51results about How to "Treatment effect" patented technology

Methods and devices for measuring the size of a body lumen and a method for ablating tissue that uses the measurement to normalize delivery of ablational energy from an expandable operative element to a luminal target of varying circumference are provided. The method includes inserting into the lumen an expandable operative element having circuitry with resistivity or inductance that varies according to the circumference of the operative element, varying the expansion of the operative element with an expansion medium, measuring the resistivity of the circuitry, and relating the resistivity or inductance to a value for the circumference of the operative element. In some embodiments the sizing circuit includes a conductive elastomer wrapped around the operative element. Other embodiments of the method apply to operative elements that include an overlapping energy delivery element support in which the overlap varies inversely with respect to the state of expansion, and which is configured with sizing electrodes that sense the amount of the overlap.

A transdermal drug administration system with microneedles which can perforate the skin (stratum corneum) by a simple operation at the time of transdermal administration of a physiologically active substance (drug) is provided. The present transdermal drug administration system with microneedles comprises microneedle device (50) having a plurality of microneedles (51) which can perforate the skin and a plurality of solution passages (52); absorbent (11) which is disposed on microneedle device (50), comprising dried drug (10) and a material which can absorb liquid; and dissolution liquid reservoir (18) which is disposed on absorbent (11) and stores dissolution liquid (16) for dissolving drug (10) and in which a diaphragm (20) provided between absorbent (11) can be broken by pressing. Dissolution liquid reservoir (18) is pressed to break diaphragm (20), and at the same time, the microneedle (51) perforates the skin (stratum corneum), and drug (10) dissolved in dissolution liquid (16) is transmitted through microneedle device (50) to the skin.

The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.

A method of connecting a terminal fitting and an electric wire, includes the steps of: providing a terminal fitting; providing an electric wire in which a core wire is covered with an insulating sheath; providing a conductive connecting member formed with an insertion hole; inserting the electric wire into the insertion hole of the connecting member; compressing the connecting member radially inwardly so as to caulk an inserted portion of the electric wire uniformly over a whole periphery thereof; and welding the connecting member and the terminal fitting by applying ultrasonic wave.

The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.

A process of removing SO2 from a flue gas with a trickling filter using modified ceramsite packing is described. The biological flue gas desulfurization process includes: feeding the flue gas containing sulfur dioxide through the column bottom into the biomembrane trickling filter at certain temperature, contacting with the modified ceramsite biomembrane packing and purifying, which purified flue gas is discharged via the column top; and spraying the nutrient fluid rich in high concentration of the desulfurization strain through the top to the modified ceramsite biomembrane packing, thereby the sulfur-bearing pollution source in the flue gas is degraded, so as to discharge a purified flue gas satisfying the environmental requirements.

The present invention provides a process, which allows working with viscous petroleum referred to as “heavy and extra heavy crudes” by adding an appropriate biosurfactant to an aqueous phase containing a biosurfactant active compound. The result is the formation of a stable crude / water emulsion even with salt present therein.

The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved Artemisinin Combination Therapy, known as Tri-ACT. The improved ACT therapy includes administering a combination of three drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is administered to the individual.

The use of extract form Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by β-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

A topical formulation for application to exposed body tissue, the formulation comprising a silver(II) oxide and zinc oxide, intimately dispersed within a carrier medium.

The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

A veterinary injection of berberine sulfate for treating the infectious dycentery, diarrhea and fever of pig is prepared through heating water to 40-80 deg.C, proportionally adding berberine sulfate, stirring while dissolving, adding activated carbon, stirring, laying aside, dissolving the glucose for injection in water at 30-70 deg.C, mixing it with said solution, and adding the water for injection proportionally.

Disclosed is a medicine for treating fatty liver which is prepared from root of herbaceous peony, oriental water plantain rhizome, polyporus umbellatus, poria cocos, oriental wormwood, talcum powder, donkey-hide gelatin, fructus garedeniae, rhubarb horsetails and coix seed. The medicament is prepared into the form of granular powder with the advantages of good taste and easy administering.

Disclosed is a composition for use in the prevention of a hypoglycemic condition, which comprises at least one compound selected from a branched amino acid, a pharmaceutically acceptable salt thereof and a derivative of the amino acid or salt as an active ingredient. The composition can promote the uptake of a saccharide into a brain cell to thereby prevent a hypoglycemic condition.

Interleukin-15 muteins and other interleukin-15-related molecules are described, as well as methods of identifying interleukin-15 muteins and other interleukin-15-related molecules. Also described herein are modifications of the foregoing, which modifications may enhance a property (e.g., half-life) of the muteins or other molecules compared to human interleukin-15. Pharmaceutical compositions and methods of use are also described herein.

The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I),their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

The invention discloses a suppository for treating vaginitis, which comprises the following components in ratio by weight: 0.001 to 0.02 percent of musk, 5 to 15 percent of radix polygalae, 15 to 25 percent of psoralea, 15 to 25 percent of rhubarb, and 45 to 50 percent of glycerin fatty acid ester. The invention also discloses a method for preparing the suppository for treating the vaginitis. The invention further discloses a method for using the suppository for treating the vaginitis. The suppository for treating the vaginitis clears away heat and toxic materials, kills insects and relieves itching, and mainly treats trichomonas vaginitis with remarkable effect.

A compound of formula (I)wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Methods are provided for using antibodies that bind one or more cysteinyl leukotrienes (cysLTs) for treatment of diseases, including inflammatory diseases and asthma, associated with aberrant levels of one or more cysLTs. Anti-cysLT antibodies and antigen-binding antibody fragments, and compositions containing such antibodies and antibody fragments, are also provided.

The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods of producing a neural cell by causing a marrow stromal cell to differentiate into a neural cell by increasing intracellular levels of cyclic AMP. Methods for treating a human patient in need of neural cells are also disclosed, as well as methods for treating a human patient having a disease, condition, or disorder of the central nervous system.

The invention provides a slice electrode which is small, exquisite and reasonable in shape design, convenient to use and multiple in function. The thickness of the slice electrode is only 2mm, and the slice electrode is of a lampshade-type shape and is formed by electrode slices and wire ports. Conducting strips, insulating strips and a heating device are arranged in a slice electrode body and connected with wires on the outside, a temperature sensor is installed between the insulating strips and the conducting strips, and the two ends of the temperature sensor are connected with a terminal through wires; the inner side of the slice electrode body is provided with heat dissipation overlapping curves which have a temperature control function and are capable of fully emitting local heat so that the slice electrode can be more convenient, more comfortable and safer to use. In the mastopathy treating process, the slice electrode can be directly put into a bra for treatment next to the skin; adjustable diagnosis models of electrical stimulation include high-frequency waves, acupuncture waves, sparse waves, fluctuant waves, discontinuous waves, audio waves and fluctuant and discontinuous waves; different therapeutic schedules can be set according to different symptoms, and the medical multi-function slice electrode has remarkable curative effects especially on female mastopathy.

The invention provides a medicament for curing chronic aplastic anemia and a preparation method thereof. The medicament is prepared by the following raw materials: purple beautyberry, notoginseng, ginseng, wolfberry fruit, donkey-hide gelatin beads, Chinese caterpillar fungus, prepared rehmannia root, white atractylodes rhizome, dogwood fruit, rhizoma discoreae, Chinese angelica, honey, and the like, and according to the characteristics of different tastes, channel tropism, function and principle indications of all the Chinese medicinal herbs, the Chinese medicinal herbs are respectively screened, processed according to the weight (portion) proportion, dried, crushed, melted, evenly mixed and milled into honeyed pills, and the sterilization and the packaging by vacuum film pressing are performed to the honeyed pills. The medicament has good effect for curing the chronic aplastic anemia, is convenient to safely and efficiently take by patients who do not need to suffer from blood transfusion and bone morrow transplantation and take hormone medicine, has low treatment cost, and the like.

The invention discloses a method for rapidly preparing and screening candida albicans-resistant medicines with an unsaturated fatty acid structure. A structure of an analogue or a derivative of a class of the candida albicans-resistant medicines is represented by a formula (II), wherein R1 represents one of linear alkyl, terminal hydroxyl or sulfydryl-substituted alkyl, oligomeric polyethylene glycol or 1,4-alkyl piperazine; R2 represents one of hydroxyl, amino and methoxyl; and the characters of the medicines are screened by virtue of a bactericidal experiment. The invention discloses a preparation method and a screening method of synthesized medicines. According to the preparation method and the screening method, the development cost of a new medicine can be lowered, and the detection efficiency of the new medicine can be effectively improved.

Use of cell autophagy (type II cell apoptosis) inhibitors for preventing and / or treating avian influenza, injury of lungs caused by avian influenza virus or nanometer materials. The cell autophagy (type II cell apoptosis) inhibitors are selected from 3-methyladenine, SB203580, LY294002, and or wortmannin. The injury of lungs includes acute respiratory distress syndrome. The avian influenza virus is H5N1, H5N2 or H9N2 avian influenza virus. The nanometer materials include PAMAM G3, G4, G5, G5.5, G6, G7, or G8.

The invention relates to the field of medical instruments, in particular to a medical device for a trauma operation of the general surgery department. The device comprises a bed board, a second bearing and a third bearing, wherein four sets of supporting legs are symmetrically arranged at four corners of the bottom end of the bed board; supports are fixedly connected to the bottom ends of the supporting legs; two sets of T-shaped sliding grooves are symmetrically formed in the front side and the rear side of the bed board; T-shaped sliding blocks are slidably connected into the T-shaped sliding grooves; six sets of binding belt fixing assemblies are fixedly connected to the outer side ends of the T-shaped sliding blocks; first fixing binding belts are fixedly connected to the binding beltfixing assemblies on the left side and the right side, a four-limb fixing binding belt is fixedly connected to each of the front side and the rear side of the bottom end of each first fixing binding belt, a second fixing binding belt is fixedly connected to the binding belt fixing assembly in the middle portion, and a waist fixing binding belt is fixedly connected to the middle of the bottom end of the second fixing binding belt. The medical device for the trauma operation of the general surgery department provided by the invention can well fix limbs of a patient and can open a wound of the patient.

The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.

The invention relates to a method adopting a compound traditional Chinese medicine to treat uterine fibroid and uterine cancer. The method is characterized in that four prescriptions are combined and taken; a prescription 1 is prepared by adding water to seven fresh earthworms with the weight of 3-5g and boiling, and then is directly taken; a prescription 2 is prepared by taking 3-5 fresh Radix Asparagis every time and steaming, and is taken, or the prescription 2 is a Radix Asparagi capsule; a prescription 3 is prepared by taking 15-20g of Blaps rynchopetera Fairmaire, 15-20g of pine mushroom, 15-20g of Jiapi, 15-20g of porcupine quill, 15-20g of Radix Notoginseng, 8-12g of Rhizoma Paridis, 8-12g of centipede, 8-12g of scorpion, 8-12g of gecko, 3-6g of Spanish fly and 15-20g of fly maggot, and grinding to form powder, and is taken; and a prescription 4 is prepared by taking 15-20g of Goldhair Hedyotis Herb, 12-20g of Scutellaria barbata, 15-20g of Japanese Peristrophe Herb, 15-20g of Himalaya Nightshade, 15-20g of honeysuckle flower, 15-20g of Herba Plantaginis and 15-20g of Adiantum capillus-veneris L., adding water and decocting to obtain a soup, and the soup is taken. The treatment effect of the method is good.