527 results about "Skin irritation" patented technology

The invention belongs to the technical field of biological simulation, and discloses an anus cleaning effect evaluation method and system.The method comprises the steps that an execution assembly is controlled to wipe an anus anatomical structure with a to-be-detected sample according to a target wiping strategy, and a multi-mode sensing assembly is controlled to collect target parameters on the anus anatomical structure; obtaining target monitoring data; according to the residual dirt amount in the target monitoring data, a cleaning efficiency score is obtained through calculation, a target mechanical simulation model is called, according to the humidity permeation gradient value and the pressure value in the target monitoring data and the to-be-detected sample, a skin stimulation risk score is obtained through calculation, and the skin stimulation risk score and the cleaning efficiency score form a cleaning effect evaluation report. Simulation and prediction of the anus cleaning process are achieved, the simulation test effect and accuracy are greatly improved, and a cleaning effect evaluation report is given to illustrate the safety of the to-be-tested sample.

The invention relates to application of a platelet reaction protein 4 in preparation of an alopecia medicine, and belongs to the field of medical biology. The invention aims to solve the technical problems of limited curative effect, obvious side effect and narrow application range of the existing alopecia treatment medicine. The invention provides an application of a platelet reaction protein 4 (THBS4) in preparation of an alopecia medicinal preparation, which can promote hair follicles to be converted from a resting period to a growing period by regulating and controlling a mechanical microenvironment around the hair follicles, enhancing the interaction between fibroblasts and hair follicle stem cells and activating regeneration signal channels in hair papilla and hair bud areas. The traditional Chinese medicine composition breaks through the limitation that existing treatment only aims at specific alopecia types, and can be widely applied to various alopecia diseases such as androgenetic alopecia, pressure alopecia and alopecia after chemotherapy. And compared with the traditional medicine, the traditional Chinese medicine composition has the advantages of quick response, no skin irritation reaction and improved hair follicle regeneration efficiency, and provides a brand new solution for safe and efficient treatment of alopecia.

An adaptive medical access garment comprising a torso portion configured to cover at least a portion of a wearer's upper body and two sleeve portions extending from the torso portion. Each sleeve portion includes an extended two-way zipper extending continuously from a distal end of the sleeve to the torso portion, terminating proximate to the wearer's clavicle or chest. The garment is constructed from hypoallergenic, breathable fabric to ensure patient comfort and minimize skin irritation risk. The extended two-way zippers enable medical professionals to access the wearer's arms and upper body without requiring garment removal. The garment may further comprise thumb holes at the sleeve distal ends, pockets for holding medical devices, and side slits on the torso portion for accessing the wearer's sides. The invention encompasses a method for providing the adaptive medical garment.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention relates to a phytoextraction external liniment for promoting black hair growth and a preparation method thereof. According to the liniment, a polygonum multiflorum extract, a cacumen biotae supercritical extract and molecular embedded black sesamin in a specific proportion are taken as cores and are matched with an azone-menthol transdermal enhancer and a propylene glycol-olive oil carrier, and black hair growth is synergistically promoted through triple mechanisms of activating tyrosinase, inhibiting melanocyte apoptosis and promoting cell migration. The preparation method adopts a gradient temperature extraction combined molecular embedding technology, the polygonum multiflorum is subjected to stepped purification at 40-60 DEG C-80 DEG C to retain thermosensitive active ingredients, the black sesamin is embedded by beta-cyclodextrin to improve the stability, and finally, the nano microemulsion is formed through two-stage homogeneous emulsification. The liniment can efficiently permeate into the deep layer of hair follicles, the efficiency of turning white hair into black is remarkably improved, and skin irritation is avoided.

The invention provides a formula of sleep-aiding essential oil containing cedar himalaya, relates to the technical field of sleep-aiding essential oil, and aims to solve the problems of single effect, poor stability and insufficient skin tolerance of existing sleep-aiding essential oil. The formula comprises the following components in parts by weight: 0.5-5 parts of Himalaya cedar essential oil, 80-95 parts of base oil, 1-10 parts of synergistic sleep-aiding essential oil, at least one of lavender essential oil, chamomile essential oil and sandalwood essential oil, and 0.1-1 part of optional antioxidant. During preparation, the components are ensured to be uniform through a process of stirring at a constant temperature of 25-35 DEG C and mixing at a rotating speed of 200-300rpm, the pH value of the product is 5.5-7.0, the retention rate of the active components is greater than or equal to 90% after the product is stored in a dark place at 25 DEG C for 6 months, and the use mode is that the product is smeared on wrists / necks / soles 1-2 hours before sleep, and 0.5-2mL of the product is smeared on each time. Tests show that the sleep time of insomnia people can be shortened to 15-22 min after the essential oil is continuously used for 28 days, the PSQI score is reduced by 40%-54%, the skin irritation is zero, the essential oil is suitable for preparing external sleep-aiding essential oil cream, ball bottles and other products, and a safe and efficient solution is provided for sleep disorder people.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention belongs to the technical field of textile fabrics, and discloses an intelligent temperature-adjusting phase change microcapsule and a preparation method of a fabric thereof. The phase change microcapsule is prepared from the following components in percentage by mass: 60 to 80 percent of organic phase change material, 6 to 15 percent of N-isopropylacrylamide, 4 to 10 percent of acrylic acid, 1 to 5 percent of polyether surfactant, 2 to 5 percent of urethane acrylate and 2 to 5 percent of initiator. Warp yarn, first weft yarn and second weft yarn containing the microcapsules are woven into the intelligent temperature-adjusting phase-change fiber fabric, the response speed of the phase-change microcapsules is increased through the thermosensitivity of the organic phase-change materials, temperature can be buffered and adjusted in a wide temperature range, the organic phase-change materials cooperate with the temperature-sensitive polymer capsule wall, heat release, warm keeping, ventilation and moisture removal are achieved, and the intelligent temperature-adjusting phase-change fiber fabric is obtained. Inlet of hot air is reduced through heat absorption and cooling, climate and air temperature adjustment is self-adapted, and somatosensory comfort is maintained. In addition, no components irritating to the skin are added in the formula, so that adverse reactions such as sensitization and the like on consumers are avoided.

The invention discloses a preparation method of a black drill truffle oil composition and application of the black drill truffle oil composition in cosmetics. The composition comprises the following components in percentage by mass: 6-10% of perigord truffle oil, 18-25% of decolorized sea buckthorn fruit oil, 15-20% of sunflower seed oil and the balance of meadowfoam seed oil. The perigord truffle oil is obtained by adopting CO2 supercritical extraction to extract perigord truffle sporocarp. The composition has multiple excellent effects of resisting oxidation, resisting aging, preserving moisture, repairing skin barrier and the like. In-vitro DPPH free radical scavenging experiments and human body efficacy tests prove that the product has extremely remarkable effects in the aspects of increasing the skin moisture content, reducing transdermal moisture loss and the like, is free of skin irritation and untoward effects, is suitable for cosmetics, is particularly suitable for high-end skin care product formulas such as eye essence, facial essence and skin care oil, and has a very good application prospect. The anti-aging, repairing and moisturizing properties of the product can be obviously improved.

The acne-removing skin-care conditioning oil is prepared from the following components in parts by weight: 90 to 95 parts of sweet almond oil, 0.5 to 1.5 parts of ginger root oil, 0.5 to 1.5 parts of peppermint oil, 1.5 to 2.5 parts of lemon peel oil, 1 to 1.5 parts of eucalyptus globulus leaf oil and 2 to 3 parts of lemongrass leaf oil. The invention also discloses a preparation method of the acne-removing skin-care conditioning oil. The acne-removing skin-care conditioning oil disclosed by the invention is small in skin irritation, wide in universality and few in allergic phenomenon, and can also achieve the effects of repairing and skin care while removing acnes.

The invention relates to the field of cosmetics, in particular to a blue copper peptide composition with instantaneous cool feeling and infiltration promotion effects and a preparation method and application of the blue copper peptide composition. The composition comprises an active component copper-blue peptide and a cooling and permeation enhancing system formed by compounding at least two of menthane formylethylamine, menthone glyceryl ketal and methyl diisopropyl propionamide, and the active component can further comprise hexapeptide-11, a blue algae extract and a yeast fermentation product. The preparation method of the composition comprises three core steps of providing a water phase, adding the active ingredients and adding the cool and refreshing infiltration promoting system and other components. Through synergistic compounding of specific fresheners, on the premise that the use amount of each single component is remarkably reduced, efficient permeation promotion of the copper-blue peptide is achieved, the layered cool feeling experience which takes effect quickly and is lasting and mild is provided, the common skin irritation problem of a traditional permeation promoter or a high-concentration single freshener is avoided, and the effect is remarkable. And the transdermal patch has excellent transdermal efficiency, active matter stability and use comfort.

The invention relates to a medicine for promoting skin injury repair and healing and a preparation method thereof, and belongs to the technical field of biological medicines.The medicine is prepared from a radix astragali preparata extract, lipidosome encapsulated panax notoginseng total saponin-RGD peptide, a honeysuckle flower-maca extract, an asiaticoside-hydroxypropyl-beta-cyclodextrin inclusion compound and dipotassium glycyrrhizinate; the radix astragali preparata extract is a product obtained by moistening radix astragali with honey, baking, extracting with deionized water, and adsorbing and purifying with a Sephadex G-15 column; the honeysuckle-maca extract is a product obtained by mixing dry honeysuckle powder and dry maca root powder according to the mass ratio of (3-5): (1-1.7), performing enzymolysis through cellulase, then performing common enzymolysis through ficin protease and papain, and performing adsorption and purification through an HPD722 macroporous adsorption resin column. All the components are compatible according to a specific proportion, so that the allergy and skin irritation risks are reduced, skin injury healing is reasonably promoted, and melanin deposition is effectively inhibited.

The invention belongs to the field of daily chemical products, and particularly relates to sulfate-free silicone-oil-free solid shampoo soap and a preparation method thereof. The solid shampoo soap comprises sodium cocoyl isethionate, sodium methyl cocoyl taurate and / or cocamidopropyl betaine, cetostearyl alcohol, behentrimethylammonium chloride, guar hydroxypropyltrimethylammonium chloride, quaternary ammonium salt-80, glycol distearate, synthetic grease, natural grease, glycerin, a humectant, a plant extract, a chelating agent and a preservative. A pH regulator, essence and pigment; the solid shampoo soap provided by the invention adopts mild and non-irritant components, avoids irritation of sulfate surfactants to skin, can effectively reduce the problems of dry skin, allergy and the like, and provides healthier and more comfortable cleaning experience for consumers due to the fact that no silicone oil is used for reducing blocking of hair follicles.

The invention relates to the technical field of cosmetics, and discloses a high-efficiency mild depilation cosmetic and a preparation method thereof, and the raw materials of the depilation cosmetic comprise, by weight, 8-10% of bromelain; 10%-12% of a turmeric root extract; 9%-11% of a calendula extract; 6%-9% of an aloe extract; 4%-7% of a soybean extract; 7%-10% of calcium thioglycolate; 2%-5% of L-cysteine; 1%-3% of sodium bicarbonate; 3%-6% of green tea polyphenol; 2%-4% of a chamomile extract; 1%-3% of dipotassium glycyrrhizinate; 0.9%-2.3% of a peptide component; 0.5%-1% of rosmarinic acid; 1%-3% of vitamin E; 2%-4% of gluconic acid; 4%-5% of beewax; 5%-10% of an emulsifier; according to the invention, dipotassium glycyrrhizinate and the chamomile extract form a dual anti-allergy barrier, the physical protection effect of aloe polysaccharide is combined to reduce skin irritation, and the turmeric root extract and the peptide component prolong the hair follicle resting period and reduce the hair regeneration rate, so that the safer and more effective hair removal cosmetic is prepared.

Provided is a cosmetic containing ascorbic acid and / or a salt thereof, which has excellent stability and reduced irritation to the skin. The cosmetic according to the present invention contains ascorbic acid and / or a salt thereof, ultrapure water, and an antioxidant, and the salt of ascorbic acid is at least one selected from the group consisting of a trimethylamine salt, a triethylamine salt, a monoethanolamine salt, a triethanolamine salt, a pyridinium salt, an arginine salt, an ammonium salt, a sodium salt, a potassium salt, a calcium salt, a magnesium salt, and an aluminum salt of ascorbic acid. The antioxidant is glutathione or sodium pyrosulfite, the pH of the cosmetic material is adjusted to 5.0-7.0, and the dissolved oxygen content of the cosmetic material is 0-5 mg / L.

The present invention relates to a composition for improving skin, which comprises beta-sitosterol and betulin and, in the case of the composition, reduces dermatoneuropathic stimulation-inducing factors, increases the expression of moisturizing-related factors, increases skin absorbance, improves skin penetration, inhibits mast cell activity, and improves skin quality. Thus, it has been confirmed that the composition has excellent skin-calming and skin-irritation-relieving effects, and thus can be usefully used in skin-improving cosmetics, pharmaceuticals, and the like.

The present application relates to the field of external ointment preparation, and provides a zinc gluconate ointment and a preparation method thereof.The ointment comprises, by mass fraction: 0.3-2.0 parts of zinc gluconate, 0.05-1.5 parts of L-histidine, 0.05-1.0 parts of polysaccharide, and the balance of purified water, wherein the polysaccharide is chitosan oligosaccharide or hyaluronic acid oligomer.The zinc gluconate, L-histidine and polysaccharide are dispersed to form hydrogel microdroplets under the condition of pH 5.0-6.0, and are further dispersed in the continuous phase of the oil phase.By establishing a complex system in a weak acid environment and using a double constraint structure of microdroplet dispersion and oil phase, the free Zn 2+ The initial release rate is reduced, skin irritation caused by the initial release of traditional preparations is avoided, and a high 24-hour cumulative release amount is maintained.The ointment exhibits excellent physical stability and particle size uniformity during storage, avoids oil-water layering and crystallization, and has both sustained release and good use feeling.

The invention provides lignan, and belongs to the technical field of medicines. According to the invention, a compound shown as a formula I and a compound shown as a formula II are extracted, separated and identified from schisandra chinensis oil for the first time, and the compound shown as the formula I and the compound shown as the formula II are superior to a positive drug group arbutin in the aspect of inhibiting generation of melanin of mouse skin melanoma cells (B16F10); an inflammatory factor release inhibition experiment research shows that the compound shown in the formula I and the compound shown in the formula II have relatively good activity in the aspect of inhibiting LPS-induced mouse mononuclear macrophage RAW264.7 from releasing IL-6 and TNF-alpha; in a skin irritation experiment, the schisandra chinensis non-saponifiable matter containing the compound shown in the formula I and the compound shown in the formula II is non-irritant to the skin of a white rabbit, and it is proved that the compound shown in the formula I and the compound shown in the formula II can be applied to preparation of whitening and anti-inflammatory products. Formula I; formula II.

The invention belongs to the technical field of cardio-cerebral oil preparation, and provides cardio-cerebral oil and a preparation method thereof. The invention aims to solve the technical problems that kapur is easy to volatilize and short in efficacy, and skin irritation is easily caused by high-concentration addition. The preparation method comprises the following steps: firstly, wrapping menthol in a molecular cavity of beta-cyclodextrin through a molecular inclusion technology to prepare a molecular capsule capable of effectively delaying volatilization and reducing irritation; secondly, preparing a bionic repair emulsion from various bionic lipids such as ceramide, cholesterol and fatty acid through an emulsification process, and taking the bionic repair emulsion as a core delivery carrier; meanwhile, components such as vanillyl derivatives are compounded to prepare a temperature-sensitive compound; the preparation method comprises the following steps: uniformly dispersing independent kapur, the molecular capsule and the temperature-sensitive compound into the bionic repair emulsion, and curing to obtain a finished product. Through molecular inclusion and the bionic repair emulsion, long-acting release of the effect of the kapur is realized, and the skin irritation of the product is reduced.

The utility model relates to the technical field of cleaning agent production, and discloses a filtering device for cleaning agent production, which comprises a first filtering box, and one end of the top of the first filtering box is fixedly connected with a feeding pipe. According to the filtering device for cleaning agent production, a user enables an external water source to flow into a first filtering box through a first top cover, then a first motor is started to stir materials in the first filtering box, and a first containing frame is installed in a first base; a water source flowing in through a first top cover is filtered by a filter element installed in a first containing frame, impurities and suspended particles in water are removed, poor water quality may affect the quality stability of the cleaning agent after production, cause secondary pollution of the product, reduce the cleaning effect of the cleaning agent and even cause skin irritation or allergy and other reactions of a user, and the cleaning effect is poor. A water source flowing into the first filter box is filtered through the filter element, so that the quality and the safety of a final product are improved.

The invention provides a corn stigma extract-containing mask mud with repairing, anti-wrinkle and freckle-removing effects and a preparation method thereof, and relates to the technical field of cosmetics. The mask mud is prepared from the following raw materials: corn stigma extract, guava fruit extract, white willow bark extract, tamarix chinensis flower extract, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and auxiliary materials. The corn stigma extract is taken as a main raw material, and the three natural extracts, namely the guava fruit extract, the white willow bark extract and the tamarix chinensis flower extract, are compounded according to a specific proportion, so that multiple effects of resisting wrinkles, removing acnes, whitening, resisting allergy, repairing, removing freckles, tightening, moisturizing, soothing and the like are realized at the same time, and the effect of the corn stigma extract is remarkably improved; sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium is used as a surfactant, so that the lotion is milder and more moisturizing, no preservative is added, and damages such as skin irritation, allergy, red and swollen skin, cuticle damage and dry skin are reduced.

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

The invention relates to the technical field of health preserving articles, and discloses a wearable ornament based on a purple sand material and a preparation method thereof.The wearable ornament based on the purple sand material is obtained by soaking 20-30 parts by weight of porous purple sand bracelet in 40-60 parts by weight of a medicament for 20-25 min. The sand bracelet does not need a built-in medicine bag, keeps attractive appearance, does not need to be in direct contact with medicines when being worn, avoids skin irritation, and realizes perfect combination of a health preserving function and fashion ornaments; the purple sand material is environment-friendly and harmless and can be used for a long time, so that resource waste of disposable health-preserving products is reduced, and the traditional Chinese medicine formula adopts natural components and has small influence on the environment.

The invention provides a posaconazole ethosome and a preparation method thereof, posaconazole is encapsulated in ethosome, and the posaconazole ethosome is composed of the following components by weight: 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, and the balance of ethanol. 1-8% of phospholipid; 0%-0.5% of cholesterol; 20%-45% of ethanol; 0-0.1% of an antioxidant; 0%-0.5% of a nonionic surfactant; and 40.9 to 78.9 percent of water. The invention has the characteristics of high encapsulation efficiency, uniform particle size distribution and no irritation to skin. And the ethosome can load both water-soluble drugs and fat-soluble drugs, and has the advantages of simple composition, high encapsulation efficiency, uniform particle size distribution, no skin irritation, simple preparation and the like.

To provide a composition for a skin protectant having not only an effect of preventing dyeing of the skin but also an effect of suppressing skin irritation caused by skin irritant components, and having both a dyeing prevention effect and a skin irritation suppression effect.SOLUTION: A composition for a skin protectant, containing a smectite-based clay component that is at least one compound selected from the group consisting of smectite-based clay minerals and organically modified smectite-based clay minerals, and an oil-soluble component, further containing a nonionic dispersion aid having an HLB of 11.0 or less, wherein a content ratio of the smectite-based clay component is 0.01-60 mass% based on the total mass, the composition being applied to the skin to form, on the skin, a protective film for protecting the skin.SELECTED DRAWING: None

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.

The present application relates to a cosmetic composition, and more particularly, to a cosmetic composition comprising an amino acid-amino acid eutectic mixture and Troxerutin as an effective ingredient, thereby providing an effect of inhibiting inflammation and relieving / reducing skin irritation.

The invention discloses an insecticidal aerosol composition and a preparation method thereof, and belongs to the technical field of pesticides, a natural plant extract and a low-dose chemically synthesized insecticide are subjected to a synergistic effect, the natural plant extract has certain insecticidal activity, and when the natural plant extract and the chemically synthesized insecticide act together, the insecticidal activity of the natural plant extract is greatly improved. On the premise of ensuring effective insect killing, the dosage of the chemically synthesized insecticide is reduced, the toxic residual quantity is reduced, and toxic substances in contact with a user in the using process are reduced, so that the health risks such as respiratory tract stimulation and skin allergy are reduced, and the body health of the user can be more effectively protected; when a traditional aerosol is used in a high-dose mode, residual toxic substances can be attached to the surface of an indoor article for a long time and enter a human body through ways such as contact and breathing, the risk is greatly reduced by optimizing component combination, and a healthier and safer use environment is provided for a user.

The article relating to this design is a nasogastric tube fixing device for guiding a nasogastric tube inserted into the nostril to the side of the patient's face and holding it in place. As shown in Reference Figure 3, which illustrates the state of use, the nasogastric tube is fitted into fixing grooves extending from the center of the main body in the left and right directions, and the ends of the main body are attached to the cheek area with fixing tape, so that the nasogastric tube is held in a state that makes it difficult to come off. Also, as shown in Reference Figures 2 and 3, which illustrate the state of use, elongated holes are formed at both ends of the main body, which also serve as retainers, and the device can also be used in a form in which a separate band is connected to these elongated holes and attached around the head. When using the band, it can be fixed without using fixing tape alone, and the device is designed to be easy to use with consideration for skin irritation, and it can also be used to hold the tube securely even when adhesion is difficult due to the shape of the area under the nose, such as when there is a beard or when there are no front teeth.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.