354 results about "Biosecurity" patented technology

Methods and systems for evaluating, mitigating, and managing biosafety and biosecurity risks. The methods and systems establish biosafety and biosecurity risk management procedures and systems, and facilitate auditing of facilities and testing individuals and companies to evaluate compliance with such procedures and systems. Systems and business methods for establishing biosafety and biosecurity risk management procedures and systems, auditing and certifying companies, facilities, systems and individuals for compliance, and analyzing biosafety and biosecurity risks for making investment decisions and for pricing and underwriting such risks in the insurance industry.

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

The invention relates to a biological sample detection vehicle and a vehicular detection system thereof. At present, a mobile lab achieving biosafety level-3 protection level is developed at home and abroad, which is called 'P3 vehicle' commonly, conventional home and abroad P3 vehicle is formed by grouping more than 2 box-type vehicles, and has large size and complicated operation. The invention aims at providing a miniature biological sample detection vehicle which has excellent maneuvering characteristic and biosafety protection function, adapts to epidemic situations or public health incidents and consists of a cockpit (1), a front cabin (9), a rear cabin (22) and an atmosphere sampler (19), wherein the front cabin is an equipment cabin, and the rear cabin is an experimental cabin. The biological sample detection vehicle integrates biological sampling, air pre-alarming and quick detection into a whole, has good maneuvering property and matched functions, has the function of carrying out various biological sampling and pathogenic microorganism detection in the field of epidemic situation in remote rural areas or urban roadways, and can be used for executing a 'bio-control' quick detection task in contingency medical rescue with high efficiency.

A RNA nanoparticle is disclosed. According to base pairing rules, a particle is formed from a chain RNA, b chain RNA and c chain RNA, wherein sequence of the a chain RNA is SEQ ID No.1; sequence of the b chain RNA is SEQ ID No.2; and sequence of the c chain RNA is SEQ ID No.3. It shows through experimental verification at the cellular and animal level that the RNA nanoparticle provided by the invention has good biosecurity and excellent gene interference effect and specificity, can effectively inhibit growth of gastric cancer cell lines and transplant subcutaneous sarcoma and can be applied in prevention, cure and diagnosis of stomach cancer.

The invention provides an antineoplastic polypeptide nanometer drug, and a preparation method and application thereof. The antineoplastic polypeptide nanometer drug comprises amphipathic antineoplastic polypeptides and acid responsiveness functional molecules link-coupled with the amphipathic antineoplastic polypeptides. Amino acid is taken as the raw material to synthesize amphipathic polypeptide molecules, and then acid responsiveness functional molecules are introduced into the amphipathic antineoplastic polypeptide molecules to be subjected to self-assembling to form the antineoplastic polypeptide nanometer drug. The antineoplastic polypeptide nanometer drug provided by the invention has good biocompatibility, smaller toxic and side effects, acid responsiveness, high bioavailability and high biosecurity. The preparation method provided by the invention is simple, covalent bonds are not produced in the self-assembling process, reverse reaction is avoided, and the prepared antineoplastic polypeptide nanometer drug has a broad application prospect.

A preparation method of porcine thrombin relates to a preparation method of thrombin. The preparation method of porcine thrombin is used for solving the problems of low yield and unsuitability for large-scale production of the existing preparation method of porcine thrombin. The method provided by the invention comprises the following steps of: 1, separating porcine plasma; 2, inactivating virus by a chemical method; 3, absorbing prothrombin; 4, collecting the prothrombin; 4, nano-filtering; 6, activating the prothrombin; and 7, freeze-drying and storing the prothrombin. The preparation method provided by the invention is capable of improving the biosecurity of the thrombin product, and simultaneously, obtains higher thrombin yield rate by employing a special ion exchange resin extraction process; specifically, 80000 IU/L plasma can be obtained. According to the invention, the method of directly and proportionally feeding the ion exchange resin into the plasma is adopted, one ton to several tons of plasma can be processed each time; therefore, large-scale production is realized. The preparation method of porcine thrombin is applied to the industrial production field of thrombin.

The invention discloses pig homologous raw material-free attracting starter compound feed for porkets. According to a technical scheme adopted by the invention, the feed is composed of the following raw materials by weight percent: 35-45% of a puffed raw material, 5-8% of a soybean protein concentrate, 10-15% of fermented soybean meal, 4-5% of hydrolyzed wheat protein, 6-10% of lactose, 4-8% of whole milk powder, 3-5% of a casein, 2-5% of a nucleotide, 2-5% of fish meal, 1-3% of amino acid, 0.5-2% of glutamine, 0.5-1% of an acidifying agent, 2-5% of plant oil, 0.02-0.1% of a composite vitamin, and 0.1-0.5% of a composite trace element. Application of the feed in the invention presents strong feed attraction to porkets which can start feed taking in1-2d with rapidly increasing intake. With balanced and comprehensive nutrition similar to breast milk, the feed provided in the invention is characterized by high digestibility in porkets, no diarrhoea, effective overcoming of weaning stress, and rapid weight gain, and can effectively increase the porket weaning weight and the weight after two weeks of weaning, as well as improve porket survival rate and production performance. Free of plasma protein powder, dried porcine soluble and other pig homologous raw materials, the feed of the invention has no risk of homologous pig pathogen infection, and boasts significant biosecurity.

The invention provides a chitosan-nano-silver wound dressing which comprises a water absorption antibiosis layer and a hydrophobic layer for gluding a wound, wherein the water absorption antibiosis layer comprises chitosan and nano-silver; according to the water absorption antibiosis layer, spongy chitosan is soaked in sol contained nano-silver, and the nano-silver is uniformly compounded on the spongy chitosan through freeze drying; the other side adopts the hydrophobic layer. A preparation method of the chitosan-nano-silver wound dressing comprises the following steps: (1) preparing chitosan-nano-silver sponge; (2) uniformly spraying an ethanol solution on one surface of the chitosan-nano-silver sponge prepared in step (1), prefreezing under minus 18 DEG C, and then performing freeze drying to obtain the chitosan-nano-silver wound dressing. According to the invention, the chitosan, the nano-silver, fatty acid and other hydrophobic modifiers for preparing the chitosan-nano-silver wound dressing have high biosecurity and have no toxic or side effects on human cells; in addition, the chitosan is of a sponge structure, excellent in softness and high in breathability.

The invention relates to a preparation method for bionic nano-silver. Silver nitrate and natural polymer or derivative of the natural polymer are raw materials and react in a water solution under stimulation of sunlight or visible light. The natural polymer is protective agents, reducing agents and photosensitizer and generates the nano-silver under stimulation of sunlight or low-frequency visible light at the room temperature. The prepared nano-silver has high safety under the protection of the natural polymer, can be applied to biomedical materials or daily chemical products, gives play to an antibacterial function, and can obviously reinforce the Raman signals of molecules to be detected when used as Raman base materials. The preparation method for the bionic nano-silver is simple, reliable, capable of meeting the requirements for the shape and performance of the nano-silver in the field of biomedicine or spectrums, good in biosecurity, capable of controlling the shape and the particle size of products, and wide in application range.

The invention relates to the technical field of photo-curing hydrogels, and in particular relates to a visible light initiating system in a medical photo-curing hydrogel and a photo-curing method thereof. The visible light initiating system in the medical photo-curing hydrogel contains the following components in part by weight: 0.5-1 part of the first component: photosensitizer, and 0.5-5 parts of the second component: auxiliary initiator; the auxiliary initiator is water-soluble sericin or fibroin powder, the photosensitive synergist is one of iodonium salt, sulfoniumsalt or phosonium salt. The system is good in solubleness in water, and excellent in biocompatibility or biosecurity; and the free radical produced after absorbing 400-700nm of visible light can efficiently initiate the polymerization and curing of the precursor aqueous solution containing unsaturated double bond, thereby preparing the multipurpose medical hydrogel.

The invention provides a composition for relieving xerostomia and a preparation method thereof. Effective constituents in the composition are one or more of a hyaluronic acid, Pulullan and a polyglutamic acid. The composition has the feature of relieving chronic and transient xerostomia caused by diseases, medicine using, radio therapy, chemotherapy and aging. The composition prepared from raw materials with high biosecurity can lubricate oral cavities and keep the oral cavities moist, and can be prepared into toothpaste, mouthrinse, chewing gum and the like. The prepared composition for relieving xerostomia does not have toxic or side effects on human bodies, and allergy or irritation is avoided.

The present inventions relate generally to the field of handling animal cages in biosafety laboratories (“BSL”), e.g. BSL 3 and 4 facilities. An animal storage facility for such facilities comprises, in typical configuration, a cage library automation system (CLAS) adapted to for storage and retrieval for animal cages, comprising a free-standing gantry; one or more animal cages; an animal cage rack adapted for insertion into the gantry and for selective retrieval and storage of the animal cage; a rack motor operatively in communication with the animal cage rack; a robotic arm adapted to transport the animal cage from the animal cage rack and a holding area; an end effector disposed about an end of the robotic arm and adapted for manipulation of the animal cage; and a controller operatively in communication with the rack motor and the robotic arm; and a holding area adapted to provide a cage queue containing a predetermined number of animal cages to provide a buffer for a BSL worker when processing an animal for a particular experiment protocol without having to wait for the robotic arm to retrieve the animal cage. Users can use the CLAS to retrieve, manipulate, and/or insert an animal cage into the animal cage racks either manually or using the robotic arm.

The invention discloses a serum-free culture medium for human umbilical cord MSCs (mesenchymal stem cells). The serum-free culture medium comprises the major ingredients of amino acid, inorganic salt ingredients, growth factors and albumin ingredients. The serum-free culture medium for human umbilical cord MSCs does not contain any serum ingredients; in addition, the ingredients are clear; the foreign protein pollution and pathogenic microorganism risks are avoided; the biosecurity problem of the MSCs clinic application is solved. When the serum-free culture medium provided by the invention is used for culturing the human umbilical cord MSCs, the high-quantity high-purity safe and high-quality umbilical cord MSCs can be obtained in vitro; meanwhile, the cell survival rate can be improved; the stem cell characteristics are maintained. The problem of insufficient cell quantity can be solved; the cell number, the survival rate and the immunophenotyping in each batch are more stable; the relevant index requirements are met.

The invention discloses a high-temperature kitchen waste degradation microbial agent and a preparing and using method thereof. A microbial strain comprises, by weight, 15-30 parts of nuby land anoxybacillus, 10-25 parts of liquefaction thermophilic bacillus, 20-40 parts of hot nitrogen bacillus and 25-50 parts of geobacillus stearothermophilus. Compared with the prior art, the high-temperature kitchen waste degradation microbial agent has the beneficial effects that as for kitchen waste with different integrants, reasonable matching on single bacterium powder can be carried out, and single bacterial strains are cooperated for degrading the kitchen waste in a collaborative mode; the number of effective viable bacteria in the single bacterium powder in the composite microbial agent is large, and when the microbial agent is used for degrading the kitchen waste, only a small number of microbial agents is needed for sufficiently and rapidly degrading the kitchen waste; components in the microbial agent are high-temperature cultures, the optimum fermentation temperature ranges from 55 DEG C to 65 DEG C, pathogenic bacteria such as escherichia coli and staphylococcus aureus in the kitchen waste can be effectively inactivated in the fermentation process, and the biosecurity is high.

The invention discloses a branched polyHPMA copolymer-DOX conjugate, and the preparation method and the application thereof, and belongs to the field of biological materials. According to the invention, the branched polyHPMA copolymer-DOX conjugate is successfully prepared through one step of RAFT polymerization. DOX in the conjugate is connected with a branched polyHPMA copolymer through a pH sensitive key, and biodegradable fragments are contained in a branched polyHPMA copolymer framework. The conjugate is excellent in biocompatibility, has dual sensitive characteristics of pH sensitivity and enzyme sensitivity, and serves as an intelligent drug delivery system to form nano particles to intensively gather in tumor sites, quickly release drug under a tumor microenvironment and be degraded to be low molecular weight fragments, therefore, excellent biosecurity is ensured while the antineoplastic effect is improved, and the branched polyHPMA copolymer-DOX conjugate has a wide application scope in tumor therapy.

The invention provides a method for producing 1,3-propylene glycol through fermentation via recombinant microbes. According to the invention, an endogenous dihydroxypropanone phosphatein phosphatase gene hdpA is over-expressed in Corynebacterium glutamicum to reinforce removal of phosphoric acid from dihydroxypropanone phosphatein so as to produce dihydroxypropanone; exogenous glycerol dehydrogenase is introduced to convert dihydroxypropanone into glycerin; and glycerin finally produces 1,3-propylene glycol under the action of exogenous glycerol dehydratase and an activator thereof and alcohol dehydrogenase. Corynebacterium glutamicum can use different cheap raw materials for fermentation, and cheap corn steep liquor can be used as a nutritional component to replace expensive yeast powder, so cost for raw materials is further reduced, and the problems in biosecurity and tolerance of the bacterial strain to a substrate and a product are overcome; and thalli obtained in the process of fermentation can be used as a product for a feed additive. The method provided by the invention produces few by-products and can further simplify the separating process of 1,3-propylene glycol.

The invention discloses a biological safety centrifugal machine. The biological safety centrifugal machine comprises a box body, a box cover, a centrifugal device and a refrigerating device, wherein an air inlet is formed on the box cover; a filter is arranged in the air inlet; an air outlet is formed on the box body; a fan is arranged in the box body and is opposite to the air outlet; a filtering device is arranged in the box body; and the filtering device is arranged between the air inlet and the air outlet. The biological safety centrifugal machine can solve the problems that in the prior art, the centrifugal machine cannot ensure that the environment in a laboratory is not polluted and cannot ensure operators are not attacked by bacteria and virus fundamentally.

The invention provides a nanofiber mask. The nanofiber mask comprises a supporting layer (4), an adsorption layer and an antimicrobial layer (1), wherein the supporting layer (4) is made of hydrophobic fiber non-woven cloth and located at the innermost layer; the adsorption layer comprises a nanofiber layer (3) and a nanofiber supporting layer (2), and the nanofiber layer (3) is located between the supporting layer (4) and the nanofiber supporting layer (2); the antimicrobial layer (1) is formed by use of an antimicrobial gauze and adjacent to the nanofiber supporting layer (2), and located at the innermost layer; one side, adjacent to the supporting layer (4), of the nanofiber layer (3) is of a fiber fluff structure. The nanofiber mask is capable of blocking organic pollutants in air in addition to particles in air, and also has the characteristics such as good expansibility, good flexibility and low thickness, and further has excellent biosecurity.

The invention disclose a product capable of maintaining beauty and keeping young and a preparation method of the product, belonging to the field of biotechnology, medical cosmetology and cosmetics. The product is prepared by adding Chinese herb extracts into human stem cell extracts, wherein the human stem cell extracts contain 0.001-90% of human stem cell active ingredients. The product can be independently used, and also can be mixed with other cosmetics for use, so as to achieve the efficacies of maintaining beauty and keeping young. According to the preparation method, a filtering method and relevant technical means including low-temperature transportation, storage and the like are combined, the technology is simple, the reaction is mild, and the biological activity of active substances in the product and the stability of the effect of the product are guaranteed; the preparation method of the product is completely free of a chemical process, so that no toxic and harmful substances including heavy metal residues and preservatives are generated, the biosecurity is high, the market promotion and application prospects are good, and the prepared product has obvious effects of caring skin and maintaining beauty.

The invention discloses a black phosphorus nano material for treating Alzheimer's disease, wherein a black phosphorus nanosheet is prepared from black phosphorus powder by an ultrasonic liquid peeling process. Moreover, the invention also discloses a preparation method and application of the nano material. According to the invention, the black phosphorus nanosheet for treating Alzheimer's disease can be used as a nano acquirer for effectively and selectively acquiring Cu<2+>, so as to reduce generation of active oxygen in cells and protect the cells from the toxicity related to non-dynamic balance of the Cu<2+>. According to the black phosphorus nanosheet medicine for treating Alzheimer's disease disclosed by the invention, the blood-brain barrier permeability can be improved through a photothermal effect, the shortcomings that a small-molecule compound or polypeptide cannot pass through blood-brain barrier and is unstable are overcome, and the efficacy is improved. The nanomaterial has the advantages of simple preparation process, no additional drug load, high stability and high biocompatibility, and thus has excellent biosecurity when used for treating Alzheimer's disease.

The invention provides a fluopicolide-containing compound bactericide which comprises active ingredients and auxiliary agents, wherein the active ingredients comprise fluopicolide and strobilurin bactericide with the weight ratio of 1-10: 1-90; and the strobilurin bactericide comprises one or more of pyraclostrobin, azoxystrobin, pyrametostrobin, enestroburin, pyraoxystrobin, flufenoxystrobin. The fluopicolide-containing compound bactericide is remarkable in synergism in the aspect of preventing and controlling fruit and vegetable oomycetes diseases. The compound bactericide is good in fast-acting property and persistence, unique in mechanism of action and multiple in acting sites, and can effectively delay the occurrence and development of bactericide resistance of pathogenic bacteria. The compound preparation is simple in preparation technology, low in cost, remarkable in economical benefit, wide in disease prevention spectrum and high in biosecurity.