86 results about "Active matter" patented technology

The invention provides kelp fucoidin with low molecular weight and high anti-anaphylaxis as well as a preparation method and application thereof, and belongs to the technical field of food processing. The preparation method comprises the following steps: mixing kelp fucoidin with water to obtain a kelp fucoidin solution; and mixing the kelp fucoidin solution with H2O2 and Vc, reacting, adjusting the pH value, dialyzing and freeze-drying to obtain the kelp fucoidin with low molecular weight and high anti-allergic property. The H2O2-Vc degradation system is innovatively applied to preparation of the low-molecular-weight kelp fucoidin and improvement of the anti-allergic activity of the low-molecular-weight kelp fucoidin. In the degradation process, the chemical composition of the fucoidin is partially changed, but monosaccharide types and functional groups are not influenced. Through multiple ways of cell model and animal model experiments, the degraded laminaria fucoidin is more prominent in anti-allergic activity. Technical support is provided for development of seaweed-derived anti-allergic functional active substances, and high-valued utilization of kelp resources in the fields of functional food and medicines is further promoted.

The invention discloses a rhodotorula mucilaginosa strain as well as a fermentation product filtrate and a biological product thereof, and belongs to the technical field of microorganisms. The rhodotorula mucilaginosa BTN-HB-L28 strain is separated and purified from meconopsis in Lijiang of Yunnan, can be used in the field of cosmetics, has the effects of resisting skin oxidation, resisting aging, repairing skin and relieving skin, can be used as an active matter in skin care products, and has practical application value. The fermentation product filtrate of the strain has excellent HAS inhibition ability, and can significantly inhibit the expression of matrix metalloproteinase 3; the fibroblast proliferation can be obviously promoted under various concentrations; the proportion of SA-beta-Gal positive cells can be remarkably reduced under various concentrations, and the anti-aging effect is achieved; the antioxidant composition has remarkable DPPH and ABTS free radical scavenging capacity and has a good antioxidant effect; the secretion amount of cell inflammatory factors NO, IL-6 and TNF-alpha can be remarkably inhibited, and the good relieving effect is achieved.

The present disclosure provides lipid nanoparticles having a sphere like structure, compositions comprising the lipid nanoparticles and methods for delivery of the agents. The lipid nanoparticles have improved properties for delivery of biologically active agents, such as RNA.

The invention discloses a method for extracting a natural antioxidant from a cyperus esculentus shell fermentation product by using subcritical water, and belongs to the technical field of plant antioxidant extraction. The preparation method comprises the following steps: fermenting cyperus esculentus shell powder to obtain fermentation liquor; performing subcritical water extraction on the fermentation liquor to obtain an extracting solution; and filtering, purifying and freeze-drying the extracting solution to obtain the natural antioxidant. The plant cell walls can be selectively and mildly degraded and deconstructed by utilizing rich enzyme systems secreted by specific microorganisms in the growth and metabolism process. The biological pretreatment not only can destroy the physical barrier of the cell wall, but also can release active substances in a combined state in the cell wall, so that the active substances are converted into a free state, and the dissolution efficiency and the yield of subsequent extraction are greatly improved. Subcritical water extraction has the outstanding advantages of high extraction efficiency, high speed, no need or great reduction of the use amount of organic solvents, environmental friendliness and the like.

The capsule may be exposed to an alternating magnetic field to release the active material, and may include a core containing the active material and a shell surrounding the core, at least one of the core and the shell may include at least one induction heating element particle heated by exposure to the alternating magnetic field.

The invention discloses a polysaccharide aldehyde modification method based on a plasma technology, relates to the technical field of biological material modification, and aims to solve the problems of environmental pollution, harsh reaction conditions and complex product purification in the conventional chemical oxidation method. Comprising the following steps: S1, preparing a polysaccharide solution; dissolving polysaccharide in a solvent, and stirring until the polysaccharide is completely dissolved to obtain a homogeneous polysaccharide solution; and S2, plasma in-situ oxidation treatment. In an inert gas atmosphere environment, plasma is generated by using a coaxial dielectric barrier discharge device, and active substances of the plasma directly act on a polysaccharide solution, so that an aldehyde group is introduced to a polysaccharide molecular chain, and an aldehyde polysaccharide solution is obtained. And S3, freeze-drying and forming. And freeze-drying the obtained aldehyde polysaccharide solution to obtain the aldehyde polysaccharide solid material with the three-dimensional porous network structure. The method is simple and convenient to operate, easy to popularize, simple in equipment, short in process, free of complex purification steps and beneficial to laboratory and large-scale production and application.

Methods of forming patterned features on a surface of a substrate are disclosed. Exemplary methods include gas-phase formation of a layer comprising an oxalate compound on a surface of the substrate. Portions of the layer comprising the oxalate compound can be exposed to radiation or active species that form exposed and unexposed portions. Material can be selectively deposed onto the exposed or the unexposed portions.

Presented are processes for the beneficial conversion of CO2 and other environmentally destructive compounds to their constituent parts by the application of thermal plasma containing activated species whereby the interaction of the plasma with the compounds and reactions of CO2 and H2 generate more environmentally friendly compounds comprising in part oxygen and hydrogen. The thermal plasma may be vibro-shear plasma generated by the superheating of either steam, gas or a combination of both.

A method for filling a gap in a substrate is disclosed. The method includes providing a substrate with a gap in a reaction chamber, forming first active species from a first reactant to create an inhibition layer near the top of the gap, and performing one or more deposition cycles to deposit material into the gap. Each deposition cycle involves introducing a second reactant to form a chemisorbed layer and generating a second active species from a third reactant using pulsed plasma power, which reacts with the chemisorbed layer to form a deposited layer. The inhibition layer partially inhibits deposition at the top of the gap. The deposited material comprises silicon nitride, which is subsequently converted to silicon oxide by providing a fourth reactant containing hydrogen and oxygen. This conversion results in volume expansion and improved gap filling.

To provide compositions and methods for mediating EPS. [Solution] This disclosure relates to a method for inhibiting the stability of a biofilm, comprising contacting the biofilm with an effective amount of an active substance that interferes with the binding of polyamines to DNA in the biofilm. Also provided herein is a method for treating a biofilm in a subject, comprising administering an effective amount of an active substance that interferes with the binding of polyamines to DNA in the biofilm to a subject infected with a biofilm. Further described herein is a method for treating a biofilm in a patient with systemic lupus erythematosus (SLE) and / or cystic fibrosis (CF), comprising administering an effective amount of an active substance that interferes with the conversion of B-DNA to Z-DNA in the biofilm or its local environment.

The invention relates to the technical field of cyanobacterial bloom treatment, and discloses a composite slow-release algal-inhibiting colloid and a preparation method and application thereof.The composite slow-release algal-inhibiting colloid comprises phenolic acid algal-inhibiting active substances, chitosan, polyvinylpyrrolidone and lactic acid, the average hydrodynamic particle size of the composite slow-release algal-inhibiting colloid is 50-800 nm, and the average hydrodynamic particle size of the composite slow-release algal-inhibiting colloid is 100-200 nm. The phenolic acid algal inhibition active substance is selected from one or more of gallic acid, pyrogallic acid and p-hydroxybenzoic acid. Targeted enrichment of algae is achieved through the electrostatic adsorption effect between positive charges of a chitosan molecular chain and negative charges on the surface of cyanobacteria cells; meanwhile, a three-dimensional network structure jointly constructed by the chitosan and the polyvinylpyrrolidone wraps the active substances, long-acting slow release is achieved, the colloid has the dual functions of targeted adsorption and long-acting slow release, and the utilization efficiency and action durability of the algal inhibition active substances are improved.

The invention provides a subject-object interface assembled double-ligand MOF and PVA mixed matrix membrane, which is prepared by the following steps: jointly dissolving metal salt and amino acid in deionized water, carrying out ultrasonic treatment, adding a solubilizer, carrying out ultrasonic treatment, adding an active substance, carrying out ultrasonic treatment, carrying out hydrothermal reaction on the obtained mixture at 60-100 DEG C for 1-3 hours, centrifuging to take a solid, and drying to obtain the subject-object interface assembled double-ligand MOF and PVA mixed matrix membrane. Washing with ethanol, and drying to obtain a subject-object interface assembled double-ligand MOF (Metal Organic Framework); dispersing the film-forming matrix in deionized water, and performing water bath at 60-100 DEG C for 1-3 hours to obtain a film-forming matrix solution; adding the host-guest interface assembled double-ligand MOF into the film-forming matrix solution, uniformly stirring to obtain a film-forming solution, carrying out tape casting on the film-forming solution, and drying to obtain a host-guest interface assembled double-ligand MOF (at) PVA mixed matrix film; the preservative is safe and non-toxic, has good hydrophobic property, barrier property and remarkable antibacterial property, and lays a solid and reliable foundation for deep research in the field of preservation.

The invention relates to a method for reducing the density of microorganisms in a usable space of a device, the method comprising heating the usable space to a process temperature such that the relative humidity in the usable space is below an upper humidity value; adjusting the relative humidity in the usable space to a first target value for a first duration, wherein a humidification system introduces an active substance; stopping the adjustment of the relative humidity; and degrading the active substance in the usable space for a degradation duration. The invention also relates to a corresponding device and a corresponding system.

It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

To provide a method for producing particles that can suppress the decrease in physiological activity during particle production. [Solution] A method for producing particles, comprising: a bioactive substance-containing solution preparation step of preparing a bioactive substance-containing solution containing a bioactive substance; a discharge step of dispensing the bioactive substance-containing solution as droplets; and a granulation step of removing the solvent from the droplets to form particles, characterized in that the bioactivity ratio {(bioactive amount B / bioactive amount A) × 100} of the bioactive amount B in the particles after the granulation step relative to the bioactive amount A in the bioactive substance before the bioactive substance-containing solution preparation step is 80% or more.

The application discloses a nanowire-nanotube hybrid sensor and a preparation method and application thereof. The nanowire-nanotube hybrid sensor has two regions of a nanochannel and a nanowire electrode by using a conical double-channel microcapillary. A substrate solution is precisely released to a specific site of a single cell through the nanochannel. After a to-be-measured glycosidase recognizes the substrate molecules, the glycosidic bond is cut to release active substances of the electrode. The nanowire electrode is used for real-time quantitative detection of the active substances, so that quantitative detection of glycosidase substances at a single / subcellular level is realized. The application constructs an efficient and universal detection strategy of non-electrochemical active glycosidase by using the nanowire-nanotube hybrid sensor and an electrical signal conversion method of the reaction of specific glycosidase and a substrate, widens the detection range of electrochemical target objects, and provides a promising method for high-time-space-resolution quantitative monitoring of hydrolytic enzymes at a single / subcellular level.

The invention relates to the technical field of water pollution treatment, in particular to a microbubble enhanced cascade discharge plasma reactor and an algae removal method. The microbubble enhanced cascade discharge plasma reactor provided by the invention adopts a three-electrode coaxial structure, a high-voltage power supply is connected to a middle porous electrode, and the center and peripheral electrodes are grounded to construct an inner-layer gas-phase pre-ionization region and an outer-layer gas-liquid mixed-phase reaction region. Working gas firstly discharges in the inner layer to generate high-concentration active particles, then the high-concentration active particles are sprayed out through the micropores to form a microbubble group carrying active substances, and secondary discharge of the outer layer is induced. Ultraviolet light, shock waves and active substances generated by cascade discharge cooperatively destroy algae cell structures, so that the algae cells are inactivated and flocculated, and rapid separation of algae residues is realized by virtue of a micro-bubble air flotation effect. The method is efficient, low in consumption, free of secondary pollution and suitable for emergency and deep treatment of the eutrophic water body.

The utility model relates to the technical field of active matter extraction, and discloses a daily chemical plant active matter extraction device which comprises a shell, the inner bottom wall of the shell is fixedly connected with a filter plate, the bottom wall of the shell is communicated with a liquid storage tank, and the right end of the front side of the liquid storage tank is fixedly connected with ultrasonic auxiliary equipment. Two crushing rollers are rotatably connected to the middle of the inner wall of the shell, gears are fixedly connected to the rear ends of the outer walls of the crushing rollers, the two gears are in meshed connection, a servo motor is fixedly connected to the top of the rear side of the shell, and the output end of the servo motor penetrates through the rear side of the shell and is fixedly connected to the rear end of the crushing roller on the left side. According to the utility model, the crushing work of plants is completed through the rotation of the two crushing rollers, so that the plant juice enters the liquid storage tank through the filter plate, and meanwhile, the juice is stirred in cooperation with the conveying of airflow under the work of the ultrasonic auxiliary equipment, so that the wall breaking of plant cells is accelerated, and the dissolution of active ingredients can be accelerated.

The invention provides a new application of L-theanine in improvement of acute plateau hypoxia tolerance (viability), and finds and verifies that L-theanine can significantly improve the survival rate of mice in an acute hypobaric hypoxia environment and also can relieve brain tissue injury and body oxidative stress injury induced by plateau hypobaric hypoxia for the first time. And the generation of brain energy is promoted. In addition, in an in-vitro cell model, the L-theanine can also effectively improve hypoxia injury of the cobalt chloride induced hippocampal neuron cell line HT22. The invention provides a natural and safe active substance capable of improving the plateau hypoxia tolerance of an organism, provides a scientific basis for research and development of a series of acute physiological and pathological reactions caused by plateau hypoxia, and has a significant application value.

PROBLEM TO BE SOLVED: To provide a culture method or the like capable of performing culture properly . SOLUTION: One aspect of the present invention provides a culture method comprising a detection step and an introduction step. In the detection step, one or more feature values are detected from a culture target and / or a culture medium in which a culture target is cultured. Here, the culture target includes one or more selected from the group consisting of microorganisms and cells. In the introduction step, an active species is introduced into the culture medium. Here, the active species includes one or more selected from the group consisting of active oxygen species, active nitrogen species, and active carbon species. In the introduction step, the mode of introduction of the active species is controlled based on the one or more feature values detected.

This invention provides a method and apparatus for perioperative fibrinogen detection, comprising the following steps: S1, modifying the working electrode surface of a screen-printed electrode with antibody-functionalized self-supporting graphene aerogel material; S2, adding the serum sample to be tested to the modified working electrode surface; S3, adding horseradish peroxidase-labeled fibrinogen detection antibody to the modified working electrode surface; S4, adding a matrix-type TMB solution containing H2O2 to the modified working electrode surface; S5, collecting the reduction current of electrochemically active substances on the electrode surface using a chronoamperometry method; S6, calculating the fibrinogen concentration based on the reduction current value and a standard curve. This invention solves the technical problems of low electron transport efficiency and detection sensitivity, structural instability, poor biocompatibility, and difficulty in enriching electroactive substances when using graphene-modified electrodes.

The present application relates to the field of biomedical technology, specifically, a kind of plasma activated water inactivation herpes simplex virus method.The plasma activated water inactivation herpes simplex virus method includes the following steps: constructing plasma jet discharge reaction system;PAW preparation system is constructed, and plasma activated water is prepared using discharge system;Establish PAW inactivation HSV system, and construct the quantitative evaluation system of virus inactivation effect.In the present application, the chemical reaction process of different gas components at gas-liquid interface is studied, and the active substances generated in PAW are characterized by quantitative analysis method, so as to deepen the understanding of the generation mechanism of PAW, and the research basis of PAW generation effect and mechanism is applied to the inactivation research of HSV, and the action mechanism of PAW on HSV inactivation is proposed, which provides a new type of technical scheme with environmental friendliness and broad-spectrum high efficiency for the prevention and control of HSV.

The invention discloses a deep sulfonation device and method for improving active matter, and relates to the technical field of sulfonation process.The deep sulfonation device comprises a tank body and an adjusting mechanism, the inner wall of the tank body is sequentially connected with a top plate, a partition plate and a bottom plate from top to bottom, and a plurality of reaction pipes are connected between the partition plate and the bottom plate in an annular array mode; the upper end of each reaction tube penetrates through the partition plate and is coaxially connected with a liquid supply cylinder, the lower end of each reaction tube penetrates through the bottom plate, the upper end of each liquid supply cylinder penetrates through the top plate, each liquid supply cylinder is provided with an annular slit, and the adjusting mechanism is installed in the tank body and used for adjusting the sulfonation reaction intensity on the inner walls of the reaction tubes. According to the invention, the sulfonation reaction intensity in the reaction tube is periodically adjusted, and the rising temperature in the high-intensity sulfonation reaction time period is cooled by utilizing the low-intensity sulfonation reaction time, so that the temperature in the reaction tube is always kept within a proper threshold value, and the generation of by-products is avoided, thereby improving the content of active matters.

The present disclosure relates to compositions of RNA encapsulated in lipid nanoparticles and methods for producing the same. The compositions can be used to deliver mRNA to a subject. The lipid nanoparticles have improved properties for delivering biologically active agents, such as RNA.

An active material particle is provided with a composite particle containing a lithium silicate phase and a silicon phase dispersed in the lithium silicate phase, and with a first coating film that coats at least a portion of the surface of the composite particle. The first coating film contains a carbon material and an oxygen deficient oxide of a first element wherein the first element is an element other than a nonmetal element.

The present disclosure discloses a method for preparing an anti-mold and odor-removing oriented strand board (OSB). The anti-mold and odor-removing OSB includes a biologically active substance. The method includes preparing the biologically active substance, preparing a molecular nest carrier, loading the molecular nest carrier with the biologically active substance, preparing a functional impregnating agent, and impregnating a OSB with the functional impregnating agent. Preparing the molecular nest carrier includes first-time modifying zeolite powder, second-time modifying zeolite powder, modifying β-cyclodextrin, mixing, and cross-linking. The anti-mold and odor-removing OSB prepared by the present disclosure exhibits excellent antibacterial, anti-mold and odor-removing performance, high mechanical strength, and superior aging resistance.