11 results about "Human colon" patented technology

The present invention relates to a polysaccharide with cytotoxic activity against human colon, human lung, human melanoma and murine leukaemia tumour cells, as well as antioxidant and healing activity. The invention also relates to a method for producing the polysaccharide, its uses and applications, particularly via drugs for treating cancer and / or antioxidant and healing compositions. The polysaccharide of the present invention can be produced from biomass, particularly from fungi, and preferably from the fungus Bovistella utriformis.

In many applications, the assessment of the internal structures of tubular structures (such as in medical imaging, blood vessels, bronchi, and colon) has become a topic of high interest. Many 3D visualization techniques, such as “fly-through” and curved planar reformation (CPR), have been used for visualization of the lumens for medical applications. However, all the existing visualization techniques generate highly distorted images of real objects. This invention provides direct manipulation based on the centerline of the object and visualization of the 3D internal structures of a tubular object without any noticeable distortion. For the first time ever, the lumens of a human colon is visualized as it is in reality. In many medical applications, this can be used for diagnosis, planning of surgery or stent placements, etc. and consequently improves the quality of healthcare significantly. The same technique can be used in many other applications.

The invention discloses a novel target of PPP2R1A as an anti-inflammatory therapeutic drug and application of the novel target, it is found for the first time that knock-down of PPP2R1A can significantly inhibit expression of an anti-inflammatory active compound PB in NF-kB, TNF-alpha and IL-1beta inflammatory factors in human colon tumor cells, and at present, the relationship between PPP2R1A protein and inflammation has not been researched. The invention provides a novel drug target for treatment of inflammatory diseases in the field, provides a practical and effective screening method for discovery of inflammation treatment leading drugs, provides a scientific basis for clinical treatment of ulcerative colitis, and has a good application prospect in the aspect of anti-inflammation.

Various embodiments of a gut microbiome modulating composition comprises a blend of a polyphenol and an oligosaccharide. Various embodiments of the polyphenol may comprise at least approximately 5% by weight chlorogenic acid. Various embodiments of the oligosaccharides may be standardized to a degree of polymerization of at least three to reduce digestibility. Administration of an effective amount of the gut microbiome modulating composition to a person or animal may stimulate the growth of at least one of Akkermansia muciniphila, Lactobacillus, and Bifidobacterium bacteria in the colon, which may reduce permeability of the colon, increases short chain fatty acid production in the colon, and / or modulate causes immunomodulation of human colon cells. The gut microbiome modulating composition may provide protective effects against obesity-related chronic diseases.

The present disclosure provides compositions and methods of modulating the response of a subject to an anti-cancer treatment, comprising fecal-derived extracellular vesicles, filtrates or compositions comprising the same, which can be administered with an anti-cancer treatment. The composition disclosed herein can be substantially free of living biological material present in the human colon and biological material less than about 5-10 kDa molecular weight.

The invention belongs to the field of biological medicine, and relates to broad-spectrum antibacterial peptide derived from periplaneta americana and anti-tumor application of the broad-spectrum antibacterial peptide. The PA-1 and the PA-2 are both novel alpha-spiral cationic peptides and show remarkable inhibitory activity on pseudomonas aeruginosa, salmonella typhimurium, staphylococcus aureus, staphylococcus epidermidis and carbapenem-resistant acinetobacter baumannii, and the minimum inhibitory concentration on the carbapenem-resistant acinetobacter baumannii reaches 11 [mu] mol / L. In addition, PA-1 and PA-2 can also obviously inhibit the growth of human colon adenocarcinoma cells SW480, cervical cancer cells Hela and gastric cancer cells HGC-27, and show better anti-tumor potential. And the PA-1 and the PA-2 have good thermal stability, pH stability, salt stability and enzyme stability. The two novel active peptides PA-1 and PA-2 provided by the invention show relatively high medicinal values in the antibacterial and anti-tumor fields, and particularly provide a new choice for clinical treatment of carbapenem-resistant acinetobacter baumannii infection.

The invention discloses application of an MPP2 gene as a prognostic marker and a therapeutic target of colon cancer, relates to the technical field of biological medicines, and is characterized in that the MPP2 gene is used as the prognostic marker and the therapeutic target of the colon cancer, and a new thought is provided for prognosis and treatment of the colon cancer. Researches in the invention show that the expression quantity of the MPP2 protein in colon cancer organizers is significantly higher than that of normal human colon tissues, and the difference has significant statistical significance (Plt; 0.05) of the method. In addition, research also finds that the expression quantity of the MPP2 protein in low-differentiation colon cancer organizers is obviously smaller than that of high-differentiation colon cancer organizers, and the difference between the MPP2 protein and the high-differentiation colon cancer organizers has obvious statistical significance (Plt; 0.05) of the method.

The application discloses an anti-digestive polysaccharide-based food colon simulation fermentation and multi-dimensional online analysis system and belongs to the technical field of food. The fermentation simulation of each colon part is completely carried out according to the human digestive fermentation process and physiological environment, and intestinal mucosa globules are added to simulate the human intestinal mucosa environment, so that the degradation process of the anti-digestive polysaccharide-based food by part microorganisms in the human colon under the ex vivo condition is simulated, and the fermentation condition of the anti-digestive polysaccharide-based food after entering the colon can be observed online, which is in line with the real human physiological environment.

The invention discloses application of spermidine and a composition thereof in preparation of medicines for preventing or treating radioactive diseases and related complications thereof. According to the application, firstly, an in-vitro experiment shows that spermidine can be used for remarkably relieving proliferation arrest of radiation-induced human colonic dry organs and inhibiting apoptosis of colonic epithelium organs; furthermore, animal in-vivo experiments show that spermidine can repair radioactive injury, including enteritis, intestinal injury, intestinal fibrosis and the like caused by radiation; the application firstly proposes and proves that spermidine can be used as a radiation protective agent and a safe medicine component for treating radioactive injury, and has a good clinical application prospect and application value.

The utility model relates to a device for assisting colon peristalsis through inflation and deflation of an air bag, and belongs to the technical field of medical instruments. According to the technical scheme, the peristaltic belt is formed by arranging and fixing a plurality of air bags on the inner side of a positioning and fixing belt, and the shape formed by arranging the air bags is consistent with the shape of the colon of the human body; the power transmission and control unit is attached to the belly of a human body through the positioning and fixing belt and connected with the air bags on the peristaltic belt; the multiple air bags generate peristaltic pressure waves consistent with colon peristaltic contraction waves in direction through inflation and deflation. The device has the advantages that the device is attached to the area, reversely projected on the surface of the abdomen, of the colon of a user, the cavity diameter of the pressed area of the colon is decreased and the internal pressure is increased through inflation and deflation of the air bag, under the pressure effect, the content of the colon is pushed to the low-pressure area, and due to the pressure conduction effect of peristaltic pressure waves, the content of the colon is reduced. And the colon content is continuously moved towards the conduction direction of waves, so that the colon peristalsis assisting effect is achieved, and the problem of retention of the colon content in the background is solved.

The invention discloses a mouse model of intestinal cancer related to colitis and a construction method thereof, and belongs to the technical field of disease animal model construction. The construction method comprises the following steps: inserting loxP sites in the upstream of a No.2 exon and the downstream of a No.4 exon of a mouse GPX4 gene respectively to construct a parent mouse 1; hybridizing the parent mouse 1 and the parent mouse 2, and screening to obtain a filial generation mouse containing the GPX4 gene and the Cre gene; azomethane induction medicine and dextran sodium sulfate are adopted to jointly induce generation of intestinal cancer related to colitis of the filial generation rats; and monitoring the morbidity condition of the mouse colitis-related intestinal cancer to complete the construction of the mouse model. The finally obtained colitis-related intestinal cancer model has the characteristics that the body weight is reduced, the DAI score is higher, the intestinal permeability is increased more obviously, the intestinal tumor load is more, the mouse lifetime is shorter, and the reduction of the intestinal GPX4 of the mouse is similar to the intestinal expression of human colitis-related intestinal cancer.