amplified. According to the invention, the fact that the epidermal protein SlituCP26 gene participates in the effect of the prodenia litura on resisting insecticides and the formation process of a resistance mechanism is clear, and the epidermal protein SlituCP26 gene has theoretical significance on the development of new insecticides.

The utility model discloses screening equipment for indoxacarb technical production, which comprises a tank body, a first blanking pipe is fixed at the bottom of the tank body, a second blanking pipe is mounted on the side surface of the tank body, a driving mechanism is mounted on the side surface of the tank body, the driving mechanism is inserted into the tank body and is connected with a screening mechanism, and the screening mechanism is connected with the tank body. And the screening mechanism is inserted into the second discharging pipe and is in sliding connection with the second discharging pipe, a guide plate is fixed to the inner wall of the tank body, the guide plate is located at the top of the screening mechanism, and a feeding pipe is installed at the top of the tank body. Compared with the prior art, the device has the advantages that the driving mechanism is arranged to drive the screening mechanism, so that the screening mechanism reciprocates in the tank body, when raw pesticide enters the tank body through the feeding pipe, the raw pesticide is screened through the reciprocating screening mechanism, large-particle raw pesticide and small-particle raw pesticide are separated, and the device is simple in structure and convenient to operate. And the screening efficiency is very high.

The present invention relates to solid compositions comprising combinations of conventional insecticides selected from the group consisting of: neonicotinoids, pyrethroids, macrolides, spinosyns, oxadiazines, isoxazolines, sulfoxaflor, flupyradifurone, indoxacarb, and hydramethylnon, and insect growth regulators for the control of pests and the protection of livestock premises from these pests.

The invention relates to the field of solenopsis invicta prevention and control, in particular to a long-acting solenopsis invicta killing bait and a preparation method thereof.The long-acting solenopsis invicta killing bait is prepared from indoxacarb, sophocarpidine, huperzine A, piperidine, modified sodium alginate, corn, wheat, fructose, potassium sorbate, calcium propionate, vitamin E and modified glycerin. The insecticide components are prepared into microcapsules which wrap insecticidal active components and have a slow release effect, and the huperzine A inhibits acetylcholin esterase, increases the concentration of acetylcholine and activates a sodium ion channel; indoxacarb blocks a sodium ion channel and inhibits nerve impulse; the matrine inhibits Na < + >-ATPase and influences the membrane potential; the effects result in that nerve cells are more susceptible to indoxacarb. The modified sodium alginate changes the permeability of cell membranes and affects ion balance. Various components have a synergistic effect, so that the neurotoxicity is enhanced, the solenopsis invicta paralysis or death is finally caused, and the termite killing effect is improved. The long-acting bait combines efficient insect killing and environment friendliness, and an innovative solution is provided for prevention and control of the solenopsis invicta.

The invention discloses an insecticidal bait composition containing a piperic acid derivative compound, the effective component of the compound insecticidal bait is composed of A and B, A is the piperic acid derivative compound, and B is one of fipronil, indoxacarb, dinotefuran, hydramizone and imidacloprid; the compounding weight ratio of A to B is (20: 1)-(1: 10). The piperic acid derivative compound is a brand-new insecticide component, is novel in action mechanism, good in lethal effect and free of repellency to sanitary pests, so that the composition can delay the resistance problem of single insecticidal bait action, improve the control effect and prolong the persistence at the same time.

The invention discloses a plurality of BVMO or mutants thereof, the BVMO or the mutants thereof can be used for effectively catalyzing 5-chloro-1-oxo-2, 3-dihydro-1H-indene-2-carboxylic acid methyl ester to generate (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester, and the (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester can be used for catalyzing 5-chloro-1-oxo-2, 3-dihydro-1H-indene-2-carboxylic acid methyl ester to generate (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester. The conversion rate and the optical purity of the 2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester can reach 99%, and excellent catalytic effect and conversion efficiency are shown. The indoxacarb intermediate is prepared by adopting a biological catalysis method, so that the production cost can be greatly reduced, the problem of environmental pollution can be avoided, and the indoxacarb intermediate has a wide application prospect and a high market value.

The invention discloses a nitrogen-doped carbon dot and a rapid fluorescence detection method thereof for indoxacarb residue, and belongs to the field of biosensor technology and food quality detection. L-theanine and ethidene diamine are used as raw materials, the nitrogen-doped carbon dots are prepared through a hydrothermal method, the N-CDs have the advantages of being stable in fluorescence emission, good in salt tolerance and excellent in photobleaching resistance, and indoxacarb can specifically quench fluorescence through the static quenching effect. By optimizing N-CDs synthesis conditions and indoxacarb detection conditions, an indoxacarb fluorescence sensing detection system with high selectivity and high sensitivity is constructed. The detection method disclosed by the invention can be suitable for detecting indoxacarb residues in environmental water samples such as tap water and river water and agricultural product matrixes such as apples and tea leaves, the standard recovery rate is good, the relative standard deviation is low, on-site rapid screening of the indoxacarb residues can be realized, and a new technical means is provided for monitoring the quality safety of the environment and agricultural products.

The present invention provides an indoxacarb-containing pesticide composition, which comprises a first effective component and a second effective component, the first effective component is a compound having a structural formula (I), the second effective component is indoxacarb, and the weight ratio of the first effective component to the second effective component is 1-50: 1-50. The invention also provides application of the pesticide composition in prevention and control of agricultural and forestry pests, especially in prevention and control of chilo suppressalis. Experiments prove that the binary composition obtained by compounding flufenican amide and indoxacarb in a proper proportion has a remarkable synergistic effect, so that the effects of improving the control effect, reducing the dosage and expanding the insecticidal spectrum are achieved. The composition disclosed by the invention has an excellent control effect on target pests such as chilo suppressalis, plutella xylostella, green peach aphid, beet armyworm, ostrinia nubilalis, thrips, flea beetle, spider mites, brown planthopper or liriomyza sativae. (I)

The application provides a compound agent for preventing and treating termites based on Serratia marcescens, which comprises 7.75x10 8 ~2.63x10 12 CFU / mL of Serratia marcescens, and a pathogenic fungus or a biological pesticide or an insect growth regulator or a chemical agent; the pathogenic fungus is Beauvaria bassiana or Metarhizium anisopliae; the biological pesticide is ivermectin; the insect growth regulator is lufenuron or buprofezin or diflubenzuron; and the chemical agent is emamectin benzoate or indoxacarb. The compound agent has obvious synergistic effect on preventing and treating termites, reduces the use amount of single agent, is lower in cost, more efficient, stable and green.

The invention relates to the technical field of pesticide manufacturing, and discloses a cyhalothrin and indoxacarb nano microcapsule suspending agent as well as a preparation method and application thereof. The nano microcapsule suspending agent is formed by mixing an indoxacarb nano suspending agent and a cyhalothrin microcapsule suspending agent; wherein when the cyhalothrin microcapsule suspending agent is prepared, methyl oleate and epoxidized soybean oil are used as solvents of an oil phase. The lambda-cyhalothrin and indoxacarb nano microcapsule suspending agent provided by the invention is prepared by mixing the indoxacarb nano suspending agent and the lambda-cyhalothrin microcapsule suspending agent, and when the lambda-cyhalothrin microcapsule suspending agent is prepared, methyl oleate and epoxidized soybean oil are used as solvents of an oil phase, so that the stability of the preparation can be improved to a great extent; therefore, the pesticide effect and the utilization rate of pesticide active ingredients are improved, the use amount and the use frequency are reduced, and pesticide residues and pollution to the environment are reduced.

The present application belongs to the field of prevention and control of Solenopsis invicta Buren, and particularly relates to a bait for preventing and controlling Solenopsis invicta Buren, a preparation method and application thereof. The composition is indoxacarb and spinosad, and the mass ratio of spinosad to indoxacarb is 5:1-1:5. The bait adopts a puffing process, has light texture, and does not affect the attraction effect on Solenopsis invicta Buren in an unfavorable environment. The present application also provides a preparation method of the bait.

The invention belongs to the technical field of pesticides, and relates to an insecticidal composition and application thereof. The insecticidal composition comprises an active component A and an active component B, the active component A is a compound represented by a formula (I), the active component B is any one of metaflumizone and indoxacarb, and the mass ratio of the active component A to the active component B is 1: 54-43: 1. The composition disclosed by the invention has a synergistic effect on prevention and control of agricultural and forestry pests within a certain proportioning range, particularly has excellent insecticidal activity on lepidoptera pest larvae, and is good in quick-acting property and safe to crops.

The utility model relates to the technical field of emamectin benzoate and indoxacarb production, and discloses processing equipment for emamectin benzoate and indoxacarb production, which comprises a support frame, a lifting mechanism is arranged at the top of the support frame, a stirring mechanism is arranged in the middle of the support frame, the lifting mechanism comprises a mounting frame, and a stirring mechanism is arranged in the mounting frame. The mounting frames are fixedly connected to the four corners of the top of the supporting frame, and threaded rods are rotationally connected to the bottoms of the interiors of the four mounting frames. According to the processing equipment for emamectin benzoate and indoxacarb production, by arranging the lifting mechanism and the liftable stirring blades, raw materials at the bottom of the stirring barrel can be stirred, the phenomenon that the raw materials are deposited in the stirring barrel is avoided, and the emamectin benzoate and indoxacarb processing effect is improved; the raw materials can be uniformly mixed and stirred under the rotation of the stirring blades, emamectin benzoate indoxacarb can be generated from the mixed raw materials at the moment, and the bottom of the stirring barrel can be cleaned through the arranged brush, so that the stirring barrel can be conveniently used next time.

The invention relates to the technical field of pesticides, and discloses a synergistic suspending agent containing lufenuron. 1000 parts by weight of the synergistic suspending agent comprises the following raw materials: 14-350 parts by weight of lufenuron, 10-250 parts by weight of indoxacarb, 10-200 parts by weight of a synergist, 50-400 parts by weight of an auxiliary agent and the balance of water, and the weight ratio of lufenuron to indoxacarb is 7: 5. The synergist is a mixture of a microbial metabolite and a polymer emulsifier, and the weight ratio of the microbial metabolite to the polymer emulsifier is (3: 1)-(1: 3). The synergistic suspending agent is used for preventing and treating spinach beet armyworms, the permeability and surface tension of the agent can be obviously improved, the disease and insect resistance of crops can be improved, the lasting period is long, and residues are small.

The present invention discloses an insecticide synergistic composition containing a piperic acid derivative compound and an application thereof. The composition consists of two active ingredients, compound A and compound B, wherein the active component A is compound I-72; the active component B is selected from any one of indoxacarb, s-indoxacarb or metaflumizone; the compound I-72 has the following structure: The composition of the present invention has the advantages of obvious synergy, delayed resistance, etc., and can be used for preventing and controlling lepidopteran and coleopteran pests on agriculture, forestry and ornamental plants, especially for use on resistant striped stem borer and resistant diamondback moth.

The application provides a resistant sanitary pest control composition containing indoxacarb and application thereof, relates to the technical field of resistant sanitary pest control, and more specifically, the resistant sanitary pest control composition is composed of active ingredient A, active ingredient B, a carrier, and adjuvants, wherein the active ingredient A is indoxacarb; the active ingredient B is R-tetrafluorobenzyl cyclopropane carboxylate pyrethroid, compared with the prior art, the application is synergistic through compounding, reduces resistance, improves the control effect on sanitary pests, especially resistant dipteran sanitary pests such as mosquitoes and flies, reduces the drug dosage, reduces the use frequency, and reduces the drug cost.

The present invention discloses an insecticide bait composition containing a piperic acid derivative compound. The compounded insecticide bait comprises active ingredients A and B, wherein A is a piperic acid derivative compound and B is one of fipronil, indoxacarb, dinotefuran, hydrazone, or imidacloprid. The weight ratio of A to B is 20:1 to 1:10. Because the piperic acid derivative compound is a brand-new insecticide ingredient with a novel mechanism of action, a good lethal effect, and no repellency to sanitary pests, the composition can delay the resistance of single insecticide baits, improve the control effect, and prolong the lasting effect.

The invention discloses a modified indoxacarb nano pesticide and a preparation method thereof, the pesticide comprises a carrier, a loaded indoxacarb active compound and oxidized sodium alginate grafted on the carrier, the carrier is an amino-containing iron-based metal organic framework material, and the aldehyde group of the oxidized sodium alginate and the amino group on the carrier material are subjected to a Schiff base reaction to obtain the modified indoxacarb nano pesticide. Grafting on a carrier; the preparation method comprises the following steps: (1) loading an indoxacarb active compound on an amino-containing iron-based metal organic framework material; and (2) adding the carrier loaded with the pesticide in the step (1) and oxidized sodium alginate into a solvent, and grafting the oxidized sodium alginate onto an iron-based metal organic framework through Schiff base reaction to obtain the modified indoxacarb nano pesticide. According to the invention, the indoxacarb active compound is loaded on the iron-based metal organic framework material, and the iron-based metal organic framework material is further modified by using the oxidized sodium alginate, so that the stability of the indoxacarb active compound and the adhesiveness of the indoxacarb active compound on plant leaf surfaces are improved.

This invention relates to the field of agricultural chemicals, particularly to the insecticide indoxacarb, and specifically to a method for preparing the synthetic intermediate of indoxacarb. The method involves constructing an α,β-unsaturated carbonyl compound using the Knoevenagel reaction, followed by further reduction to obtain the target compound. Compared to the nucleophilic substitution reaction conditions in the original literature, this method offers milder conditions and greater solvent selectivity, making it suitable for large-scale industrial production of acyl halide derivatives. This method is not only simple and efficient, but also boasts high yield and high purity, allowing the target compound to be obtained through simple purification steps.

The invention discloses a group of KASP primers for detecting insecticide resistance mutation of tomato leaf miner (also known as tomato leaf miner) and application of the KASP primers, and relates to the technical field of agricultural biology. The KASP marker primer disclosed by the invention comprises a primer combination which is used for detecting resistance mutations of deltamethrin, indoxacarb, chlorpyrifos and spinetoram, such as TabsM918TTC, TabsT929I, TabsL1014FCT, TabsF1845Y, TabsV1848I, TabsA201S and TabsG275E. The KASP marker primer disclosed by the invention comprises a primer combination which is used for detecting resistance mutations of deltamethrin, indoxacarb, chlorpyrifos and spinetoram. And one or more primer combinations are used for detecting the drug resistance mutation of the tomato leptochloa moth. The group of KASP labeled primers is good in specificity and high in sensitivity, and can accurately detect the pesticide resistance mutation frequency of the tomato lepidoptera moth to the pesticide.

The invention relates to the technical field of chemical purification of pesticides, and discloses a refining and purifying method of indoxacarb. The method comprises the following steps: dissolving an indoxacarb crude product, performing contact adsorption on the dissolved indoxacarb crude product and a temperature-sensitive imprinted silicon material, performing separation to obtain a liquid phase rich in R-isomers and a solid phase loaded with S-isomers, performing recrystallization purification on the liquid phase to obtain R-indoxacarb, performing gradient elution on the solid phase to remove impurities, and performing desorption to obtain high-purity S-indoxacarb, the adsorbent takes mesoporous silica as a carrier, is synthesized in situ through a temperature-sensitive polymer guided by template molecules, and can accurately capture S-isomers at low temperature and quickly desorb during heating. According to the method, high-temperature side reaction is avoided, the process stability is high, the dependence of traditional recrystallization on solubility difference is broken through, the core problem of low chiral separation efficiency is solved, meanwhile, high-selectivity separation is achieved, and the optical purity and yield of the product are remarkably improved.

The application discloses application of an epidermal protein gene SlituCP26 in prevention and treatment of Spodoptera litura, and relates to the technical field of biotechnology.The nucleotide sequence of the SlituCP26 gene is shown as SEQ ID NO:1, the gene is highly expressed in indoxacarb-resistant strains, the dsRNA of the gene is prepared, and the dsRNA is microinjected into the bodies of Spodoptera litura larvae; after the injection, the expression level of the SlituCP26 gene is significantly reduced, the body size of the larvae is obviously reduced, the epidermal thickness is significantly thinned, and the sensitivity to indoxacarb is significantly improved.The application further provides a SlituCP26 gene promoter, and the difference on the sequence amplified through the promoter can be used for detecting the drug resistance of Spodoptera litura.The application confirms that the epidermal protein SlituCP26 gene is involved in the action of Spodoptera litura to insecticides and the formation process of the resistance mechanism, and has theoretical significance for development of new insecticides.

This utility model relates to the technical field of indoxacarb screening equipment, specifically disclosing a screening device for the production of indoxacarb technical grade, including a support mechanism and a screening mechanism. The screening mechanism is arranged on the upper inner side of the support mechanism. The support mechanism includes a support frame, with two mounting blocks symmetrically arranged at both ends of the lower part of the support frame. Telescopic rods are arranged below each of the four mounting blocks. The screening mechanism includes a screen box, with a screen plate connected to the inner side of the screen box. A top plate and a hopper are respectively connected to the upper and lower ends of the screen box. Support plates are connected to both ends of the screen box. A cam is arranged in the lower center of each of the two support plates. Multiple springs arranged in a linear array are arranged on both sides of the cam. This equipment can continuously screen indoxacarb technical grade, ensuring the continuity of the screening operation, improving the screening efficiency of indoxacarb technical grade, reducing the workload of disassembling and assembling related parts, and reducing the risk of users coming into contact with indoxacarb technical grade.

The invention discloses a preparation method of an indoxacarb high-purity intermediate, and belongs to the technical field of pesticide synthesis. Mixing chlorobenzene, 3-chloropropionyl chloride and the modified charcoal, stirring and reacting to obtain a first mixed solution; heating and stirring the first mixed solution for reaction to obtain a second mixed solution; adding dimethyl carbonate and anhydrous potassium carbonate into the second mixed solution, mixing and performing reflux reaction to obtain a third mixed solution; and sequentially carrying out reduced pressure distillation and ethanol recrystallization on the third mixed solution to obtain the high-purity indoxacarb intermediate. According to the invention, a molecular imprinting-coordination-sulfur doping synergistic catalysis system is constructed through three-step modification, so that precise recognition and efficient catalysis cooperation are realized, and the reaction selectivity and the product purity are improved. The modified charcoal has excellent stability and can be recycled, the production process is simplified, and the separation difficulty is reduced.

The invention discloses a catalytic synthesis process of an indoxacarb intermediate, and belongs to the technical field of organic synthesis.The catalytic synthesis process comprises the steps that silicon dioxide is coprecipitated on the surfaces of microspheres assembled through a hydrothermal reaction of sucrose, hydroxyl on the surfaces reacts with amino in chitosan, and chitosan / carbon silicon microspheres are obtained; then carrying out esterification reaction on hydroxyl groups on the surface and phosphoric acid groups of inositol hexaphosphate, removing the silicon dioxide template to obtain hollow carbon phosphide microspheres as carriers to load MOF-Pd, and carbonizing to obtain a palladium phosphide carbon-based catalyst; the palladium phosphide carbon-based catalyst has extremely high specific surface area and porous and macroporous properties, can significantly reduce diffusion resistance and prevent the influence of mass transfer limitation on catalytic efficiency in a process of catalyzing synthesis of an indoxacarb intermediate, not only retains high adsorbability, but also guarantees rapid mass transfer, thereby improving the catalytic efficiency of the catalyst and reducing the cost of the catalyst. The indoxacarb intermediate prepared by the synthesis process has the characteristics of high product conversion rate, high raw material utilization rate and few byproducts.

The application relates to the technical field of indoxacarb production, in particular to a filtering device for indoxacarb production, which comprises a first filtering mechanism for filtering small impurities in indoxacarb particles, and a second filtering mechanism for filtering large-volume impurities in the indoxacarb particles and arranged at the bottom of the first filtering mechanism; the first filtering mechanism comprises a first filtering box, a first rotating shaft is rotationally arranged in the first filtering box, a plurality of equidistant first spiral blades are fixedly arranged on the outer surface of the first rotating shaft, a plurality of dust removal holes are formed through the surface of the first rotating shaft, and the hole diameter of the dust removal holes is smaller than the diameter of the indoxacarb particles; the filtering device solves the problems in the prior art that, although the filtering process of the chemical raw materials can be realized, the filtering holes are prone to be blocked during the filtering process, the filtering effect is affected, the filtering process is even paused, and the filtering effect is poor because the impurities of different specifications cannot be filtered in the prior art.

The invention relates to the technical field of chemical purification of pesticides, and particularly discloses a post-treatment process of indoxacarb. According to the process, metal ions, colored impurities and byproducts in reaction liquid are deeply removed by adopting a composite adsorbent composed of chelate resin loaded nano zinc oxide and beta-cyclodextrin; a high-purity crystal is obtained by combining a mixed solvent with ultrasonic-assisted gradient crystallization; and further treating by using a melting sweating technology under nitrogen protection, and dehydrating crystallization mother liquor through a molecular sieve to realize high-efficiency recovery of the mixed solvent. The purity and quality stability of indoxacarb are remarkably improved and the production cost and environmental pollution are reduced through deep impurity removal by composite adsorption, crystallization efficiency and crystal quality improvement by optimizing a solvent crystallization system, mild refining by melting sweating and efficient solvent recycling.