Preparation method for polyazobenzene multifunctional nanoparticles based on rare earth up-conversion material
A technology of rare earth up-conversion and nano-particles, which is applied in the fields of photodynamic therapy, biological imaging, biological detection, and targeted drug delivery. It can solve problems such as difficult tracking, separation of tumor diagnosis and treatment, and achieve high drug loading efficiency.
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Embodiment 1
[0028] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 15 ml of 1-octadecene and 7 ml of oleic acid in a 100 ml four-necked flask, and then add 3.975 ml of yttrium chloride aqueous solution (0.2mol / L) and 1 ml of chlorinated Ytterbium aqueous solution (0.2mol / L) and 25 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 120 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to 150 °C After keeping at ℃ for 50 min, remove the heating mantle, cool to room temperature naturally, mix 5 ml methanolic sodium hydroxide solution (0.5 mol / L) and 8 ml ammonium fluoride methanolic solution (0.5 mol / L) evenly, and quickly add four Then, the reaction solution was stirred at room temperature for 1 h; the temperature was slowly raised to 100 °C to remove methanol and water, and then the temperature was rapidly raised to 260 °C and ke...
Embodiment 2
[0033] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4Core / shell up-conversion nanoparticles: a): Add 10ml of 1-octadecene and 5ml of oleic acid into a 100ml four-neck flask, then add 1ml of yttrium chloride aqueous solution (0.2mol / L), 0.5ml of chlorine ytterbium chloride aqueous solution (0.2mol / L) and 10 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 150 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to After keeping at 200°C for 60 min, remove the heating mantle, and after cooling down to room temperature naturally, mix 3 ml of methanolic sodium hydroxide solution (0.5mol / L) and 5 ml of methanolic ammonium fluoride solution (0.5mol / L) evenly and add them quickly In a four-necked flask, the reaction solution was then stirred at room temperature for 1 h; the temperature was slowly raised to 150 °C to remove methanol and water, and then the temperature was...
Embodiment 3
[0038] (1) Preparation of NaYF 4 : 0.5%Yb 3+ , 30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 20 ml of 1-octadecene and 10 ml of oleic acid into a 100 ml four-neck flask, then add 5 ml of yttrium chloride aqueous solution (0.2mol / L), 4 ml of chlorine ytterbium chloride aqueous solution (0.2mol / L) and 30 µL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 130 °C under nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to After keeping at 170°C for 55 minutes, remove the heating mantle, and after cooling down to room temperature naturally, mix 6 ml of methanolic sodium hydroxide solution (0.5mol / L) and 10 ml of methanolic ammonium fluoride solution (0.5mol / L) evenly and add them quickly In a four-neck flask, the reaction solution was then stirred at room temperature for 1 h; the temperature was slowly raised to 130 °C to remove methanol and water, and then the tempera...
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