1results about How to "Antiproliferative activity" patented technology

This invention is a divisional application of patent application number 202311457833.6. This invention belongs to the field of compound synthesis technology, specifically relating to an indole compound that targets and inhibits HDAC6, its preparation method, and its applications. The indole compound that targets and inhibits HDAC6 of this invention is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. Experimental results show that the indole compound that targets and inhibits HDAC6 provided by this invention not only has superior selective inhibitory activity against HDAC6 protein but also inhibits the proliferation of gastric cancer cells in a concentration-dependent manner. Therefore, the compound of this invention has good application prospects in the preparation of inhibitory drugs based on the HDAC6 target and drugs that inhibit the proliferation activity of gastric cancer cells, and is of great significance in the development of anti-tumor drugs and the treatment of related diseases.