2results about How to "High drug loading rate" patented technology

The invention relates to the technical field of nano materials, in particular to a preparation method of a Zn-based bimetal MOFs material and application of the Zn-based bimetal MOFs material as a medical drug carrying material. The preparation method comprises the following steps: preparing Zn, Mn and a ligand according to a molar ratio of 1: 1: (72-80), and mainly comprises the steps of preparation of metal salt solutions, coordination polymerization reaction, separation and purification, and drying. The process for preparing the Zn-based bimetallic MOFs material is simple and environmentally friendly, the obtained product has the excellent performance of being small in particle size, regular and stable, and the material loaded with doxorubicin hydrochloride has high loading rate and has potential clinical conversion value.

The present application provides a kind of aceclofenac enteric microcapsule and its preparation method, the microcapsule includes core and coating, the core includes pill core, aceclofenac, adhesive;The coating includes enteric coating material, plasticizer, anti-adhesive. By screening and optimizing the type and proportion of adhesive and enteric material, optimizing and controlling the preparation process parameters, effectively improve the stability and long-term stability of aceclofenac sustained-release microcapsule, block the release of drug in mouth and stomach, direct the drug to small intestine and slowly release, and the release effect is long-acting and durable.