Cyhalothrin and indoxacarb nano microcapsule suspending agent as well as preparation method and application of cyhalothrin and indoxacarb nano microcapsule suspending agent

Abstract

The invention relates to the technical field of pesticide manufacturing, and discloses a cyhalothrin and indoxacarb nano microcapsule suspending agent as well as a preparation method and application thereof. The nano microcapsule suspending agent is formed by mixing an indoxacarb nano suspending agent and a cyhalothrin microcapsule suspending agent; wherein when the cyhalothrin microcapsule suspending agent is prepared, methyl oleate and epoxidized soybean oil are used as solvents of an oil phase. The lambda-cyhalothrin and indoxacarb nano microcapsule suspending agent provided by the invention is prepared by mixing the indoxacarb nano suspending agent and the lambda-cyhalothrin microcapsule suspending agent, and when the lambda-cyhalothrin microcapsule suspending agent is prepared, methyl oleate and epoxidized soybean oil are used as solvents of an oil phase, so that the stability of the preparation can be improved to a great extent; therefore, the pesticide effect and the utilization rate of pesticide active ingredients are improved, the use amount and the use frequency are reduced, and pesticide residues and pollution to the environment are reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticide manufacturing, and specifically relates to a beta-cyhalothrin and indoxacarb nano microcapsule suspension and its preparation method and application. Background Art

[0002] A suspension concentrate, also known as a colloidal suspension concentrate, refers to a stable dispersion system in which a technical material that is insoluble or poorly soluble in water is dispersed in water under the action of additives (such as dispersants, thickeners, pH adjusters, stabilizers, and defoamers). The suspension concentrate has an opaque appearance, a particle size range of 1 - 5 μm, and belongs to a thermodynamically unstable polydisperse system. It can be uniformly mixed and dispersed with water in any proportion, is hardly affected by water quality and water temperature, and is convenient for processing. This formulation has the advantages of small active ingredient particles, high suspension rate, good efficacy; using water as the matrix, hardly using organic solvents such as methyl oleate; and being convenient to use.

[0003] Indoxacarb is a newly developed novel low-toxic, highly effective, and broad-spectrum insecticide by DuPont Company of the United States, and has excellent control effects on resistant pests such as cotton bollworms, beet armyworms, and diamondback moths. Its mechanism of action is a sodium channel inhibitor, mainly blocking the sodium channels in the nerve cells of pests, resulting in target pests being disordered, paralyzed, and ultimately dying. The agent enters the insect body through contact and ingestion. Insects stop feeding within 0 - 4 hours, and due to paralysis and decreased coordination ability, fall from the crops. Generally, they are paralyzed and killed within 4 - 48 hours after application, and are effective against larvae of all instars. Indoxacarb has larvicidal and ovicidal effects, and the main modes of action are stomach toxicity and contact toxicity. At the same time, indoxacarb also has good rainfastness. Indoxacarb can be used as an insecticide for crops such as cotton, fruit trees, vegetables, and forest trees.

[0004] Beta-cyhalothrin, also known as lambda-cyhalothrin, is a broad-spectrum pyrethroid insecticide that has repellent and contact effects on insects, mainly acting on the axon part of insects, and is widely used in the agricultural field for crops such as cotton, apples, potatoes, wheat, barley, rice, tomatoes, olives, cabbages, soybeans, grapes, and corn. Beta-cyhalothrin is easily soluble in methanol, solvent oil, acetone, and organic solvents, and is stable under light. However, beta-cyhalothrin is irritating to human skin and has an irritating odor, which limits its application.

[0005] Nanopesticides are pesticide forms in which active ingredients exist in the preparation at the nanoscale through physical, chemical, or physical-chemical means. Nanopesticides have excellent mechanisms of action, mainly including: expanding the target mechanism of action, promoting plant systemic absorption, enhancing the leaf surface adhesion ability, etc. Due to the smaller particle size of nano suspension concentrates, the Brownian motion is more intense, and the increase in temperature will accelerate the Brownian motion. Therefore, there is a greater risk of particle size growth during storage. The stability of pesticide particles is a key technical issue in the preparation of nanopesticides, and the dispersants and other additives used in the suspension concentrates of different pesticides or pesticide combinations are often different.

[0006] As a type of sustained-release preparation, microcapsules can encapsulate the active ingredients, reduce the impact of the environment on the active ingredients, mitigate the acute contact toxicity to non-target organisms, and at the same time enable the slow release of the active ingredients. However, microcapsules are generally made of oily materials and are hydrophobic, resulting in poor dispersibility in water; moreover, they are not stable enough during storage. During dilution or storage, pesticide microcapsules are prone to unstable phenomena such as water separation, stratification, and precipitation, and need to be shaken well again, which affects the use effect. Summary of the Invention

[0007] The purpose of the present invention is to overcome the problems existing in the prior art and provide a beta-cyfluthrin and indoxacarb nano-microcapsule suspension, its preparation method and application, which can be used to control plant pests.

[0008] To achieve the above purpose, in the first aspect of the present invention, a beta-cyfluthrin and indoxacarb nano-microcapsule suspension is provided, wherein the nano-microcapsule suspension is composed of an indoxacarb nano-suspension and a beta-cyfluthrin microcapsule suspension; wherein, when preparing the beta-cyfluthrin microcapsule suspension, methyl oleate and epoxidized soybean oil are used as the solvent of the oil phase.

[0009] In the second aspect of the present invention, a preparation method of the beta-cyfluthrin and indoxacarb nano-microcapsule suspension according to the first aspect is provided, wherein the preparation method includes: mixing the indoxacarb nano-suspension and the beta-cyfluthrin microcapsule suspension to obtain the beta-cyfluthrin and indoxacarb nano-microcapsule suspension.

[0010] In the third aspect of the present invention, the application of the beta-cyfluthrin and indoxacarb nano-microcapsule suspension according to the first aspect or the beta-cyfluthrin and indoxacarb nano-microcapsule suspension obtained by the preparation method according to the second aspect in controlling Pieris rapae, aphids, whiteflies, planthoppers, beetles, Plutella xylostella, Pieris rapae, Spodoptera litura, Mamestra brassicae, Helicoverpa armigera, Heliothis assulta, leafrollers, Cydia pomonella, leafhoppers, Earias vittella, Leptinotarsa decemlineata is provided.

[0011] Through the above technical solutions, the beneficial technical effects obtained by the present invention are as follows:

[0012] The beta-cyfluthrin and indoxacarb nano-microcapsule suspension provided by the present invention is composed of mixing the indoxacarb nano-suspension and the beta-cyfluthrin microcapsule suspension, and when preparing the beta-cyfluthrin microcapsule suspension, methyl oleate and epoxidized soybean oil are used as the solvent of the oil phase, which can greatly improve the stability of the preparation, thereby improving the efficacy and utilization rate of the pesticide active ingredients, reducing the usage amount and frequency, and reducing pesticide residues and environmental pollution. Detailed Embodiments

[0013] The endpoints and any values disclosed in this text for a range are not limited to that precise range or value. These ranges or values should be understood to include values close to those ranges or values. For numerical ranges, the values between the endpoint values of each range, between the endpoint values of each range and individual point values, and between individual point values can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be regarded as specifically disclosed in this text.

[0014] The first aspect of the present invention provides a beta-cyfluthrin and indoxacarb nano-microcapsule suspension, wherein the nano-microcapsule suspension is formed by mixing an indoxacarb nano-suspension and a beta-cyfluthrin microcapsule suspension.

[0015] Wherein, when preparing the beta-cyfluthrin microcapsule suspension, methyl oleate and epoxidized soybean oil are used as the solvent for the oil phase.

[0016] In some embodiments of the present invention, the mass ratio of methyl oleate to epoxidized soybean oil in the solvent is 2 - 3:3 - 2, preferably 1:1.

[0017] In some embodiments of the present invention, in the raw materials for preparing the beta-cyfluthrin and indoxacarb nano-microcapsule suspension, the mass percentage of methyl oleate is 6.4 - 9.6%, preferably 8%; the mass percentage of epoxidized soybean oil is 6.4 - 9.6%, preferably 8%.

[0018] In some embodiments of the present invention, the beta-cyfluthrin and indoxacarb nano-microcapsule suspension comprises the following raw materials for preparation by mass percentage: beta-cyfluthrin 1 - 20%, indoxacarb 1 - 10%, solvent 10 - 20%, co-dispersant 1 - 5%, wall material 0.1 - 10%, core material 0.1 - 10%, emulsifier 1 - 5%, defoamer 0.1 - 1%, dispersant 3 - 20%, antifreeze 1 - 10%, preservative 0.1 - 0.3%, thickener 0.1 - 5%, and the balance is water.

[0019] In some embodiments of the present invention, the co-dispersant is selected from at least one of TERSPERSE 2500, TERSPERSE 5500, and PS80.

[0020] In some embodiments of the present invention, the wall material is selected from at least one of GT-27 and RA-001.

[0021] In some embodiments of the present invention, the core material is selected from at least one of GT-34 and CS-007.

[0022] In some embodiments of the present invention, the emulsifier is G-5002L.

[0023] In some embodiments of the present invention, the defoaming agent is a modified polyether defoaming agent L27.

[0024] In some embodiments of the present invention, the dispersant includes a first dispersant and a second dispersant.

[0025] In some embodiments of the present invention, the first dispersant is DX251.

[0026] In some embodiments of the present invention, the second dispersant is selected from at least one of 1603, CS-70, and SC-29.

[0027] In some embodiments of the present invention, the antifreeze is ethylene glycol.

[0028] In some embodiments of the present invention, the preservative is Kathon LX150.

[0029] In some embodiments of the present invention, the thickener is selected from at least one of xanthan gum and magnesium aluminum silicate.

[0030] In some embodiments of the present invention, the beta-cyfluthrin and indoxacarb nano microcapsule suspension includes the following preparation raw materials by mass percentage: beta-cyfluthrin 5-20%, indoxacarb 5-15%, methyl oleate 8%, epoxidized soybean oil 8%, TERSPERSE 2500 5%, GT-34 6%, GT-27 5%, G-5002L 3%, SC-29 5%, DX251 20%, ethylene glycol 4%, Kathon LX150 1%, xanthan gum 5.3%, magnesium aluminum silicate 2%, L27 0.5%, and the balance is deionized water.

[0031] In some embodiments of the present invention, the mass percentage of beta-cyfluthrin is 10%.

[0032] In some embodiments of the present invention, the mass percentage of indoxacarb is 5%.

[0033] The second aspect of the present invention provides a preparation method of the beta-cyfluthrin and indoxacarb nano microcapsule suspension according to the first aspect, wherein the preparation method includes: mixing the indoxacarb nano suspension and the beta-cyfluthrin microcapsule suspension to obtain the beta-cyfluthrin and indoxacarb nano microcapsule suspension.

[0034] In some embodiments of the present invention, the preparation method includes the following steps:

[0035] S1. Mix indoxacarb, the first dispersant, the co-dispersant, a part of the defoamer, and a part of the thickener with 30% of the total amount of water, stir and grind until the particle size of indoxacarb is 100 - 450 nm. After defoaming with the remaining defoamer and thickening with the remaining thickener, add 20% of the remaining total amount of water, and stir to form a homogeneous dispersion system, thus obtaining the indoxacarb nano-suspension;

[0036] S2. Dissolve lambda-cyhalothrin in a solvent, and then mix it with the wall material to obtain the oil phase; mix the core material, a part of the second dispersant, and the remaining water to obtain the water phase; add the oil phase to the water phase and add an emulsifier for high-speed shear emulsification to obtain an emulsion; heat the emulsion to solidify it and carry out an interfacial polymerization reaction. After the reaction, add an antifreeze, a preservative, and the remaining second dispersant, and keep warm to obtain the lambda-cyhalothrin microcapsule suspension;

[0037] S3. Mix the indoxacarb nano-suspension obtained in S1 with the lambda-cyhalothrin microcapsule suspension obtained in S2 to obtain the lambda-cyhalothrin indoxacarb nano-microcapsule suspension.

[0038] In the present invention, the particle size refers to D90, which is measured by a particle size analyzer.

[0039] The third aspect of the present invention provides the application of the lambda-cyhalothrin indoxacarb nano-microcapsule suspension according to the first aspect or the lambda-cyhalothrin indoxacarb nano-microcapsule suspension obtained by the preparation method according to the second aspect in controlling Pieris rapae, aphids, whiteflies, planthoppers, beetles, Plutella xylostella, Pieris rapae, Spodoptera litura, Mamestra brassicae, Helicoverpa armigera, Heliothis assulta, leafrollers, Cydia pomonella, leafhoppers, Earias vittella, Leptinotarsa decemlineata.

[0040] The present invention will be described in detail below through examples.

[0041] For those not specifying specific conditions in the following examples and comparative examples, they are carried out according to conventional conditions or the conditions recommended by the manufacturer. For the reagents or instruments not indicating the manufacturer, they are all conventional products that can be obtained through commercial channels.

[0042] Example 1

[0043] This example is used to illustrate the preparation of the lambda-cyhalothrin indoxacarb nano-microcapsule suspension.

[0044] The raw materials include (by mass percentage): lambda-cyhalothrin 10%, indoxacarb 5%, methyl oleate 8%, epoxidized soybean oil 8%, TERSPERSE 2500 5%, GT-34 6%, GT-27 5%, G-5002L 3%, SC-29 5%, DX251 20%, ethylene glycol 4%, Kathon LX150 1%, xanthan gum 5.3%, magnesium aluminum silicate 2%, defoamer L27 0.5%, and the balance is deionized water.

[0045] The specific preparation method is as follows:

[0046] S1. Mix 5% indoxacarb, 20% DX251, 5% TERSPERSE 2500, 0.2% L27, 2% magnesium aluminum silicate with 30% of the total amount of water, stir for 5 min, put it into a nano grinder for grinding. After repeating the grinding in the nano grinder for 3 h, stop grinding when the particle size of indoxacarb is detected to be 150 nm. Use 0.3% L27 to defoam and 5.3% of an aqueous solution of xanthan gum with a concentration of 1.5% to thicken, and add 20% of the total amount of water, stir evenly to form a homogeneous dispersion system, thus obtaining a 5% indoxacarb nano-suspension with a particle size of 150 nm;

[0047] S2. Dissolve 10% lambda-cyhalothrin with a mixed solvent of 8% methyl oleate and 8% epoxidized soybean oil, then mix it with 5% GT-27 to obtain an oil phase; mix 6% GT-34, 2% SC-29 and the remaining water to obtain an aqueous phase; add the oil phase to the aqueous phase and add 3% G-5002L, carry out high-speed shear emulsification to obtain an emulsion; heat up and solidify the emulsion to carry out an interfacial polymerization reaction. After the reaction, add 4% ethylene glycol, 1% Kathon LX150 and 3% SC-29, and keep warm to obtain a 10% lambda-cyhalothrin microcapsule suspension;

[0048] S3. Under the stirring action of 400 r / min, slowly mix the indoxacarb nano-suspension obtained in S1 with the lambda-cyhalothrin microcapsule suspension obtained in S2 to obtain a lambda-cyhalothrin and indoxacarb nano-microcapsule suspension.

[0049] Example 2

[0050] Prepare the lambda-cyhalothrin and indoxacarb nano-microcapsule suspension according to the method of Example 1, except that the mass percentage of lambda-cyhalothrin in the raw materials is 20% and the mass percentage of indoxacarb is 10%.

[0051] Example 3

[0052] Prepare the lambda-cyhalothrin and indoxacarb nano-microcapsule suspension according to the method of Example 1, except that the mass percentage of lambda-cyhalothrin in the raw materials is 5% and the mass percentage of indoxacarb is 10%.

[0053] Example 4

[0054] Prepare the lambda-cyhalothrin and indoxacarb nano-microcapsule suspension according to the method of Example 1, except that the mass percentage of lambda-cyhalothrin in the raw materials is 5% and the mass percentage of indoxacarb is 15%.

[0055] Example 5

[0056] Prepare the beta-cyfluthrin and indoxacarb nano microcapsule suspension according to the method of Example 1, except that the mass percentage of methyl oleate in the raw materials is 6.4%, the mass percentage of epoxidized soybean oil is 9.6%, and the mass ratio of the two is 2:3.

[0057] Example 6

[0058] Prepare the beta-cyfluthrin and indoxacarb nano microcapsule suspension according to the method of Example 1, except that the mass percentage of methyl oleate in the raw materials is 9.6%, the mass percentage of epoxidized soybean oil is 6.4%, and the mass ratio of the two is 3:2.

[0059] Comparative Example 1

[0060] Prepare the beta-cyfluthrin and indoxacarb suspension according to the method of Example 1, except that the mass percentage of beta-cyfluthrin in the raw materials is 20%;

[0061] The operation of S1 is adjusted as follows: Mix 5% indoxacarb, 20% DX251, 5% TERSPERSE 2500, 0.2% L27, 2% magnesium aluminum silicate with 30% of the total amount of water, stir for 5 min, then perform high-speed shearing and put it into a common grinder for grinding for 3 h. After detecting that the particle size of indoxacarb is 4 μm, stop grinding, defoam with 0.3% L27, thicken with 5.3% aqueous solution of xanthan gum with a concentration of 1.5%, and add 20% of the total amount of water, stir evenly to form a homogeneous dispersion system to obtain 5% indoxacarb suspension.

[0062] Comparative Example 2

[0063] Prepare the beta-cyfluthrin and indoxacarb suspension according to the method of Example 1, except that methyl oleate, epoxidized soybean oil, GT-34 and GT-27 are omitted;

[0064] The operation of S2 is adjusted as follows: Mix 10% beta-cyfluthrin, 4% ethylene glycol, 1% Kathon LX150 and 5% SC-29, then perform high-speed shearing, and then put it into a common grinder for grinding for 3 h. After detecting that the particle size of beta-cyfluthrin is 4 μm, stop grinding and add the remaining water, stir evenly to form a homogeneous dispersion system to obtain 10% beta-cyfluthrin suspension.

[0065] Comparative Example 3

[0066] Prepare the beta-cyfluthrin and indoxacarb suspension according to the method of Example 1, except that methyl oleate, epoxidized soybean oil, GT-34 and GT-27 are omitted;

[0067] The operation of S1 was adjusted as follows: Mix 5% indoxacarb, 20% DX251, 5% TERSPERSE 2500, 0.2% L27, 2% magnesium aluminum silicate with 30% of the total amount of water, stir for 5 min, then perform high-speed shearing and put it into a common grinder for grinding for 3 h. After detecting that the particle size of indoxacarb is 4 μm, stop grinding. Use 0.3% L27 to defoam and 5.3% of an aqueous solution of xanthan gum with a concentration of 1.5% to thicken, and add 20% of the total amount of water, stir evenly to form a homogeneous dispersion system, and obtain a 5% indoxacarb suspension concentrate.

[0068] The operation of S2 was adjusted as follows: Mix 10% lambda-cyhalothrin, 4% ethylene glycol, 1% Kathon LX150 and 5% SC-29, perform high-speed shearing, then put it into a common grinder for grinding for 3 h. After detecting that the particle size of lambda-cyhalothrin is 4 μm, stop grinding and add the remaining water, stir evenly to form a homogeneous dispersion system, and obtain a 10% lambda-cyhalothrin suspension concentrate.

[0069] Comparative Example 4

[0070] Prepare the lambda-cyhalothrin-indoxacarb suspension concentrate according to the method of Example 1, except that 8% methyl oleate and 8% epoxidized soybean oil are replaced with 16% methyl oleate.

[0071] Comparative Example 5

[0072] Prepare the lambda-cyhalothrin-indoxacarb suspension concentrate according to the method of Example 1, except that 8% methyl oleate and 8% epoxidized soybean oil are replaced with 16% epoxidized soybean oil.

[0073] Comparative Example 6

[0074] Prepare the lambda-cyhalothrin-indoxacarb suspension concentrate according to the method of Example 1, except that 8% methyl oleate and 8% epoxidized soybean oil are replaced with 16% xylene

[0075] Test Example 1 Suspension rate test

[0076] Determine the preparations obtained in Examples 1-6 and Comparative Examples 1-6 with reference to Method 2 for suspension concentrates dedicated to suspension concentrates in GB / T 14825-2023 "Determination Method for Suspension Rate of Pesticides".

[0077] Table 1

[0078]

[0079] It can be seen from Table 1 that the suspension rates of the preparations in Examples 1-6 are better than those in Comparative Examples 1-6. The mixing process of the nano-microcapsules is more sufficient, and the agents and adjuvants are fully mixed during the mixing process, and sedimentation is not likely to occur.

[0080] Test Example 2 Field efficacy test

[0081] The test was conducted according to the test method in GB / T 17980.13 - 2000 "Pesticide Field Efficacy Test Guidelines". The test agents were the preparations obtained in Examples 1 - 6 and Comparative Examples 1 - 6. The agent used in the blank control was clear water. The application rate was 15 mL / mu for both, and the water consumption was 30 kg / mu.

[0082] The medicine was applied once at the peak of the low - instar larvae of Pieris rapae, with three replicates. The number of live insects was investigated and recorded before application, 3 days after application, 7 days after application, and 14 days after application, and the control efficacy was calculated. The five - point sampling method was used for investigation and recording. The formula for calculating the control efficacy is as follows:

[0083]

[0084] The results are shown in Table 2.

[0085] Table 2

[0086]

[0087] It can be seen from Table 2 that the preparations of Examples 1 - 6 in the field efficacy test had better control efficacy against the low - instar larvae of Pieris rapae than the preparations of Comparative Examples 1 - 6, with good slow - release effect, longer effective period, and greater application potential.

[0088] Test Example 3 Other Performance Tests

[0089] The following tests were carried out on the preparations obtained in Examples 1 - 6 and Comparative Examples 1 - 6:

[0090] (1) Determination of particle size and distribution

[0091] The particle size of the suspending agent was determined by a particle size analyzer, with the measurement result of D90 as the benchmark.

[0092] (2) Determination of low - temperature stability

[0093] It was carried out according to the method for determining the low - temperature stability of pesticides in GB / T 19137 - 2003. The preparation was placed at (0 ± 2)°C for 1 h, and the appearance was observed for any change. It was continued to be tested at (0 ± 2)°C for 7 days. After 7 days, it was taken out and restored to room temperature for observation. The qualified index for low - temperature was: no phenomena such as stratification, solidification and caking occurred, and the emulsion was uniform and flowable.

[0094] (3) Determination of thermal storage stability

[0095] It was carried out according to the method for determining the thermal storage stability of pesticides in GB / T 19136 - 2003. The preparation was placed at (54 ± 2)°C for 14 days. The qualified index for thermal storage was: no phenomena such as water separation, stratification, wall - hanging, solidification, etc. occurred, and the emulsion was uniform and flowable.

[0096] (4) Determination of normal - temperature stability

[0097] It is the same as the thermal storage stability determination method, only adjusting the temperature to room temperature.

[0098] Table 3

[0099]

[0100]

[0101] It can be seen from Table 3 that the beta-cyfluthrin and indoxacarb nano-microcapsule suspension of the present invention has good stability and can be better applied to the control of crop pests.

[0102] In the beta-cyfluthrin and indoxacarb nano-microcapsule suspension of the present invention, the indoxacarb nano-suspension and the beta-cyfluthrin microcapsule, two suspensions with different unique properties, are combined, which is unique. The product has more advantages and has a better control effect on the corresponding harmful organisms.

[0103] The beta-cyfluthrin and indoxacarb nano-microcapsule suspension of the present invention has stable performance, is easy to produce and store, is environmentally friendly, and is safe for humans and livestock. It has been proved by experiments that it has good effects on various pests such as Lepidoptera, Diptera and Hemiptera of wheat, corn, cotton and various fruit trees and vegetables, has good safety, and has no phytotoxicity to crops.

[0104] The indoxacarb nano-suspension in the beta-cyfluthrin and indoxacarb nano-microcapsule suspension of the present invention has a strong initial control effect on the control of corresponding harmful insects, and the beta-cyfluthrin microcapsule has a sustainable control effect on the corresponding harmful insects. The product of the present invention has a better continuous and strong control effect on the corresponding harmful insects.

[0105] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited thereto. Within the technical concept of the present invention, various simple modifications can be made to the technical solutions of the present invention, including any other suitable combination of each technical feature. These simple modifications and combinations should also be regarded as the content disclosed by the present invention and fall within the protection scope of the present invention.

Claims

1. A beta-cyfluthrin indoxacarb nano microcapsule suspension, characterized in that, The nano-microcapsule suspension is prepared by mixing indoxacarb nano-suspension and beta-cyfluthrin microcapsule suspension; Among them, when preparing the beta-cyfluthrin microcapsule suspension, methyl oleate and epoxidized soybean oil are used as the solvents of the oil phase.

2. The beta-cyhalothrin and indoxacarb nano-microcapsule suspension according to claim 1, wherein, The mass ratio of methyl oleate to epoxidized soybean oil in the solvent is 2-3:3-2, preferably 1:

1.

3. The beta-cyhalothrin and indoxacarb nano microcapsule suspension according to claim 1 or 2, wherein, Among the raw materials for preparing the beta-cyfluthrin indoxacarb nano-microcapsule suspension, the mass percentage of methyl oleate is 6.4-9.6%, preferably 8%; the mass percentage of epoxidized soybean oil is 6.4-9.6%, preferably 8%.

4. The lambda-cyhalothrin and indoxacarb nano-microcapsule suspension according to any one of claims 1-3, wherein, The beta-cyfluthrin indoxacarb nano-microcapsule suspension comprises the following raw materials for preparation in mass percentage: beta-cyfluthrin 1-20%, indoxacarb 1-10%, solvent 10-20%, co-dispersant 1-5%, wall material 0.1-10%, core material 0.1-10%, emulsifier 1-5%, defoamer 0.1-1%, dispersant 3-20%, antifreeze 1-10%, preservative 0.1-0.3%, thickener 0.1-5%, and the balance is water.

5. The beta-cyhalothrin and indoxacarb nano microcapsule suspension according to claim 4, wherein, The co-dispersant is selected from at least one of TERSPERSE 2500, TERSPERSE 5500 and PS80; Preferably, the wall material is selected from at least one of GT-27 and RA-001; Preferably, the core material is selected from at least one of GT-34 and CS-007; Preferably, the emulsifier is G-5002L; Preferably, the defoamer is a modified polyether defoamer L27; Preferably, the dispersant comprises a first dispersant and a second dispersant; Preferably, the first dispersant is DX251; Preferably, the second dispersant is selected from at least one of 1603, CS-70 and SC-29; Preferably, the antifreeze is ethylene glycol; Preferably, the preservative is Kathon LX150; Preferably, the thickener is selected from at least one of xanthan gum and magnesium aluminum silicate.

6. The beta-cyhalothrin indoxacarb nano-microcapsule suspension according to any one of claims 1-5, wherein, The beta-cyfluthrin indoxacarb nano-microcapsule suspension comprises the following raw materials for preparation in mass percentage: beta-cyfluthrin 5-20%, indoxacarb 5-15%, methyl oleate 8%, epoxidized soybean oil 8%, TERSPERSE 2500 5%, GT-34 6%, GT-27 5%, G-5002L 3%, SC-29 5%, DX251 20%, ethylene glycol 4%, Kathon LX150 1%, xanthan gum 5.3%, magnesium aluminum silicate 2%, L27 0.5%, and the balance is deionized water.

7. The beta-cyhalothrin and indoxacarb nano-microcapsule suspension according to claim 6, wherein, The mass percentage of beta-cyfluthrin is 10%; Preferably, the mass percentage of indoxacarb is 5%.

8. A preparation method of the beta-cyhalothrin indoxacarb nano microcapsule suspension according to any one of claims 1-7, characterized in that, The preparation method includes: mixing indoxacarb nano-suspension and beta-cyfluthrin microcapsule suspension to obtain the beta-cyfluthrin indoxacarb nano-microcapsule suspension.

9. The preparation method according to claim 8, wherein, The preparation method includes the following steps: S1. Mix indoxacarb, the first dispersant, the co-dispersant, a part of the defoamer, and a part of the thickener with 30% of the total amount of water, stir and grind until the particle size of indoxacarb is 100 - 450 nm. After defoaming with the remaining defoamer and thickening with the remaining thickener, add 20% of the total amount of water and stir to form a homogeneous dispersion system, thus obtaining the indoxacarb nano-suspension; S2. Dissolve lambda-cyhalothrin in a solvent, and then mix it with the wall material to obtain an oil phase; mix the core material, a part of the second dispersant, and the remaining water to obtain an aqueous phase; add the oil phase to the aqueous phase and add an emulsifier for high-speed shear emulsification to obtain an emulsion; heat up and solidify the emulsion for interfacial polymerization reaction. After the reaction, add an antifreeze, a preservative, and the remaining second dispersant, and keep warm to obtain the lambda-cyhalothrin microcapsule suspension; S3. Mix the indoxacarb nano-suspension obtained in S1 with the lambda-cyhalothrin microcapsule suspension obtained in S2 to obtain the lambda-cyhalothrin indoxacarb nano-microcapsule suspension.

10. The application of the lambda-cyhalothrin indoxacarb nano-microcapsule suspension according to any one of claims 1 - 7 or the lambda-cyhalothrin indoxacarb nano-microcapsule suspension obtained by the preparation method according to claim 8 or 9 in controlling Pieris rapae, aphids, whiteflies, planthoppers, beetles, Plutella xylostella, Pieris rapae, Spodoptera litura, Mamestra brassicae, Helicoverpa armigera, Heliothis assulta, leafrollers, Cydia pomonella, leafhoppers, Earias spp., Leptinotarsa decemlineata.

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