673 results about "Skin irritation" patented technology

The invention belongs to the technical field of biological simulation, and discloses an anus cleaning effect evaluation method and system.The method comprises the steps that an execution assembly is controlled to wipe an anus anatomical structure with a to-be-detected sample according to a target wiping strategy, and a multi-mode sensing assembly is controlled to collect target parameters on the anus anatomical structure; obtaining target monitoring data; according to the residual dirt amount in the target monitoring data, a cleaning efficiency score is obtained through calculation, a target mechanical simulation model is called, according to the humidity permeation gradient value and the pressure value in the target monitoring data and the to-be-detected sample, a skin stimulation risk score is obtained through calculation, and the skin stimulation risk score and the cleaning efficiency score form a cleaning effect evaluation report. Simulation and prediction of the anus cleaning process are achieved, the simulation test effect and accuracy are greatly improved, and a cleaning effect evaluation report is given to illustrate the safety of the to-be-tested sample.

The invention belongs to the technical field of biological medicine, and particularly relates to a luliconazole composition containing essential oil, cream and a preparation method and application of the luliconazole composition. The present application provides a composition containing tea tree essential oil that promotes the skin permeability of luliconazole and has an antibacterial function, the tea tree essential oil and luliconazole form a synergistic antifungal effect, the transdermal absorption is enhanced by a natural terpene component, and the irritation to the skin is significantly reduced.

The invention relates to the technical field of medicine formulas, in particular to a fluralamide moxidectin composite drop and a preparation process thereof. The invention relates to a fluralan-moxidectin emulsion which is prepared from the following raw materials in percentage by mass: 26 to 30 percent of fluralan, 1.1 to 1.7 percent of moxidectin, 32 to 36 percent of solvent, 0.1 to 0.3 percent of butylated hydroxytoluene, 10 to 16 percent of polymer carrier and the balance of tetrahydrofuran polyethylene glycol ether. The coexisting drug is stabilized through the core-shell structure polymer carrier, phase separation is prevented, a neutral environment is maintained, long-acting stability is ensured, the transdermal absorption rate is optimized, skin irritation is reduced, and the synergistic drug effect is improved. Meanwhile, the slow release period of the medicine is prolonged, the metabolic interference and accumulated toxicity are reduced, and the dissolution efficiency and the skin mildness are both considered.

The invention relates to the technical field of cooling ice compress, and discloses a reusable rapid cooling ice compress device which comprises an ice compress bag. The two hook-and-loop fastener thorn surfaces are fixedly mounted at the two ends of the ice compress bag; the winding box is arranged at one end of the ice compress bag; and the two connecting boxes are symmetrically and fixedly mounted on the top surface of the winding box. The independent design of the ice compress bag enables the ice compress bag to be easily frozen and taken out for use at any time, self-care of a patient is facilitated, the use of the packing paper roll provides a sanitary and sterile barrier for the ice compress process, the comfort of the patient in the use process is ensured due to the soft and water-absorbing characteristics of the packing paper roll, and meanwhile, the use of the packing paper roll is facilitated. According to the ice compress bag, the ice compress bag can be prevented from being in direct contact with the skin of a patient, the risk of bacterial cross infection is reduced, possible skin irritation or anaphylaxis is prevented, it is ensured that ice compress is clean and sanitary each time due to the disposable use characteristic of the packing paper roll, and more secure use experience is provided for the patient.

The invention relates to application of a platelet reaction protein 4 in preparation of an alopecia medicine, and belongs to the field of medical biology. The invention aims to solve the technical problems of limited curative effect, obvious side effect and narrow application range of the existing alopecia treatment medicine. The invention provides an application of a platelet reaction protein 4 (THBS4) in preparation of an alopecia medicinal preparation, which can promote hair follicles to be converted from a resting period to a growing period by regulating and controlling a mechanical microenvironment around the hair follicles, enhancing the interaction between fibroblasts and hair follicle stem cells and activating regeneration signal channels in hair papilla and hair bud areas. The traditional Chinese medicine composition breaks through the limitation that existing treatment only aims at specific alopecia types, and can be widely applied to various alopecia diseases such as androgenetic alopecia, pressure alopecia and alopecia after chemotherapy. And compared with the traditional medicine, the traditional Chinese medicine composition has the advantages of quick response, no skin irritation reaction and improved hair follicle regeneration efficiency, and provides a brand new solution for safe and efficient treatment of alopecia.

The present application relates to the technical field of daily chemical cleaning products, and discloses a kind of wormwood leaf, enzyme laundry detergent, including the following components, by weight percentage: wormwood leaf enzyme: 30-50wt%, environmental protection enzyme: 10-20wt%, composite surfactant: 5-10wt%, including fatty alcohol polyoxyethylene ether sulfate and alkyl glycoside, wherein fatty alcohol polyoxyethylene ether sulfate accounts for 60-80wt% of the total amount of composite surfactant, and alkyl glycoside accounts for 20-40wt% of the total amount of composite surfactant; Dispersant: 0.3-1wt%; Enzyme-surfactant composite catalyst: 1-5wt%. The present invention adopts the technical scheme of combining wormwood leaf enzyme with environmental protection enzyme, extracts active enzyme and natural functional ingredients by fermentation, and realizes efficient decomposition of organic stains such as grease and protein. Compared with the scheme of using only chemical surfactant in the prior art, the problem of environmental pollution and skin irritation of chemical detergent is solved, and the safety and environmental protection of washing are significantly improved.

The present invention relates to a composition capable of improving the sunscreen performance of a sunscreen, and a preparation method and application thereof. The preparation method of the composition capable of improving the sunscreen performance of a sunscreen comprises the following steps: mixing and dissolving a metal ion salt and silk fibroin in water to obtain a silk fibroin metal ion complex solution; mixing the silk fibroin metal ion complex solution with hydroxyapatite to obtain a hydroxyapatite silk fibroin metal ion mixed solution; mixing the hydroxyapatite silk fibroin metal ion mixed solution with sericin to obtain the composition capable of improving the sunscreen performance of a sunscreen. The composition has excellent ultraviolet absorption performance, can be compatible with chemical sunscreens, improve the sunscreen performance of the sunscreen, and can avoid direct contact between the chemical sunscreen and the skin, thereby reducing the sensitization and skin irritation of the chemical sunscreen.

An adaptive medical access garment comprising a torso portion configured to cover at least a portion of a wearer's upper body and two sleeve portions extending from the torso portion. Each sleeve portion includes an extended two-way zipper extending continuously from a distal end of the sleeve to the torso portion, terminating proximate to the wearer's clavicle or chest. The garment is constructed from hypoallergenic, breathable fabric to ensure patient comfort and minimize skin irritation risk. The extended two-way zippers enable medical professionals to access the wearer's arms and upper body without requiring garment removal. The garment may further comprise thumb holes at the sleeve distal ends, pockets for holding medical devices, and side slits on the torso portion for accessing the wearer's sides. The invention encompasses a method for providing the adaptive medical garment.

The invention provides a non-invasive high-precision blood glucose sensor and a preparation method thereof. The blood glucose sensor comprises two symmetrical sensing areas prepared on a flexible substrate layer, each sensing area comprises a glucose sensor working electrode, a glucose sensor auxiliary electrode / reference electrode, a sodium ion sensor working electrode, a pH sensor working electrode and a sodium ion / pH sensor common reference electrode; the electrodes are distributed in an axial symmetry mode along the central axis of the sensor plane and are prepared through silk-screen printing. Due to the symmetrical structural design of the blood glucose sensor, the electrode polarity of the extraction electrode can be exchanged during two adjacent times of extraction so as to reduce electrode consumption and skin stimulation, the change of the extraction amount of intercellular fluid can be corrected by the integrated sodium ion and pH sensor, and therefore high-precision blood glucose monitoring is achieved.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention provides recombinant VII type collagen with a whitening effect as well as a preparation method and application thereof, and belongs to the technical field of bioengineering. Research finds that the recombinant VII type collagen with a whitening effect, the expression quantity of the recombinant VII type collagen is improved by taking a genetic engineering technology as a means, and expression production of the recombinant VII type collagen is carried out by using a pichia eukaryotic expression system; the recombinant VII type collagen disclosed by the invention is expressed in pichia pastoris, can be efficiently secreted and expressed outside cells, and is not easy to degrade in a purification stage, so that the purification difficulty is reduced; the recombinant VII type collagen has an excellent whitening effect, is suitable for sensitive skin, does not cause skin irritation, itching and scorching hot, and has good practicability.

The invention relates to the technical field of active artificial limbs, in particular to a bionic artificial limb with a knee-ankle linkage function. Comprising a fixing frame, a receiving cavity is connected to the fixing frame, first air bags are arranged on the inner side of the receiving cavity at intervals, clamping blocks are connected to the first air bags at intervals, air escape valves are arranged on the first air bags, an air conveying mechanism is arranged on the fixing frame, and the air conveying mechanism is used for alternately conveying air into the different first air bags. The first air bags with the clamping blocks are combined with the air conveying mechanism, so that the first air bags can be alternately expanded and deflated, intermittent fixation and relaxation of limbs are achieved, blood circulation disorder caused by long-time continuous compression of a traditional rigid or semi-rigid receiving cavity is effectively avoided through the dynamic adjusting mode, and the medical treatment effect is improved. The probability of occurrence of complications such as skin irritation, redness and swelling and even pressure sores is remarkably reduced, and the wearing comfort and safety are improved.

The present invention provides a composition for inhibiting the TRPV1 pathway and reducing skin irritation, comprising camellia extract and purslane extract, the mass ratio of camellia extract to purslane extract being 0.01-10:0.01-10. The composition of the present invention for inhibiting the TRPV1 pathway and reducing skin irritation comprises camellia extract and purslane extract, which inhibit the TRPV1 pathway. Both exhibit a synergistic effect in increasing the irritation response threshold, reducing the skin sensitivity reaction, and relieving tingling, itching, and burning sensations of the skin due to TRPV1 channel activation.

The invention relates to a phytoextraction external liniment for promoting black hair growth and a preparation method thereof. According to the liniment, a polygonum multiflorum extract, a cacumen biotae supercritical extract and molecular embedded black sesamin in a specific proportion are taken as cores and are matched with an azone-menthol transdermal enhancer and a propylene glycol-olive oil carrier, and black hair growth is synergistically promoted through triple mechanisms of activating tyrosinase, inhibiting melanocyte apoptosis and promoting cell migration. The preparation method adopts a gradient temperature extraction combined molecular embedding technology, the polygonum multiflorum is subjected to stepped purification at 40-60 DEG C-80 DEG C to retain thermosensitive active ingredients, the black sesamin is embedded by beta-cyclodextrin to improve the stability, and finally, the nano microemulsion is formed through two-stage homogeneous emulsification. The liniment can efficiently permeate into the deep layer of hair follicles, the efficiency of turning white hair into black is remarkably improved, and skin irritation is avoided.

The invention discloses a whitening compound as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The structural formula of the whitening compound is as follows: # imgabs0 #, R1 and R2 independently comprise alpha glucoside, beta glucoside or phenolic hydroxyl groups, and R1 and R2 are not phenolic hydroxyl groups at the same time. The whitening compound has higher stability, is not easy to generate self-oxidation reaction, and is beneficial to prolonging the shelf life of the product and prolonging the durability of the whitening effect; moreover, the whitening compound is suitable for sensitive skin, and can reduce skin irritation and reduce adverse reactions such as red and swollen, stabbing pain, dryness and the like; in addition, the whitening compound can promote proliferation of beneficial bacteria on epidermis, and can improve or improve the skin whitening effect to a certain extent.

The invention discloses low-irritation cyhalothrin and a preparation method and application thereof, and belongs to the technical field of pesticide preparations, the low-irritation cyhalothrin comprises silicon dioxide nanoparticles with the surfaces grafted with amphiphilic copolymers, cyhalothrin and an anti-allergic drug, the silicon dioxide nanoparticles with the surfaces grafted with the amphiphilic copolymers are dispersed in a solvent, and the anti-allergic drug is added to the silicon dioxide nanoparticles with the surfaces grafted with the amphiphilic copolymers to prepare the low-irritation cyhalothrin. The preparation method comprises the following steps: taking porous silicon dioxide nanoparticles as a carrier, modifying a layer of amphiphilic polymer on the surface of silicon dioxide in situ, then adding cyhalothrin and an anti-allergic drug, continuously stirring, and drying the obtained product to obtain the low-irritation cyhalothrin. The cyhalothrin and the anti-allergic drug are loaded in silicon dioxide pore channels, and the anti-allergic agent is used in cooperation, so that the skin irritation of the cyhalothrin is reduced. The cyhalothrin with low irritation provided by the invention is simple in preparation method, can be used as a cyhalothrin insecticide raw medicine, and has relatively great market application potential.

The invention provides a formula of sleep-aiding essential oil containing cedar himalaya, relates to the technical field of sleep-aiding essential oil, and aims to solve the problems of single effect, poor stability and insufficient skin tolerance of existing sleep-aiding essential oil. The formula comprises the following components in parts by weight: 0.5-5 parts of Himalaya cedar essential oil, 80-95 parts of base oil, 1-10 parts of synergistic sleep-aiding essential oil, at least one of lavender essential oil, chamomile essential oil and sandalwood essential oil, and 0.1-1 part of optional antioxidant. During preparation, the components are ensured to be uniform through a process of stirring at a constant temperature of 25-35 DEG C and mixing at a rotating speed of 200-300rpm, the pH value of the product is 5.5-7.0, the retention rate of the active components is greater than or equal to 90% after the product is stored in a dark place at 25 DEG C for 6 months, and the use mode is that the product is smeared on wrists / necks / soles 1-2 hours before sleep, and 0.5-2mL of the product is smeared on each time. Tests show that the sleep time of insomnia people can be shortened to 15-22 min after the essential oil is continuously used for 28 days, the PSQI score is reduced by 40%-54%, the skin irritation is zero, the essential oil is suitable for preparing external sleep-aiding essential oil cream, ball bottles and other products, and a safe and efficient solution is provided for sleep disorder people.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention relates to the technical field of cosmetics, in particular to a composition with a blackhead removing effect and application of the composition in the cosmetics, mandelic acid and salicylic acid in the composition can permeate deep pores to dissolve grease and cutin so as to achieve the effect of reducing formation of blackheads, tea tree essential oil can remove bacteria and dirt in the pores, and therefore the blackhead removing effect is achieved. Antibacterial and anti-inflammation effects can be realized on the basis of removing blackheads, pricking pain caused by skin allergy can be relieved by adding carboxymethyl yeast glucan, and moisturizing effects can be realized; the herba portulacae extract has the effects of resisting inflammation, resisting allergy and enhancing the skin immune function, when the herba portulacae extract is used in the composition with the blackhead removing effect, the effect of accelerating skin recovery can be achieved, and the D-panthenol has the effect of rapidly permeating into the skin cuticle and can stimulate the growth of epidermal cells so as to accelerate skin barrier repair after blackhead removing. And the chitosan-based gel is combined, so that the probability that the skin is irritated and allergic can be reduced.

The invention discloses an oil-in-water type sunscreen product and a preparation method thereof, and belongs to the technical field of cosmetics. The oil-in-water type sunscreen product is prepared from the following components in parts by weight: 0.01 to 1 part of thickening agent and 0.01 to 5 parts of dispersion stabilizer, wherein the thickening agent comprises carbomer, an acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer and a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer; the dispersion stabilizer is prepared from disteardimonium hectorite and polyhydroxystearic acid. The oil-in-water type sunscreen product has the advantages of good sunscreen effect, good stability, small skin irritation, fresh and cool skin feeling and good conformity. The preparation method comprises the step of mixing the preparation raw materials of the oil-in-water type sunscreen product according to a preset ratio, and the method is simple, easy to operate and suitable for industrial production.

The invention discloses a mild oil-purifying acne-removing cleaning composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The cleaning composition is prepared from the following components in parts by weight: 15 to 35 parts of water / potassium cocoyl glycinate, 10 to 30 parts of water / potassium cocoate, 1 to 10 parts of water / potassium palmitate, 0.1 to 5 parts of water / sodium PEG-7 (Polyethylene Glycol) olive oil carboxylate, 0.1 to 10 parts of water / glycolipid and 0.01 to 1 part of water / glycosylglycerol / 1, 2-pentanediol. According to the cleaning composition disclosed by the invention, all the components are matched according to a specific proportion, so that the cleaning composition has mild and efficient oil-purifying and acne-removing effects. Various surfactants such as potassium cocoyl glycinate and the like have a synergistic effect, so that the skin irritation is reduced while the cleaning power is ensured; special functional components such as glycolipid further optimize the cleaning, moisturizing and acne removing effects. The preparation method comprises the following steps: firstly, mixing part of the components, heating to 70-90 DEG C, uniformly stirring, cooling to 40-45 DEG C, adding the rest of the components, and cooling to 30-35 DEG C to obtain a final product with the pH value of 7-8.5. The composition can be widely applied to various cleaning products such as facial cleanser, scrub cream, shower gel and the like, provides an innovative solution for the field of skin cleaning and nursing, meets the requirements of consumers on mild and effective oil-purifying and acne-removing cleaning products, and has a wide market application prospect.

The invention discloses a hydrogel patch for promoting blood circulation to remove meridian obstruction and a preparation method thereof. The formula of the hydrogel patch for promoting blood circulation to remove meridian obstruction comprises a traditional Chinese medicine concentrated solution for promoting blood circulation to remove meridian obstruction, an oil-in-water emulsion for promoting blood circulation to remove meridian obstruction, sodium polyacrylate, polyacrylic acid, glycerol, azone, dihydroxyaluminum aminoacetate, tartaric acid, disodium ethylene diamine tetraacetate, methylparaben and deionized water. The traditional Chinese medicine concentrated solution for promoting blood circulation to remove meridian obstruction is 70% ethanol extract of vinegar-processed rhizoma corydalis, ligusticum wallichii, philippine flemingia root, safflower, frankincense, myrrh, radix angelicae and liquorice; the oil-in-water emulsion capable of promoting blood circulation to remove meridian obstruction is prepared from a vinegar rhizoma corydalis sesame oil extract, wintergreen oil, methyl glucose sesquistearate, stearate, cetostearyl alcohol, polydimethylsiloxane and deionized water; the blood-activating collateral-dredging hydrogel patch has no skin irritation, belongs to weak sensitization, and has the function of assisting in relieving pain.

The invention belongs to the technical field of textile fabrics, and discloses an intelligent temperature-adjusting phase change microcapsule and a preparation method of a fabric thereof. The phase change microcapsule is prepared from the following components in percentage by mass: 60 to 80 percent of organic phase change material, 6 to 15 percent of N-isopropylacrylamide, 4 to 10 percent of acrylic acid, 1 to 5 percent of polyether surfactant, 2 to 5 percent of urethane acrylate and 2 to 5 percent of initiator. Warp yarn, first weft yarn and second weft yarn containing the microcapsules are woven into the intelligent temperature-adjusting phase-change fiber fabric, the response speed of the phase-change microcapsules is increased through the thermosensitivity of the organic phase-change materials, temperature can be buffered and adjusted in a wide temperature range, the organic phase-change materials cooperate with the temperature-sensitive polymer capsule wall, heat release, warm keeping, ventilation and moisture removal are achieved, and the intelligent temperature-adjusting phase-change fiber fabric is obtained. Inlet of hot air is reduced through heat absorption and cooling, climate and air temperature adjustment is self-adapted, and somatosensory comfort is maintained. In addition, no components irritating to the skin are added in the formula, so that adverse reactions such as sensitization and the like on consumers are avoided.

Improved personal protective equipment facial wear including, in one embodiment, an at least partly adhesive mask, and one or more adhesive eye shields. In one implementation, the mask avoids significant contact with the delicate periorbital skin of the wearer, yet provides a substantially airtight seal so as to preclude moisture vapor transfer and “fogging” of eyeware or instruments. In another implementation, adherence of the eye shield is at least partially overlapping with the mask and creates an at least partial seal around a perimeter of the eye shield. Further, an at least partial seal is formed around a perimeter of the mask. The mask and eye shield additionally prevent nasal air flow obstruction, and address the problem of skin irritation and attachment during normal facial expression and movement of the wearer.

A retinol derivative or a salt thereof, as well as a preparation method therefor and the use thereof. The retinol derivative or the salt thereof retains the anti-aging effect of retinol and reduces the side effects skin irritation and allergy thereof. In addition, the retinol derivative or the salt thereof further has the effects of whitening, resisting light-induced injury, resisting inflammation, resisting oxidation, repairing and the like, and thus has good application prospects in the field of cosmetic raw materials.

The present application discloses a plant extract antibacterial soothing wet wipes liquid, a preparation method thereof and the wet wipes obtained, and belongs to the field of plant extract products. A plant extract antibacterial soothing wet wipes liquid, comprising the following raw materials in weight percentage: 0.1%~5% camellia alcohol extract; 0.005%~0.05% camellia essential oil; 0.05%~10.1% plant extract composition; 1.0%~3.0% skin care moisturizer; 0.03%~0.1% pH adjuster; 0.05%~0.5% biological antibacterial agent; 0~0.8% preservative; 0~0.5% antioxidant; the balance is water; the ingredients of the plant extract composition include one or more of Cnidium monnieri extract, Sophora flavescens extract, Stemona extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract. The wet wipes liquid of the present application has the effect of antibacterial, reducing skin irritation and maintaining long-term stability.

The invention discloses a preparation method of a black drill truffle oil composition and application of the black drill truffle oil composition in cosmetics. The composition comprises the following components in percentage by mass: 6-10% of perigord truffle oil, 18-25% of decolorized sea buckthorn fruit oil, 15-20% of sunflower seed oil and the balance of meadowfoam seed oil. The perigord truffle oil is obtained by adopting CO2 supercritical extraction to extract perigord truffle sporocarp. The composition has multiple excellent effects of resisting oxidation, resisting aging, preserving moisture, repairing skin barrier and the like. In-vitro DPPH free radical scavenging experiments and human body efficacy tests prove that the product has extremely remarkable effects in the aspects of increasing the skin moisture content, reducing transdermal moisture loss and the like, is free of skin irritation and untoward effects, is suitable for cosmetics, is particularly suitable for high-end skin care product formulas such as eye essence, facial essence and skin care oil, and has a very good application prospect. The anti-aging, repairing and moisturizing properties of the product can be obviously improved.

The acne-removing skin-care conditioning oil is prepared from the following components in parts by weight: 90 to 95 parts of sweet almond oil, 0.5 to 1.5 parts of ginger root oil, 0.5 to 1.5 parts of peppermint oil, 1.5 to 2.5 parts of lemon peel oil, 1 to 1.5 parts of eucalyptus globulus leaf oil and 2 to 3 parts of lemongrass leaf oil. The invention also discloses a preparation method of the acne-removing skin-care conditioning oil. The acne-removing skin-care conditioning oil disclosed by the invention is small in skin irritation, wide in universality and few in allergic phenomenon, and can also achieve the effects of repairing and skin care while removing acnes.

The invention relates to the field of cosmetics, in particular to a blue copper peptide composition with instantaneous cool feeling and infiltration promotion effects and a preparation method and application of the blue copper peptide composition. The composition comprises an active component copper-blue peptide and a cooling and permeation enhancing system formed by compounding at least two of menthane formylethylamine, menthone glyceryl ketal and methyl diisopropyl propionamide, and the active component can further comprise hexapeptide-11, a blue algae extract and a yeast fermentation product. The preparation method of the composition comprises three core steps of providing a water phase, adding the active ingredients and adding the cool and refreshing infiltration promoting system and other components. Through synergistic compounding of specific fresheners, on the premise that the use amount of each single component is remarkably reduced, efficient permeation promotion of the copper-blue peptide is achieved, the layered cool feeling experience which takes effect quickly and is lasting and mild is provided, the common skin irritation problem of a traditional permeation promoter or a high-concentration single freshener is avoided, and the effect is remarkable. And the transdermal patch has excellent transdermal efficiency, active matter stability and use comfort.

The invention relates to a medicine for promoting skin injury repair and healing and a preparation method thereof, and belongs to the technical field of biological medicines.The medicine is prepared from a radix astragali preparata extract, lipidosome encapsulated panax notoginseng total saponin-RGD peptide, a honeysuckle flower-maca extract, an asiaticoside-hydroxypropyl-beta-cyclodextrin inclusion compound and dipotassium glycyrrhizinate; the radix astragali preparata extract is a product obtained by moistening radix astragali with honey, baking, extracting with deionized water, and adsorbing and purifying with a Sephadex G-15 column; the honeysuckle-maca extract is a product obtained by mixing dry honeysuckle powder and dry maca root powder according to the mass ratio of (3-5): (1-1.7), performing enzymolysis through cellulase, then performing common enzymolysis through ficin protease and papain, and performing adsorption and purification through an HPD722 macroporous adsorption resin column. All the components are compatible according to a specific proportion, so that the allergy and skin irritation risks are reduced, skin injury healing is reasonably promoted, and melanin deposition is effectively inhibited.