192 results about "Oxaliplatin" patented technology

The invention discloses application of an anti-CD20 antibody drug conjugate or a drug combination thereof in preparation of a drug for treating diffuse large B-cell lymphoma. The drug combination comprises the anti-CD20 antibody drug conjugate, gemcitabine and oxaliplatin, the anti-CD20 antibody drug conjugate or the drug combination therapy containing the anti-CD20 antibody drug conjugate has a better curative effect compared with the existing clinical second-line standard therapy.

The invention relates to the field of tumor treatment, in particular to application of a small molecule compound in preparation of a medicine for treating colorectal cancer. The AKT pathway specific inhibitor MK2206 disclosed by the invention can inhibit the proliferation of colorectal cancer, induce cell cycle arrest, induce apoptosis and enhance the sensitivity of colorectal cancer cells to oxaliplatin and 5-fluorouracil. The MK2206 is used for inhibiting the activity of an AKT pathway, so that the effects of inhibiting proliferation of colorectal cancer cells, inducing apoptosis of the colorectal cancer cells and improving the sensitivity of the colorectal cancer cells to chemotherapeutic drugs oxaliplatin and 5-fluorouracil are achieved, and the MK2206 can be used for preparing drugs for treating the colorectal cancer.

The invention belongs to the technical field of microorganisms, and particularly relates to application of parabacteroides dielsii SYSU-210 and metabolites thereof in cancer treatment. The parabacteroides dieldrii is a parabacteroides dieldrii SYSU-210 strain, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32494, and the preservation date is November 04, 2024. According to the application disclosed by the invention, by carrying out anti-tumor treatment on tumor-bearing mice with colon cancer and breast cancer by using the single parabacteroides dieldrii SYSU-210 and a metabolite thereof, the screened SYSU-210 has a good treatment effect on both the colon cancer and the breast cancer, and effector T cell infiltration in tumors of the mice in a treatment group is remarkably increased; and when the compound is combined with an immunotherapy alpha PD-1 inhibitor or a chemotherapeutic drug oxaliplatin for use, the effect of synergistically enhancing the curative effect is shown.

The invention discloses an application of a small molecular compound LZ-A4 in preparation of a preparation or a medicine for treating malignant tumors. The chemical formula of the small molecule compound LZ-A4 is C19H11Cl2N3O3S, and the small molecule compound LZ-A4 can promote degradation of LGMN in malignant tumor cells, inhibit proliferation of tumor cells and inhibit polarization of macrophages to M2 type. The research on a colorectal cancer mouse transplantation tumor model proves that the development of the colorectal cancer can be effectively inhibited by single treatment of the LZ-A4, and the volume of the tumor can be further reduced after the LZ-A4 is combined with a clinical first-line chemotherapeutic drug Oxaliplatin for the colorectal cancer. Meanwhile, the LZ-A4 can inhibit M2 type polarization of macrophages in a tumor microenvironment in vivo, promote infiltration of cytotoxic T cells, remodel the tumor microenvironment and activate anti-tumor immunity. In addition, the A4 has good toxic and side effects, and does not cause further reduction of the body weight of the mouse after being combined with chemotherapeutic drugs.

The invention discloses a pH-responsive deformable dual-targeting nano protein and a preparation method and application thereof, the method comprises the following steps: activating carboxylated mannose through an EDC / NHS system, reacting with an albumin solution, and dialyzing and purifying to obtain mannose modified albumin; and mixing the mannose modified albumin with an inhibitor IRG1-IN-1, and loading the IRG1-IN-1 through a hydrophobic effect to obtain the mannose albumin nanoparticles, ferritin serves as a carrier, oxaliplatin is loaded through a solvent replacement method, and ferritin nanoparticles are obtained; cHO-PEG2k-CHO is used as a coupling agent, and the mannose albumin nanoparticles and the ferritin nanoparticles are crosslinked through a Schiff base reaction, so that the large-size pH-responsive dual-targeting nano-protein is formed. The nano protein has the characteristic of double-targeting separability, so that specific treatment can be realized, immune cell metabolism is interfered while tumor cells are killed, metabolic immunosuppression is blocked, and anti-tumor immunotherapy is promoted.

The invention discloses application of a target protein circPIAS1-108aa inhibitor combined with oxaliplatin in preparation of a medicine synergistic composition for treating cancers, the specific action mechanism of circPIAS1-108aa in colon cancer treatment is found for the first time, and further research shows that by using siRNA to knock down circPIAS1-108aa, colon cancer cell proliferation can be remarkably inhibited, and the effect of treating the colon cancer can be achieved. Furthermore, the target spot protein circPIAS1-108aa inhibitor can be used for enhancing the treatment effect of the oxaliplatin. Therefore, when the circPIAS1-108aa expression is inhibited in a targeted manner and the oxaliplatin is combined for use, the circPIAS1-108aa can be obviously used for preventing and treating cancers, the dosage and toxic and side effects of the oxaliplatin are reduced, and a new synergistic strategy is provided for tumor treatment.

The invention is applicable to the technical field of biological medicines, provides application of a natural compound of a targeted colon cancer drug resistance related protein, and particularly relates to application in preparation of drugs for preventing or treating colon cancer. According to the invention, a natural small molecule compound neohesperidin dihydrochalcone targeting the colon cancer drug resistance related protein TAGLN is screened out, and a new scheme is provided for reversing colon cancer drug resistance, so that the situation that no drug is available to the target spot is solved. Secondly, the invention also provides a scheme for combined use of neohesperidin dihydrochalcone and oxaliplatin, the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, and a new choice is provided for clinical treatment of colon cancer.

The invention relates to the technical field of medicine, in particular to a preparation method and application of a photodynamic-chemotherapy nano platform targeting tumor endogenous YAP1. The nano platform is hollow mesoporous silica nanoparticles (M (at) O-VNPs) loaded with oxaliplatin and VP of a macrophage membrane coating. The preparation method comprises the following steps: S1, synthesizing hollow mesoporous silica nanoparticles; s2, preparing the organic silicon nanoparticles loaded with the Verteporfin, and preparing the organic silicon nanoparticles loaded with the Verteporfin; s3, loading of the oxaliplatin; and S4, extraction and coating of a macrophage membrane. According to the invention, the macrophage membrane wrapped on the surface of the nano platform is utilized to provide good tumor targeting for the M (at) O-VNPs, and by camouflaging the macrophage membrane and the M (at) O-VNPs, not only are recognition and removal of an organism immune system successfully avoided, but also Verteporfin (VP) and oxaliplatin (OXA) can be delivered to a tumor site in a targeting manner, so that the tumor targeting of the drug is remarkably enhanced, and the drug has a good application prospect. The non-specific distribution in healthy tissues is reduced, and the systemic toxicity is reduced.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for relieving side effects of oxaliplatin chemotherapy. The traditional Chinese medicine composition composed of radix paeoniae alba and liquorice is used for relieving various side reactions caused by oxaliplatin, wherein the side reactions comprise peripheral neurotoxicity, hematological toxicity and systemic reaction. The traditional Chinese medicine composition plays a role in relieving peripheral neurotoxicity caused by oxaliplatin through multiple ways, on one hand, neuroinflammatory response in dorsal root ganglions is inhibited, the dorsal root ganglions are responsible for receiving and conducting sensory nerve impulse, the injury is mainly represented as sensory disorders such as numbness of hands and feet, stabbing pain and delayed feeling, and on the other hand, the neuroinflammatory response in the dorsal root ganglions is inhibited; therefore, OIPN can be relieved by inhibiting the inflammatory reaction; on the other hand, the blood flow of microvessels is promoted, and the circulation disorder of the microvessels at the tail ends of the limbs is improved to relieve OIPN. Moreover, the traditional Chinese medicine composition does not influence the anti-tumor effect of oxaliplatin, is good in safety, and does not damage important organs such as heart, liver, spleen, lung and kidney.

The present application relates to a kind of pH / H2O2 dual-response drug-loaded hydrogel and its preparation method and application, by ε-polylysine derivative as antitumor active ingredient, with oxidized dextran through Schiff base reaction crosslinking rapid gelation. While using 2-formylphenyl boronic acid covalently package CD73 small molecule inhibitor APCP. ε-polylysine derivative has oncolytic activity, can induce ICD and promote the infiltration of immune cells in tumor cells. CD73 small molecule inhibitor APCP can block extracellular CD39-CD73-adenosine pathway, reduce the level of immunosuppressive metabolite adenosine in tumor tissue, so as to activate the infiltrated immune cells, restore its anti-tumor function. The hydrogel of ε-polylysine derivative and APCP co-delivery synergistically inhibits the effect of tumor growth, and its curative effect is greater than the treatment effect of single drug, and is superior to positive control drug oxaliplatin (OXA). The pH / H2O2 dual-response hydrogel is rapidly gelled, and has good biological safety under mild reaction conditions.

The invention relates to the technical field of medicines, and provides application of ibrutinib as a platinum drug sensitizer in gastric cancer treatment. Furthermore, the invention also provides an application of ibrutinib combined with platinum drugs in preparation of drugs for treating CREB1 high-expression gastric cancer, and further provides a pharmaceutical composition for treating gastric cancer. A mouse in-vivo experiment shows that the size and the growth speed of a stomach tumor overexpressed with CREB1 can be obviously reduced by combined use of ibrutinib and oxaliplatin, so that the platinum drug sensitivity of CREB1 high-expression stomach cancer cells is enhanced; through a gastric cancer organ model and an in-vitro cytology experiment, the ibrutinib can reduce the activity of CREB1 by inhibiting phosphorylation of various proteins of an EGFR-PI3K-AKT-CREB1 pathway, so that proliferation of gastric cancer cells is inhibited, the ferroptosis level of the gastric cancer cells is increased, and IC50 of the ibrutinib can be remarkably reduced by combined use of the ibrutinib and platinum drugs. The invention provides a new basis for the ibrutinib or the derivative thereof to inhibit the growth of CREB1 high-expression gastric cancer cells and enhance the sensitivity of platinum drugs.

The invention relates to Ackermania muciniphila and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the ackermania muciniphilaSYSU-85 is adopted as the ackermania muciniphilaSYSU-85, and has been preserved in the China General Microbiological Culture Collection Center (CGMCC) on August 8, 2024, and the preservation number of the ackermania muciniphilaSYSU-85 is CGMCC NO.46070; the Ackermania muciniphila SYSU-85 disclosed by the invention is weak in dependence on mucin, grows well in a BHI culture medium added with cysteine, and is resistant to oxaliplatin. The Ackermansiella muciniphila SYSU-85 provided by the invention alleviates adverse reactions caused by oxaliplatin, and is combined with oxaliplatin or a PD-1 inhibitor to significantly slow down a tumor growth curve and significantly reduce the tumor volume, thereby improving the tumor treatment effect.

The invention discloses a method for predicting peripheral neurotoxicity induced by treatment of colorectal cancer through oxaliplatin, and relates to the technical field of drug application, and the method comprises the following steps: obtaining pre-drug patient information before treatment of a patient with oxaliplatin and clinical feature data after use; processing and feature analysis are carried out based on pre-drug patient information and clinical feature data, and a core feature data set related to neurotoxin is determined; and based on the core feature data set, predicting the oxaliplatin-induced peripheral neurotoxicity of the patient by adopting a pre-trained gradient boosting decision tree model, and outputting a prediction risk result. According to the method, the occurrence risk of peripheral neurotoxicity can be accurately predicted according to clinical indexes so as to guide clinical accurate medication.

The invention discloses application of circFAM126A in preparation of a medicine for reversing oxaliplatin resistance of gastric cancer, and belongs to the technical field of molecular biology. According to the application disclosed by the invention, by constructing a lentivirus for targeted interference of novel circFAM126A and transfecting gastric cancer cells, it is proved that the lentivirus carrying a specific interference sequence can stably knock down circFAM126A expression in the gastric cancer cells, the drug resistance of the gastric cancer cells to oxaliplatin is effectively reversed, the tumor cell death effect induced by chemotherapeutic drugs is remarkably enhanced, and the tumor cell death effect is remarkably improved. Meanwhile, the proliferation and clone formation capability of gastric cancer cells is inhibited. Meanwhile, it is found that circFAM126A is highly expressed in oxaliplatin-resistant gastric cancer cells and is in positive correlation with poor prognosis of gastric cancer patients, a detection reagent aiming at circFAM126A can be used for auxiliary diagnosis of gastric cancer prognosis conditions, and the drug resistance degree of the gastric cancer cells to oxaliplatin can be evaluated by detecting the expression level of circFAM126A.

The invention discloses an application of homocapsaicin II in preparation of an anti-tumor drug, the homocapsaicin II is used in the anti-tumor drug independently or in combination with 5-fluorouracil or in combination with oxaliplatin, and when the homocapsaicin II is used in preparation of an anti-colorectal cancer drug, the drug concentration is 20-200 [mu] M. It is found that high capsaicin II can inhibit growth of intestinal cancer cells in vivo and in vitro, and nude mice have good tolerance to the natural compound. When the compound is used together with a first-line chemotherapeutic drug 5-fluorouracil, the drug concentration of the 5-fluorouracil can be remarkably reduced while the same treatment effect is achieved, a synergistic cancer inhibition effect is achieved, and a new research and development approach is found for anti-colorectal cancer drugs.

This invention discloses a composite nanozyme that enhances the clinical efficacy of oxaliplatin, its preparation method, and its application. The composite nanozyme consists of indium ruthenium nanozyme and an iliximab embedding and anchoring layer. The indium ruthenium nanozyme consists of indium ruthenium nanoparticles and a carbon-nitrogen framework, with the indium ruthenium nanoparticles loaded on the surface and within the pores of the carbon-nitrogen framework. The iliximab embedding and anchoring layer consists of a dithiol polyethylene glycol coating layer and iliximab. Preparation method: ZIF-8 is prepared by co-precipitation of zinc salt methanol solution and 2-methylimidazole methanol solution, followed by calcination to obtain the carbon-nitrogen framework. The carbon-nitrogen framework dispersion is then stirred in an oil bath with indium nitrate solution and ruthenium trichloride solution to prepare a nanozyme precursor, followed by calcination to obtain indium ruthenium nanozyme. The indium ruthenium nanozyme is dispersed in a dithiol polyethylene glycol solution, and iliximab solution is added dropwise. The resulting solid product is then dried. This invention can solve problems such as strong drug tolerance, insufficient intracellular accumulation, and severe tumor immunosuppression in oxaliplatin treatment.

The present invention relates to methods of treating B-cell proliferative disorders, e.g., primary refractory or relapsed diffuse large B-cell lymphoma (DLBCL), by administering glofitamab in combination with gemcitabine and oxaliplatin. Further the invention related to an optimized corticosteroid prophylaxis for glofitamab resulting in lower incidence of cytokine release syndrome (CRS).

The application belongs to the technical field of biological medicine, and provides application of a natural compound targeting colon cancer drug resistance related protein, in particular, application in preparation of a drug for preventing or treating colon cancer; the application screens out a natural small-molecule compound hesperetin dihydrochalcone targeting colon cancer drug resistance related protein TAGLN, and provides a new scheme for reversing colon cancer drug resistance, so as to solve the situation that no drug is available for the target point. In addition, the application further provides a scheme in which hesperetin dihydrochalcone is combined with oxaliplatin, and the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, thereby providing a new choice for clinical treatment of colon cancer.

The invention discloses an application of a combination of Molephantin and a platinum chemotherapeutic drug in preparation of a drug for treating nasopharynx cancer. The purpose of the invention is to show the pharmaceutical application of Molephantin in tumor growth resistance. In-vitro and in-vivo experiments are combined, and the result shows that the growth of nasopharyngeal carcinoma can be inhibited by combining the Molephantin with the cis-platinum and the oxaliplatin. The invention provides a new application of the combination of the Molephantin and the cis-platinum, and provides a new drug source for adjuvant therapy of cancers.

The invention belongs to the technical field of biological medicine, and particularly provides application of a PLA1A gene / protein as an anti-tumor target. The key effect of the PLA1A gene / protein in promoting chemotherapy drug resistance is disclosed for the first time, and a new mechanism that the PLA1A gene / protein affects chemotherapy sensitivity by regulating a tumor microenvironment (especially macrophage polarization) is deeply clarified. Researches prove that knockdown of the PLA1A gene or inhibition of the protein activity of the PLA1A gene can significantly enhance the sensitivity of tumor cells to chemotherapeutic drugs (such as oxaliplatin), so that the therapeutic effect is improved, and the sensitization provides a new strategy for overcoming tumor chemotherapeutic drug resistance. In animal model experiments, knockdown of the PLA1A is combined with oxaliplatin for treatment, so that growth of mouse transplanted tumors and liver metastases is remarkably inhibited, the survival time of tumor-bearing mice is prolonged, and it is indicated that the PLA1A has important clinical application value and wide application prospects as an anti-tumor target.

This invention discloses a composite nanodelivery system encapsulated in a fusion membrane, its preparation method, and its applications. The nanodelivery system comprises a Ti3C2 / TiO2 / CuInS2 composite material, oxaliplatin loaded thereon, and a fusion membrane encapsulating the outer layer; the fusion membrane is formed by the fusion of Fusobacterium nucleatum extravesicles and M1 macrophage membranes. This invention also discloses a method for preparing the nanodelivery system, including the steps of preparing the Ti3C2 / TiO2 / CuInS2 composite material, preparing the fusion membrane, loading oxaliplatin, and encapsulating it in the fusion membrane. The nanodelivery system prepared by this invention exhibits pH-responsive drug release characteristics, generating H2S in the tumor microenvironment and H2 under light irradiation, while also possessing photocatalytic activity. This invention combines chemotherapy, photoelectrocatalytic therapy, and the regulation of multiple active substances, and can be used to prepare drugs for treating malignant tumors of the digestive system.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a series of 15-membered ring quadruple lactone derivatives with neoantimycin mother nucleus structures, a preparation method of the 15-membered ring quadruple lactone derivatives and application of the 15-membered ring quadruple lactone derivatives in antitumor drugs, wherein the 15-membered ring quadruple lactone derivatives are generated by feeding chemical precursors in the fermentation process of streptomyces S.conglobatusATCC 31005. The compound is a fifteen-membered ring quadruple lactone derivative, the C-2 position of the derivative is connected with a carbonyl group or a hydroxyl group, the C-4 position and the C-9 position are substituted by aliphatic chains with different lengths, and the C-6 position of the derivative is connected with a benzoic acid group containing F atoms or hydroxyl groups. The compounds have obvious tumor cell proliferation inhibition activity on colorectal cancer cells and lung cancer cells, the inhibition activity is equivalent to that of a control drug oxaliplatin, and the compounds have weak toxicity on non-cancer cell strains. A novel lead compound is provided for research and development of novel antitumor drugs, and the compound is expected to be developed into a tumor inhibitor.

The invention belongs to the technical field of biomedicine, and particularly relates to application of SOX4 in preparation of a preparation for improving sensitivity of cervical cancer to chemotherapeutic drugs, and the amino acid sequence of the SOX4 is as shown in SEQ ID NO.1. An SOX4 knocked-down stable transfection cell line is constructed in a Hela cell, then carboplatin and oxaliplatin are respectively added into the SOX4 knocked-down Hela cell, and the IC50 of the cell to the carboplatin and the oxaliplatin is obviously reduced, which indicates that the sensitivity of the Hela cell to the carboplatin and the oxaliplatin is enhanced by SOX4 knock-down. By reducing the expression of SOX4, the sensitivity of Hela cells to chemotherapeutic drugs such as carboplatin and oxaliplatin is enhanced, so that the treatment effect of the chemotherapeutic drugs such as carboplatin and oxaliplatin is effectively improved. Results of the invention prove that inhibition of SOX4 is beneficial to recovery of chemosensitivity of cervical cancer cells to drugs such as carboplatin and oxaliplatin, and a new treatment strategy is provided for treatment of drug-resistant cervical cancer.

To provide a method of treating gastric cancer in a subject.SOLUTION: The method comprises administering, to a subject having gastric cancer, a therapeutically effective amount of an anti-fibroblast growth factor receptor 2 IIIb (anti-FGFR2-IIIb) antibody and modified FOLFOX6 (mFOLFOX6) chemotherapy (oxaliplatin, leucovorin, 5-fluorouracil).SELECTED DRAWING: Figure 1

The invention discloses an application of indoleacetic acid in preparation of a medicine for preventing or treating neuropathic toxicity caused by chemotherapeutics. Experimental results show that the indoleacetic acid (IAA) can significantly relieve pain sensitivity of mice caused by neuropathic toxicity (OIPN) caused by oxaliplatin (OXA), improve morphological damage of dorsal root ganglion (DRG) of the mice and reduce the inflammation level in colon of the mice; however, these benefits are significantly blocked when antagonists are used for the aromatic hydrocarbon receptor (AhR). This indicates that the therapeutic effect of IAA may depend on the activation of the aromatic hydrocarbon receptor (AhR) pathway. The invention provides a new method for treating neuropathic toxicity caused by chemotherapeutics, and expands the application of indoleacetic acid at the same time.

The invention provides application of combined use of ophiopogonin D and oxaliplatin in preparation of a medicine for treating colorectal cancer. The invention also provides a nano-drug delivery system containing co-assembly of ophiopogonin D and oxaliplatin, and the nano-drug delivery system is prepared by the following steps: by taking ZIF-8, ophiopogonin D and oxaliplatin as raw materials, synthesizing ZIF-8 (at) OPHamp, taking the ZIF-8 (at) OPHamp as a carrier, and taking the ZIF-8 (at) OPHamp as a carrier to prepare the nano-drug delivery system containing co-assembly of ophiopogonin D and oxaliplatin. The invention relates to an OXA nanoparticle (ZOX NPs). The invention also provides a co-assembled nano-drug delivery system containing the hyaluronic acid. According to the invention, ophiopogonin D and oxaliplatin are co-assembled by using a nano traditional Chinese medicine delivery system, and the nano preparation HZOX NPs is successfully synthesized, so that the drug can be more enriched at a tumor site, and the problems of poor stability, poor water solubility, low bioavailability and the like of ophiopogonin D are solved. The nanoparticles are uniform in particle size, high in stability and good in biocompatibility, the nano traditional Chinese medicine delivery system can resist colorectal cancer chemical resistance, and a promising strategy is provided for colorectal cancer treatment.

The present invention provides a Chinese medicine composition having the function of significantly improving oxaliplatin-induced peripheral neuropathic pain, and a preparation method and application thereof. The Chinese medicine composition is composed of astragalus, cinnamon twig, white peony root, geranium, flue gastrodia elata, ginger, angelica, reed root, cypress leaf, motherwort, senecio, loofah, aloe, acanthopanax bark, jujube, curculigo orchioides, and sappan wood.

The present invention relates to Akkermansia muciniphila and its applications, belonging to the technical field of microbiology. The Akkermansia muciniphila described in the present invention is Akkermansia muciniphila SYSU-85, which was deposited on August 8, 2024 at the General Microbiological Center of the China General Microbiological Culture Collection Center, and its deposit number is: CGMCC NO. 46070. The Akkermansia muciniphila SYSU-85 of the present invention has a weak dependence on mucin, grows well in BHI medium supplemented with cysteine, and is resistant to oxaliplatin. The Akkermansia muciniphila SYSU-85 of the present invention alleviates the adverse reactions caused by oxaliplatin, and in combination with oxaliplatin or PD-1 inhibitor, significantly slows down the tumor growth curve and significantly reduces the tumor volume, improving the tumor treatment effect.

The present invention relates to platinum (IV) prodrug lipid-based amphiphiles and compositions thereof. In particular, it relates to cisplatin, oxaliplatin and carboplatin prodrugs with the capacity to make stable liquid crystalline nanoparticles and crystalline nanoparticles, and uses thereof to treat cancer in animals, including humans.

The invention discloses a diphosphonic acid manganese nanoparticle, a preparation method thereof and application of the diphosphonic acid manganese nanoparticle in tumor treatment. The preparation method comprises the following steps: dropwise adding a water-in-oil emulsion system of diphosphonate into a water-in-oil emulsion system of manganese ions in stirring to establish a coordination skeleton, curing by absolute ethyl alcohol, adding a certain proportion of fat material, performing vortex hydration by a film dispersion method, and extruding to pass through a film. The diphosphonic acid manganese nanoparticle is small in particle size and good in stability, and has a pH-sensitive release characteristic; the constructed nanoparticles have a remarkable immune regulation effect, and the ICD effect and the cytotoxic effect of oxaliplatin are enhanced by directly acting on tumor cells. The diphosphonic acid manganese nanoparticles cooperate with Oxp to effectively inhibit digestive tract tumor growth and distal metastatic tumors, the dosage of Oxp can be further reduced, and the diphosphonic acid manganese nanoparticles have good in-vivo safety.