3results about How to "Antiproliferative activity" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to a dipicolinate ester derivative and application thereof. The dipicolinate ester derivative has broad-spectrum antitumor activity, can significantly inhibit the proliferation activity of lung cancer cells, pancreatic cancer cells and prostate cancer cells, and has more excellent inhibitory activity on lung cancer cells, and can significantly inhibit the growth of mouse subcutaneous small cell lung cancer transplanted tumors. In addition, the dipicolinate ester derivative has no toxic effect on normal cells of the body, can be applied to preparation of anticancer drugs, and has broad application prospects in the aspect of anticancer.

This invention is a divisional application of patent application number 202311457833.6. This invention belongs to the field of compound synthesis technology, specifically relating to an indole compound that targets and inhibits HDAC6, its preparation method, and its applications. The indole compound that targets and inhibits HDAC6 of this invention is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. Experimental results show that the indole compound that targets and inhibits HDAC6 provided by this invention not only has superior selective inhibitory activity against HDAC6 protein but also inhibits the proliferation of gastric cancer cells in a concentration-dependent manner. Therefore, the compound of this invention has good application prospects in the preparation of inhibitory drugs based on the HDAC6 target and drugs that inhibit the proliferation activity of gastric cancer cells, and is of great significance in the development of anti-tumor drugs and the treatment of related diseases.

The application belongs to the technical field of medicine, and particularly relates to application of trifluperidol in treatment of cerebrovascular diseases. Trifluperidol is a D1 / D2 dopamine receptor antagonist with oral activity and a novel PI3K inhibitor, and trifluperidol has anti-proliferative activity on cancer cells and induces apoptosis. The application discloses trifluperidol for the first time, and no report is found on effective treatment of trifluperidol against ischemic stroke, especially the application creatively proposes that trifluperidol significantly reduces the volume of acute cerebral infarction of a mouse with focal cerebral ischemia, which indicates that trifluperidol can be used for treating ischemic stroke.