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Preparation method for polyazobenzene multifunctional nanoparticles based on rare earth up-conversion material

A technology of rare earth up-conversion and nano-particles, which is applied in the fields of photodynamic therapy, biological imaging, biological detection, and targeted drug delivery. It can solve problems such as difficult tracking, separation of tumor diagnosis and treatment, and achieve high drug loading efficiency.

Inactive Publication Date: 2018-06-22
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical problem is that the diagnosis and treatment of tumors are separated, and it is difficult to track them during treatment. The development of diagnostic and therapeutic agents that integrate diagnosis and treatment has been a hot research topic for scientific and technological workers.

Method used

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  • Preparation method for polyazobenzene multifunctional nanoparticles based on rare earth up-conversion material
  • Preparation method for polyazobenzene multifunctional nanoparticles based on rare earth up-conversion material
  • Preparation method for polyazobenzene multifunctional nanoparticles based on rare earth up-conversion material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 15 ml of 1-octadecene and 7 ml of oleic acid in a 100 ml four-necked flask, and then add 3.975 ml of yttrium chloride aqueous solution (0.2mol / L) and 1 ml of chlorinated Ytterbium aqueous solution (0.2mol / L) and 25 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 120 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to 150 °C After keeping at ℃ for 50 min, remove the heating mantle, cool to room temperature naturally, mix 5 ml methanolic sodium hydroxide solution (0.5 mol / L) and 8 ml ammonium fluoride methanolic solution (0.5 mol / L) evenly, and quickly add four Then, the reaction solution was stirred at room temperature for 1 h; the temperature was slowly raised to 100 °C to remove methanol and water, and then the temperature was rapidly raised to 260 °C and ke...

Embodiment 2

[0033] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4Core / shell up-conversion nanoparticles: a): Add 10ml of 1-octadecene and 5ml of oleic acid into a 100ml four-neck flask, then add 1ml of yttrium chloride aqueous solution (0.2mol / L), 0.5ml of chlorine ytterbium chloride aqueous solution (0.2mol / L) and 10 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 150 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to After keeping at 200°C for 60 min, remove the heating mantle, and after cooling down to room temperature naturally, mix 3 ml of methanolic sodium hydroxide solution (0.5mol / L) and 5 ml of methanolic ammonium fluoride solution (0.5mol / L) evenly and add them quickly In a four-necked flask, the reaction solution was then stirred at room temperature for 1 h; the temperature was slowly raised to 150 °C to remove methanol and water, and then the temperature was...

Embodiment 3

[0038] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 20 ml of 1-octadecene and 10 ml of oleic acid into a 100 ml four-neck flask, then add 5 ml of yttrium chloride aqueous solution (0.2mol / L), 4 ml of chlorine ytterbium chloride aqueous solution (0.2mol / L) and 30 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 130 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to After keeping at 170°C for 55 minutes, remove the heating mantle, and after cooling down to room temperature naturally, mix 6 ml of methanolic sodium hydroxide solution (0.5mol / L) and 10 ml of methanolic ammonium fluoride solution (0.5mol / L) evenly and add them quickly In a four-neck flask, the reaction solution was then stirred at room temperature for 1 h; the temperature was slowly raised to 130 °C to remove methanol and water, and then the tempera...

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Abstract

The invention discloses a preparation method for polyazobenzene multifunctional nanoparticles based on a rare earth up-conversion material. The preparation method comprises the following steps: 1) synthesizing NaYF4: Tm<3+>, Yb<3+>, Tm<3+> / NaYF4 core / shell up-conversion nanoparticles; 2) coating a silica shell layer onto the surface of hydrophobic UCNPs through a reversed-phase microemulsion method, carrying out functional modification with an MPS silane coupling agent, and allowing particle surface to obtain carbon-carbon double bonds so as to make a preparation for subsequent polymerizationreaction; 3) preparing a double response shell with photoresponse azobenzene as a cross-linking agent and methacrylic acid as a monomer; and 4) etching a silicon layer so as to prepare multifunctionalnanoparticles with rare earth nanoparticles as a core and a double response shell-yolk structure as a shell. According to the invention, by utilization of the up-conversion effect of the rare earth nanoparticles to near-infrared laser, ultraviolet light and visible light are generated, so a microsphere shell azobenzene element can control drug release under the action of a light switch, and a novel idea and a route are provided for solving the problem that stimuli responsiveness of a carrier is limited in an ultraviolet area.

Description

technical field [0001] The invention belongs to the fields of biological development and imaging, biological detection, photodynamic therapy and targeted drug delivery, and in particular relates to the preparation of polyazobenzene multifunctional composite nanoparticles based on rare earth up-conversion materials. Background technique [0002] Upconversion nanoparticles UCNPs, especially nanocrystals doped with lanthanide elements, is a functional material capable of converting low-energy photons into high-energy photons with anti-Stoke luminescence. Infrared light is favored for converting it into visible and ultraviolet light. The recently developed rare-earth up-conversion nanoparticles have a unique energy level structure, which can absorb two or more photons under the excitation of low-energy (long-wavelength) near-infrared light, and upconvert the energy to emit light from the ultraviolet to the visible region. . Studies have shown that near-infrared lasers (700~110...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/85C08F292/00A61K47/32A61K47/04A61P35/00A61K49/00
CPCA61K47/02A61K47/32A61K49/0017C08F292/00C09K11/025C09K11/7773
Inventor 王小涛黄桐叶晓铁
Owner HUBEI UNIV OF TECH
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