15 results about "Multifunctional nanoparticles" patented technology

The invention discloses a load ICGamp. The invention discloses ZIF-8 nano-particles of CBF, and belongs to the technical field of preparation of nano-drug particles. The multifunctional nanoparticles are formed by simultaneously encapsulating indocyanine green (ICG) and cinobufagin (CBF) components by ZIF-8, and the drug loading capacities of the two drugs are both not lower than 5%. The preparation method comprises the following steps: slowly adding a solution containing cinobufagin and zinc nitrate into a mixed solution containing indocyanine green, bovine serum albumin and 2-methylimidazole, and carrying out centrifugal filtration, washing and drying on a reaction product to obtain the cinobufagin zinc oxide. The multifunctional nano-particles prepared by a one-step synthesis method are uniform in particle size and good in stability, indocyanine green and cinobufagin are uniformly distributed in a carrier, the multifunctional nano-particles have pH and near-infrared light dual response drug release characteristics, triple synergy of chemotherapy, photothermal therapy and photodynamic therapy can be realized, and the multifunctional nano-particles are simple in preparation process and suitable for popularization and application.

The present invention relates to a CRISPR-Cas12a-based exosomal miRNA one-pot analysis method and device using an hourglass structure. The present invention provides an miRNA analysis method and device which can continuously perform the isolation and amplification of exosomes and the analysis of CRISPR Cas signals in a single reaction vessel by using multifunctional nanoparticles and an hourglass structure. The analysis method according to the present invention is characterized by: using an exosome isolation method using magnetic nanoparticles and an immune response without external equipment such as a centrifuge, thereby enabling selective isolation of only human cell-derived exosomes in a simple manner and at low cost; amplifying miRNA with CRISPR RNA (crRNA) instead of an aptamer, thus simplifying the amplification process; and analyzing a signal generated when a chromogenic enzyme immobilized via DNA is cleaved by Cas protein, thereby enabling analysis with the naked eye without separate fluorescence analysis equipment.

The application discloses a kind of nanoparticles with tumor microenvironment regulation, multifunctional nanoparticles and preparation method and application thereof, including core, the core is Prussian blue analogue nanoparticle;Protective layer, covers the surface of the core, the protective layer has the characteristics of degradation in acidic environment;And, targeting agent connected on protective layer.The application has the ability to respond and adjust to tumor microenvironment (TME), can realize photothermal therapy and photodynamic therapy under the guidance of two modes of imaging, such as photothermal and nuclear magnetic, under single NIR laser irradiation.The material has the advantages of simple preparation process, low cost, good biocompatibility, tumor microenvironment response and modification, can realize targeted, non-invasive, efficient killing of tumor cells, so as to have broad clinical application prospect in tumor treatment.

The invention discloses pH color-changing photo-thermal particles with bacteria monitoring and antibacterial functions, a composite film and a preparation method and application of the composite film, and relates to the technical field of functional film materials. The method comprises the following steps: preparing a silver nanorod by a gold seed method; preparing an ion-doped composite material with a core-shell structure through a sol-gel method; performing functional group modification on the ion-doped composite material with the core-shell structure; and carrying out pH indicator loading on the ion-doped composite material with the core-shell structure after functional group modification. The multifunctional nano-particles with the core-shell structure are loaded through electrostatic spinning, the particles have the good near-infrared light thermal response characteristic, the pH recognition color-changing characteristic and the good antibacterial performance, and the multifunctional film can be simply and conveniently prepared by carrying the particles.

The application provides a multifunctional nanoparticle targeting cancer cells and capable of regulating tumor immune microenvironment and a preparation method and application thereof; the preparation method comprises the following steps: a) mixing K3[Fe(CN)6], a Mo source, water and polyvinylpyrrolidone, and performing a hydrothermal reaction in the presence of a hydrochloric acid solution to obtain a reaction mixture; then the solid in the reaction mixture is separated, and then is sequentially subjected to washing and drying to obtain molybdenum-doped prussian blue nanoparticles; b) mixing the molybdenum-doped prussian blue nanoparticles with a cancer cell membrane, and performing coating to obtain a composite; and then the composite is washed with water to obtain the multifunctional nanoparticle. The product not only significantly improves the efficiency of photothermal therapy, but also generates active oxygen and consumes antioxidant glutathione in the tumor microenvironment, thereby enhancing chemical dynamic therapy and promoting the presentation of tumor-associated antigens; the coating of the cancer cell membrane as a warehouse of tumor-associated antigens further improves the immunotherapy potential of the product.

The application discloses a suede composite fabric and a preparation method thereof, and belongs to the technical field of fabrics. The fabric has a gradient sandwich structure and comprises a multifunctional nano-particle modified suede layer, a nano-particle enhanced water-based PU adhesive layer and a high-strength base cloth layer. The multifunctional nano-particle is prepared by using hexachlorocyclotriphosphazene as a core skeleton and grafting organosilicon prepolymer, long fluorocarbon chain silane and silane coupling agent; the modified suede layer endows the fabric with multifunctionality, the adhesive layer strengthens the interface bonding, and the base cloth layer improves the mechanical strength. The application is prepared by using a one-pot in-situ grafting process, the fabric has excellent flame-retardant, hydrophobic and wear-resistant properties, has strong washing resistance, meanwhile, retains the delicate touch and the simulated leather texture of the suede, and the process is environmentally friendly and simple, and is suitable for application in multiple scenes.

This invention provides a multifunctional nanoparticle formulation with thrombin targeting capability, comprising a gold nanoparticle matrix, a paramagnetic small molecule, and a thrombin-targeting nucleic acid aptamer. The thrombin-targeting nucleic acid aptamer endows the nanoparticle formulation with thrombin-targeting binding ability; the paramagnetic small molecule endows the nanoparticle formulation with T1-weighted magnetic resonance imaging capability and reactive oxygen species scavenging capability; the gold nanoparticle matrix endows the nanoparticle formulation with CT imaging capability and near-infrared photothermal conversion capability; the nanoparticle formulation can achieve thrombin-dependent enrichment within the thrombus.

The application belongs to the technical field of high polymer composite materials, and particularly relates to a high-performance CA-based nanocomposite film and a preparation method and application thereof, which is prepared from the following raw materials: cellulose acetate, glycerol and multifunctional nanoparticles. The application further provides a preparation method of the high-performance CA-based nanocomposite film. The multifunctional nanoparticles are used as fillers based on the CA matrix, so that the performance of the CA-based composite material can be effectively improved. The high-performance CA-based nanocomposite film prepared by the application has excellent ultraviolet shielding performance, high-energy short-wave blue light blocking performance, mechanical performance and ammonia gas response color-changing performance. The composite material preparation process is simple, environmentally friendly, low in cost and suitable for large-scale production, and has wide application value in the fields of food packaging, intelligent materials, ammonia gas detection, environmental monitoring and safety.

The invention belongs to the technical field of LED display screens, and particularly relates to a protective coating material, a UV-resistant LED display module with a protective coating consistent with high ink color and a preparation method of the UV-resistant LED display module. The protective coating material provided by the invention contains multifunctional nano-particles, and is formed by coating rare earth nano-particles with silicon dioxide and modifying black nano-particles, so that the multifunctional nano-particles have multiple functions of resisting UV and light diffusion, improving blackness, reducing reflectivity, preventing dazzle and the like at the same time; therefore, the protective coating material has relatively high UV resistance and ink color regulation and control performance at the same time; moreover, due to the use of the multifunctional nanoparticles, the protective coating material does not need to add extra core components in traditional common coating materials such as a matte agent, carbon black color paste, a UV absorbent and the like, so that the content of the nanoparticles in the coating material is greatly reduced, the hardness and wear resistance of the coating are improved, meanwhile, the production process is simplified, and the production cost is reduced. And the production cost is reduced.

The application discloses a suede composite fabric and a preparation method thereof, and belongs to the technical field of fabrics. The fabric has a gradient sandwich structure and comprises a multifunctional nano-particle modified suede layer, a nano-particle enhanced water-based PU adhesive layer and a high-strength base cloth layer. The multifunctional nano-particle is prepared by using hexachlorocyclotriphosphazene as a core skeleton and grafting organosilicon prepolymer, long fluorocarbon chain silane and silane coupling agent; the modified suede layer endows the fabric with multifunctionality, the adhesive layer strengthens the interface bonding, and the base cloth layer improves the mechanical strength. The application is prepared by using a one-pot in-situ grafting process, the fabric has excellent flame-retardant, hydrophobic and wear-resistant properties, has strong washing resistance, meanwhile, retains the delicate touch and the simulated leather texture of the suede, and the process is environmentally friendly and simple, and is suitable for application in multiple scenes.

The application relates to a CuS-GSNO@RBCM multifunctional nanoparticle and a preparation and application thereof, and belongs to the technical field of medicine preparation. The CuS-GSNO nanoparticle is prepared by taking CuS as a carrier to load GSNO, and the CuS-GSNO@RBCM nanoparticle is prepared by coating the CuS-GSNO nanoparticle with mouse red blood cell membranes RBCM. The application effectively solves the problems of CuS-GSNO agglomeration and the poor consistency between the ROS generated by CuS through PDT and the NO released by GSNO by adopting CuS to load GSNO and then coating the CuS-GSNO with RBCM. Through the multiple synergistic effects of ROS generated by PDT, the reaction of ROS and NO to generate RNS, and the thermoelectric effect to promote the generation of RNS, the killing effect of the nanoparticle on MRSA is improved.

The preparation method comprises the following steps: taking 3, 3 ', 5, 5'-tetramethyl benzidine (TMB), polyoxyethylene polyoxypropylene ether (Pluronic F-127) and polydopamine as raw materials under a dark condition to prepare mesoporous polydopamine nano-microspheres, adding the mesoporous polydopamine nano-microspheres into the mesoporous polydopamine nano-microspheres, carrying out ultrasonic dispersion on the mesoporous polydopamine nano-microspheres, carrying out ultrasonic dispersion on the mesoporous polydopamine nano-microspheres, carrying out ultrasonic dispersion on the mesoporous polydopamine nano-microspheres, and carrying out ultrasonic dispersion on the mesoporous polydopamine nano-microspheres so as to obtain the mesoporous polydopamine nano-microspheres. Dispersing the nanoparticles into a buffer solution, and sequentially adding the fuzhangling and a CCL2 antibody to obtain the sequential targeting multifunctional nanoparticles loaded with the fuzhangling. According to the invention, the removal rate of the monkshood on the ocular surface is slowed down through a porous nanostructure, and active oxygen is removed to relieve oxidative stress while CCL2 and corneal epithelial cell mitochondria are sequentially targeted and inflammatory circulation participated by cytokines (IL-1beta, IL-6 and TNF-alpha), MMP9 and T cells is blocked.

Disclosed herein is a method for producing a chitosan-based nanocomposite film, the method comprising steps of synthesizing one or more nanoparticles from precursors of one or more metal oxides by utilizing plant-based extracts and agricultural waste, mixing precursors of one or more metal oxide at predetermined concentration and pH level to obtain a nanocomposite mixture, dissolving chitosan in an acetic acid solution, embedding the nanoparticles into a chitosan matrix, cross-linking the nanoparticles with the chitosan matrix and extending the nanocomposite mixture to form a multi-layered film.

The invention discloses a photo-thermal controlled-release multifunctional nanoparticle as well as a preparation method and application thereof. Through electrostatic adsorption and coating modification strategies, copper sulfide and catechin carbon dots are combined through electrostatic interaction, and the temperature control coating of lauric acid and stearic acid is used for packaging. Through layer-by-layer structural design, the nano-enzyme can realize photo-thermal controllable release on a wound surface and exert a multifunctional synergistic curative effect. Under the irradiation of near-infrared light, copper sulphide generates a photothermal effect to melt the coating, catechin carbon dots are released to play an anti-inflammatory role, and excessive inflammation of the wound surface is regulated; the core copper sulphide gives play to the activity of superoxide dismutase and peroxyperhydrogenase, superoxide anions and hydrogen peroxide are removed, and oxygen is generated, so that the effects of resisting oxidation, relieving tissue hypoxia and improving the microenvironment are synergistically achieved. The nano enzyme provided by the invention provides an innovative solution for efficient treatment of diabetic wounds through the synergistic effect of multiple mechanisms of inflammation resistance, oxidation resistance and vascular regeneration promotion.

The invention discloses a multifunctional cast film surface treatment method based on a nano-coating, relates to the technical field of cast film surface treatment, and aims to solve the problems that most of existing multifunctional cast film surface treatment methods are directly carried out through a hot melting mixed material method, so that the function is fixed after a cast film is formed, and the service life of the cast film is prolonged. In order to solve the problems that in the prior art, the temperature of an integrally formed cast film is fixed and cannot be adjusted according to actual conditions, the forming effect of an added material is reduced and the compounding effect of the added material is poor due to the fact that the temperature of the integrally formed cast film is fixed and cannot be adjusted according to a corresponding material, the main points of the technical scheme are as follows: S1, cleaning a base film of the cast film; s2, surface treatment of a base film of the cast film; s3, blending the nano particles for the first time; s4, carrying out secondary blending on the nano particles; and S5, drying and curing. The effect that the cast film can have corresponding nano particles after being formed is achieved, the overall forming effect is improved, and the multifunctional nano particle adding effect is achieved.