Black phosphorus material as well as preparation method and application thereof

A technology for preparing black phosphorus and drugs, which is applied in the field of two-dimensional materials and can solve problems such as inability to improve dispersion

Pending Publication Date: 2021-07-20
SUN YAT SEN UNIV SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these methods can prevent the oxidation of BP to a certain extent and achieve th...

Method used

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  • Black phosphorus material as well as preparation method and application thereof
  • Black phosphorus material as well as preparation method and application thereof
  • Black phosphorus material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0051] This embodiment has prepared a kind of black phosphorus material, and specific process is:

[0052] S1: Black phosphorus crystals are ground into black phosphorus powder in a mortar. Then the black phosphorus powder is dispersed in N-methyl-2-pyrrolidone (NMP), the mass volume ratio of black phosphorus powder and NMP is 0.5:1g / L, and ultrasonic 4-6h in ice bath probe (switch cycle: 5s / 5s). The obtained dispersion liquid was centrifuged at 3000 rpm for 10 min to obtain black phosphorus microflakes. The length×width×height of the black phosphorus microflakes was about 1.0 μm×0.4 μm×20 nm.

[0053] S2: In N,N-dimethylformamide, the black phosphorus microflakes prepared in S1 and azidopolyethylene glycol (N 3 -PEG) were mixed and added to a round-bottomed two-necked flask with a condensing device. The reactants were degassed and protected by repeated freezing in liquid nitrogen, vacuuming, and filling with nitrogen. After the liquid returned to room temperature, it was...

Embodiment 2

[0056] This embodiment has prepared a kind of black phosphorus material, and specific process is:

[0057] S1: Black phosphorus crystals are ground into black phosphorus powder in a mortar. Then disperse the black phosphorus powder in NMP, the mass volume ratio of black phosphorus powder and NMP is 1:1g / L, and ultrasonicate in the ice bath probe for 6-10h (on / off cycle: 5s / 5s). The obtained dispersion was centrifuged at 7000rpm for 20min to remove the unstripped large black phosphorus precipitate and collect the supernatant. The supernatant was centrifuged at 12000rpm for 20min to obtain black phosphorus nanosheets (BPNs), and the length×width×height of black phosphorus nanosheets (BPNs) was about 100nm×100nm×15nm.

[0058] S2: In N,N-dimethylformamide, black phosphorus nanosheets (BPNs) prepared in S1 and azidopolyethylene glycol (N 3 -PEG) were mixed and added to a round-bottomed two-necked flask with a condensing device. The reactants were degassed and protected by repea...

Embodiment 3

[0065] This embodiment has prepared a kind of black phosphorus material, and specific process is:

[0066] S1: Black phosphorus crystals are ground into black phosphorus powder in a mortar. Then disperse the black phosphorus powder in NMP, the mass volume ratio of black phosphorus powder and NMP is 1.5:1g / L, and ultrasonically in the ice bath probe for 6-10h (switch cycle: 5s / 5s), and then in a constant temperature water bath at 16°C Mid-ultrasound 8~10h (switching cycle: 5s / 5s). The resulting dispersion was centrifuged at 12,000 rpm for 20 min to remove unstripped large black phosphorus precipitates and collect the supernatant. The supernatant was centrifuged at 20000rpm for 20min to obtain black phosphorus quantum dots (BPQDs), and the length×width×height of the black phosphorus quantum dots (BPQDs) was about 5nm×5nm×2nm.

[0067] S2: In N,N-dimethylformamide, black phosphorus quantum dots (BPQDs) prepared in S1 and azidopolyethylene glycol (N 3 -PEG) were mixed and added...

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Abstract

The invention discloses a black phosphorus material as well as a preparation method and application thereof, and belongs to the technical field of two-dimensional materials. The black phosphorus material comprises a black phosphorus unit and an azide high-molecular polymer, wherein the azide high-molecular polymer is connected with the black phosphorus unit through a covalent bond. In the black phosphorus material, the azide high-molecular polymer and the black phosphorus unit form a covalent bond, so that the stability and dispersity of the black phosphorus material in different systems such as water, PBS, a cell culture medium, simulated gastric juice, simulated intestinal juice and human colon fluid are improved, and the black phosphorus material can be widely applied to photothermal therapy of tumors or preparation of black phosphorus nano preparations for oral administration.

Description

technical field [0001] The invention belongs to the technical field of two-dimensional materials, and in particular relates to a black phosphorus material and its preparation method and application. Background technique [0002] As a new type of two-dimensional material, black phosphorus (BP) has shown surprising promise in biomedical fields such as tumor therapy, drug delivery, and gene therapy due to its excellent optical properties, biocompatibility, and biodegradability. Applications. Although black phosphorus nanomaterials have great potential as a new type of medical biomaterial, there are still some problems and difficulties that need to be solved urgently in its practical application. Among them, the greatest impact on its application is the instability of BP in an oxygen-containing and humid environment. The instability of BP includes its easy degradation and aggregation. Studies have shown that black phosphorus materials are easily degraded by reacting with oxyge...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/16A61K41/00A61K47/60A61P35/00
CPCA61K47/02A61K47/16A61K41/0052A61K47/60A61P35/00
Inventor 刘赣邓文斌齐军阳黄琦林珣熊月曹锦秀和福美刘泽琦
Owner SUN YAT SEN UNIV SHENZHEN
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