7476 results about "Microbial agent" patented technology

The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.

Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.

The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid—producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds. The present invention also discloses methodologies for: (i) the selective breeding and isolation of probiotic, lactic acid-producing bacterial strains which possess resistance or markedly decreased sensitivity to anti-microbial agents (e.g., antibiotics, anti-fungal agents, anti-yeast agents, and anti-viral agents); and (ii) treating or preventing bacteria-mediated infections of the gastrointestinal tract by use of the aforementioned probiotic bacterial strains with or without the concomitant administration of antibiotics. While the primary focus is on the treatment of gastrointestinal tract infections, the therapeutic compositions of the present invention may also be administered to buccal, vaginal, optic, and like physiological locations.

An antimicrobial composition that involves a synergistic mixture in terms of active agents, of a primary antimicrobial agent, such as polyhexamethylene biguanide (PHMB), a secondary antimicrobial agent, and optionally an organic acid against various kinds of microbes is described. Various additional processing aids, such as alcohols and surfactants, may also be incorporated within the mixture. The composition allows one to use a significantly less concentration of individual constituent antimicrobial agents to achieve the same or a better degree of antimicrobial efficacy. The antimicrobial composition can be applied to the surface of almost any kind of substrate material, and can achieve a killing-efficacy of about 3 Log₁₀ reduction in microbes within 30 minutes under ambient conditions.

The invention relates to a compound microbial fertilizer and a method for producing the compound microbial fertilizer. The compound microbial fertilizer comprises the following components by weight: 5-15 parts of inorganic fertilizer, 20-45 parts of organic fertilizer, 4-10 parts of medium trace elements, 10-25 parts of chelating agent and 1-8 parts of microbial agent. The compound microbial fertilizer is rich in organic matters, efficient chelating agent and functional micro-organisms and can improve the physical and chemical properties of soil, increase the utilization rate of the medium trace elements, keep the soil nutrient balance, restrain the occurrence of soil-borne diseases and enhance the crop yield and quality.

The invention discloses a method for managing town black and olid river pollution in situ by utilizing biological repair technology, which takes the steps and measures of aerating and oxygenizing in riverway, adding a complex microbial agent, biologically repairing bottom sediment, arranging a bio-nest system and the like, so as to control and eliminate the exogenous and endogenous pollution of the river, purify the water quality of the river, improve the self-purification ability of the water body and achieve the purpose of eliminating black and olid. The method does not need to build structures in the riverway or lead the river water out of the riverway to be treated, or dredge the bottom sediment in the river, therefore the method is generally applicable to incomplete sewage interception and dredging or the rivers which can not be intercepted sewage or dredged temporarily, and the in situ treatment to the riverway which is affected by tide and has complicated fluid variation. Therefore, the method which can lead the water body to recover normal ecological function provides the practical, economic and convenient treatment method for various town black and olid rivers.

The invention discloses a soil heavy mental repairing agent and a preparation method and an application thereof. The soil heavy mental repairing agent is composed of an organic material, a mineral raw material, a carbon material, an inorganic fertilizer and a microbial agent, wherein the viable count of the microbial agent is 1*10<7>-1*10<10>, the content of N, P2O5 and K2O is 8%-15% of the content of total nutrient, the content of the organic material is 20%-40% and pH is 5.5-8.5. The invention also provides an application method of the soil heavy mental repairing agent. The dosage is 80-150kg/mu; the effective heavy metal content of the soil can be effectively reduced; the heavy metal absorption of the crop can be obviously restrained; the crop yield and quality can be improved; the yield and income can be increased; the soil heavy mental repairing agent has significance in promoting social stability, economic growth and environmental diplomacy and guaranteeing ecological safety, food safety and human health.

Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

A topical composition for treating a cutaneous wound includes whole colostrum or one or more growth factors, as well as a base by which the whole colostrum or one or more growth factors are carried. The topical composition may also include, without limitation, immunomodulators, lactoferrin, enzymes, vitamins, minerals, amino acids, or combinations thereof. Other components may also be included in the topical composition, including, but not limited to, antiseptics, antimicrobial agents, and anesthetics. When applied to a wound, the bioactive topical composition promotes healing of the treated wound.

The invention discloses a microbial agent for treating ammonia-containing waste water and a preparation method thereof. The microbial agent for treating ammonia-containing waste water mainly comprises three bacterial strains of nitrobacter sp, nitrosobacteria nitrosomonas sp., denitrobacter sp., and the contents of the three bacterial strains can be regulated or proportioned according to specificcultivation conditions and product requirements through methods of oriented domestication, and the like. The cultivation method comprises the following steps of: enriching a bacterial source, purifying and amplifying stage by stage for cultivating. The microbial agent can be used for oriented domestication according to a waste water treatment result so as to improve the content of a target bacterial strain. The cultivation method has the advantages of high cultivation efficiency, large production capacity, and the like and is suitable for commercially producing complex microorganisms for treating the ammonia-containing waste water in a large scale. The obtained microbial agent can effectively treat low-COD (Chemical Oxygen Demand) and high-ammonia-nitrogen waste water, such as waste water of catalyst production, and the like.

Polymeric anti-microbial agents produced by substituting the nitrogen atoms in the backbone of ethylenimine polymers are provided. The agents are believed to have low human toxicity while being effective against a variety of pathogens and are useful in applications involving human contact, such as cosmetics, hair care products and textiles, as well as in applications with much less human contact, such as coatings.

The invention relates to a compound microbial agent for degrading antibiotic and pesticide residues as well as preparation and application thereof, and belongs to the field of biotechnology and environmental protection. Multi-thallus compound microbial powder is prepared from the compound microbial agent according to the weight percentage of living microbes to the total amount of compound microbial powder as follows: 10%-15% of bacillus subtilis, 10%-15% of aspergillus niger, 10%-15% of bacillus mucilaginosus, 10%-15% of enterococcus faecalis, 8%-12% of bacillus licheniformis, 8%-12% of bacillus megaterium, 8%-12% of pseudomonas fluorescens, 5%-8% of lactobacillus plantarum, 5%-8% of bacillus polymyxin and 6%-8% of streptococcus thermophiles. The compound microbial agent has the effects of degrading antibiotic and pesticide residues, fermenting and composting organic matter, acting as functional fertilizer and repairing the environment, and can solve the problems of secondary pollution caused by antibiotic residues in culture feces and resource utilization of organic waste and realizes biodegradation of the antibiotic and pesticide residues in soil when applied to the agricultural ecological environment, thereby being of great value and practical significance in restoration of agricultural ecological environment and protection of human health.

An antimicrobial composition that contains an antimicrobial agent and a sugar alcohol is provided. The sugar alcohol is more generally more biocompatible and biodegradable than the antimicrobial agent. In addition, without intending to be limited by theory, it is believed that sugar alcohols increase the attraction of the antimicrobial agent to microorganisms (e.g., the cytoplasmic membrane of bacteria). Because a greater percentage of the antimicrobial agent molecules are brought into contact with the microorganisms, the efficiency of growth inhibition is increased. Thus, the antimicrobial composition provides good efficacy without the need for high levels of an antimicrobial agent.

The invention discloses a salt-tolerant microbial agent and a preparation method thereof. The microbial agent contains staphylococcus cohnii FSND-C, arthrobacter creatinolyticus FDN-1, flavobacterium mizutaii FDN-2, paracoccus denitrificans DN-3 and methylobacterium phyllosphaerae SDN-3. The microbial agent can achieve removal of ammonia nitrogen, total nitrogen and CODcr in the same reactor, has a good wastewater treatment effect, and can achieve short-cut nitrification and denitrification or simultaneous nitrification and denitrification while removing COD. Staphylococcus cohnii FSND-C can utilize various carbon sources, has certain salt tolerance, can be applied to the high-salinity wastewater treatment process, simultaneously can secrete a substance under environmental stimulus to enhance the flocculability of sludge, and further widens the application range of the microbial agent.

This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such as doxycycline. The Wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents as well as bioactive agents. More generally, this invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymeric molecules and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.

Susceptibility of sessile microorganisms to antimicrobial agents is tested with a method comprising growing the microorganisms on a support to form a biofilm, contacting the biofilm with a metabolic substrate having a chromogenic and/or fluorogenic moiety to continue a base-line metabolic activity of the biofilm, contacting the biofilm with one or more antimicrobial agents, determining an experimental metabolic activity of the biofilm by measuring a signal from the metabolic substrate, and comparing the base-line metabolic activity with the experimental activity. The biofilm may be grown in a device comprising a plurality of wells, each well having a planar bottom and at least on wall, a plurality of supports comprising discs for growing the biofilm, each support disposed within a well perpendicular to the planar bottom, and at least one cover that fittably seals the top of each well.

The present invention is directed to novel compositions and methods utilizing nanoparticles comprising protein cages for delivery of imaging and antimicrobial agents to biofilm forming bacterial colonies.