The invention discloses a vehicle safety control system and method for lane line detection temporary loss in automatic drive, and the system comprises an automatic drive decision-making module, an image processing module, a light controller, an execution mechanism, an HMI module and a camera, wherein the image processing module, the light controller, the execution mechanism and the HMI module are respectively connected with the automatic drive decision-making module, and the camera is connected with the image processing module. The image processing module carries out the processing of an image, and carries out the detection of a lane line. The automatic drive decision-making module carries out the planning of a driving path of a vehicle based on the lane line, and controls the running of the vehicle. When the image processing module cannot detect the lane line, the automatic drive decision-making module obtains a passable region of a road according to a historical track of the vehicle and the information detected by a radar group, and controls the vehicle to reduce the speed and run in the passable region, and the light controller turns on an emergency light, and the HMI module continuously reminds a driver of taking charge of the vehicle. When the lane line cannot be detected in a short time, the system can guarantee that the vehicle is in a safety state, and guarantees the safety of the driver.