330 results about "Oxaliplatin" patented technology

The present invention relates to liposome comprising encapsulated oxaliplatin and methods for making encapsulated oxaliplatin. The invention also relates to liposomes comprising oxaliplatin and another anticancer drug. The liposomes of the invention are useful in cancer treatments.

The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the probable resistance of a patient's tumor to treatment with 5-FU and oxaliplatin-based therapies by examination of the amount of TS and/or ERCC1 mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level for those genes. More specifically, the invention provides to oligonucleotide primer pairs ERCC1 and TS and methods comprising their use for detecting levels of ERCC1 and TS mRNA, respectively.

The invention relates to a nano micelle of a biodegradable macromolecular-bonding Pt(IV) anti-cancer medicament and a preparation method thereof. The structural formula of the anti-cancer medicament is defined in the specification, wherein the biodegradable macromolecule is tri-block copolymer, namely polyethylene glycol-b-polyester-b-polylysine; and tetravalency platinum coordination compound Pt(IV) is connected with a side amino on the block of polylysine on a macromolecular carrier through alpha, omega-polyethylene glycol. The carrier is non-toxic and is water-soluble, thus being convenient for reacting with the platinum(IV) coordination compound in water phase; a nano micelle form can be formed through self assembly; a platinum(IV) coordination compound is reduced to platinum(II), namely, cis-platinum, Carboplatin or Oxaliplatin, and the anti-cancer effect is known; the synthesis of the nano micelle is easy; the reduction potential of platinum(IV) is low, so that the platinum(IV) can be rapidly reduced to platinum(II) in cancer cells to take treatment effect; and the platinum(IV) is connected to the side chain of the macromolecule rather than the end of a chain, a macromolecular chain can be connected with multiple platinum(IV)s, and the content of platinum can be as high as 10-20%.

The invention relates to a composite developing thermosensitive gel embolizing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a mixed aqueous solution of an anticancer active substance, a thermosensitive material and a developing agent into composite developing thermosensitive gel; secondly, forming a composite developing thermosensitive gel embolizing agent by the composite developing thermosensitive gel and a coagulant on the scene, wherein the thermosensitive material is hydroxyl C1-4 alkyl cellulose, Pluronic, alginate or a mixture of the substances; the anticancer active substance is arsenic trioxide, docetaxel, cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin, miriplatin, siRNA or a mixture of the substances; the developing agent is a water-soluble developing agent of iodixanol, ioversol or iohexol and the like. The preparation method disclosed by the invention is simple and convenient, is suitable for industrial large-scale production, is particularly suitable for preparing an embolizing agent which is biodegradable and good in biocompatibility and is used for hemorrhagic diseases, and is especially suitable for preparing the composite developing thermosensitive gel embolizing agent for treating liver cancer, kidney cancer, lung cancer, prostate cancer, uterine myoma or splenic tumor and the like.

Methods, devices, and medicaments that include oxaliplatin are provided for use in the treatment of bladder cancer by locally administering oxaliplatin into the bladder of a patient to achieve a sustained concentration of oxaliplatin in urine in the bladder sufficient to produce a therapeutic concentration of oxaliplatin in bladder tissue. The oxaliplatin may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the oxaliplatin into the urine in the bladder over an extended period of hours or days.

The invention provides a quadrivalent-platinum glycosyl complex for treating tumors and a preparation method thereof. The synthesized compound has good anti-tumor activity better than that of cisplatin and oxaliplatin, and has better stability than that of bivalent platinums such as cisplatin, carboplatin and oxaliplatin. In addition, since the quadrivalent platinum with galactosylated modification has better targeting for tumor cells, the high selectivity to the tumor cells is improved. Furthermore, the compound provided by the invention has the advantages that the problems of poor solubility and more troublesome clinical compatibility of the original bivalent-platinum anti-tumor medicine are solved, and both fat solubility and water solubility are better. The quadrivalent-platinum glycosyl derivative not only can improve the in-vivo availability and enhance the curative effect, but also can reduce the toxic and side effects of the original bivalent-platinum medicine on the kidney and the like.

The invention discloses a method for simultaneously detecting multiple anti-tumor drugs in a blood sample. A pretreated sample to be detected is detected by adopting ultra-high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The pretreatment process comprises the following steps: adding serum into a mixed solution of methanol and acetonitrile, oscillating and centrifuging,taking out the centrifuged supernatant, drying, dissolving the dried powder into a methanol aqueous solution, and filtering to obtain a sample to be detected. The method can be used for simultaneously detecting 13 kinds of anti-tumor drugs such as methotrexate, 5-fluorouracil, apatinib, busulfan, carboplatin, cyclophosphamide, docetaxel, gemcitabine, imatinib, illinotecan, lenalidomide, oxaliplatin, paclitaxel and the like in blood.

A nano-class suspension injection of oxaliplatin-phoshpatide composition for intravenous injection is proportionally prepared from oxaliplatin, surfactant, pH regulator, isotonic agent, antioxidant, water for injection, and optional excipient (for the freeze-dried powder injection).

The invention discloses a liposome preparation containing antineoplastic metallic complex which is derived by hydrophilic polymers and aglycones, in one embodiment, the antineoplastic metallic complex includes Oxaliplatin, the hydrophilic polymers include polyethylene glycol, the aglycone is transferrin. In accordance with the invention, the transferring expressed on the surface of the tumor cell can facilitate the absorption of agent in the liposome by the tumor cells. The invention also provides the pharmaceutical composition containing the liposome and method for application.

The invention relates to a novel oxaliplatin derivative of (1R, 2R-cyclohexanediamine.2, 2-Bis (hydroxymethyl)-1, 3-malonato-platinum (II)) and ((1R, 2R-cyclohexanediamine).2, 2-Bis (hydroxymethyl)malonato-platinum (II)). The derivative is prepared with the steps that the cis-(PtA2I2) (A2 is equal to 1R, 2R-cyclohexanediamine) is adopted as the raw material and quantitatively reacts with the 2, 2-Bis (hydroxymethyl)-1, 3-malonate silver, and a crude product then is obtained through the mother liquor concentration and freeze-drying after the AgI is filtered and separated; a pure product is obtained by recrystallizing the crude product in a system that the ratio of water to ethanol is 1:1. The anti-caner activity of the complex of the derivative is obviously higher than the oxaliplatin and the toxic side effect is obviously less than the oxaliplatin, and can be prepared into freeze-dried powders or injections and used for treating the cancer clinically.

The invention relates to a pharmaceutical composition prepared by freeze-drying in vacuo, containing oxaliplatin as the active component and a pharmaceutically acceptable carrier, wherein the carrier is at least one alcoholic sugar of non-animal origin, the weight ratio of oxaliplatin to the alcoholic sugar of non-animal origin or alcoholic sugars of non-animal origin being 1:3 to 1:7. The invention also relates to the method of manufacturing of said composition and to the use of this composition in the treatment of tumors sensitive to oxaliplatin.

Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

Disclosed is a combination of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate (chemical name: 2′-Deoxy-2′,2′-difluoro-D-cytidine-5′-O-[phenyl (benzoxy-L-alaninyl)]phosphate) (NUC-1031) and a platinum-based anticancer agent selected from carboplatin, dicycloplatin, oxaliplatin, satraplatin and nedaplatin. The combinations are useful in the treatment of cancer and particularly ovarian cancer.

The invention relates to a high optical purity trans-dextro oxaliplatin lyophilized powder injection and a preparation method thereof. The lyophilized powder injection contains high optical purity trans-dextro oxaliplatin with treatment effective dose and pharmaceutically acceptable lyophilized excipient, and does not contain animal-based auxiliary lactose, wherein the optical purity of the trans-dextro oxaliplatin is not lower than 99.95 percent; the pharmaceutically acceptable lyophilized excipient is one or more of cane sugar, trehalose, glycine, histidine, dextran, polyethylene glycol andcyclodextrin. The preparation method of the lyophilized powder injection comprises the following steps: dissolving raw and auxiliary materials in water; subpackaging, pre-freezing, lyophylizing, performing analytic drying; infiltering nitrogen into subpackaged bottles after the lyophilization is completed; and pressing plugs and caps. The high optical purity trans-dextro oxaliplatin lyophilized powder injection is used for preparing an anti-cancer medicament, and can be applied in a parenteral way after being re-dissolved with a compatible solution.

The invention discloses an amphipathic oxaliplatin precursor and a preparation method thereof. The amphipathic oxaliplatin precursor comprises an oxaliplatin unit and hydrophobic and hydrophilic functional groups. The amphipathic oxaliplatin precursor can be self-assembled solely into a micelle in water, the hydrophobic functional group of the amphipathicoxaliplatin precursor can form a hydrophobic core through hydrophobic interaction, the hydrophilic functional group forms a hydrophilic shell layer to maintain colloid stability of the self-assembled micelle. In addition, the invention further discloses application of the amphipathic oxaliplatin precursor. The amphipathicoxaliplatin precursor is mainly used for preparing cancer treatment drugs.

The present invention relates to preparation method of anticancer drug oxaliplatin which comprise that material cis-dihalo(trans-(-)-1,2- diamino cyclohexane)platium(II), silver nitrate, univalent metal ion or ammonium oxalate and oxygen-free deionized water are together prepared for oxaliplatin in one step. The invention has a simple process, product is good in color, and material is easy to get which is fit for industrial production.

The invention discloses a pegylated oxaliplatin prodrug as well as a preparation method and application thereof. The pegylated oxaliplatin prodrug has a structure as shown in the formula 1 or 2, wherein the linkage unit L is as shown in the description. The pegylated oxaliplatin prodrug is mainly used for preparing medicaments for cancer treatment and can be independently self-assembled into micelles in water. In addition, the invention also discloses pegylated oshari. The formulae 1 and 2 are as shown in the description.

The invention discloses a preparation method of miriplatin hydrate, which comprises the following steps: controlling the temperature to 40-90 DEG C, adding Oxaliplatin and C13H27COOM in a dissolved reaction solvent, and reacting for 1-6d to prepare the miriplatin hydrate, wherein the molar ratio of the Oxaliplatin to the C13H27COOM is 1:0.5-5, and M is sodium, potassium, ammonia, calcium or nitrogenous organic alkali. Compared with the existing preparation method of miriplatin hydrate, the preparation method disclosed by the invention has the outstanding advantages of environment-friendly synthesis lines, no silver ion residues, no toxic solvents, short lines and convenience in operation, the obtained product has good quality (chemical purity of 99.5% and optical purity more than 99.9%), high yield (more than 92%) which is 10% higher than that of other lines and low cost, is public-benefit and environment-friendly, is easy for industrial production, has good practicability and can produce better economic and social benefits. In addition, the miriplatin hydrate used for injection prepared according to the preparation method of the miriplatin hydrate disclosed by the invention has low production cost and high quality, and can reduce adverse reactions and treatment cost for patients to a great extent.