A preparation method and application of glutathione-responsive Berlin Green nanoparticles

A nanoparticle, glutathione technology, applied in the direction of wave energy or particle radiation treatment materials, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve the problem of reducing the effect of photodynamic therapy and limiting tumors. Phototherapy effect and other issues, to achieve the effect of good photothermal conversion efficiency, rich source of raw materials, and optimized dispersibility

Active Publication Date: 2021-02-19
GUANGXI NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Glutathione (GSH), as an overexpressed substance in the tumor microenvironment, severely limits the effect of tumor phototherapy, especially for photodynamic therapy
Due to the overexpression of GSH, GSH traps the generated reactive oxygen species, which greatly reduces the therapeutic effect of photodynamic therapy.

Method used

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  • A preparation method and application of glutathione-responsive Berlin Green nanoparticles
  • A preparation method and application of glutathione-responsive Berlin Green nanoparticles

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Experimental program
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Embodiment

[0032] To prepare glutathione-responsive Berlin Green nanoparticles, pre-preparation: Weigh 6.0 g of polyvinylpyrrolidone, add 100 ml of water, and divide into two parts evenly after dissolution;

[0033] S1. Weigh 0.1645 g potassium hexacyanoferrate K 3 [Fe(CN) 6 ] Add one part of the above-mentioned dissolved polyvinylpyrrolidone aqueous solution, stir to dissolve, and obtain the mixed solution A;

[0034] S2. Weigh 0.127 g ferric chloride FeCl 3 Add another part of the above-mentioned dissolved polyvinylpyrrolidone aqueous solution, stir and dissolve to obtain the mixed solution B;

[0035] S3. Slowly add the mixed solution B to the mixed solution A, stir at room temperature, and react for 72 h to obtain an aqueous solution containing Perlin Green nanoparticles;

[0036] S4. Add 40 mL of acetone to the prepared green solution, and centrifuge with a centrifuge to obtain a green solid C;

[0037] S5. Wash the green solid C with distilled water, then centrifuge, and repeat...

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Abstract

The invention discloses a preparation method and application of glutathione-responsive berlin green nanoparticles. During preparation, polyvinylpyrrolidone aqueous solution, potassium hexacyanoferrate and iron salt are used to synthesize glutathione-responsive berlin green nanoparticles in one step. Green nanoparticles. The preparation method of the invention is simple and convenient to operate, and the raw materials are safe and easy to obtain. The prepared perlin green nanoparticles have low cytotoxicity, good biocompatibility and good dispersibility in aqueous solution. At the same time, under the incubation of glutathione, it shows enhanced absorption in the near-infrared region, with enhanced photothermal conversion efficiency. The perlin green nanoparticles prepared by the invention can be used for glutathione response-enhanced photothermal and photodynamic therapy in the tumor microenvironment, and have broad application prospects in the field of cancer treatment.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a preparation method and application of glutathione-responsive perlin green nanoparticles. Background technique [0002] Tumor, as a new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors, has a complex microenvironment. Developing cancer therapeutics around the tumor microenvironment has attracted a lot of attention in recent years. Glutathione (GSH), as an overexpressed substance in the tumor microenvironment, severely limits the effect of phototherapy on tumors, especially for photodynamic therapy. Due to the overexpression of GSH, GSH traps the generated reactive oxygen species, which greatly reduces the therapeutic effect of photodynamic therapy. Therefore, the development of new nanomaterials with simple preparation, low cost, stable structure, reliable biological safety, and GSH responsive reagents for consuming ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/32A61P35/00
CPCA61K9/5138A61K41/0052A61K41/0057A61P35/00
Inventor 沈星灿周波蒋邦平
Owner GUANGXI NORMAL UNIV
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