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440 results about "Cell system" patented technology

System and methods for ai-enhanced cellular modeling and simulation

The AI-enhanced cellular modeling and simulation platform is a computational system designed to enhance biomedical research and development and personalized medicine and wellness. This platform integrates simulation modeling, machine learning and artificial intelligence, multi-omics data, and sophisticated data fusion and decision-support techniques to create comprehensive models of cellular systems and processes across multiple scales. It enables researchers and clinicians to simulate complex biological interactions, predict disease progression, and design or optimize treatment strategies or medical devices with improved accuracy and efficacy. The system's architecture allows for integration of various components, including real-time data processing, federated learning, and quantum computing enhancements. From personalized drug discovery and cancer therapies to synthetic biology and epidemiological analysis, this platform offers powerful tools for understanding and manipulating cellular systems and bioengineered systems. By bridging the gap between molecular-level interactions between cells and materials and organism-wide effects, it enables significant advancements in healthcare and biological sciences.
Owner:QOMPLX INC

Unmanned aerial vehicle hydrogen-electricity hybrid power system and energy management method

The unmanned aerial vehicle hydrogen-electricity hybrid power system comprises a vehicle body, a hydrogen fuel cell system, a power cell system and an energy management system are arranged in the vehicle body, and electric energy output by the hydrogen fuel cell system and the power cell system supplies power to a motor through the energy management system; the motor controls the spiral blades, the rotating speed of the motor is independently adjusted, and the posture and movement of the unmanned aerial vehicle are controlled by changing the direction and size of the lifting force; the energy management system is used for performing energy conversion during air speed change and braking of the unmanned aerial vehicle, converting mechanical energy into electric energy, inputting the electric energy into the power battery system, and meanwhile, converting the electric energy to judge whether the unmanned aerial vehicle has a high-power energy supply demand currently so as to adjust energy supply; according to the invention, the service life of the galvanic pile monomers can be prolonged, so that the service life of the hydrogen-electricity hybrid power system module can be prolonged; according to the energy management method, unnecessary energy loss is reduced, and the endurance time of the unmanned aerial vehicle is further prolonged.
Owner:XI AN JIAOTONG UNIV

Photovoltaic cell hot spot intelligent detection method fusing multi-modal data

The invention discloses a photovoltaic cell hot spot intelligent detection method fusing multi-modal data. The method comprises the following steps: S1, collecting multi-modal data of a photovoltaic cell; s2, carrying out preprocessing on the multi-modal data; s3, constructing a photovoltaic cell sample data set; s4, extracting features of the multi-modal data; s5, fusing the multi-modal features to generate a comprehensive feature vector; s6, training and optimizing a dynamic hot spot detection model based on the space-time convolutional network; s7, identifying a hot spot area in the photovoltaic cell by using the model; s8, positioning and outputting a hot spot detection result; and S9, optimizing the detection model in real time in combination with a dynamic adaptive algorithm. According to the method, the multi-modal data fusion, the space-time convolutional network and the dynamic adaptive optimization algorithm are introduced, so that the hot spots in the photovoltaic cell can be detected and positioned more accurately and quickly, the false detection rate in a complex environment is effectively reduced, and the operation efficiency and reliability of a photovoltaic cell system are remarkably improved.
Owner:XUZHOU YAORI ENERGY RESEARCH CO LTD

Sidelink positioning in cellular system

A solution for sidelink-assisted positioning of a terminal device. In an embodiment, a procedure in the terminal device includes transmitting, over a sidelink, a message including at least one information element requesting at least one anchor terminal device to report its location to the terminal device; receiving, over the sidelink from the at least one anchor terminal device, a location report including at least one information element indicating a location of the reporting anchor terminal device and an accuracy metric indicating accuracy of the location; determining a location estimate of the terminal device based on the accuracy metric and the location of the at least one anchor terminal device.
Owner:NOKIA TECHNOLOGIES OY

Systems and methods for manufacturing waveguide cells

Systems for the manufacturing of waveguide cells in accordance with various embodiments can be configured and implemented in many different ways. In many embodiments, various deposition mechanisms are used to deposit layer(s) of optical recording material onto a transparent substrate. A second transparent substrate can be provided, and the three layers can be laminated to form a waveguide cell. Suitable optical recording material can vary widely depending on the given application. In some embodiments, the optical recording material deposited has a similar composition throughout the layer. In a number of embodiments, the optical recording material spatially varies in composition, allowing for the formation of optical elements with varying characteristics. Regardless of the composition of the optical recording material, any method of placing or depositing the optical recording material onto a substrate can be utilized.
Owner:DIGILENS INC

Carnot cell system based on coal-fired power generation unit and operation method of Carnot cell system

The invention belongs to the technical field of coal-fired power generation, and particularly relates to a Carnot battery system based on a coal-fired power generation unit and an operation method of the Carnot battery system. The Carnot cell system comprises a heat pump system taking supercritical carbon dioxide as a working medium, a heat storage system and a coal-fired power generation system; the heat pump system comprises a first compressor, a second compressor, a first heat regenerator, a second heat regenerator, a third heat regenerator, a first turbine and a second turbine; the heat storage system comprises a hot tank and a cold tank; the coal-fired power generation system comprises a coal-fired boiler, a high-pressure cylinder, an intermediate-pressure cylinder, a low-pressure cylinder, a power generator, a condenser, an eighth low-pressure heater, a seventh low-pressure heater, a sixth low-pressure heater, a fifth low-pressure heater, a deaerator, a first high-pressure heater, a second high-pressure heater and a third high-pressure heater. The split-flow compression process and the split-flow expansion process are matched with the multi-stage heat regenerator and the multi-stage fused salt heater, the energy efficiency coefficient of the Carnot battery in the electricity-to-heat conversion process is improved, and therefore the round-trip efficiency of the Carnot battery is improved.
Owner:STATE GRID HENAN ELECTRIC POWER ELECTRIC POWER SCI RES INST +1

Lithium supplement agent, preparation method thereof, positive plate and secondary battery

The invention relates to the technical field of batteries, particularly provides a lithium supplement agent and a preparation method thereof, a positive plate and a secondary battery, and aims to solve the problem that an existing lithium oxalate lithium supplement agent cannot adapt to a battery cell system due to overhigh decomposition voltage. In order to achieve the purpose, the lithium supplementing agent comprises lithium oxalate, a conductive agent and an auxiliary lithium supplementing agent, and the auxiliary lithium supplementing agent generates a substance capable of catalyzing lithium removal of the lithium oxalate in the formation process of the lithium ion battery adopting the lithium supplementing agent and does not generate a substance which reacts with an electrolyte of the lithium ion battery. The auxiliary lithium supplementing material in the lithium supplementing agent generates a substance capable of catalyzing lithium removal of lithium oxalate in the battery formation process, so that the lithium oxalate can be decomposed at lower voltage to release more capacity, the decomposition voltage of the lithium oxalate is effectively reduced, meanwhile, the auxiliary lithium supplementing material is decomposed and does not generate a product which reacts with an electrolyte, and the lithium supplementing efficiency is improved. The lithium oxalate lithium supplement agent can be suitable for a battery cell system, and the subsequent battery cell performance is prevented from being influenced.
Owner:JIANGSU TIANHE ENERGY STORAGE CO LTD

Modular and scalable quanutm computer with trapezoidal unit cells

Systems and techniques that facilitate scalable cryostats and cryogenic systems are provided. In an embodiment, a cryogenic system can comprise a plurality of unit cells joined together, wherein each unit cell comprises: a trapezoidal-shaped frame, wherein frames from adjacent unit cells are connected in a vacuum-tight manner to form a continuous, global vacuum enclosure, and wherein the unit cells are capable of being horizontally removed from or inserted into the plurality of joined unit cells. Furthermore, each unit cell can comprise at least one temperature shell, wherein temperature shells from adjacent unit cells are connected to form a continuous, global temperature shell. Moreover, each unit cell can comprise at least one cryogenic payload located within the at least one temperature shell, that is cooled by at least one retrofitted version of a standard dilution refrigerator.
Owner:INTERNATIONAL BUSINESS MACHINE CORPORATION

Systems and Methods for Manufacturing Waveguide Cells

Systems for the manufacturing of waveguide cells in accordance with various embodiments can be configured and implemented in many different ways. In many embodiments, various deposition mechanisms are used to deposit layer(s) of optical recording material onto a transparent substrate. A second transparent substrate can be provided, and the three layers can be laminated to form a waveguide cell. Suitable optical recording material can vary widely depending on the given application. In some embodiments, the optical recording material deposited has a similar composition throughout the layer. In a number of embodiments, the optical recording material spatially varies in composition, allowing for the formation of optical elements with varying characteristics. Regardless of the composition of the optical recording material, any method of placing or depositing the optical recording material onto a substrate can be utilized.
Owner:DIGILENS INC

Optical multi-pass pool modeling and optimizing method

The invention discloses an optical multi-pass pool modeling and optimizing method, and belongs to the technical field of optical detection. In order to solve the problems that an existing multi-pass cell is too long in length, large in size and inconvenient to carry or transfer, and meanwhile, the mirror surface utilization rate of the multi-pass cell is low, a light path in a multi-pass cell system is accurately modeled by adopting a light ray tracing principle, and the system does not depend on traditional paraxial approximation. The problems that in the prior optical design, due to the fact that equipment is large in size, carrying is inconvenient, and due to the fact that aberration is neglected due to paraxial approximation, large deviation is generated between a calculated value and an actual value are solved. In addition, the light spot distribution is automatically optimized through the genetic algorithm, and the design and debugging time of the optical system is shortened. According to the innovative design strategy, the utilization rate of the reflector is improved, space waste is avoided, the sensitivity and accuracy of a reflection system can be remarkably improved, and further development of the optical multi-pass cell technology is promoted.
Owner:SHANXI UNIV

Carnot cell system for heating heat supply network water in cascade mode and operation method of Carnot cell system

The invention discloses a Carnot battery system for cascade heating of heat supply network water and an operation method of the Carnot battery system, and belongs to the technical field of Carnot battery systems, the system comprises a steam turbine power generation system, a heat supply network water heating system, an electricity-to-heat system and a storage tank heat storage and release system. Based on a traditional Carnot battery system, the heat supply network heat exchanger is additionally arranged on the heat storage part of the storage tank system, so that the thermoelectric load characteristic interval of the system is expanded, and the operation flexibility of the system is improved. And meanwhile, abandoned electricity of a new energy station can be reduced, and the network access rate of new energy is increased. In addition, the temperature of the heat storage medium entering the heat source heat exchanger is reduced by heating heat supply network water, so that the COP and the round-trip efficiency of the system are improved; the heat exchange loss of heat supply network water is reduced due to the cascade heating system, and the energy utilization rate is increased. Compared with a traditional Carnot cell system, the system has higher efficiency and lower coal consumption, and theoretical reference and technical transformation can be provided for coal-electricity low-carbon flexible transformation.
Owner:STATE GRID HENAN ELECTRIC POWER ELECTRIC POWER SCI RES INST

Bubble-free interface optimization electrolysis cell system

PendingCN119876977ACellsEngineeringCell system
The invention belongs to the technical field of green hydrogen energy production, and particularly relates to a bubble-free interface optimization electrolytic bath system. The electrolytic bath comprises a bath body, the bath body is provided with a hydrogen channel, an oxygen channel, a liquid inlet hole and a liquid outlet hole, the hydrogen channel and the oxygen channel are located on the upper portion of the bath body, a diaphragm is arranged in the bath body, an anode chamber and a cathode chamber are arranged between the two sides of the diaphragm and the bath body respectively, the anode chamber is communicated with the oxygen channel, and the cathode chamber is communicated with the hydrogen channel; an anode plate and a cathode plate are respectively arranged in the anode chamber and the cathode chamber; the middle part of the diaphragm covers the electrode, and the periphery of the diaphragm exceeds the periphery of the electrode; and the part, exceeding the periphery of the electrode, of the diaphragm extends into the liquid inlet channel and is provided with micropores, and the pore diameter of the micropores is 1-5 microns. According to the electrolytic cell, the performance limit of a traditional alkaline electrolytic cell is broken through, the efficient range is increased to 93% or above, the efficiency limit existing in the traditional electrolytic process is effectively relieved, and the cost burden of hydrogen production is reduced.
Owner:HUADIAN CAOFEIDIAN HEAVY IND

Application of controllable delivery of multi-membraneless-zone interventricular substances in cell-free system

PendingCN119592598Aachieve deliveryRealize self-regulationBacteria peptidesPolypeptide with His-tagHypermetabolismCell system
According to the application of the controllable delivery of the multi-membraneless compartment interlamellar substances in the cell-free system, two independent and coexisting protein enrichment phases are rapidly formed in the optimized cell-free system by utilizing the protein expression of a protein expression vector and adding histidine tag (His Tag) protein, namely, after the multi-membraneless compartment is formed, the two independent and coexisting protein enrichment phases are separated from the cell-free system, and the cell-free system can be used for controlling the delivery of the multi-membraneless compartment interlamellar substances in the cell-free system. And controllable delivery of micromolecular substances and macromolecular substances in multiple membrane-free zone chambers is carried out. The multiple membrane-free compartments constructed by the invention can controllably enrich specific active components and biochemical reactions in a cell-free system into the compartments and separate the specific active components and biochemical reactions from other complex metabolic reactions, and due to the high dynamic nature of the compartments, controllable communication between biomolecules and the external environment and among multiple compartments can be realized; further, the accuracy and controllability of metabolic reaction are greatly improved, and a solid foundation is laid for application of a cell-free system in the aspects of complex metabolic pathway exploration, multi-enzyme catalysis, drug delivery and the like.
Owner:SHANGHAI JIAOTONG UNIV

High-temperature methanol reforming fuel cell system for realizing carbon cycle and operation process

The invention belongs to the technical field of fuel cells, and particularly relates to a high-temperature methanol reforming fuel cell system for realizing carbon cycle and an operation process. The system comprises an electric pile, a methanol steam reforming hydrogen production reactor, a carbon dioxide hydrogenation methanol production reactor and an electrolyzed water module, hydrogen prepared by the methanol steam reforming hydrogen production reactor enters an anode of the galvanic pile through a pipeline, a cathode of the galvanic pile is supplied by an air pump, and the hydrogen and oxygen are subjected to electrochemical reaction in the galvanic pile to realize external power supply; liquid water recovered from the electric pile tail gas is introduced into the water electrolysis module, and water electrolysis is performed to generate hydrogen; carbon dioxide in the stack tail gas and hydrogen generated by the water electrolysis module enter the carbon dioxide hydrogenation methanol preparation reactor through the gas inlet pipeline to prepare methanol. According to the invention, the circulation of carbon in the high-temperature methanol fuel cell system is realized, the emission of carbon dioxide is reduced, the circulation of hydrogen and oxygen is realized, and the energy utilization efficiency of the system is jointly improved through the circulation of carbon, hydrogen and oxygen.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Antibodies comprising chimeric constant domains

Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.
Owner:REGENERON PHARMACEUTICALS INC

Optical multi-pass cell system, gas absorption data detection method, and terminal device

An optical multi-pass cell system, a gas absorption data detection method, and a terminal device. The optical multi-pass cell system comprises: an optical multi-pass cell (11), which comprises an input end (101) and an output end (102); and a driving mechanism (12), which is used for driving M sub-mirrors of the optical multi-pass cell (11) to perform periodic reciprocating motion in a Z-axis direction during each data collection process of a gas absorption data detection process, wherein the Z-axis direction is parallel to the optical axis of the optical multi-pass cell (11), M≥1, and the detection process comprises: when the optical multi-pass cell (11) is filled with a gas to be detected, a detection beam is inputted from the input end (101), is reflected multiple times in the optical multi-pass cell (11), and then forms an interference beam that is outputted from the output end (102). Optically noise-smoothed gas absorption data can be obtained, such that the sensitivity of detecting gas absorption data on the basis of an optical multi-pass cell system can be improved.
Owner:XUZHOU XUHAI OPTO ELECTRONICS TECH CO LTD

SgRNA for pedigree tracing by targeting Rosa26 gene and application of sgRNA

The invention belongs to the technical field of gene engineering, and discloses sgRNA for pedigree tracing of a targeted Rosa26 gene, the sgRNA comprises sgRNA1, sgRNA2, sgRNA5, sgRNA6 and sgRNA7, and the nucleotide sequences of corresponding DNA double strands of the sgRNA1, the sgRNA2, the sgRNA5, the sgRNA6 and the sgRNA7 are sequentially shown as SEQ ID NO: 1-2, SEQ ID NO: 3-4, SEQ ID NO: 5-6, SEQ ID NO: 7-8 and SEQ ID NO: 9-10. The sgRNA can target a mouse Rosa26 gene, is combined with a CRISPR / Cas9 targeting vector, and can cut different sites of the Rosa26 gene to generate different bar codes, the diversity of the obtained bar codes can be used for reconstructing a cell lineage and tracing the cell lineage, meanwhile, the transcription of the Rosa26 gene is not influenced after cutting, and the cell lineage relationship can be comprehensively tracked in a complex cell system.
Owner:SHANXI UNIV

A flow cell method drug dissolution closed-loop sampling system and its usage method

A closed-loop sampling system for drug dissolution by flow-through cell method and its use method, comprising a constant-temperature water bath system, a flow-through cell system, a lifting mechanism, a circulating heating system, a solvent monitoring system, a solvent circulation system and a sampling system; the constant-temperature water bath system includes a constant-temperature water bath frame, a constant-temperature water bath, a solvent cup holder, a solvent cup and a solvent cup cover; the flow-through cell system is arranged at the top of the constant-temperature water bath system; the lifting mechanism is arranged on one side of the constant-temperature water bath frame; the circulating heating system includes a heating device and a water circulation pump; the circulating inlet end of the solvent monitoring system is communicated with the heating device, and the circulating outlet end of the solvent monitoring system is respectively communicated with the solvent cup and the flow-through cell; the solvent circulation system includes a solvent circulation pump and a pulse valve; the sampling system includes a sampling mechanism, a sampling pipeline, a sampling valve and a sampling pump. The device of the present invention has a compact structure, high heating efficiency of the heating device, uniform water temperature distribution in the water bath, accurate water temperature control, and temperature and pressure monitoring of the solvent.
Owner:LUGEN (SHANGHAI) LIFE TECH CO LTD

Power control method for fuel cell system of mine truck

The invention relates to the technical field of new energy special vehicles, and discloses a mine truck fuel cell system power control method, which comprises the following steps: obtaining total output power required to be output by a fuel cell total system according to the whole vehicle required power and the SOC of a power cell system; according to the state of each fuel cell subsystem in the fuel cell total system, obtaining the number of fuel cell subsystems capable of outputting power in the fuel cell total system; comparing the number of the fuel cell subsystems capable of outputting power with a set threshold value, and if the number is greater than the set threshold value, averagely distributing the total output power to the fuel cell subsystems capable of outputting power; if not, the total system output power of the fuel cell is zero, and the power cell system is closed; the demand power response speed is high, and the problems that the service life of an electric pile is shortened and attenuation is aggravated due to frequent power load changing of a fuel cell total system are effectively solved.
Owner:HYDROGEN (SHANGHAI) NEW ENERGY TECH CO LTD

Preparation of 10-trifluoromethoxy camptothecin derivative and application of 10-trifluoromethoxy camptothecin derivative in anti-tumor aspect

The invention relates to preparation of 10-trifluoromethoxy camptothecin compounds and application of the 10-trifluoromethoxy camptothecin compounds in antitumor drugs. The structural formula of the compounds is shown in the specification. In-vitro cytotoxic activity screening results show that the 10-trifluoromethoxy camptothecin compound has broad-spectrum anti-tumor activity, and shows relatively strong inhibitory activity on human liver cancer cells (HepG2), human non-small cell lung cancer cells (A549), human colon cancer cells (SW480), human bile duct cancer cells (QBC939), human breast cancer cells (MCF-7), human pancreatic cancer cells (PANC-1) and human pancreatic cancer cells (BxPC-3). The compound 10-trifluoromethoxy camptothecin I and the compound 7-ethyl-10-trifluoromethoxy camptothecin II have a relatively strong inhibition effect on the detected seven tumor cell lines, and the IC50 (half maximal inhibitory concentration) values of the compound 10-trifluoromethoxy camptothecin I and the compound 7-ethyl-10-trifluoromethoxy camptothecin II are respectively 0.913 to 0.0661 mu M and 4.932 to 0.0578 mu M, which are obviously superior to those of a contrast drug topotecan. Wherein the compound I and the compound II show the strongest inhibitory activity on a BxPC-3 cell line, and the IC50 values of the compound I and the compound II are 0.0661 + / -0.0065 [mu] M and 0.0578 + / -0.0043 [mu] M respectively. Therefore, the 10-trifluoromethoxy camptothecin compound is expected to be developed into a novel antitumor drug. # imgabs0 #
Owner:LANZHOU UNIV

Marine fuel cell system attenuation model considering influence of salt spray environment, and power control method and service life prediction method of marine fuel cell system attenuation model

The invention discloses a marine fuel cell system attenuation model considering the influence of a salt mist environment, and a power control method and a service life prediction method thereof, and the model comprises the following three parts: a first part, an attenuation model considering the influence of the salt mist environment on the performance of a marine hydrogen fuel cell during use; the second part is a power control method based on the attenuation model; and the third part is a marine fuel cell system life prediction method based on historical operation data and the attenuation model. According to the invention, the attenuation model of the marine fuel cell system including the influence of the salt mist environment is established for the first time, and the power control method of the marine fuel cell system is provided based on the attenuation model, so that the power of the fuel cell system is accurately controlled; in addition, a life prediction method of the marine fuel cell system is provided based on the attenuation model and historical operation data, so that the life and residual life prediction of the fuel cell system becomes simple, convenient and effective.
Owner:CHINA MERCHANTS MARINE & OFFSHORE RES INST CO LTD +1

Cell-stack system for a fuel-cell system

PCT designated stage expiredWO2025024876A1Reactant parameters controlThermodynamicsFuel cells
The present invention relates to a cell-stack system (100) for a fuel-cell system (102), comprising a number of cell stacks (110), which are arranged in at least one cell-stack unit (20), wherein each cell stack (110) has an anode portion and a cathode portion, comprising a pipe system (50), which runs in a longitudinal direction (52) and is intended for conducting anode feed gas (AZG) and cathode feed gas (KZG) to the cell stacks (110) and for conducting anode off gas (AAG) and cathode off gas (KAG) away from the cell stacks (110), and comprising a manifold system (10) for each cell stack (110), wherein each manifold system (10) connects the anode portion and the cathode portion of the corresponding cell stack (110) to the pipe system (50) for fluid communication, and wherein each manifold system (10) has an anode feed portion (122) for feeding the anode feed gas (AZT) from an anode feed pipe (62) of the pipe system (50), an anode discharge portion (124) for discharging the anode off gas (AAG) to an anode discharge pipe (66) of the pipe system (50), a cathode feed portion (132) for feeding the cathode feed gas (KZG) from a cathode feed pipe (64) of the pipe system (50), and a cathode discharge portion (134) for discharging the cathode off gas (KAG) to a cathode discharge pipe (68) of the pipe system (50).
Owner:AVL LIST GMBH

Carnot cell system

The invention aims to provide the Carnot battery system and the operation method thereof, the system and the operation method adopt a CO2 hydrate cold storage mode, only CO2 and water are used as cold storage materials, the CO2 hydrate cold storage technology is latent heat cold storage, the phase change latent heat can reach 500kJ / kg and is far higher than that of water cold storage, and the Carnot battery system has the advantages of low material cost, low energy consumption and the like. The chemical safety and the stability are high. Through cooperative work of energy charging circulation, energy discharging circulation, the heat storage subsystem and the cold storage subsystem of the Carnot battery system, efficient energy storage and release are achieved, the admitting ability of a power grid to new energy is improved, peak clipping and valley filling are achieved, frequency modulation and voltage regulation are participated, and then the overall efficiency and economical efficiency of a power system are improved.
Owner:JIAXING RES INST ZHEJIANG UNIV +2

Ginseng cell engineering tumor vaccine as well as preparation method and application thereof

The invention relates to the technical field of biological medicine, and provides a ginseng cell engineering tumor vaccine as well as a preparation method and application thereof. The ginseng cell engineering tumor vaccine comprises an exosome derived from a recombinant ginseng cell capable of expressing a tumor antigen; the recombinant ginseng cell capable of expressing the tumor antigen is obtained by introducing a recombinant plasmid containing tumor antigen DNA into a ginseng cell. According to the invention, ginseng cells in Chinese herbal medicines are taken as host cells for recombinant expression of tumor antigens, large-scale production of tumor vaccines can be realized through construction of an engineering recombinant cell system, biocompatibility and uniformity of the vaccines can be maintained, and safety risks can be reduced. Meanwhile, the prepared tumor antigen recombinant expression ginseng cell exosome can integrate the antigen, an adjuvant and a carrier, and the antigen phagocytosis, maturation and antigen peptide presentation capabilities of APCs are enhanced.
Owner:NANJING UNIV OF TRADITIONAL CHINESE MEDICINE

Systems, methods and apparatus for the automated culture of cells

Systems and methods for the automated culture of cells and apparatus and methods for dissociating one or more colonies in a culture of cells are described. The automated systems include at least an imaging module, a pipette module, a handling module, and optionally a stage module. Coordinated operation of the foregoing modules is effected by at least one processor based on one or more characteristics of the culture of cells calculated from one or more images captured at a first time point and at one or more subsequent time points. The apparatus includes a mounting surface, having one or more impact bumpers, connected to a rotatable drive, a platform rotatable dependently or independently of the drive, and one or more impact brackets connected to the platform and collidable with the one or more impact bumpers to transmit a dissociative force to a culture of cells in a cell culture vessel upon the platform.
Owner:STEMCELL TECHNOLOGIES CANADA INC

Solid oxide cell system

In a solid oxide cell system (1) having a solid oxide cell module (100) with at least one solid oxide cell stack (10) and capable of switching between an SOFC mode and an SOEC mode, the solid oxide cell stack (10) that switches from one of the SOEC mode and the SOFC mode to the other mode is continuously operated in one of the modes, and the temperature of the solid oxide cell stack (10) is controlled so as to approach a preset operating temperature of the other mode through a thermal reaction of the solid oxide cell stack (10) due to operation in one mode.
Owner:MITSUBISHI ELECTRIC CORP

Crispr-CAS9 based tools: potential novel therapeutic approaches for machado-joseph disease

The present disclosure relates to Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), an autosomal dominantly inherited neurodegenerative disorder that is caused by an over-repetition of the polyglutamine-codifying region in the ataxin-3 (ATX7V3) gene. Expanded ATXN3 is prone to aggregate and disturbs diverse cellular systems, ultimately leading to cell dysfunction and death in specific neuronal populations. To date, no treatment able to reverse or stall MJD / SCA3 progression has been developed. Strategies based on the suppression of the deleterious gene products have demonstrated promising results in pre-clinical studies. Nonetheless, these strategies do not target the root cause of the disease, producing an incomplete and / or transient therapeutic effect in target cells or tissues. Recently, gene-based therapeutics, including the bacterial clustered regularly interspaced short palindromic repeat (CRISPR) systems for gene edition, have been successfully used to permanently inactivate and correct disease-related genes, holding promise for the development of a definitive cure for inherited diseases.
Owner:UNIVE DE COIMBRA

Cellular system

A system includes a cellular transceiver to communicate with a predetermined target; one or more antennas coupled to the 5G or 6G transceiver each electrically or mechanically steerable to the predetermined target; a processor to control a directionality of the one or more antennas in communication with the predetermined target; and an edge processing module coupled to the processor and the one or more antennas to provide low-latency computation for the predetermined target.
Owner:FRACTAL NETWORKS LLC

Construction of artificial multicellular system and application of artificial multicellular system in nitrogen reduction

The invention discloses construction of an artificial multicellular system and application of the artificial multicellular system in nitrogen reduction, and belongs to the technical field of fermentative degradation. According to the artificial multi-cell system constructed by the method disclosed by the invention, a direct ammoxidation gene dnfABC is over-expressed by adopting Shinella zoogloeoides ATCC19623, and a urea degradation gene cluster ureDABCJEFG is over-expressed by adopting Paracoccus denrificans DYTN-1; the constructed recombinant bacteria are independently or jointly used for nitrogen reduction. According to the method, the synergistic effect of microorganisms in the nitrogen degradation process is utilized, the artificial multicellular system meeting the nitrogen pollution wastewater treatment requirement is developed, the degradation effect and the process stability are remarkably improved, and rapid degradation of nitrogen is achieved.
Owner:JIANGNAN UNIV