The invention discloses a water-soluble micro
powder containing
florfenicol and a preparation method thereof. The micro
powder is prepared from the following raw materials in percentage by weight: 5 to 10 percent of
florfenicol, 2.5 to 2.75 percent of PVPK30, 2.5 to 2.75 percent of SDS and the balance
anhydrous glucose. PVPK30, SDS and
florfenicol are mixed uniformly, crushed, pass through a 150mesh screen, and then are added with the
anhydrous glucose to be mixed uniformly. The micro
powder also can be combined with other medicines to prepare water-soluble compound florfenicol micro powder. The grain size of the florfenicol through micro powder treatment is finer and more uniform, so the surface area is increased, the
porosity is increased, the absorbability and the
solubility are improved, the medicines can be well dispersed and dissolved in gastric juice, the contact area with
gastric mucosa is enlarged, so that the medicines can be absorbed by the
gastrointestinal tract more easily, thereby greatly improving the
bioavailability. The preparation method is more convenient than a
coating process, and is more applicable to large-scale production.