310 results about "Skin irritation" patented technology

An adaptive medical access garment comprising a torso portion configured to cover at least a portion of a wearer's upper body and two sleeve portions extending from the torso portion. Each sleeve portion includes an extended two-way zipper extending continuously from a distal end of the sleeve to the torso portion, terminating proximate to the wearer's clavicle or chest. The garment is constructed from hypoallergenic, breathable fabric to ensure patient comfort and minimize skin irritation risk. The extended two-way zippers enable medical professionals to access the wearer's arms and upper body without requiring garment removal. The garment may further comprise thumb holes at the sleeve distal ends, pockets for holding medical devices, and side slits on the torso portion for accessing the wearer's sides. The invention encompasses a method for providing the adaptive medical garment.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention provides a formula of sleep-aiding essential oil containing cedar himalaya, relates to the technical field of sleep-aiding essential oil, and aims to solve the problems of single effect, poor stability and insufficient skin tolerance of existing sleep-aiding essential oil. The formula comprises the following components in parts by weight: 0.5-5 parts of Himalaya cedar essential oil, 80-95 parts of base oil, 1-10 parts of synergistic sleep-aiding essential oil, at least one of lavender essential oil, chamomile essential oil and sandalwood essential oil, and 0.1-1 part of optional antioxidant. During preparation, the components are ensured to be uniform through a process of stirring at a constant temperature of 25-35 DEG C and mixing at a rotating speed of 200-300rpm, the pH value of the product is 5.5-7.0, the retention rate of the active components is greater than or equal to 90% after the product is stored in a dark place at 25 DEG C for 6 months, and the use mode is that the product is smeared on wrists / necks / soles 1-2 hours before sleep, and 0.5-2mL of the product is smeared on each time. Tests show that the sleep time of insomnia people can be shortened to 15-22 min after the essential oil is continuously used for 28 days, the PSQI score is reduced by 40%-54%, the skin irritation is zero, the essential oil is suitable for preparing external sleep-aiding essential oil cream, ball bottles and other products, and a safe and efficient solution is provided for sleep disorder people.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention belongs to the field of daily chemical products, and particularly relates to sulfate-free silicone-oil-free solid shampoo soap and a preparation method thereof. The solid shampoo soap comprises sodium cocoyl isethionate, sodium methyl cocoyl taurate and / or cocamidopropyl betaine, cetostearyl alcohol, behentrimethylammonium chloride, guar hydroxypropyltrimethylammonium chloride, quaternary ammonium salt-80, glycol distearate, synthetic grease, natural grease, glycerin, a humectant, a plant extract, a chelating agent and a preservative. A pH regulator, essence and pigment; the solid shampoo soap provided by the invention adopts mild and non-irritant components, avoids irritation of sulfate surfactants to skin, can effectively reduce the problems of dry skin, allergy and the like, and provides healthier and more comfortable cleaning experience for consumers due to the fact that no silicone oil is used for reducing blocking of hair follicles.

The present invention relates to a composition for improving skin, which comprises beta-sitosterol and betulin and, in the case of the composition, reduces dermatoneuropathic stimulation-inducing factors, increases the expression of moisturizing-related factors, increases skin absorbance, improves skin penetration, inhibits mast cell activity, and improves skin quality. Thus, it has been confirmed that the composition has excellent skin-calming and skin-irritation-relieving effects, and thus can be usefully used in skin-improving cosmetics, pharmaceuticals, and the like.

The present application relates to the field of external ointment preparation, and provides a zinc gluconate ointment and a preparation method thereof.The ointment comprises, by mass fraction: 0.3-2.0 parts of zinc gluconate, 0.05-1.5 parts of L-histidine, 0.05-1.0 parts of polysaccharide, and the balance of purified water, wherein the polysaccharide is chitosan oligosaccharide or hyaluronic acid oligomer.The zinc gluconate, L-histidine and polysaccharide are dispersed to form hydrogel microdroplets under the condition of pH 5.0-6.0, and are further dispersed in the continuous phase of the oil phase.By establishing a complex system in a weak acid environment and using a double constraint structure of microdroplet dispersion and oil phase, the free Zn 2+ The initial release rate is reduced, skin irritation caused by the initial release of traditional preparations is avoided, and a high 24-hour cumulative release amount is maintained.The ointment exhibits excellent physical stability and particle size uniformity during storage, avoids oil-water layering and crystallization, and has both sustained release and good use feeling.

The invention belongs to the technical field of cardio-cerebral oil preparation, and provides cardio-cerebral oil and a preparation method thereof. The invention aims to solve the technical problems that kapur is easy to volatilize and short in efficacy, and skin irritation is easily caused by high-concentration addition. The preparation method comprises the following steps: firstly, wrapping menthol in a molecular cavity of beta-cyclodextrin through a molecular inclusion technology to prepare a molecular capsule capable of effectively delaying volatilization and reducing irritation; secondly, preparing a bionic repair emulsion from various bionic lipids such as ceramide, cholesterol and fatty acid through an emulsification process, and taking the bionic repair emulsion as a core delivery carrier; meanwhile, components such as vanillyl derivatives are compounded to prepare a temperature-sensitive compound; the preparation method comprises the following steps: uniformly dispersing independent kapur, the molecular capsule and the temperature-sensitive compound into the bionic repair emulsion, and curing to obtain a finished product. Through molecular inclusion and the bionic repair emulsion, long-acting release of the effect of the kapur is realized, and the skin irritation of the product is reduced.

The invention provides a corn stigma extract-containing mask mud with repairing, anti-wrinkle and freckle-removing effects and a preparation method thereof, and relates to the technical field of cosmetics. The mask mud is prepared from the following raw materials: corn stigma extract, guava fruit extract, white willow bark extract, tamarix chinensis flower extract, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and auxiliary materials. The corn stigma extract is taken as a main raw material, and the three natural extracts, namely the guava fruit extract, the white willow bark extract and the tamarix chinensis flower extract, are compounded according to a specific proportion, so that multiple effects of resisting wrinkles, removing acnes, whitening, resisting allergy, repairing, removing freckles, tightening, moisturizing, soothing and the like are realized at the same time, and the effect of the corn stigma extract is remarkably improved; sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium is used as a surfactant, so that the lotion is milder and more moisturizing, no preservative is added, and damages such as skin irritation, allergy, red and swollen skin, cuticle damage and dry skin are reduced.

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

The invention relates to the technical field of health preserving articles, and discloses a wearable ornament based on a purple sand material and a preparation method thereof.The wearable ornament based on the purple sand material is obtained by soaking 20-30 parts by weight of porous purple sand bracelet in 40-60 parts by weight of a medicament for 20-25 min. The sand bracelet does not need a built-in medicine bag, keeps attractive appearance, does not need to be in direct contact with medicines when being worn, avoids skin irritation, and realizes perfect combination of a health preserving function and fashion ornaments; the purple sand material is environment-friendly and harmless and can be used for a long time, so that resource waste of disposable health-preserving products is reduced, and the traditional Chinese medicine formula adopts natural components and has small influence on the environment.

The invention provides a posaconazole ethosome and a preparation method thereof, posaconazole is encapsulated in ethosome, and the posaconazole ethosome is composed of the following components by weight: 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, and the balance of ethanol. 1-8% of phospholipid; 0%-0.5% of cholesterol; 20%-45% of ethanol; 0-0.1% of an antioxidant; 0%-0.5% of a nonionic surfactant; and 40.9 to 78.9 percent of water. The invention has the characteristics of high encapsulation efficiency, uniform particle size distribution and no irritation to skin. And the ethosome can load both water-soluble drugs and fat-soluble drugs, and has the advantages of simple composition, high encapsulation efficiency, uniform particle size distribution, no skin irritation, simple preparation and the like.

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.

The present application relates to a cosmetic composition, and more particularly, to a cosmetic composition comprising an amino acid-amino acid eutectic mixture and Troxerutin as an effective ingredient, thereby providing an effect of inhibiting inflammation and relieving / reducing skin irritation.

The article relating to this design is a nasogastric tube fixing device for guiding a nasogastric tube inserted into the nostril to the side of the patient's face and holding it in place. As shown in Reference Figure 3, which illustrates the state of use, the nasogastric tube is fitted into fixing grooves extending from the center of the main body in the left and right directions, and the ends of the main body are attached to the cheek area with fixing tape, so that the nasogastric tube is held in a state that makes it difficult to come off. Also, as shown in Reference Figures 2 and 3, which illustrate the state of use, elongated holes are formed at both ends of the main body, which also serve as retainers, and the device can also be used in a form in which a separate band is connected to these elongated holes and attached around the head. When using the band, it can be fixed without using fixing tape alone, and the device is designed to be easy to use with consideration for skin irritation, and it can also be used to hold the tube securely even when adhesion is difficult due to the shape of the area under the nose, such as when there is a beard or when there are no front teeth.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

The application discloses a sunscreen composition based on the ultraviolet absorption characteristics of yellow water of liquor, and a preparation method and application thereof. The sunscreen composition comprises 10-60 parts by weight of a yellow water extract of a strong-flavor liquor, 20-70 parts by weight of a yellow water extract of a Maotai-flavor liquor, and 0-40 parts by weight of a yellow water extract of a light-flavor liquor. It is found that the yellow water of different flavor liquors has characteristic ultraviolet absorption spectrum, wherein the yellow water of the strong-flavor liquor has strong absorption in the UVB band (290-320 nm), the yellow water of the Maotai-flavor liquor has strong absorption in the UVA band (340-380 nm), and the yellow water of the light-flavor liquor has relatively uniform absorption in a wide band. According to the spectral complementarity, the natural sunscreen composition is obtained. The sunscreen composition has an in-vitro SPF value of 15-35, a PA value of ++~++++, good light stability and low skin irritation.

The invention discloses a lower limb traction massage device for assisting knee joint stiffness treatment. The lower limb traction massage device comprises a main supporting plate, a traction supporting plate, a massage assembly installed on the traction supporting plate, an application mechanism in a leg limiting sleeve and a telescopic pipe connected with a steam heating mechanism and the application mechanism. The supporting plate is provided with a supporting table with a steam heating mechanism; the traction supporting plate is hinged to the main supporting plate, and the traction supporting plate is provided with a leg limiting sleeve and a traction assembly. The massage assembly is used for massage, and the atrophy phenomenon caused by knee joint stiffness is effectively avoided; the traction assembly is matched with the traction supporting plate, so that muscles at knee joints are relaxed; the steam heating mechanism and the dressing mechanism are matched to perform constant-temperature application treatment on the knee joint, so that the application time is effectively shortened, and the problem of skin allergy of a patient due to long application time of the dressing is solved; the device replaces part of work of medical staff, the situation that the massage effect is affected by the skill degree can be avoided, and the labor intensity of the medical staff can be relieved.

The stomach tube fixing device with the adjusting function comprises an ear hanging piece of a semi-open surrounding structure, the shape and the size of the ear hanging piece are matched with those of an auricle, and the ear hanging piece comprises an auricle part and a bottom supporting part which are integrally formed. A fixing plate fixed to the bottom supporting part is arranged on the side, away from the ears of the patient, of the bottom supporting part, and the two ends of a U-shaped plastic bolt penetrate through the fixing plate and are fixed to the bottom supporting part, so that the fixing plate and the plastic bolt form a fixing space for fixing a stomach tube. The design of the semi-open ear hanging piece matched with the auricle is adopted, stability and comfort are guaranteed, skin irritation is relieved, the comfort degree of a patient is improved, operation of medical staff is facilitated, in addition, the fixing plate is matched with the plastic bolt, the adjustable fixing space is achieved, the requirements of various stomach tube models are met, and clinical popularization value is achieved.

The invention relates to the technical field of cotton fabric manufacturing, in particular to a charge transfer and transition bacteriostatic pure cotton non-woven fabric and a manufacturing method thereof.The manufacturing method includes the steps that raw cotton is degreased, opened and carded, base cloth is manufactured through a spunlace method, and the pretreated pure cotton non-woven fabric is obtained after drying and impurity removing; the preparation method comprises the following steps: soaking cotton fibers into a charge transfer transition reagent containing alizarin and waterborne polyurethane, accurately loading through a four-roller unit, and curing through 254nm-365nm ultraviolet light, so that the reagent and the cotton fibers form covalent bonds to realize charge transfer transition. An ultrathin polymer film layer is formed on the cloth cover of the product, million-level electron-hole pairs are contained, the initial bacteriostasis rate exceeds 99%, and a good bacteriostasis effect is still kept after the product is washed with water for 150 times. The antibacterial non-woven fabric adopts a natural antibacterial agent, is free of skin irritation and toxic residues, is environment-friendly in production process, has skin friendliness and mechanical strength, is suitable for medical and hygienic products such as surgical gown and medical dressing, and solves the problems of poor washability, potential safety hazards and the like of the traditional antibacterial non-woven fabric.

This application relates to the field of webbing, and discloses a silk webbing. A silk webbing is woven and heat-set from a blended yarn containing silk fibers. The blended yarn is made from 55-60 wt% pretreated silk fibers, 18-23 wt% spandex fibers, and 19-24 wt% nylon fibers. The pretreated silk fibers are obtained by sequentially soaking, enzymatically hydrolyzing, fluffing, and drying the silk fibers. This application, through pretreatment of the silk fibers, produces a silk webbing with good breathability, softness, and shape retention. When used in underwear shoulder straps, it is less prone to deformation and shrinkage after long-term wear and washing, and it is less likely to cause sweating and skin irritation, thus improving comfort in contact with the skin.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

The invention belongs to the technical field of biological medicine, and particularly relates to a formula and application of a microcrystal patch containing polysulfonic acid mucopolysaccharide. The microcrystal patch disclosed by the invention is prepared from the following components in percentage by mass: 96 to 97 percent of purified water, 0.6 percent of polyvinyl alcohol, 1 to 2 percent of sodium hyaluronate with the molecular weight of 50,000 to 10,000, 0.6 to 1 percent of sodium hyaluronate with the molecular weight of 400,000 to 800,000 and 1 to 2 percent of polysulfonic acid mucopolysaccharide. The result of the embodiment shows that the patch with weak mechanical property is adaptive to the part with weak cuticle and sensitive skin, and the patch with strong mechanical property is adaptive to the part with thick cuticle. Through the physical permeation promotion effect of microcrystals, polysulfonic acid mucopolysaccharide can be efficiently carried to penetrate through a skin barrier to directly reach a target part, and the medicine utilization rate is remarkably increased; the formula is simple in components, the skin irritation risk is reduced from the source, and the production cost is reduced.

This application relates to the field of antioxidant skincare products, specifically an astaxanthin essence with natural antioxidant effects and its preparation method. An astaxanthin essence with natural antioxidant effects comprises: an aqueous phase: 15%-30% natural plant extracts, 3%-8% moisturizers, 0.3%-1.5% thickeners, and preservatives; an oil phase: 5%-14% plant oils, 1%-4% lecithin, 0.5%-2% rosemary extract, and 0.3%-1.5% green tea extract; 0.8%-4% astaxanthin liposomes; gum arabic; a pH adjuster; and water; wherein the natural plant extracts include aloe vera juice and cucumber juice. This application aims to improve the stability and bioavailability of astaxanthin and enhance the antioxidant properties of the essence by using natural raw materials and innovative processes; while ensuring the product is natural and gentle, reducing skin irritation, and meeting consumers' demand for high-quality natural skincare products.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The invention provides a mild refreshing borneol essential oil compound as well as a preparation method and application thereof. The borneol essential oil compound is prepared from the following components in parts by weight: 1 to 50 parts of borneol, 0.1 to 50 parts of menthol, 1 to 10 parts of natural camphor, 0.1 to 0.5 part of herba dendrobii essential oil, 35 to 70 parts of carrier oil, 0.2 to 1 part of vitamin E, 1 to 3 parts of eudesmol, 0.2 to 1 part of limonene and 0.5 to 5 parts of cinnamomum camphora essential oil clathrate compound. The borneol essential oil compound prepared by the invention has the advantages of better stability, high essential oil retention rate, freshness and durability, mild components without skin irritation, and refreshing effect, and can be applied to preparation of products such as snorting essential oil, roll-on essential oil or vehicle-mounted fragrance and the like.

The present invention relates to skin adhesive formulations. The skin adhesive formulations of the present invention may be useful in wound-closing applications and other medical applications. Ideally the skin adhesive formulations of the present invention exhibit higher viscosity than known skin adhesive formulations. Ideally the skin adhesive formulations of the present invention cause fewer allergic reactions and skin irritation issues in patients relative to known skin adhesives. Ideally the skin adhesive formulations are UV curable in the visible range of 400-500nm rather than moisture cure.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The present application relates to the technical field of external use patch, disclose a kind of neck shoulder waist leg pain health care patch and its preparation method, the health care patch includes backing layer, ointment layer and anti-adhesion release layer;Ointment layer raw material includes: traditional Chinese medicine extract flow leaching paste, L- (+) -tartaric acid, PVP K30, PEG-400, ternary eutectic solvent, polyacrylate pressure sensitive adhesive matrix and ultrafine medicinal powder.Preparation, after flow leaching paste, tartaric acid etc. are mixed, gel precursor is formed by vacuum dewatering and dealcoholization, swelling is added again with eutectic solvent, and then mixed with pressure sensitive adhesive matrix and medicinal powder high shear, finally coating solidification.The present application constructs physical crosslinking gel network in colloid interior and promotes effective component acid-base salt formation, effectively avoids polar component crystallization precipitation, reduces the skin irritation caused by drug burst release, simultaneously improves the cohesion of ointment, realizes long-acting smooth drug release.