15 results about "Active matter" patented technology

The present disclosure provides lipid nanoparticles having a sphere like structure, compositions comprising the lipid nanoparticles and methods for delivery of the agents. The lipid nanoparticles have improved properties for delivery of biologically active agents, such as RNA.

Methods of forming patterned features on a surface of a substrate are disclosed. Exemplary methods include gas-phase formation of a layer comprising an oxalate compound on a surface of the substrate. Portions of the layer comprising the oxalate compound can be exposed to radiation or active species that form exposed and unexposed portions. Material can be selectively deposed onto the exposed or the unexposed portions.

A method for filling a gap in a substrate is disclosed. The method includes providing a substrate with a gap in a reaction chamber, forming first active species from a first reactant to create an inhibition layer near the top of the gap, and performing one or more deposition cycles to deposit material into the gap. Each deposition cycle involves introducing a second reactant to form a chemisorbed layer and generating a second active species from a third reactant using pulsed plasma power, which reacts with the chemisorbed layer to form a deposited layer. The inhibition layer partially inhibits deposition at the top of the gap. The deposited material comprises silicon nitride, which is subsequently converted to silicon oxide by providing a fourth reactant containing hydrogen and oxygen. This conversion results in volume expansion and improved gap filling.

The application discloses a nanowire-nanotube hybrid sensor and a preparation method and application thereof. The nanowire-nanotube hybrid sensor has two regions of a nanochannel and a nanowire electrode by using a conical double-channel microcapillary. A substrate solution is precisely released to a specific site of a single cell through the nanochannel. After a to-be-measured glycosidase recognizes the substrate molecules, the glycosidic bond is cut to release active substances of the electrode. The nanowire electrode is used for real-time quantitative detection of the active substances, so that quantitative detection of glycosidase substances at a single / subcellular level is realized. The application constructs an efficient and universal detection strategy of non-electrochemical active glycosidase by using the nanowire-nanotube hybrid sensor and an electrical signal conversion method of the reaction of specific glycosidase and a substrate, widens the detection range of electrochemical target objects, and provides a promising method for high-time-space-resolution quantitative monitoring of hydrolytic enzymes at a single / subcellular level.

This invention provides a method and apparatus for perioperative fibrinogen detection, comprising the following steps: S1, modifying the working electrode surface of a screen-printed electrode with antibody-functionalized self-supporting graphene aerogel material; S2, adding the serum sample to be tested to the modified working electrode surface; S3, adding horseradish peroxidase-labeled fibrinogen detection antibody to the modified working electrode surface; S4, adding a matrix-type TMB solution containing H2O2 to the modified working electrode surface; S5, collecting the reduction current of electrochemically active substances on the electrode surface using a chronoamperometry method; S6, calculating the fibrinogen concentration based on the reduction current value and a standard curve. This invention solves the technical problems of low electron transport efficiency and detection sensitivity, structural instability, poor biocompatibility, and difficulty in enriching electroactive substances when using graphene-modified electrodes.

The present invention provides a method for producing a protein having a supramolecular structure in which a bioactive substance is encapsulated, the method comprising (I) bringing a subunit of the protein forming the supramolecular structure, a bioactive substance, and a solution for forming, from the subunit, the protein having the supramolecular structure, into contact with each other in a flow micro mixer.

This invention discloses a highly active exogenous cell care preparation derived from natural biological macrocells and its applications, belonging to the fields of biomedicine and cell care technology. This invention uses natural biological macrocells from algae, woody plants, herbaceous plants, fungi, and animals as raw materials, employing a low-temperature, mild purification process to retain the original active substances, and then compounding them with medical excipients to produce oral or sterile intravenous infusion preparations. The active ingredients of the preparation are natural, native components, mild and safe, with no obvious toxic side effects. At conventional doses, they are essentially metabolized within 24 hours, and at high doses, they are completely excreted within 1-2 days, without long-term accumulation in the body. This invention achieves cell activity repair, microenvironment regulation, and cell homeostasis maintenance through an exogenous, non-invasive method, without involving invasive cell modification. It has a wide range of applications, high safety, and a clearly defined scope of protection, possessing significant scientific research and industrial application value.

A method including receiving, by a processing device, first data characterizing a film on a surface of a substrate processed within a recess of a sensor assembly positioned in a first region of a processing chamber. The processed surface of the film corresponds to a substrate processing procedure. The method further includes determining, based on the first data, a rate of advancement of a first processed surface boundary of the film across the surface of the substrate. The method further includes determining, using the rate of advancement, a dosage strength of a reactive species delivered to the first region of the processing. The method may further include preparing an indication of the dosage strength for presentation on a graphical user interface (GUI). The method may further include altering an operation of the processing chamber based on the dosage strength.

An integrated microstructure patch processing device includes a container body unit (1), a support unit (2), a coating device (3), and a processing unit (6). The container body unit (1) includes a shell body (11) that defines an accommodation space (12). The support unit (2) includes a support platform (21) that is disposed in the accommodation space (12), and that has a supporting part (211) for carrying microstructure patches (91). The coating device (3) is disposed in the accommodation space (12) and conducts a coating process which impart a transdermally active substance the microstructure patches. The processing unit (6) is disposed in the accommodation space (12) to conduct a first processing procedure on the microstructure patches (91). A method of processing microstructure patches (91) is included.

This assembly (1) comprises a tubular body (2) and a cap (4) configured to be attached to the tubular body (2) so as to define a chamber (6) for an active material (5). The tubular body (2) comprises a transverse wall (20) and a peripheral wall (22), whereas the cap (4) comprises a base wall (40) and a side wall (42). The chamber (6) is delimited by a part (24) of the tubular body (2) including the transverse wall (20) and is closed by the cap (4). The side wall (42) of the cap (4) comprises on its periphery a plurality of longitudinal features in relief (47) configured to cooperate by mutual engagement with complementary longitudinal features in relief (27) provided on the peripheral wall (22) of the tubular body (2) substantially parallel to its longitudinal axis (X2), and at least one longitudinal feature in relief (27, 47) of one among the cap (4) and the tubular body (2) has two flanks inclined with respect to a radial direction of the cap or tubular body passing through the feature in relief. The cap (4) is anchored relative to the tubular body (2) by surface interference and, in the anchored configuration, both inclined flanks of the at least one longitudinal feature in relief of the one among the cap and the tubular body are in contact with a complementary longitudinal feature in relief of the other one among the cap and the tubular body.

The invention relates to the technical field of biology, in particular to mytilus coruscus exosome-like nano-vesicles and application thereof in preparation of osteogenesis products. The functional activity research system of the exosome-like nano vesicles from aquatic products can be improved in the academic level, meanwhile, novel safe and efficient active substances are explored for the bone health field, high-value utilization of shellfish resources can be promoted, the academic value is remarkable, and the method has important industrial application prospects.

In a large molecule transdermal microemulsion system capable of effectively performing a planned action through the dermis and for the use thereof, the large molecule transdermal microemulsion system comprises an effective amount of a large molecule active substance capable of performing a planned action, wherein, based on the mass percentage of the total weight of the large molecule transdermal microemulsion system, the composition of the large molecule transdermal microemulsion system has an oil phase share of 7 to 36%, a water phase share of 57% to 88%, and an emulsifier share of 8% to 20%.

The invention relates to a method for decontaminating a thermoplastic preform (14) by exposing at least a portion of the preform (14) to reactive species (RS) obtained by mixing a precursor agent (AP) with a plasma (P), the plasma (P) being generated by injecting a carrier gas (G) into a reactor (40), characterized in that the mixing of the precursor agent (AP) and the plasma (P) is carried out exclusively outside the reactor (40) before coming into contact with the preform (14). The invention also relates to a decontamination device (50) for implementing the method.