Biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle and preparation method thereof

A biodegradable and macromolecular technology, applied in the field of chemical synthesis of new drugs and their preparations, can solve problems such as lack of photoactivity
CN102416181AActive Publication Date: 2012-04-18吉林市博禹祥实工贸有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
吉林市博禹祥实工贸有限公司
Publication Date
2012-04-18

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Abstract

The invention provides a biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle and a preparation method thereof, which relate to the field of novel chemical synthesis medicaments and preparations thereof and are used for solving the problem that a high-polymer-platinum (IV) bonded medicament does not have optical activity in the prior art. In an anticancer medicament, ethylene glycol-b-polyester-b-polylysine serving as a biodegradable triblock copolymer or polyethylene glycol-b-poly(ester-co-carbonic ester) serving as a diblock copolymer is taken as a carrier polymer, and Pt (IV) is a photoactive tetravalent platinum composition coordinated with dihydroxyl in the axial direction. The invention further provides a preparation method of the biodegradable high-polymer bonded photoactive Pt (IV) anticancer medicament micelle. The anticancer medicament prepared with the method has remarkable optical activity; under the irradiation of UV (Ultraviolet) of 365 nanometers, Pt (IV) is reduced into Pt (II); a cis-platinum or oxaliplatin antitumor active part is contained; and the mass content of platinum can be up to 10-20 percent.
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Description

technical field

[0001] The invention belongs to the field of chemically synthesized new drugs and preparations thereof, in particular to a biodegradable macromolecular bonded photoactive Pt (IV) anticancer drug micelle and a preparation method. Background technique

[0002] Since the discovery of cisplatin's anticancer activity in 1967, the research and application of platinum-based metal anticancer drugs have been greatly developed. Thousands of platinum series compounds have been screened successively, dozens of them have entered clinical research, and several have been approved to enter the market.

[0003] Cis-dichlorodiammine platinum (II), also known as cisplatin (cisplatin), is a cell cycle non-specific drug and the most clinically used divalent platinum drug, which can combine with DNA to form cross-links. Thereby disrupting the replication function of DNA. Clinical practice has proved that cisplatin has a broad anticancer spectrum, strong effect, synergistic effec...

Claims

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