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A preparation method of polyazobenzene multifunctional nanoparticles based on rare earth up-conversion materials

A rare earth up-conversion and nanoparticle technology, applied in the directions of luminescent materials, chemical instruments and methods, preparations for in vivo tests, etc., can solve the problems of difficult tracking, tumor diagnosis and treatment separation, and achieve the effect of high drug loading rate

Inactive Publication Date: 2020-06-16
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical problem is that the diagnosis and treatment of tumors are separated, and it is difficult to track them during treatment. The development of diagnostic and therapeutic agents that integrate diagnosis and treatment has been a hot research topic for scientific and technological workers.

Method used

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  • A preparation method of polyazobenzene multifunctional nanoparticles based on rare earth up-conversion materials
  • A preparation method of polyazobenzene multifunctional nanoparticles based on rare earth up-conversion materials
  • A preparation method of polyazobenzene multifunctional nanoparticles based on rare earth up-conversion materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of NaYF 4 :0.5%Yb 3+ ,30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): In a 100ml four-necked flask, add 1-octadecene 15ml and oleic acid 7ml, then add 3.975ml yttrium chloride aqueous solution (0.2mol / L) and 1ml ytterbium chloride aqueous solution ( 0.2mol / L) and 25μL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated up to 120°C under a nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to 150°C and kept for 50min. After removing the heating mantle and cooling to room temperature naturally, 5ml of methanolic sodium hydroxide solution (0.5mol / L) and 8ml of methanolic ammonium fluoride solution (0.5mol / L) were mixed evenly and quickly added to the four-necked flask, followed by the reaction The solution was stirred at room temperature for 1 hour; the temperature was slowly raised to 100°C to remove methanol and water, then the temperature was rapidly raise...

Embodiment 2

[0034] (1) Preparation of NaYF 4 :0.5%Yb 3+ ,30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 10ml of 1-octadecene and 5ml of oleic acid into a 100ml four-neck flask, then add 1ml of yttrium chloride aqueous solution (0.2mol / L) and 0.5ml of ytterbium chloride aqueous solution (0.2mol / L) and 10μL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated to 150°C under a nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to 200°C for 60min. Finally, the heating mantle was removed, and after natural cooling to room temperature, 3ml of methanolic sodium hydroxide solution (0.5mol / L) and 5ml of methanolic ammonium fluoride solution (0.5mol / L) were mixed evenly and then quickly added to the four-necked flask, followed by The reaction solution was stirred at room temperature for 1 h; the temperature was slowly raised to 150°C to remove methanol and water, then the temperature was rapidly ...

Embodiment 3

[0039] (1) Preparation of NaYF 4 :0.5%Yb 3+ ,30%Tm 3+ / NaYF 4 Core / shell up-conversion nanoparticles: a): Add 1-octadecene 20ml and oleic acid 10ml in a 100ml four-necked flask, then add 5ml yttrium chloride aqueous solution (0.2mol / L), 4ml ytterbium chloride aqueous solution ( 0.2mol / L) and 30μL thulium chloride aqueous solution (0.1mol / L), the mixed solution was slowly heated up to 130°C under a nitrogen atmosphere to remove moisture and oxygen in the reaction system, and then continued to heat up to 170°C and kept for 55min. After removing the heating mantle and cooling to room temperature naturally, 6ml of methanolic sodium hydroxide solution (0.5mol / L) and 10ml of methanolic ammonium fluoride solution (0.5mol / L) were mixed evenly and quickly added to the four-necked flask, followed by the reaction The solution was stirred at room temperature for 1 hour; the temperature was slowly raised to 130°C to remove methanol and water, and then the temperature was rapidly raised ...

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Abstract

The invention discloses a preparation method for polyazobenzene multifunctional nanoparticles based on a rare earth up-conversion material. The preparation method comprises the following steps: 1) synthesizing NaYF4: Tm<3+>, Yb<3+>, Tm<3+> / NaYF4 core / shell up-conversion nanoparticles; 2) coating a silica shell layer onto the surface of hydrophobic UCNPs through a reversed-phase microemulsion method, carrying out functional modification with an MPS silane coupling agent, and allowing particle surface to obtain carbon-carbon double bonds so as to make a preparation for subsequent polymerizationreaction; 3) preparing a double response shell with photoresponse azobenzene as a cross-linking agent and methacrylic acid as a monomer; and 4) etching a silicon layer so as to prepare multifunctionalnanoparticles with rare earth nanoparticles as a core and a double response shell-yolk structure as a shell. According to the invention, by utilization of the up-conversion effect of the rare earth nanoparticles to near-infrared laser, ultraviolet light and visible light are generated, so a microsphere shell azobenzene element can control drug release under the action of a light switch, and a novel idea and a route are provided for solving the problem that stimuli responsiveness of a carrier is limited in an ultraviolet area.

Description

technical field [0001] The invention belongs to the fields of biological development and imaging, biological detection, photodynamic therapy and targeted drug delivery, and in particular relates to the preparation of polyazobenzene multifunctional composite nanoparticles based on rare earth up-conversion materials. Background technique [0002] Upconversion nanoparticles UCNPs, especially lanthanide-doped nanocrystals, are functional materials that can convert low-energy photons into high-energy photons with anti-Stoke luminescence. Infrared light is favored for converting it into visible and ultraviolet light. The recently developed rare-earth up-conversion nanoparticles have a unique energy level structure, which can absorb two or more photons under the excitation of low-energy (long-wavelength) near-infrared light, and upconvert the energy to emit light from the ultraviolet to the visible region. . Studies have shown that near-infrared lasers (700-1100nm) can penetrate ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/85C08F292/00A61K47/32A61K47/04A61P35/00A61K49/00
CPCA61K47/02A61K47/32A61K49/0017C08F292/00C09K11/025C09K11/7773
Inventor 王小涛黄桐叶晓铁
Owner HUBEI UNIV OF TECH
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