7results about How to "High drug loading rate" patented technology

The invention relates to the technical field of nano medicines, in particular to a tanshinol-containing copper-based metal organic framework nano material and a preparation method and application thereof.According to the prepared tanshinol-containing copper-based metal organic framework nano material, tanshinol is dissolved in a dimethylimidazole aqueous solution, copper ions are rapidly added into the solution, and the tanshinol-containing copper-based metal organic framework nano material is obtained after the tanshinol is dissolved in the dimethylimidazole aqueous solution; the tanshinol-loaded copper-based metal organic framework nano-material is prepared from the copper-based metal organic framework nano-material, the tanshinol-loaded copper-based metal organic framework nano-material has high drug loading rate and acid-sensitive drug release performance, and the defects that a small-molecule drug tanshinol is poor in stability in an articular cavity and is easily removed by synovial fluid can be overcome. Compared with a natural enzyme, the nano-enzyme formed by combining tanshinol and copper-based MOF has the active oxygen scavenging capacity, and the treatment effect on osteoarthritis is jointly improved.

The invention relates to the technical field of nano materials, in particular to a preparation method of a Zn-based bimetal MOFs material and application of the Zn-based bimetal MOFs material as a medical drug carrying material. The preparation method comprises the following steps: preparing Zn, Mn and a ligand according to a molar ratio of 1: 1: (72-80), and mainly comprises the steps of preparation of metal salt solutions, coordination polymerization reaction, separation and purification, and drying. The process for preparing the Zn-based bimetallic MOFs material is simple and environmentally friendly, the obtained product has the excellent performance of being small in particle size, regular and stable, and the material loaded with doxorubicin hydrochloride has high loading rate and has potential clinical conversion value.

This invention discloses a liposome, a drug-loaded liposome, its preparation method, and its applications. The liposome comprises a liposome backbone and a targeting ligand; wherein the liposome backbone comprises the following components: phospholipids, cholesterol, cationic lipids, and PEGylated phospholipids; the cationic lipids are (2,3-dioleoyl-propyl)-trimethylammonium chloride and / or 1,2-dioleoyl-3-trimethylammonium propane; and the targeting ligands are sodium hyaluronate and / or hyaluronic acid. This liposome possesses excellent basic properties and excellent targeting ability; after encapsulating the active pharmaceutical ingredients (doxacin hydrochloride and berberine hydrochloride), its targeting ability can be further enhanced in practical applications, thereby increasing its efficacy.

The invention relates to the technical field of biological medicine, in particular to bionic naringenin polydopamine nanoparticles and application thereof. Comprising the following steps: dissolving pluronic and dopamine hydrochloride in an ethanol water solution, then adding a 3, 3 ', 5, 5'-tetramethyl benzidine solution, and carrying out ultrasonic treatment for 5-15 minutes; adjusting the pH value to 7.5-8.5, violently stirring at room temperature for 3-5 hours, centrifuging, collecting precipitate to obtain mesoporous polydopamine nanoparticles, and storing at 0-5 DEG C for later use; the mesoporous polydopamine nanoparticles are added into absolute ethyl alcohol to be dissolved, naringenin is added, ultrasonic treatment, stirring and centrifugal collection are conducted on precipitates, and naringenin polydopamine nanoparticles are obtained; carrying out co-incubation on the naringenin polydopamine nanoparticles and the neutrophile granulocytes; therefore, the bionic naringenin polydopamine nano-particles are obtained. The invention further discloses application of the bionic naringenin polydopamine nano-particles in a medicine for treating thoracic aortic aneurysm.

The present invention discloses an application of a dehydrogenated short peptide in the controlled release of anti-tumor drugs, wherein the dehydrogenated short peptide is applied to load chlorambucil to form a dehydrogenated short peptide-loaded chlorambucil gel DHPN1-CLB, thereby realizing the control of the in vitro release of chlorambucil, improving the aggregation of chlorambucil in cells during in vitro release, strengthening the anti-leukemia cell proliferation effect, and inducing cell apoptosis by decreasing the mitochondrial membrane potential of leukemia cells. The results show that the cell uptake experiment shows that the dehydrogenated short peptide-loaded chlorambucil gel DHPN1-CLB has a larger amount of aggregation in cells and is easier to enter cells. DHPN 1 can increase the aggregation of chlorambucil in cells, thereby enhancing the anti-leukemia cell proliferation effect. The chlorambucil-dehydrogenated peptide nanosystem induces cell apoptosis by decreasing the mitochondrial membrane potential of leukemia cells, and is time- and dose-dependent.

The present application provides a kind of aceclofenac enteric microcapsule and its preparation method, the microcapsule includes core and coating, the core includes pill core, aceclofenac, adhesive;The coating includes enteric coating material, plasticizer, anti-adhesive. By screening and optimizing the type and proportion of adhesive and enteric material, optimizing and controlling the preparation process parameters, effectively improve the stability and long-term stability of aceclofenac sustained-release microcapsule, block the release of drug in mouth and stomach, direct the drug to small intestine and slowly release, and the release effect is long-acting and durable.

The invention belongs to the field of preparation of plant-derived functional materials, and particularly relates to puerarin-pueraria starch-Span80 gel beads as well as a preparation method and application of the puerarin-pueraria starch-Span80 gel beads. The method is realized by the following steps: firstly, weighing pueraria starch, and dispersing the pueraria starch in ultrapure water containing sodium alginate to obtain a gelatinized pueraria starch solution; adding a surfactant into the gelatinized pueraria starch solution, stirring, dropwise adding the puerarin-ethanol solution, and continuously stirring after dropwise adding; and sucking the supernate, dripping into a calcium lactate solution, curing into balls, and performing vacuum freeze drying to obtain the product. The puerarin-embedded gel bead prepared by the invention has pores on the surface, and the structure is of a porous three-dimensional network structure, so that the adsorption and embedding of subsequent active substances are facilitated; a texture result shows that in addition to elasticity, the hardness, cohesiveness, gelatinization, chewiness and resilience of the gel beads before freeze-drying are as follows: puerarin-pueraria starch-Span80 gel beads > puerarin-pueraria starch gel beads > pueraria starch gel beads; and the swelling property is good and can reach 6.94 + / -6.34%.