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Preparation method and application of Jieguqili tablet

A technology of hot bone drynaria and extraction, which is applied in the field of preparation of jieguqili tablets, can solve the problems of large dosage for patients, affect clinical application, and many impurities, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-06-18
FIRST AFFILIATED HOSPITAL HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of microwave technology in the extraction and preparation of Jiegu Qili Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take and serious. Affected the clinical application of this product

Method used

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  • Preparation method and application of Jieguqili tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 100g of fried frankincense, 100g of fried myrrh, 150g of Angelica sinensis, 250g of Chinese soft-shelled turtle, 150g of drynaria, 100g of borax, 150g of dried blood, 100g of calcined natural copper, 100g of fried rhubarb with wine, crushed, add 2L of 70% ethanol, put in Microwave extraction was carried out in a microwave extraction device, the extraction power was 400W, and the extraction was performed twice for 4 minutes each time. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and collected for 5 times the column volume. De-liquid, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch, granulate with 70% ethanol, dry, press into tablets, and make 1000 tablets, coated, each tablet weighs 0.3g

Embodiment 2

[0016] Take 100g of fried frankincense, 100g of fried myrrh, 150g of Angelica sinensis, 250g of Chinese soft-shelled turtle, 150g of drynaria, 100g of borax, 150g of dried blood, 100g of calcined natural copper, 100g of fried rhubarb with wine, crushed, add 2L of 70% ethanol, put in Microwave extraction was carried out in a microwave extraction device, the extraction power was 500W, and the extraction was performed twice for 5 minutes each time. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and collected for 5 times the column volume. De-liquid, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch, granulate with 70% ethanol, dry, press into tablets, and make 1000 tablets, coated, each tablet weighs 0.3g

Embodiment 3

[0018] Take 100g of fried frankincense, 100g of fried myrrh, 150g of Angelica sinensis, 250g of Chinese soft-shelled turtle, 150g of drynaria, 100g of borax, 150g of dried blood, 100g of calcined natural copper, 100g of fried rhubarb with wine, crushed, add 2L of 70% ethanol, put in Microwave extraction was carried out in a microwave extraction device, extraction power was 600W, extraction was performed twice, 8 minutes each time, the extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and collected for 5 times the column volume. De-liquid, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, add starch, granulate with 70% ethanol, dry, press into tablets, and make 1000 tablets, coated, each tablet weighs 0.3g

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Abstract

The invention provides a preparation method of Jieguqili tablet. The Jieguqili tablet is prepared by the following raw medicines by weight: 100g of stir-baked olibanum, 100g of stir-baked myrrh, 150g of angelica sinensis, 250g of ground beetle, 150g of hot rhizoma drynariae, 100g of borax, 150g of sanguis draconis, 100g of calcinated native copper, and 100g of wine-fired rhubarb through adopting a microwave extraction method, so that the content is greatly increased, and the usage amount is reduced. The invention further provides applications of the Jieguqili tablet in preparing drugs for inhibiting proliferation of human colon carcinoma HT29 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Jiegu Qili tablets. Background technique [0002] Jiegu Qi Li pieces are recorded in the ministerial standard (WS3-B-0620-91), the prescription is 100g of fried frankincense, 100g of fried myrrh, 150g of angelica, 250g of soil soft-shelled turtle, 150g of dried bones, 100g of borax, 150g of dried blood, 100g of calcined natural copper, 100g of rhubarb stir-fried with wine, the above nine flavors, crushed into fine powder, sieved, mixed, add appropriate amount of auxiliary materials, mixed, granulated, pressed into tablets, and coated with sugar. It can promote blood circulation and remove blood stasis and relieve pain by bridging bones. For bruises, continuation of tendons and bones, blood stasis pain. [0003] In the prior art, there is no report that microwave technology is used in extraction and prepar...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61K9/28A61P35/00A61K33/22A61K33/34A61K35/64
Inventor 严白双
Owner FIRST AFFILIATED HOSPITAL HEILONGJIANG UNIV OF CHINESE MEDICINE
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