90 results about "Skin irritation" patented technology

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

The present application relates to a cosmetic composition, and more particularly, to a cosmetic composition comprising an amino acid-amino acid eutectic mixture and Troxerutin as an effective ingredient, thereby providing an effect of inhibiting inflammation and relieving / reducing skin irritation.

The article relating to this design is a nasogastric tube fixing device for guiding a nasogastric tube inserted into the nostril to the side of the patient's face and holding it in place. As shown in Reference Figure 3, which illustrates the state of use, the nasogastric tube is fitted into fixing grooves extending from the center of the main body in the left and right directions, and the ends of the main body are attached to the cheek area with fixing tape, so that the nasogastric tube is held in a state that makes it difficult to come off. Also, as shown in Reference Figures 2 and 3, which illustrate the state of use, elongated holes are formed at both ends of the main body, which also serve as retainers, and the device can also be used in a form in which a separate band is connected to these elongated holes and attached around the head. When using the band, it can be fixed without using fixing tape alone, and the device is designed to be easy to use with consideration for skin irritation, and it can also be used to hold the tube securely even when adhesion is difficult due to the shape of the area under the nose, such as when there is a beard or when there are no front teeth.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

The application discloses a sunscreen composition based on the ultraviolet absorption characteristics of yellow water of liquor, and a preparation method and application thereof. The sunscreen composition comprises 10-60 parts by weight of a yellow water extract of a strong-flavor liquor, 20-70 parts by weight of a yellow water extract of a Maotai-flavor liquor, and 0-40 parts by weight of a yellow water extract of a light-flavor liquor. It is found that the yellow water of different flavor liquors has characteristic ultraviolet absorption spectrum, wherein the yellow water of the strong-flavor liquor has strong absorption in the UVB band (290-320 nm), the yellow water of the Maotai-flavor liquor has strong absorption in the UVA band (340-380 nm), and the yellow water of the light-flavor liquor has relatively uniform absorption in a wide band. According to the spectral complementarity, the natural sunscreen composition is obtained. The sunscreen composition has an in-vitro SPF value of 15-35, a PA value of ++~++++, good light stability and low skin irritation.

This application relates to the field of webbing, and discloses a silk webbing. A silk webbing is woven and heat-set from a blended yarn containing silk fibers. The blended yarn is made from 55-60 wt% pretreated silk fibers, 18-23 wt% spandex fibers, and 19-24 wt% nylon fibers. The pretreated silk fibers are obtained by sequentially soaking, enzymatically hydrolyzing, fluffing, and drying the silk fibers. This application, through pretreatment of the silk fibers, produces a silk webbing with good breathability, softness, and shape retention. When used in underwear shoulder straps, it is less prone to deformation and shrinkage after long-term wear and washing, and it is less likely to cause sweating and skin irritation, thus improving comfort in contact with the skin.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The present application relates to the technical field of external use patch, disclose a kind of neck shoulder waist leg pain health care patch and its preparation method, the health care patch includes backing layer, ointment layer and anti-adhesion release layer;Ointment layer raw material includes: traditional Chinese medicine extract flow leaching paste, L- (+) -tartaric acid, PVP K30, PEG-400, ternary eutectic solvent, polyacrylate pressure sensitive adhesive matrix and ultrafine medicinal powder.Preparation, after flow leaching paste, tartaric acid etc. are mixed, gel precursor is formed by vacuum dewatering and dealcoholization, swelling is added again with eutectic solvent, and then mixed with pressure sensitive adhesive matrix and medicinal powder high shear, finally coating solidification.The present application constructs physical crosslinking gel network in colloid interior and promotes effective component acid-base salt formation, effectively avoids polar component crystallization precipitation, reduces the skin irritation caused by drug burst release, simultaneously improves the cohesion of ointment, realizes long-acting smooth drug release.

The utility model discloses a kind of anti-infiltration devices for abdominal cavity drainage tube, it is related to medical auxiliary appliance technical field, when using conventional drainage tube, because the suture gap exists between the smaller drainage tube diameter and abdominal wall puncture hole, postoperative ascites is easily leaked outside through the gap inserted by drainage tube, increase the risk of infection and off pipe, and wound exudate is alkaline, continuous skin irritation aggravates patient's pain, delay healing time, increase patient's medical cost.The utility model provides a kind of anti-infiltration device for abdominal cavity drainage tube, including drainage tube, annular groove is arranged on the drainage tube, negative pressure disc is arranged on the annular groove, the negative pressure disc is slidably connected with drainage tube, expansion air bag capable of extruding negative pressure disc is also arranged on the annular groove, fixed air bag is also arranged on the drainage tube, the fixed air bag is arranged at one side of annular groove, and expansion air bag is respectively arranged at both sides of negative pressure disc, can avoid drainage tube off pipe, avoid exudate leakage.

This invention provides an internal fixation device for cancellous bone, belonging to the field of medical device technology. It includes a fixation plate with a plurality of screw holes and positioning holes arranged in a linear array on its top outer wall; and a guide assembly connected to the fixation plate, used to guide the hollow self-drilling screws. By incorporating the guide assembly, this invention not only guides the hollow self-drilling screws, preventing them from deviating from their pre-operatively assessed position during insertion, thus affecting their fixation effect on the fracture site, but also holds the screws during the guiding process, preventing the screw head from tilting and protruding, which could cause skin irritation and affect postoperative recovery.

The application discloses a compound morinda officinalis color-increasing liniment for treating vitiligo and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, wherein the liniment is prepared from morinda officinalis, spilanthes acmella, giant knotweed, caesalpinia sappan, psoralea corylifolia, radix angelicae dahuricae and rhizoma smilacis glabrae as raw medicinal materials. The preparation method comprises the following steps: dynamic reflux extraction, percolation extraction, macroporous adsorption resin purification and preparation molding. Through the classification extraction and purification process, the photosensitive active ingredients are retained, and the photo-toxic impurities are effectively removed, so that the photo-toxicity is completely negative. The pharmacodynamic test shows that the liniment has a significant curative effect on vitiligo. The safety test shows that the liniment has no skin irritation and no allergenicity, and has excellent light safety. The quality research shows that the quality of the liniment is stable and controllable. The liniment has definite curative effect, high safety and stable quality, and has a good clinical application prospect.

An ostomy bag can include one or more sensors for measuring one or more metrics. An ostomy wafer can also include one or more sensors for measuring one or more metrics. The sensors can be temperature sensors and / or capacitive sensors, for example, and the metrics can include bag fill, leakage, skin irritation, and phase of stoma output, among others.

This application discloses a razor head assembly and a razor having the same. The razor head assembly includes a base, a razor head holder, and a floating mechanism. The base has an axis; the razor head holder is equipped with the razor assembly; the floating mechanism connects the base and the razor head holder, and allows the razor head holder to deflect relative to the axis under the action of an external force, and allows the razor head holder to return to its original position after the external force is removed. This application, through the floating mechanism, allows the razor head holder to deflect relative to the axis of the base during shaving, thereby maintaining a good fit between the razor assembly and the user's face; it also helps to tighten the facial skin, allowing the hair roots to be better exposed on the skin surface, improving shaving cleanliness, while also enhancing shaving comfort and experience, reducing pressure on the skin during shaving, and minimizing skin irritation; furthermore, the razor head holder can return to its initial position after the external force is removed for subsequent use.

This invention relates to the field of cosmetic technology, specifically disclosing a synergistic exfoliating composition and a method for preparing a controlled-release carrier containing the composition. The synergistic exfoliating composition is a compound of adenosine, N-acetylneuraminic acid, and lactobionic acid. This invention has the advantage of maintaining good exfoliating efficacy while reducing skin irritation.

Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and / or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

This invention belongs to the field of cosmetic technology, specifically relating to an anti-aging composition containing lactoferrin and its application. The anti-aging composition provided by this invention, through scientific compounding, achieves synergistic effects in anti-aging among four components: medicinal Fomitopsis thunbergii extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin. This results in excellent elastase inhibition, preventing the degradation of elastin in the dermis and effectively strengthening the elastin scaffold, thereby enhancing the anti-aging effect of the composition. When applied to a prepared emulsion, this anti-aging composition can improve skin firmness (R0 change rate), skin elasticity (R2 change rate), and facial wrinkles (wrinkle change rate), exhibiting anti-aging effects of improving wrinkle reduction and firmness, and promoting skin elasticity. Furthermore, it does not cause skin irritation, possessing safe and gentle characteristics, a wide range of applications, and high consumer acceptance.

This invention discloses a soothing and acne-reducing fermented composition and its application in cosmetics. The fermented composition comprises the following raw materials in parts by weight: 10-50 parts yeast / rice fermentation product filtrate; 1-10 parts lactobacillus fermentation lysate; and 0.01-0.05 parts Bacillus fermentation product. The advantages are that this invention combines yeast / rice fermentation product filtrate, lactobacillus fermentation lysate, and Bacillus fermentation product in a specific ratio to form a fermented composition. The three fermentation products exhibit synergistic effects in anti-inflammatory, soothing, and acne-reducing properties. Cosmetics containing this composition can regulate the skin's microecology while exerting multiple effects such as anti-inflammatory, soothing, and acne-reducing properties, thereby effectively improving acne-prone skin and reducing skin irritation and discomfort. This composition, derived from a fermentation system, is mild, safe, and can be formulated with conventional base materials in appropriate proportions to create various types of skin care products.

This invention provides a composition that inhibits the tyrosinase enzyme involved in melanin production and also inhibits the action of collagen-degrading enzymes, thereby promoting collagen synthesis and achieving sufficient effects of skin whitening and elasticity improvement without inducing skin irritation due to skin allergies. [Solution] A composition having skin whitening and skin elasticity improving effects, according to one embodiment of the present invention, contains ginger extract as an active ingredient, and the ginger extract can be extracted using methylene chloride.

The present application relates to a kind of high-efficiency targeted penetration supermolecular oil-tea camellia seed oil and its preparation method and application, the supermolecular oil-tea camellia seed oil is to use palmitoyl tripeptide-1 and the specific interaction of tea saponin in oil-tea camellia seed oil constructs hydrogen bond and π-π stacking double action ordered self-assembly supramolecular system, the supramolecular has water oil amphiphilic structure characteristics, can be spontaneously emulsified, realize targeted delivery and slow-release balance, simultaneously avoid the skin irritation problem caused by adding emulsifier;And based on the amphiphilic characteristics of supramolecular core structure, it can be used to simultaneously adapt oil-soluble, water-soluble skin care formulations, respectively adapt polar and non-polar functional components, break through the penetration limit problem of traditional single carrier, greatly widen the application scene of oil-tea camellia seed oil in cosmetic field.

The present utility model relates to a natural cooling powder primarily formulated with Yerba Buena (Clinopodium douglasii) extract, designed to provide soothing relief and skin refreshment in hot and humid environments. The powder addresses the demand for preservative-free, plant-based personal care products by offering an alternative to traditional talc-based formulations. It is composed of natural carriers including cornstarch, arrowroot powder, and tricalcium phosphate, blended with active ingredients such as Yerba Buena extract, peppermint (Mentha piperita L.) oil, and spearmint (Mentha spicata L.) fragrance oil. Free from synthetic additives, the product is ideal for individuals prone to sweat and skin irritation, such as athletes, outdoor workers, and commuters. The utility model provides a sustainable, nongreasy, and skin-safe alternative that enhances comfort while promoting wellness through natural ingredients.

The present utility model relates to method for producing a natural herbal bath soap utilizes a controlled oil-infusion and botanical integration process. The method comprises extracting a bio-active essence from oregano (Origanum vulgare) leaves into a carrier oil to form an infused oil, melting a soap base, and sequentially blending the oregano-infused oil with oatmeal and additives prior to solidifying the mixture in a mold. By employing controlled thermal infusion and sequential blending, this method prevents botanical degradation, uneven particle distribution, and skin irritation, yielding a stable, moisturizing bath soap free from synthetic additives.

This invention discloses a skin-friendly, hypoallergenic composite functional fiber, its preparation method, and its applications, relating to the field of functional textile materials technology. This invention utilizes transglutaminase (TG enzyme) to catalyze the formation of transamide covalent complex macromolecules from chitosan and gelatin, collagen, or collagen hydrolysates. These macromolecules are then blended with spinning dosing and introduced in situ into the fiber matrix through a spinning process. This ensures the functional components are uniformly distributed across the fiber cross-section and surface, forming a continuous, stable, and biocompatible skin-friendly protective film on the fiber surface. Through application, structural, and process innovations, this invention solves the problems of poor wash resistance, easy functional loss, and skin irritation in traditional hypoallergenic textiles. The resulting fiber exhibits long-lasting allergen adsorption, hypoallergenic skin-friendliness, antibacterial and soothing properties, and high wash resistance, making it suitable for intimate apparel, baby products, home textiles, and medical protective textiles.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

The application provides a long-acting hydrogen slow-release sanitary napkin and a preparation method thereof, and relates to the technical field of sanitary products. The long-acting hydrogen slow-release sanitary napkin comprises a skin-friendly surface layer, a long-acting hydrogen slow-release functional layer, a flow guide layer, an absorbent core, an anti-seepage bottom film, a back adhesive layer and release paper, and the skin-friendly surface layer, the long-acting hydrogen slow-release functional layer, the flow guide layer, the absorbent core, the anti-seepage bottom film, the back adhesive layer and the release paper are sequentially stacked from top to bottom. The long-acting hydrogen slow-release functional layer is composed of a flexible carrier substrate loaded with long-acting hydrogen slow-release microcapsules. The application solves the problems of existing hydrogen functional sanitary products, such as easy hydrogen escape, poor storage stability, short slow-release time, uncontrollable hydrogen production, strong skin irritation and unreasonable structure design, while guaranteeing the biological safety of the product. On the premise of not affecting the basic absorption and anti-seepage performance of the sanitary napkin, the product is endowed with excellent antioxidant, anti-inflammatory, antibacterial and pain relief effects.

The application belongs to the technical field of bioengineering, and relates to a marine-derived antibacterial peptide FP2606 and a use of the marine-derived antibacterial peptide FP2606 in preparation of a skin antibacterial drug. Streptomyces globisporus The application also provides a DNA molecule encoding the antibacterial peptide, a recombinant expression vector and an engineering strain, and realizes high-efficiency heterologous expression of the FP2606 in vitro. Experimental verification shows that the antibacterial peptide FP2606 has strong bacteriostatic activity on common pathogenic bacteria causing skin infection of children, has extremely high biological safety, has no hemolytic activity, no skin cell toxicity and no skin irritation, perfectly adapts to the physiological characteristics of the tender skin of children, and can be widely applied to preparation of a skin external antibacterial preparation for children, a skin infection prevention and treatment drug for children and a skin barrier care product for children.

This invention belongs to the field of pharmaceutical formulation technology, specifically disclosing a gastrodin transdermal patch and its preparation method. The patch consists of a backing layer, a drug-containing matrix layer, and an anti-adhesive layer, using gastrodin as the active ingredient. It employs HP-β-CD inclusion technology, combined with an HPMC and PVP polymer backbone and an oleic acid-menthol composite transdermal enhancement system. The preparation utilizes solvent casting and low-temperature vacuum drying processes, which are mild and controllable. This invention effectively solves the problems of difficult transdermal absorption, easy recrystallization, and low bioavailability of gastrodin. The resulting patch has excellent adhesion, no skin irritation, high transdermal penetration, and good skin biocompatibility. It can efficiently cross the blood-brain barrier, regulate the neuroinflammatory microenvironment in the brain, significantly inhibit the colonization and progression of non-small cell lung cancer brain metastases, and strongly reverse tumor-related anxiety and depression-like mood disorders. It provides a novel drug delivery regimen with great clinical translational potential for the non-invasive synergistic treatment of brain tumors and their associated mood disorders.

The present invention provides a disinfectant composition that is excellent in suppressing skin irritation and has a good effect in inactivating non-enveloped viruses, an article impregnated with the disinfectant composition, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition. [Solution] A disinfectant composition containing (A) 40% to 95% by mass of ethanol, (B) 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts, and (C) 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol, with a pH of 5.0 or less at 25°C.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for controlling obesity. The traditional Chinese medicine composition comprises Pueraria pedunculata, Lantana camara, Curcuma longa, Curcuma wenyujin, Curcuma roxburghii, Angelica sinensis, Boswellia carterii, Commiphora myrrha, Semen Persicae, Radix Polygoni multiflori and Rubus corchorifolius. The traditional Chinese medicine composition can effectively regulate blood fat by external use, thereby achieving the effects of improving obesity-related metabolic disorders and controlling obesity. In addition, the traditional Chinese medicine composition has no skin irritation when used externally, and has no acute toxicity at a dosage much higher than a clinical dosage, and is safe and reliable to use, and has a wide application prospect in controlling obesity.

This application relates to the field of air purification technology, specifically to a biomedical-based odor-removing and antibacterial air freshener, mainly composed of the following raw materials in parts by weight: 2.5-5.5 parts modified lysozyme microcapsules, 2.5-4.5 parts modified quaternary ammonium salt-β-cyclodextrin inclusion complex, 1.5-2.5 parts plasma amine oxidase, 2.0-3.5 parts compound plant extract, 0.2-0.3 parts citric acid, 0.5-0.6 parts lactic acid, and the balance being food-grade deionized water; the air freshener has a pH value of 6.0-8.5. The mist particle size is 10-50μm; the air freshener does not contain fragrances, alcohol, pigments, preservatives, chlorine disinfectants, hypochlorous acid, drugs, hormones and other irritating ingredients. All raw materials and modified carriers are food-grade and edible. Through a triple deodorization system of plasma amine oxidase, β-cyclodextrin and compound plant extracts, the ammonia removal rate is ≥95%, the odor suppression time is ≥100h, the product has a skin irritation level of 0, and the acute oral toxicity LD50 is >5000mg / kg, achieving a balance between mild and non-irritating properties and highly effective sterilization.