Tissue engineering bracket material capable of physically embedding active substances and preparation method thereof

Abstract

The invention relates to a tissue engineering bracket material capable of physically embedding active substances and a preparation method thereof. The tissue engineering bracket material capable of physically embedding the active substances is prepared from 100 weight parts of biodegradable macromolecular substance and 0 to 20 weight parts of active substances, wherein the weight part of the active substances is not equal to zero; 100 weight parts of biodegradable macromolecular substance consists of 50 to 100 weight parts of synthetic macromolecular substance and 0 to 50 weight parts of natural macromolecular substance; the macromolecular substances and the active substances form a micromolecular nanofiber membrane or a composite macromolecular nanofiber membrane; and the active substances are bonded on the surface of the fiber membrane uniformly. The tissue engineering bracket material capable of physically embedding the active substances has high biocompatibility and sufficient mechanical strength, can be biodegraded, is suitable for proliferation and directed differentiation of stem cells, and has the functions of promoting cell migration adhesion and capturing the stem cells so as to induce regeneration of tissues such as bones, cartilages, nerves, skin and the like.

Description

technical field

[0001] The invention relates to a biological material, in particular to a biological scaffold material capable of trapping stem cells, inducing stem cell proliferation and directional differentiation, and inducing tissue regeneration, as well as its preparation method and medical application. Background technique

[0002] The main idea of ​​tissue engineering is to design and prepare three-dimensional biomimetic tissue, construct a biomaterial scaffold with structure and function similar to natural extracellular matrix, and provide an ideal microenvironment for cell growth, development and intercellular communication in vitro.

[0003] Electrospinning technology can continuously prepare nanoscale or submicron nanofibers, and the scaffolds constructed by it have high porosity, good channel connectivity and high specific surface area, which is a hot research topic at home and abroad. By adjusting the concentration of the solution and the parameters of the spinn...

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