Preparation method and use of degradable polymer nano-microcapsules

A technology for degrading polymers and nano-microcapsules. It is applied in the direction of microcapsules, nanocapsules, and medical preparations of non-active ingredients. It can solve the problems of adverse therapeutic effects and low drug loading, and achieve fast release speed and preparation The effect of simple process and uniform molecular weight distribution
CN103830752AInactive Publication Date: 2014-06-04FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2014-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method and a use of degradable polymer nano-microcapsules. The preparation method comprises the following steps of carrying out backflow deposition on an acrylic acid monomer to produce uncross-linked polymer nano-microspheres, carrying out backflow deposition to coat a disulfide bond cross-linked polymer shell layer on the surface of the uncross-linked polymer nano-microsphere by disulfide bond-containing N,N'-bis(acryloyl)cystamine as a cross-linking agent, transferring the prepared core-shell composite microspheres into ethanol or water, and carrying out uncross-linked polymer core etching to obtain the degradable polymer nano-microcapsules having monodispersity. The preparation method can be carried out fast, has simple aftertreatment processes, is free of an etching process adopting strong acid or strong alkali and is safe and efficient. After freeze-drying treatment, the degradable polymer nano-microcapsule can carry doxorubicin as a cancer-resistant drug and the cavity of the degradable polymer nano-microcapsule is further filled with perfluorohexane having ultrasonic response so that the degradable polymer nano-microcapsule is effectively used as an ultrasonic contrast agent and a drug carrier. The ultrasonic contrast agent can be fast decomposed to form very low molecular-weight linear molecules (Mn<5000) in the presence of glutathione or dithiothreitol as a reducing agent.
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Description

technical field

[0001] The invention relates to a method for preparing novel degradable polymer nano-microcapsules and its application in ultrasonic contrast agents and drug carriers, belonging to the technical fields of new materials and biomedicine. Background technique

[0002] Ultrasound imaging (US) technology is one of the most widely used imaging technologies in the world. Because low-intensity ultrasound causes little damage to human tissue, it has the advantages of safety, wide application, real-time, repeatable inspection, strong ability to identify soft tissues, high flexibility and low price, making ultrasound image diagnosis the first choice for medical image diagnosis. . However, compared with CT imaging and magnetic resonance imaging, the sensitivity and resolution of ultrasound imaging are very low. When the two soft tissue interfaces have similar acoustic impedance, the reflected echoes between the two are very similar, so only ultrasound diagnosis is used....

Claims

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