35results about How to "Achieving Photodynamic Therapy" patented technology

The invention provides a compound nano graphene oxide drug carrier, which is the drug carrier is used for combining a natural anti-neoplastic extract wedelolactone and a photosensitizer indocyanine green to the surface of the nano graphene oxide through Phi-Phi stacking interaction. A preparation method of the compound nano graphene oxide drug carrier comprises the following steps: graphene oxideis processed through an ultrasonic method, the nano graphene oxide is obtained, the Phi-Phi stacking interaction is used, and wedelolactone and indocyanine green are loaded on the surface of the nanographene oxide in order. The preparation method is simple, the particle size of the nano graphene oxide is controlled at 100-200 nm, cycle time of the drug carrier in body can be prolonged, the compound nano graphene oxide drug carrier can absorb 600-900 nm near infrared, luminous energy is transformed to heat energy, photo-thermal treatment is realized, under irradiation of 808 nm near infrared,active oxygen is generated, and a purpose of photodynamic therapy is realized.

The invention provides a PDT compound and its preparation method and application. Stable complexes are formed by axial ligands, ionic ligands, and structurally adjusted porphyrin compounds, so that the absorption spectrum of the compound is red-shifted, and a compound with strong phototoxicity, large tissue penetration depth, and good biocompatibility is obtained. PDT compounds also have both photothermal effect and fluorescence properties, which help to improve the therapeutic effect and reduce the damage of photodynamic therapy to the body.

The invention relates to a nanoparticle (Apt-TNP) for integration of breast cancer diagnosis and treatment and a preparation method thereof. The Apt-TNP utilizes polylactic acid-polyethylene glycol as a carrier, the interior of the Apt-TNP is embedded with a pH-responsive fluorescent probe BDP-688 and a near-infrared photosensitizer R16FP, and the surface of the Apt-TNP is covalently coupled with a breast cancer-specific aptamer. The Apt-TNP can specifically bond with breast cancer cells and reach to lysosome, the lysosome triggers the BDP-688 in an acidic pH environment so that fluorescence is produced and accurate imaging of cancer cells is realized. The R16FP is activated by laser having wavelength of 808nm and produces active oxygen, and release of cathepsin in lysosome is initiated so that cancer cell apoptosis is realized and photodynamic therapy is realized. Cell apoptosis develops along with pH change so that BDP-688 fluorescence is reduced and real-time monitoring of curative effects is realized. The Apt-TNP has functions of breast cancer targeting imaging, high-efficiency treatment and curative effect monitoring and has a good clinical application potential.

The invention relates to a mesoporous silica nanoparticle having a two-photon absorption function and a preparation method and application thereof. The preparation method includes: cross-linking amino-functionalized polyglycerol with fluorescein, performing purifying to obtain fluorescein-modified polyglycerol, absorbing silica precursor, and performing hydrolysis, solid-liquid separation, washing and drying to obtain the mesoporous silica nanoparticle having the two-photon absorption function. The invention further provides a pharmaceutical composition prepared with the mesoporous silica nanoparticle; the pharmaceutical composition comprises a photosensitive pharmaceutical carried on the mesoporous silica nanoparticle. The preparation method is simple, conditions are mild, the cost is low, and no toxic or harmful matters occur to a reaction process; the prepared nanoparticle has regular shape, moderate pore diameter density and particle size and good dispersity and enables fluorescence to rarely quench; the pharmaceutical enables resonance transfer of fluorescence energy under stimulation of two photons and enters deep in in-vivo tumor tissues for treatment.

The invention relates to a lysosome-targeted photosensitizer, a synthesis method and an application in biological imaging. The lysosome-targeted photosensitizer (MP-TPEDCH) is formed by linking MP as a lysosome-targeting group and TPEDCH as a photosensitive molecule through a synthetic reaction. The lysosome-targeted photosensitizer can spontaneously and stably fluoresce through the aggregation-induced effect in aqueous media. Under laser irradiation, it is excited to transfer electrons to surrounding oxygen molecules to generate reactive oxygen species, resulting in strong cytotoxicity and killing Tumor cells for photodynamic therapy. The present invention also relates to a method for synthesizing the lysosome-targeted photosensitizer, and its use in biological imaging.