59 results about "Multifunctional nanoparticles" patented technology

Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

Compositions containing multifunctional nanoparticles are provided. The compositions are the reaction product of fluoroelastomer having at least one cure site, and the reaction product of nanosilica with more than one type of silane coupling agent. The compositions can be used to form abrasion resistant anti-reflective coatings.

The present invention involves multifunctional nanoparticle dispersions and methods for making them using sol-gel chemistry, doping, and sonication. These methods avoid the high thermal budget processes of the reference art. The dispersions can accommodate greater concentrations of nanoparticles, dopants, and ions than has previously been possible since these components can be added during synthesis. The unique optical, magnetic, luminescent, metallic, insulating, semi-conducting, and/or conducting properties of these particles can be utilized to enhance photovoltaic cells, portable electronic devices, and biomedical techniques among other applications.

Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are useful for the targeted delivery of antitumor agents and imaging agents to tumors in vivo. Methods are also disclosed for detecting and treating such tumors.

The invention provides a variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 nano-short rod particle and a preparation method thereof. The method consists of: firstly making solid colloidal tungstic acid as a tungsten source, mixing the tungsten source with an M source, an appropriate solvent and an inducing agent, adding a proper amount of a variable valency metal A salt, and carrying out thermal reaction to synthesize the variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 multifunctional nanoparticle. The synthesized Ax-MyWO3 nano-short rod particle has excellent visible light permeability and near-infrared shielding performance and photothermal conversion ability, can be widely used for preparation of glass transparent thermal insulation paint, transparent and heat insulation compounds, photothermal absorbing coatings, solar thermal collectors, solar water heater coatings, heating fiber and photothermal therapy nanoparticles, etc. At the same time, the synthesized variable valency metal catalyzed and doped tungsten bronze Ax-MyWO3 nano-short rod particle also has excellent photocatalysis ability, and can be widely applied to the photocatalytic degradation field of organic pollutants.

The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member.

Disclosed herein are multifunctional nanoparticles, comprising: polymer nanoparticles formed by loading a drug into a polymer; a gold thin film deposited on a portion of the surface of the polymer nanoparticles; and an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered, the antibody being conjugated to the gold thin film. Also disclosed is a method for preparing multifunctional nanoparticles, the method comprising the steps of: loading a drug into a polymer to prepare polymer nanoparticles; depositing a portion of the surface of the polymer nanoparticles with a gold thin film; conjugating to the gold thin film an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered; and separating from the resulting nanoparticles those in which a portion of the surface of the polymer nanoparticles is deposited with the gold thin film and conjugated with the antibody. Furthermore, disclosed are a composition containing the multifunctional nanoparticles and a method for diagnosing and treating disease using the composition.

The invention relates to the technical field of biological medicine and discloses a targeting multifunctional nanoparticle wrapping IR780. The targeting multifunctional nanoparticle comprises a polylactic acid-glycolic acid copolymer PLGA shell and the IR780 iodide embedded into the polylactic acid-glycolic acid copolymer PLGA shell, wherein a cyclic arginyl-glycyl-aspartic acid cRGD targeting peptide fragment is connected to the polylactic acid-glycolic acid copolymer PLGA shell. By the targeting multifunctional nanoparticle, the problems that tumor is prone to relapse and the treatment effect is poor due to the fact that the nanoparticles are not uniformly distributed on a tumor part in the prior art are solved.

Method for labeling and detecting liver cancer cells using an anti-glycipan-3 antibody as a targeting agent and a magnetic nanoparticle as an imaging agent.

The present invention relates to silica capsules having nano-holes or nano-pores on the surface thereof, and preparation methods thereof. More specifically, relates to silica capsules having holes with a size ranging from a few nanometers (nm) to a few hundreds of nanometers (nm), on the surface thereof, multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles, and preparation methods thereof. According to the present invention, the silica capsules having holes on the surface thereof can be prepared by making an emulsion system using two fluids having different surface tensions, and selectively evaporating only one fluid of the two fluids during a process of forming a silica layer. In addition, the multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles can be prepared by loading various multifunctional nanoparticles into the two fluids.

The invention provides a nanoparticle for delivery of therapeutic agents, comprising a polymeric nanosphere and one or more detection agents, said detection agents for use in detecting the location of the nanoparticle. The invention further provides a transfection agent comprising an aforementioned nanoparticle.

The invention relates to a multifunctional nanoparticle for tumor fluorescence imaging and photothermal/photodynamic therapy, and relates to a preparation method of the multifunctional nanoparticle and applications of the multifunctional nanoparticle in tumor diagnosis and treatment. structure diagram of the multifunctional nanoparticle for the tumor fluorescence imaging and photothermal/photodynamic therapy is represented by a figure which is shown in the description. Membrane components of the multifunctional nanoparticle include near infrared dyes used for fluorescence imaging and photothermal therapy, lipids containing photosensitizer functional groups and used for photodynamic therapy and conventional phospholipids. A ratio of photothermal and photosensitive medicine can be regulatedaccording to needs, and the medicine loading amount is greatly increased. Under the guidance of near-infrared fluorescence, photothermal and photodynamic therapy are combined to inhibit the growth oftumors so as to improve the treatment efficiency of the tumors.

The invention discloses a multifunctional organic fluorescent nanoparticle based on diketopyrrolopyrrole compounds and tetraphenyl ethylene compounds as well as preparation and application. The multifunctional organic fluorescent nanoparticle is formed by diketopyrrolopyrrole compounds and tetraphenyl ethylene compounds through molecular self-assembly. The multifunctional nanoparticle is high in stability, simultaneously has double-fluorescence emission and double-photon excitation induction fluorescence emission capabilities, is capable of achieving detection of ratio type Hg<2+> and dual-mode (double channels and double photons) cell imaging, and can be widely applied to the fields such as environmental engineering, biological imaging, biological medicines and the like.

The invention relates to targeted multifunctional nanoparticles and a preparation method and application thereof, and belongs to the technical field of biological medicines. The targeted multifunctional nanoparticles are prepared by an ultrasonic double-emulsification method, covalent binding is carried out by branching PEI and PLGA, PLGA nanoparticles which have negative charge originally are modified into kation nanoparticles with positive charge, plasmids can be adsorbed effectively, it ensures that the plasmid cannot drop due to physical effect in a circulation system, and after the plasmid enters cells, the possibility that the plasmid is degraded by endoenzyme is also reduced. The nanoparticles further contain IR780 which can target tumor cell mitochondria, meanwhile, by strong fluorescent light and photosensitizer characteristics of IR780, the nanoparticles become a great fluorescent and photoacoustic imaging medium, and thus, tumors can be convenient to observe. The nanoparticles can carry drug to facilitate combination with transgenic therapy, tumor cells are killed favorably, and furthermore, toxic and side effects of chemotherapy drugs can further be reduced. The preparation method of the targeted multifunctional nanoparticles is simple, is easy to operate, and is suitable for expanded production.

The invention discloses a multifunctional nanoparticle preparation capable of preventing drug tolerance and a preparation method thereof. The preparation method comprises the following steps of: dissolving docetaxel and perifosine and a copolymer in an organic solvent to serve as an oil phase; regarding a PVA solution as an aqueous phase; dripping the oil phase into the aqueous phase at the presence of ultrasound ice-bath to obtain a mixed emulsion; performing reduced pressure distillation to remove the organic solvent; carrying out centrifugal treatment; re-dissolving collected nanoparticle after water-washing; and carrying out vacuum freeze drying to obtain the nanoparticle preparation. The prepared multifunctional nanoparticle preparation has good grain size, good encapsulation efficiency and good drug loading capacity, and can improve cytotoxicity and cell intake amount efficiently.

The present disclosure provides multifunctional nanoparticles. More particularly, the present disclosure relates to multifunctional nanoparticles having one or more of nucleic acid ligands; and methods of using such nanoparticles for treatment and/or diagnosis of diseases and conditions.

Provided is a method of preparing a stimuli-responsive multifunctional nanoparticle, including in sequence the steps of: (a) conjugating covalently an active targeting moiety to a hydrophilic polymer to form a targeted polymer, (b) conjugating covalently a redox-responsive moiety to the hydrophilic polymer of the targeted polymer to form a targeted redox-responsive polymer, (c) conjugating covalently a pH-responsive moiety of a drug complex to the redox-responsive moiety of the targeted redox-responsive polymer to form a targeted stimuli-responsive polymer-drug conjugate, wherein the drug complex includes a hydrophobic drug covalently linked to the pH-responsive moiety, and (d) adding the targeted stimuli-responsive polymer-drug conjugate and optionally an imaging agent into an aqueous liquid to allow self-assembly into a stimuli-responsive multifunctional nanoparticle, wherein the hydrophobic drug of the stimuli-responsive multifunctional nanoparticle forms a hydrophobic core, and the imaging agent is incorporated within the hydrophobic core.

The invention provides a preparation method of rare earth fluoride/poly-azobenzene/N-isopropyl acrylamide composite multifunctional nano-particles. The composite multifunctional nano-particle is provided with a yolk structure, and has the intelligent response characteristic due to the dual-responsiveness of a shell layer; the yolk structure enables the nano-particle has sufficient storage space, thereby realizing the effective load and controllable release of the anti-tumor medicine. The method comprises the following steps: 1) synthesis of homogeneous rare earth nuclear shell nano-particle; 2) cladding a silica layer with shell layer thickness of about 15nm through a reverse micro-emulsion method; 3) preparing dual-responsive shell by taking photo-responsive azobenzene as crosslinking agent and N-isopropyl acrylamide as the monomer; and 4) preparing the multifunctional nano-particle of the yolk structure with inner core as the rare earth nano-particle and the shell as the dual-responsive shell layer through a HF etching silica layer. The multifunctional rare earth nano-particle provided by the invention can be applied in the biological medicine field to a certain degree.

The invention belongs to the field of biological medicines and discloses an alveolar macrophage-like multifunctional nanoparticle loaded with an aggregation-induced emission photothermal material anda preparation method and use of the alveolar macrophage-like multifunctional nanoparticle. The nanoparticle is obtained by taking an aggregation-induced emission photosensitive molecule 2TPE-2NDTA anda polylactic acid/glycollic acid copolymer as a co-carrier to form a core of a nano-drug and coating the 2TPE-2NDTA and the polylactic acid/glycollic acid copolymer with an alveolar macrophage membrane through a design and synthesis. The nanoparticle also has a characteristics of a photo-thermal agent and can be excited by near-infrared laser, and generated heat is used for photo-thermal killingof novel coronaviruses. Meanwhile, since the alveolar macrophage membrane on an outer layer of a nano-drug has related receptors on a surface, the nano-drug can adsorb SARS-CoV-2 and cytokines, so that a purpose of resisting a cytokine storm is achieved. The alveolar macrophage-like multifunctional nanoparticle can also solve a disadvantage and a deficiency of a poor curative effect in a traditional antiviral treatment scheme and becomes a new antiviral treatment strategy.

The invention relates to the technical field of nano atherosclerotic plaque treatment drugs and imaging agents, in particular to targeted ferrite-loaded multifunctional nanoparticles as well as a preparation method and application thereof. Each targeted ferrite-loaded multifunctional nanoparticle comprises a shell formed by a polylactic acid-glycolic acid copolymer, and spinel ferrite and hematoporphyrin monomethyl ether are wrapped in the shell. According to the scheme, the technical problem that the safety and sensitivity of an existing imaging agent cannot meet the detection requirements of the atherosclerotic vulnerable plaques is solved. The nanoparticle is an MRI (Magnetic Resonance Imaging), opto-acoustic and ultrasonic imaging agent with relatively ideal safety and sensitivity, and can be used for detecting and identifying atherosclerosis vulnerable plaques; and the nanoparticles can also be used for effectively intervening artery plaque neovascularization through a sonodynamic therapy, and can be used in medical practice of early recognition and treatment of atherosclerotic plaque neovascularization.

The invention relates to the technical field of nano-drug presentation systems and contrast agents, in particular to multifunctional nanoparticles based on a metal organic framework as well as a preparation method and application of the multifunctional nanoparticles. A multifunctional nanoparticle based on a metal organic framework comprises the metal organic framework, and the metal organic framework is loaded with a medicine AQ4N activated under an anoxic condition and is modified with polydopamine. The nanoparticle can solve the technical problem of unsatisfactory curative effect caused by oxygen deficit of tumor tissues in the process of pure photo-thermal or photodynamic therapy, is a multi-stimulus inertial response nano system, and can overcome the inherent defects of multiple biological obstacles and a single-stimulus response system; the method has great application value in noninvasive diagnosis and treatment of tumors.