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A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. Viruses are infectious agents that can replicate in their host organism, however virosomes do not replicate. The properties that virosomes share with viruses are based on their structure; virosomes are essentially safely modified viral envelopes that contain the phospholipid membrane and surface glycoproteins. In clinically designed virosomes, the viral genetic material are substituted with therapeutic agents. As a drug or vaccine delivery mechanism they are biologically compatible with many host organisms and are also biodegradable. The use of reconstituted virally derived proteins in the formation of the virosome allows for the utilization of what would otherwise be the immunogenic properties of a live-attenuated virus, but is instead a safely killed virus. A safely killed virus can serve as a promising vector because it won’t cause infection and the viral structure allows the virosome to recognize specific components of its target cells.
Spleen cell line of ptereleotris punctatus and application thereof
PendingCN122256249AViral antigen ingredientsMicrobiological testing/measurementLeopardus colocoloGermplasm
The application discloses a Plectropomus leopardus spleen cell line and application thereof. Plectropomus leopardus The spleen cell line PLS has a preservation number of GDMCC No: 68131. The PLS is obtained through primary culture and multiple subculture, has a fast cell growth speed, has been stably subcultured for more than 60 generations, has good activity after cryopreservation, and lays a foundation for Plectropomus leopardus gene germplasm resource preservation. Meanwhile, the PLS is sensitive to fish nervous necrosis virus and iridovirus, can be applied to exogenous gene function research, fish virus isolation, virus infection pathogenesis, virus host interaction and virus in-vitro infection model, and provides a high-efficiency amplification system for Plectropomus leopardus virus vaccine preparation.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY
Regulatory nucleic acid sequences
The present invention relates to regulatory nucleic acid sequences, in particular CNS-specific promoters, and elements thereof. The present invention also relates to expression constructs, vectors, virions, pharmaceutical compositions, and cells comprising such promoters, and methods of their use. The regulatory nucleic acid sequences are particularly useful for gene therapy applications.
Owner:ASKBIO INC