Multifunctional nanoparticle based on metal organic framework as well as preparation method and application of multifunctional nanoparticle

A metal-organic framework and multi-functional technology, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, nanotechnology, etc., can solve the problems of easy activation of cancer cells and unsatisfactory curative effect, and achieve optimal treatment The effect of the program
CN114344482AActive Publication Date: 2022-04-15THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
Publication Date
2022-04-15

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Abstract

The invention relates to the technical field of nano-drug presentation systems and contrast agents, in particular to multifunctional nanoparticles based on a metal organic framework as well as a preparation method and application of the multifunctional nanoparticles. A multifunctional nanoparticle based on a metal organic framework comprises the metal organic framework, and the metal organic framework is loaded with a medicine AQ4N activated under an anoxic condition and is modified with polydopamine. The nanoparticle can solve the technical problem of unsatisfactory curative effect caused by oxygen deficit of tumor tissues in the process of pure photo-thermal or photodynamic therapy, is a multi-stimulus inertial response nano system, and can overcome the inherent defects of multiple biological obstacles and a single-stimulus response system; the method has great application value in noninvasive diagnosis and treatment of tumors.
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Description

technical field

[0001] The invention relates to the technical field of nano drug delivery system and contrast agent, in particular to a multifunctional nano particle based on metal organic framework and its preparation method and application. Background technique

[0002] Light-based therapeutic approaches such as photothermal therapy (PTT) and photodynamic therapy (PDT) have gained popularity in cancer treatment due to their non-invasiveness, high spatiotemporal precision, controllability, negligible drug resistance, and localized treatment. received widespread attention. Although light-based therapeutics have received extensive attention in cancer treatment, how to improve the specificity and effectiveness of this therapeutic approach remains a great challenge. The abnormal physical and chemical tumor microenvironment, hypoxia, and acidic pH value caused by tumor autologous disorders and irregular blood vessel distribution induce or participate in the generation of drug r...

Claims

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