67 results about "Macromolecular Substances" patented technology

The application relates to the technical field of materials, and discloses a kind of corrosion-resistant coated steel pipes and preparation method thereof, the coated steel pipe includes steel pipe body and is coated in functional coating, functional coating is formed by coating functional coating on the surface of steel pipe body, and is cured, functional coating is formed by mixing with epoxy resin as film-forming material and glass flake modified material as additive, glass flake modified material is modified by macromolecular material with benzene sulfone-fluorosilane alternate connection structure on the surface of glass flake, due to the benzene sulfone structure in the structure of macromolecular material can produce pi-pi conjugation between epoxy resin matrix, the compatibility of glass flake and epoxy resin is improved, the strength and corrosion resistance of coating are enhanced, macromolecular material can form highly hydrophobic layer on the surface of coating, construct the synergistic effect of "interface strengthening-network crosslinking-corrosion prevention", greatly enhance the corrosion resistance of coating.

The application discloses a kind of fermentation complex microbial inoculant and preparation method and application thereof, the fermentation complex microbial inoculant includes the following weight parts of component: bacillus subtilis microbial inoculant 2-5 parts, bacillus mucilaginosus microbial inoculant 5-10 parts, yeast microbial inoculant 2-10 parts, trichoderma harzianum microbial inoculant 10-20 parts, aspergillus niger microbial inoculant 10-20 parts and streptococcus thermophilus microbial inoculant 2-5 parts;The fermentation complex microbial inoculant of the application is prepared by selecting each strain and amount, is added to pigeon manure and is fermented to prepare organic fertilizer, can better decompose macromolecular substance, significantly improve the organic matter and total nitrogen content in preparation organic fertilizer, and can better improve seed germination rate;In addition, the preparation method of pigeon manure organic fertilizer of the application is simple in process, easy to operate, and convenient for production.

The application discloses a method for preparing an oat-based beverage through biological enzymolysis and a product thereof, and comprises the following steps: continuously hydrolyzing starch, cellulose, protein and other substances in oat slurry by using high-temperature-resistant amylase, cellulase, saccharifying enzyme, papain and alkaline protease, sufficiently releasing reducing substances in the oat, simultaneously generating reducing peptides, improving the free radical scavenging capacity of the oat slurry, and improving the emulsification stability of the oat slurry due to the moderate degradation of macromolecular substances such as starch, cellulose and protein; glycerol is added in three stages at a controlled speed, so that the glycerol is fully mixed with flaxseed oil, and excessive glycerol is avoided from adhering to lipase to reduce the activity of the enzyme, thereby improving the reaction efficiency.

This product relates to the field of eyewash production technology, providing a filter for eyewash production, including a raw material tank for storing the eyewash concentrate, a coarse filter for filtering large particulate impurities, and a cross-flow filter including a filter tube and a filter membrane. One end of the filter tube is connected to the coarse filter, and the other end passes through the cross-flow filter and connects to the raw material tank. An opening is provided at the bottom of the filter tube located inside the cross-flow filter. The filter membrane is positioned on the opening and parallel to the flow direction of the eyewash through the filter tube, used to filter large molecular impurities in the eyewash. This filter removes large molecules through the opening parallel to the flow direction of the eyewash and the filter membrane, and washes away any remaining large molecules on the filter membrane surface through the flow of the eyewash, preventing large molecules from clogging the filter membrane and improving the utilization rate of the filter membrane.

The invention relates to the technical field of materials, and discloses a polypropylene material with high strength and strong anti-pressure ability and a preparation method, the polypropylene material is prepared by taking polypropylene as a base material and a linen fiber modified additive and the like as auxiliary materials through mixing and extrusion processes, the linen fiber modified additive is prepared by modifying macromolecular substances with norbornane-erythritol alternate connection structures on the surfaces of linen fibers, and the macromolecular substances can react with anhydride groups of maleic anhydride grafted polypropylene in the subsequent melt extrusion process, so that interlocking can be formed between the linen fibers and a polypropylene matrix; according to the present invention, the macromolecular substance structure contains the high bond energy silicon-oxygen bond and the rigid ring structure, such that the stability of the polypropylene can be improved so as to further enhance the impact resistance and other mechanical properties of the polypropylene.

The invention relates to the technical field of polyester fibers, and discloses an antistatic polyester fiber for clothing and a preparation method thereof.The polyester fiber contains an antistatic agent, a wear-resistant functional material and other additives, and the antistatic agent is prepared by modifying quaternary ammonium cations on the surface of graphene oxide; the existence of quaternary ammonium cations can enable the surfaces of graphene oxide particles to carry strong positive charges, so that the graphene oxide particles are separated from one another and are uniformly dispersed in the fiber, and the antistatic performance of the fiber is improved by utilizing the conductive effect of graphene, and the wear-resistant functional material is prepared by modifying a polyester type macromolecular substance on the surface of nano tungsten disulfide; pi-Pi conjugation can be formed between the polyester type macromolecular substance and a PET matrix, and a molecular chain of the polyester type macromolecular substance is intertwined and interwoven with a PET molecular chain, so that the nano tungsten disulfide fully plays a role, the strength of the polyester fiber can be enhanced, and the wear resistance of the polyester fiber can be improved by utilizing the self effect of the nano tungsten disulfide.

The application belongs to the technical field of non-antibiotic compounds as bacteriostatic agents, and discloses an application of a known non-antibiotic compound, cladrabine, in inhibiting the growth of multi-drug resistant Klebsiella pneumoniae. The application finds that cladrabine can inhibit the growth of multi-drug resistant Klebsiella pneumoniae, and the minimum bacteriostatic concentration reaches 64 mg / L. Further exploration of the bacteriostatic mechanism finds that after exposure to cladrabine, the permeability of the bacterial cell membrane is enhanced, and the macromolecular substances (nucleic acids and proteins) in the cell are excreted, causing the integrity of the bacterial cell membrane to be destroyed, and further causing the death of Klebsiella pneumoniae. The application proposes that cladrabine can destroy the cell membrane of bacteria, change the permeability of the cell membrane, has a good inhibitory effect on multi-drug resistant Klebsiella pneumoniae, and can be further applied to the preparation of related drugs.

The invention relates to the technical field of separation and concentration of biological macromolecules, in particular to a concentration column for biological macromolecular substances, which comprises a chamber filled with a water absorption material layer and a separation membrane arranged at the bottom of the chamber, the water absorbing material can absorb solvent components to generate osmotic pressure difference to drive solvents in a solution and other substances with the particle size smaller than that of the biological macromolecular substances to pass through the separation membrane, and the biological macromolecular substances are intercepted by the separation membrane. The concentration column can realize separation and / or concentration of biological macromolecular substances without depending on external pressure or centrifugal force.

The invention belongs to the technical field of biological pharmacy, and relates to a method for preparing tremella aurantialba polyphenol by utilizing tremella aurantialba TA58.21 fungus chassis cell fermentation, which comprises the following steps: adding a cooked soybean meal culture medium and a tremella aurantialba seed solution into a fermentation tank, introducing sterile oxygen, controlling the stirring rotating speed of the fermentation tank and the culture temperature to be 25-30 DEG C, continuously culturing for 5-8 days, and when the fermentation liquor becomes red, stopping the fermentation; when a large amount of foam is generated, closing an exhaust valve, keeping the tank pressure at 0.1 MPa, increasing the fermentation temperature to 50 DEG C, continuing to culture for 24 hours, increasing the stirring rotating speed of the fermentation tank, heating the fermentation liquor to 80-90 DEG C, keeping the temperature for 4-8 hours, stopping stirring, continuing to heat to 120 DEG C, and keeping the temperature for 30 minutes; centrifuging the fermentation liquor to remove precipitates and mycelia; collecting supernate, and pre-treating macromolecular substances and thallus fragments; collecting permeate liquid, and intercepting through a nanofiltration membrane to obtain a concentrated solution; and carrying out spray drying or freeze drying treatment on the concentrated solution to obtain a high-purity product. According to the invention, the tremella aurantialba polyphenol product with good water solubility, heat resistance, acid resistance and molecular weight of less than 10000 Da can be obtained.

The invention discloses a fermentation type seaweed granular fertilizer and a fermentation method thereof, and belongs to the technical field of biological fertilizers, plant active substances of enzymolysis seaweed active powder, grain byproducts and organic nutrition of soybean meal are fused, after microbial fermentation, nutrition release is more balanced, robust growth of crops can be promoted, and the yield and quality can be improved; seaweed residues are secondarily utilized through an enzymolysis technology, macromolecular substances are degraded into micromolecular active components through alginate lyase and cellulase, enzymolysis seaweed active powder is prepared, the nutritive value of seaweed is excavated to the maximum extent, the cost of raw materials is reduced, nano zeolite serves as a carrier of microelements, iron ions are reduced and stabilized through potassium borohydride, and then iron ions are reduced and stabilized through potassium borohydride; and then the nitrohumic acid is used for chelating elements such as zinc, iron and boron, and the adsorption performance of the nano zeolite is combined, so that the double stability of the chelated trace elements and the porous carrier is realized.

The application relates to the technical field of paint, and discloses a high-voltage-resistant light-cured insulating paint and a preparation method thereof. The paint is formed by mixing two-functionality polyurethane acrylate, isobornyl acrylate, isobornyl methacrylate and the like as UV monomers and adding modified mica functional material and the like as an additive. The modified mica functional material is prepared by modifying macromolecular substances with anthracene-perfluoro block alternating connection structure and containing unsaturated alkenyl functional groups on the surface of mica powder. The unsaturated alkenyl functional groups in the macromolecular substances can participate in the polymerization process of the UV monomers, the mica powder is uniformly distributed in the coating, a continuous and stable physical barrier layer is formed, and the voltage resistance of the coating is improved. Meanwhile, the rigid anthracene ring and a large amount of fluorine elements contained in the structure of the macromolecular substances can effectively enhance the heat resistance and high-voltage breakdown resistance of the coating.

This invention discloses a universal method and composition for solving the pilling problem in cold-formulated cosmetics. Adding an effective amount of glyceryl oleate, citrate / caprylic / capric triglyceride to a cosmetic composition containing a pilling-prone cold-formulated emulsifier can significantly reduce or eliminate pilling. This substance has been discovered for the first time to have a novel anti-pilling application, effective against pilling caused by the emulsifier's own characteristics, high dosage, electrolyte interference, or the addition of large molecules, and is universally applicable to different types of cold-formulated emulsifier systems. This invention is particularly suitable for systems using electrolyte-rich natural plant extracts as the aqueous phase, fundamentally solving the pilling problem and providing a reliable solution for preparing high-feel, all-natural cold-formulated cosmetics.

The application discloses a preparation method of tree moss extract rich in mono-aryl compounds. The application utilizes aged fermentation of fresh tree moss by Aspergillus niger to prepare the tree moss extract rich in mono-aryl compounds. The method provided by the application can degrade macromolecular substances in the tree moss into small-molecule aroma substances, i.e., mono-aryl compounds, so as to improve the content of aroma components and active components, i.e., mono-aryl compounds, in the tree moss extract. The prepared tree moss extract rich in mono-aryl compounds can be used in the field of cigarettes and the like to highlight the style characteristics of tree moss. The tree moss extract prepared by the method has strong antioxidant activity, and can further meet the demand of daily chemical products for natural antioxidant active components in the field of daily chemicals.

This utility model discloses a continuous production apparatus for traditional Chinese medicine liquid preparations, including a filtration device, a buffer device, a concentration device, a first booster pump, a second booster pump, and a controller. The filtration device is used to remove insoluble particulate matter and macromolecules from the liquid medicine. The filtration membrane assembly includes a filtration membrane inlet, a filtrate outlet, and a macromolecule outlet. The buffer tank is equipped with a magnetostrictive level alarm. The concentration device includes a concentration membrane assembly, a fifth pipeline, and a sixth pipeline. The concentration device is used to remove excess water from the liquid medicine. The concentration membrane assembly includes a concentration inlet, a drain outlet, and a concentrate outlet. The first booster pump is located on the first pipeline, and the second booster pump is located on the fourth pipeline. The continuous production apparatus for traditional Chinese medicine liquid preparations provided by this utility model eliminates the influence of differences in filtration and concentration rates between different types of liquid medicines without changing the membrane components, ensuring a stable and continuous production process.

The application belongs to the technical field of cosmetic raw materials, and particularly relates to avocado oil split yeast fermentation filtrate and a preparation method and application thereof. The preparation method comprises the following steps: S1, performing squeezing treatment on dried avocado pulp to obtain avocado oil; S2, adding the avocado oil and a nitrogen source into a basic culture medium, inoculating split yeast for fermentation treatment, and filtering to obtain the avocado oil split yeast fermentation filtrate. The application takes avocado oil as a research object, combines split yeast for fermentation treatment, and adds a specific nitrogen source to optimize the fermentation process, so as to effectively improve the proliferation speed of the strain, and then ensure that macromolecular substances in the avocado oil are effectively converted into small molecular substances with higher activity. Through the conversion, the compound avocado oil split yeast fermentation filtrate not only maintains the original activity, but also has split yeast fermentation metabolic small molecular active products, so that the finally obtained fermentation filtrate has more excellent multiple effects such as in-vitro antioxidant effect.

The invention discloses a composite biological inoculant for promoting alcoholization of crude tobacco, which is prepared by the following steps: by taking bacillus licheniformis CICC 10037, candida utilis CICC 1769 and thermolysis thermophila ATCC 27730 as core functional strains, respectively activating and enlarging culture, then carrying out thallus resuspension by using a stable protective agent solution consisting of trehalose, sodium glutamate and sodium carboxymethyl cellulose, and finally, carrying out fermentation, so as to obtain the composite biological inoculant for promoting alcoholization of crude tobacco. The three strains are mixed according to a specific volume ratio to prepare a compound bacterium suspension, and finally the compound bacterium suspension is uniformly adsorbed to a sterilized homologous tobacco powder carrier, so that macromolecular substances such as starch, protein and cellulose in tobacco leaves can be efficiently degraded through the synergistic effect of the three strains, and the variety and content of aroma components are remarkably increased; the method effectively reduces irritant substances such as ammonia and acetaldehyde and harmful ingredients such as nitrosamine specific to tobacco, reduces offensive odor and irritation, improves taste, ensures uniformity and stability of the alcoholization effect, and achieves multiple purposes of quality improvement, aroma enhancement, harm reduction and efficiency improvement in the crude tobacco alcoholization process.

The invention belongs to the technical field of fishery breeding, particularly relates to a fish and vegetable symbiotic system and a symbiotic method thereof, and aims to solve the problems that when water is pumped out for replacement at present, the pumped-out water needs to be treated to be discharged, but if substances contained in the water cannot be utilized, resources are wasted. A supporting plate is rotationally connected into the fishpond, a conical cover is fixedly installed on the left side of the bottom of the supporting plate, a conveying pipe is fixedly installed at the rear end of the conical cover, a connecting assembly is installed at the top of the supporting plate, and the top of the connecting assembly extends to the position above the fishpond. According to the device, fish manure generated in a fish pond can be pumped out and filtered, filtered water can be used for watering vegetables, macromolecular substances in the water are absorbed by the vegetables, and therefore resource utilization of the fish manure is achieved while water treatment is achieved, and good economic sustainability is achieved.

The invention discloses a preparation method of cereal multi-glucoamylase enzymolysis fermentation feed syrup, and relates to the technical field of feed processing. The method comprises the following steps: S1, uniformly mixing corn and soybean powder, performing micro-powder baking and explosion treatment, mixing with water, and stirring and mixing to form uniform thick slurry; s2, performing staged temperature-controlled enzymolysis on the thick slurry to obtain enzymatic hydrolysate; s3, performing staged mixed fermentation on the enzymatic hydrolysate to obtain the feed syrup. Through three key steps of physical pretreatment wall breaking, staged enzymolysis saccharification and staged mixed fermentation, macromolecular substances such as starch, cellulose and protein in corn and soybean meal are gradually converted into micromolecular saccharides, amino acids and beneficial metabolites which are easy to digest and absorb, and finally the feed syrup which is rich in nutrition and good in palatability is formed.

The application relates to the technical field of wastewater purification, in particular to a phosphorus-containing wastewater treatment system. The system comprises a pre-purification unit, a deep purification unit, a membrane concentration unit and a multi-effect evaporation unit which are connected in sequence; the pre-purification unit is used for diluting and filtering impurities of the phosphorus-containing wastewater; the deep purification unit is used for receiving the wastewater treated by the pre-purification unit and filtering out multivalent metal cations, macromolecular substances and divalent salts in the wastewater; the membrane concentration unit is used for receiving the wastewater treated by the deep purification unit, evaporating water under low temperature in vacuum negative pressure and steam heating, and concentrating phosphoric acid; the multi-effect evaporation unit is used for receiving the phosphoric acid concentrated by the membrane concentration unit, further evaporating water under steam heating, further concentrating the phosphoric acid, and obtaining a phosphoric acid product which reaches the selling standard. The system has low operation energy consumption, can realize efficient recycling of the phosphorus-containing wastewater, reduces pollution to the environment, realizes the improvement of economic benefits through recycling of phosphorus resources.

The invention discloses a preparation method for synthesizing an anti-aging drug through fermentation of a traditional Chinese medicine composition and NMN, and relates to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: raw material compatibility and pretreatment: taking 10-30 parts by mass of rhizoma polygonati, 8-25 parts by mass of lucid ganoderma, 5-20 parts by mass of roxburgh rose, 5-20 parts by mass of lily, 5-20 parts by mass of radix rehmanniae preparata, 5-20 parts by mass of American ginseng, 3-15 parts by mass of pseudo-ginseng, 3-15 parts by mass of syngnathus, 3-15 parts by mass of hippocampus and 5-20 parts by mass of herba epimedii; polygonatum sibiricum and ganoderma lucidum are used as monarch drugs to tonify qi, nourish yin, soothe nerves and promote intelligence; animal medicinal materials such as syngnathus, hippocampus and penis et testis cervi are matched to tonify the kidney, strengthen yang and strengthen In combination with modern anti-aging components of NMN, cell energy is activated, and the aging process is delayed in multiple ways; macromolecular substances are converted into micromolecular active components through fermentation of the compound probiotics, so that the absorption rate is increased; the activity of heat-sensitive components is protected by low-temperature crushing and drying processes; the stability and the palatability of the product are ensured through the scientific matching of the auxiliary materials; tests prove that the traditional Chinese medicine composition has multiple effects of resisting fatigue, improving sleep, enhancing sexual function, improving immunity and the like.

The invention discloses a paper-based micro-fluidic chip device ([mu] PAD) and a method for instantly detecting a blood metabolism marker by using the paper-based micro-fluidic chip device ([mu] PAD). The micro-PAD is a paper-based micro-fluidic chip device (MOG-micro-PAD) based on metal organic gel (MOG), and the micro-PAD is a paper-based micro-fluidic chip device (MOG-micro-PAD) based on metal organic gel (MOG). According to the device, MOG with peroxidase-like activity is used as a catalyst, and the detection activity can still be maintained after the device is placed at room temperature for 90 days, so that the device is convenient to store and transport. According to the method, the blood metabolism marker is detected based on MOG-[mu] PAD, a Cu / Co-MOG dispersion liquid with the concentration of 3-9 mg / mL is firstly added as a filtering medium, then a whole blood or plasma sample is added, red blood cells and colored macromolecular substances in the blood sample can be blocked and filtered in situ, detection can be completed without an additional separation process, operation is easy and convenient, cost is low, and the method is suitable for large-scale popularization and application. The method is suitable for instantly detecting the blood metabolism marker in a resource-deficient region.

The utility model discloses a glucuronic acid production device, and relates to the technical field of pharmacy, an inlet of a conversion kettle is respectively communicated with an inositol solution tank, an inositol oxidase tank and an ammonia water solution tank, an outlet of the conversion kettle is communicated with a ceramic membrane device, and a clear liquid outlet of the ceramic membrane device is communicated with a concentration tank; an inlet of the concentration tank is respectively communicated with a first ethanol tank and a seed crystal tank, an outlet of the concentration tank is communicated with a first filter, and a solid phase outlet of the first filter is communicated with a glucuronic acid crude product tank. In the conversion process, the pH is adjusted to 7.0-8.0 through ammonia water, solid impurities and macromolecular substances in reaction liquid can be effectively separated through the high-precision filtering characteristic of a ceramic membrane device, a clear glucuronic acid solution is obtained, the solubility of the solution can be changed by adding ethyl alcohol, glucuronic acid is promoted to be crystallized and separated out, and the purity of the glucuronic acid is improved. And the addition of the seed crystal can guide the crystallization process, so that the crystallization is more uniform and rapid, and the quality and yield of the glucuronic acid crude product are improved.

The invention belongs to the technical field of photocatalysis, and relates to a metal organic framework AE / Fe-MOF-PVDF photocatalytic membrane as well as a preparation method and application thereof. The invention relates to a metal organic framework AE / Fe-MOF-PVDF (Polyvinylidene Fluoride) photocatalytic membrane, which is formed by introducing AE (Aloe-emodin) into Fe-MOF to construct a heterojunction and immobilizing the heterojunction on a PVDF membrane. In the heterojunction, the mass ratio of AE to Fe is (0.5-2): 1. The metal organic framework AE / Fe-MOF-PVDF photocatalytic membrane prepared by the method has a self-cleaning effect, pollution of the PVDF membrane is avoided, the utilization rate of the membrane is improved, meanwhile, the separation efficiency of photon-generated carriers can be promoted, and the photocatalytic degradation efficiency of macromolecular substances in traditional Chinese medicine wastewater is improved.

The invention relates to a method for improving cigar tobacco quality through mixed enzyme enhanced fermentation, cigar tobacco and application of the cigar tobacco, and belongs to the technical field of tobacco processing. According to the method, a cigar tobacco raw material is sequentially subjected to cellulase treatment and protease treatment, and chemical components such as cellulose, protein, saccharides and amino acid in cigar tobacco are regulated and controlled under mild conditions by combining solid state fermentation. Compared with a single enzyme treatment method or a traditional fermentation method, the method has the advantages that the content of unfavorable macromolecular substances in cigar tobacco can be reduced, and accumulation of aroma precursor substances is promoted, so that the aroma release characteristic and smoke comfort of the cigar tobacco under the condition of lower heating temperature are improved; the method is suitable for improving the quality of cigar tobacco raw materials for heat-not-burn tobacco products, and has good stability and industrial application prospects.

The invention provides an external traditional Chinese medicine composition with a bacteriostatic effect and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises 20-40 parts of pepper, 20-40 parts of fructus cnidii, 10-30 parts of ligusticum, 5-15 parts of pogostemon cablin, 20-40 parts of schizonepeta, 10-30 parts of senecio scandens and 20-40 parts of mint. A response surface experiment design is adopted to optimize an extraction process of traditional Chinese medicinal materials and medicine residues, and the content of effective components such as total flavonoids in the extract is increased; the oil-soluble matrix and the water-soluble matrix are selected, so that the water-soluble medicine components and the oil-soluble medicine components can be better mixed, and the stability is high. The traditional Chinese medicine composition disclosed by the invention can inhibit the formation of bacterial cell membranes and destroy the structures of the bacterial cell membranes, and the permeability of the cell membranes is improved, so that macromolecular substances and proteins are leaked; the intracellular ATP content is reduced, and the extracellular alkaline phosphatase is increased, so that the growth of bacteria is finally inhibited or the bacteria are killed. According to the extraction process, effective components of the medicine are extracted to the maximum extent, and efficient utilization of the medicinal materials is guaranteed.

This application provides a soluble microneedle patch for treating nail fungal infections. The microneedles in the patch comprise: 0.1-7% of a drug component by weight, with the remainder being a matrix component. The matrix component comprises macromolecules with polar bonds having an average molecular weight of 0.05-30,000, macromolecules with polar bonds having an average molecular weight of 100,000-900,000, and macromolecules with polar bonds having an average molecular weight of 1,000,000-2,600,000. The drug component and microneedles work together to allow the drug to penetrate the nail plate directly to the deep connective tissue of the nail bed, killing the fungus. The patch exhibits high effective drug concentration, strong transdermal ability, significant therapeutic effect, no irritation, and no toxic side effects. Furthermore, the microneedles demonstrate excellent short-term rapid treatment and long-term sustained-release therapeutic effects.

The present application relates to a method and system for detecting macromolecules in water. The present application utilizes the interaction between particles and polymers under flow conditions, especially the high sensitivity of particle retention to macromolecular substances, to detect macromolecular information in water through the retention of particles at microchannel obstacles. The detection method of the present application has high sensitivity, short time consumption, low cost and small implementation difficulty compared with conventional chromatographic methods. In addition, due to the specificity of particle-polymer interaction, it is not easily disturbed by other small molecular substances compared with TOC, UV254, COD and other methods, and has high specificity.

This invention relates to a transdermal firming composition that acts on the deep supporting structure of the skin and its application. The invention discloses a composition containing Panax notoginseng extract, Saussurea involucrata extract, and a biotransformation complex, and its preparation method. The composition is obtained by homogenization, filtration, and freeze-drying of 20 parts Panax notoginseng extract, 15 parts Saussurea involucrata extract, and 45 parts biotransformation complex. This invention effectively degrades macromolecular substances in plant raw materials through a specific "enzyme-bacterial synergistic" biotransformation process, improving the release rate of active ingredients and skin permeability. This composition can be widely used in cosmetics with anti-aging and transdermal firming effects.

The invention provides a traditional Chinese medicine oral liquid clarity stability pre-judgment method and application thereof and a modified Huoxiang Zhengqi mixture, and relates to the technical field of medicine detection. According to the pre-judgment method, by quantitatively detecting the content of known macromolecular substances prone to precipitation in the liquid medicine and comparing the content with a preset critical value which is scientifically verified, whether precipitation occurs in the whole preset storage period or not can be predicted when product production is completed or the product is released; the pre-judgment method can be effectively applied to pre-judgment of the clarity stability of the flavored Huoxiang Zhengqi mixture. Meanwhile, the invention further provides the modified Huoxiang Zhengqi mixture, the total content of neutral sugar, acid sugar and protein in the modified Huoxiang Zhengqi mixture oral liquid is smaller than or equal to 106 mg / ml, the content of the neutral sugar is smaller than 100 mg / ml, and it can be pre-judged that the modified Huoxiang Zhengqi mixture oral liquid has qualified clarity stability under the long-term storage condition as long as the standard is met through verification.

This invention belongs to the field of biopharmaceutical technology and relates to a method for preparing *Auricularia auricula-judae* polyphenols by fermentation of the basal cells of *Auricularia auricula-judae* TA58.21 fungus. The method includes: adding cooked soybean powder culture medium and *Auricularia auricula-judae* seed liquid to a fermenter; introducing sterile oxygen; controlling the stirring speed of the fermenter; maintaining the culture temperature at 25-30℃; continuously culturing for 5-8 days; when the fermentation broth turns red and produces a large amount of foam; closing the exhaust valve; maintaining the tank pressure at 0.1 MPa; increasing the fermentation temperature to 50℃; continuing culture for 24 hours; increasing the stirring speed of the fermenter; raising the temperature of the fermentation broth to 80-90℃; maintaining this temperature for 4-8 hours; stopping stirring; and continuing to raise the temperature to 120℃; maintaining this temperature for 30 minutes; centrifuging the fermentation broth to remove precipitates and mycelia; collecting the supernatant for pretreatment of macromolecules and fungal fragments; collecting the permeate and passing it through a nanofiltration membrane to obtain a concentrated solution; and spray-drying or freeze-drying the concentrated solution to obtain a high-purity product. This invention enables the production of auricularia polyphenol products with good water solubility, heat resistance, and acid resistance, and a molecular weight of less than 10,000 Da.