59 results about "Multifunctional nanoparticles" patented technology

Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods for using the conjugates to deliver therapeutic and / or imaging agents to cells. Also disclosed are methods for using the conjugates to treat particular disorders, such as proliferative disorders.

Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

The invention provides a variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 nano-short rod particle and a preparation method thereof. The method consists of: firstly making solid colloidal tungstic acid as a tungsten source, mixing the tungsten source with an M source, an appropriate solvent and an inducing agent, adding a proper amount of a variable valency metal A salt, and carrying out thermal reaction to synthesize the variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 multifunctional nanoparticle. The synthesized Ax-MyWO3 nano-short rod particle has excellent visible light permeability and near-infrared shielding performance and photothermal conversion ability, can be widely used for preparation of glass transparent thermal insulation paint, transparent and heat insulation compounds, photothermal absorbing coatings, solar thermal collectors, solar water heater coatings, heating fiber and photothermal therapy nanoparticles, etc. At the same time, the synthesized variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 nano-short rod particle also has excellent photocatalysis ability, and can be widely applied to the photocatalytic degradation field of organic pollutants.

The invention discloses a multifunctional nanosized ferrite composite material with a double-shell structure and a preparation method of the multifunctional nanosized ferrite composite material. The composite material is prepared from spinel type nanosized ferrite as a nucleus, silicon dioxide as an intermediate layer and titanium dioxide as an outer shell layer. With adoption of the intermediatelayer, on one hand, chemical stability of a magnetic nucleus of the nanosized ferrite can be improved and the applicable range of the material can be extended, and on the other hand, influence of themagnetic nucleus on performance of the outer shell layer is prevented; the outer shell layer not only can endow the material with special characteristics of light, electricity, catalysis and the like,but also can be integrated with the characteristics of the magnetic nucleus, so that multifunctional nanoparticles are obtained. The preparation method mainly comprises steps as follows: a three-stepsol-gel method for material preparation, surface modification with function of improving dispersity and coating effect, ball milling, heat treatment process under atmosphere control and the like. Thenanosized ferrite particles with the double-shell structure have the advantages of relatively good dispersity, high specific surface area, tight combination of the shell layer and the nucleus; meanwhile, the application field of the material can be further expanded by modification of the shell layer.

The present disclosure provides multifunctional nanoparticles. More particularly, the present disclosure relates to multifunctional nanoparticles having one or more of nucleic acid ligands; and methods of using such nanoparticles for treatment and / or diagnosis of diseases and conditions.